Electrophilic Aromatic Trifluoromethylthiolation with the Second Generation of Trifluoromethanesulfenamide

Abstract Direct trifluoromethylthiolation of various aromatic and heteroaromatic compounds, variously substituted, can be performed with the second generation of trifluoromethanesulfenamide via a ‘Friedel–Crafts-like reaction’. This reaction requires mild conditions with a catalytic amount of protic...

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Bibliographic Details
Published in:Synlett 2015-01, Vol.26 (1), p.76-78
Main Authors: Alazet, Sébastien, Billard, Thierry
Format: Article
Language:English
Subjects:
Chemical Sciences
cluster
Organic chemistry
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Summary:Abstract Direct trifluoromethylthiolation of various aromatic and heteroaromatic compounds, variously substituted, can be performed with the second generation of trifluoromethanesulfenamide via a ‘Friedel–Crafts-like reaction’. This reaction requires mild conditions with a catalytic amount of protic or Lewis acid. Good results have been obtained, even with aromatic compounds bearing deactivating substituents.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0034-1379501