Binder liquid distribution during granulation process and its relationship to granule size distribution

The aim of this study is to characterize the impact of binder liquid distribution on granule properties during the wet granulation process. A new parameter, namely the binder liquid transfer coefficient, is used to characterize binder liquid distribution. The relationships between binder liquid dist...

Full description

Saved in:
Bibliographic Details
Published in:Powder technology 2009-10, Vol.195 (2), p.105-112
Main Authors: Smirani-Khayati, N., Falk, V., Bardin-Monnier, N., Marchal-Heussler, L.
Format: Article
Language:English
Subjects:
Agglomeration kinetics
Applied sciences
Binder liquid distribution
Binder liquid transfer coefficient
Chemical and Process Engineering
Chemical engineering
Engineering Sciences
Exact sciences and technology
Miscellaneous
Sintering, pelletization, granulation
Solid-solid systems
Wet granulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study is to characterize the impact of binder liquid distribution on granule properties during the wet granulation process. A new parameter, namely the binder liquid transfer coefficient, is used to characterize binder liquid distribution. The relationships between binder liquid distribution coefficient and granule size distribution are discussed. Granules are made of lactose alpha-monohydrate (97.5% w/w, d 50 = 31 μm) and polyvinylpyrrolidone (2.5% w/w, d 50 = 89 μm) and are manufactured in a Mi-Pro high shear mixer (Pro-C-epT, Belgium). Nigrosine is incorporated as a tracer in the binder liquid in order to detect its distribution in the granules during the process. The results show that the binder liquid is heterogeneously distributed at the beginning of the process whereas it tends to be evenly distributed in the powder during the process. The binder liquid transfer in granule classes obeys a first-order law and the binder liquid transfer coefficient appears to be related to operating conditions: high rotation speed, low liquid flow rate and low liquid viscosity favour the achievement of high liquid transfer coefficient. In addition, the higher the coefficient, the earlier the homogenization and the wider the granule mean diameters. Thus, granule size distribution can be controlled by the binder liquid distribution process. A binder liquid distribution mechanism is proposed, which makes it possible to discuss the influence of the operating parameters on the granule construction process. Relationships between the final d 50 of granules prepared by wet granulation and binder liquid transfer coefficient are established. Depending on the binder liquid formulation, the final d 50 of the granule population depends or does not depend on the binding liquid transfer coefficient which can be adjusted by changing the mixer rotation speed. [Display omitted]
ISSN:0032-5910
1873-328X
DOI:10.1016/j.powtec.2009.05.020