A[beta] Deposits in the Neocortex of Adult and Infant Hypoxic Brains, Including in Cases of COVID-19

The brain of a 58-year-old woman was included as a civilian control in an ongoing autopsy study of military traumatic brain injury (TBI). The woman died due to a polysubstance drug overdose, with Coronavirus Disease 2019 (COVID-19) serving as a contributing factor. Immunohistochemical stains for [be...

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Bibliographic Details
Published in:Journal of neuropathology and experimental neurology 2022-12, Vol.81 (12), p.988
Main Authors: Priemer, David S, Rhodes, Charles Harker, Karlovich, Esma, Perl, Daniel P, Goldman, James E
Format: Article
Language:English
Subjects:
Amyloid beta-protein
Autopsy
Brain
Causes of
Communicable diseases in children
Complications and side effects
Health aspects
Injuries
Methods
Neocortex
Organic mental disorder
Patient outcomes
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Summary:The brain of a 58-year-old woman was included as a civilian control in an ongoing autopsy study of military traumatic brain injury (TBI). The woman died due to a polysubstance drug overdose, with Coronavirus Disease 2019 (COVID-19) serving as a contributing factor. Immunohistochemical stains for [beta]-amyloid (A[beta]), routinely performed for the TBI study, revealed numerous, unusual neocortical A[beta] deposits. We investigated the autopsied brains of 10 additional young patients (
ISSN:0022-3069
1554-6578
DOI:10.1093/jnen/nlac095