Loading…
Assessing the Intense Influenza Apdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation
The COVID-19 pandemic had a profound impact on influenza activity worldwide. However, as the pandemic progressed, influenza activity resumed. Here, we describe the influenza epidemic of high intensity of the 2022–2023 season. The epidemic had an early start and peaked in week 51.2022. The extremely...
Saved in:
| Published in: | Viruses 2023-08, Vol.15 (8) |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | |
| container_issue | 8 |
| container_start_page | |
| container_title | Viruses |
| container_volume | 15 |
| creator | Sominina, Anna Danilenko, Daria Komissarov, Andrey B Pisareva, Maria Fadeev, Artem Konovalova, Nadezhda Eropkin, Mikhail Petrova, Polina Zheltukhina, Alyona Musaeva, Tamila Eder, Veronika Ivanova, Anna Komissarova, Kseniya Stolyarov, Kirill Karpova, Ludmila Smorodintseva, Elizaveta Dorosh, Anna Krivitskaya, Vera Kuznetzova, Elena Majorova, Victoria Petrova, Ekaterina Boyarintseva, Anastassia Ksenafontov, Andrey Shtro, Anna Nikolaeva, Julia Bakaev, Mikhail Burtseva, Elena Lioznov, Dmitry |
| description | The COVID-19 pandemic had a profound impact on influenza activity worldwide. However, as the pandemic progressed, influenza activity resumed. Here, we describe the influenza epidemic of high intensity of the 2022–2023 season. The epidemic had an early start and peaked in week 51.2022. The extremely high intensity of the epidemic may have been due to a significant decrease in herd immunity. The results of PCR-testing of 220,067 clinical samples revealed that the influenza A(H1N1)pdm09 virus dominated, causing 56.4% of positive cases, while A(H3N2) influenza subtype accounted for only 0.6%, and influenza B of Victoria lineage—for 34.3%. The influenza vaccine was found to be highly effective, with an estimated effectiveness of 92.7% in preventing admission with laboratory-confirmed influenza severe acute respiratory illness (SARI) cases and 54.7% in preventing influenza-like illness/acute respiratory illness (ILI/ARI) cases due to antigenic matching of circulated viruses with influenza vaccine strains for the season. Full genome next-generation sequencing of 1723 influenza A(H1N1)pdm09 viruses showed that all of them fell within clade 6B.1A.5.a2; nine of them possessed H275Y substitution in the NA gene, a genetic marker of oseltamivir resistance. Influenza A(H3N2) viruses belonged to subclade 3C.2a1b.2a.2 with the genetic group 2b being dominant. All 433 influenza B viruses belonged to subclade V1A.3a.2 encoding HA1 substitutions A127T, P144L, and K203R, which could be further divided into two subgroups. None of the influenza A(H3N2) and B viruses sequenced had markers of resistance to NA inhibitors. Thus, despite the continuing circulation of Omicron descendant lineages, influenza activity has resumed in full force, raising concerns about the intensity of fore coming seasonal epidemics. |
| doi_str_mv | 10.3390/v15081780 |
| format | article |
| fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A762549664</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A762549664</galeid><sourcerecordid>A762549664</sourcerecordid><originalsourceid>FETCH-LOGICAL-g674-1d4c2cdfbb99100c05bd3723ac8367f3f3f6f157232bac23177d0c5f4cc977b53</originalsourceid><addsrcrecordid>eNptT8FKAzEUDKJgrR78g4DnrclmN2mOS211oVDR0mvJvrzUSJstzbYH8eONVaEHmcM85s2b4RFyy9lACM3uD7xkQ66G7Iz0uNY6KzQvz0_mS3IV4ztjUmqmeuSzihFj9GFFuzekdegwxG926z2GD0Orrd0wTcdbb3HjgZpg6cIA-IB07BxC5w8YUgT14Rjx3MYuG80W9QN9RRPb8Ld42aceE-gELe5M59twTS6cWUe8-eU-mU_G89FTNp091qNqmq2kKjJuC8jBuqbRmjMGrGysULkwMBRSOZEgHS-TkjcGcsGVsgxKVwBopZpS9MndT-zKrHHpg2u7nYGNj7CslMzLQktZJNfgH1fC8e82oPNJPzn4AtUbbgU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Assessing the Intense Influenza Apdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation</title><source>PubMed Central（OA）</source><source>ProQuest Publicly Available Content database</source><creator>Sominina, Anna ; Danilenko, Daria ; Komissarov, Andrey B ; Pisareva, Maria ; Fadeev, Artem ; Konovalova, Nadezhda ; Eropkin, Mikhail ; Petrova, Polina ; Zheltukhina, Alyona ; Musaeva, Tamila ; Eder, Veronika ; Ivanova, Anna ; Komissarova, Kseniya ; Stolyarov, Kirill ; Karpova, Ludmila ; Smorodintseva, Elizaveta ; Dorosh, Anna ; Krivitskaya, Vera ; Kuznetzova, Elena ; Majorova, Victoria ; Petrova, Ekaterina ; Boyarintseva, Anastassia ; Ksenafontov, Andrey ; Shtro, Anna ; Nikolaeva, Julia ; Bakaev, Mikhail ; Burtseva, Elena ; Lioznov, Dmitry</creator><creatorcontrib>Sominina, Anna ; Danilenko, Daria ; Komissarov, Andrey B ; Pisareva, Maria ; Fadeev, Artem ; Konovalova, Nadezhda ; Eropkin, Mikhail ; Petrova, Polina ; Zheltukhina, Alyona ; Musaeva, Tamila ; Eder, Veronika ; Ivanova, Anna ; Komissarova, Kseniya ; Stolyarov, Kirill ; Karpova, Ludmila ; Smorodintseva, Elizaveta ; Dorosh, Anna ; Krivitskaya, Vera ; Kuznetzova, Elena ; Majorova, Victoria ; Petrova, Ekaterina ; Boyarintseva, Anastassia ; Ksenafontov, Andrey ; Shtro, Anna ; Nikolaeva, Julia ; Bakaev, Mikhail ; Burtseva, Elena ; Lioznov, Dmitry</creatorcontrib><description>The COVID-19 pandemic had a profound impact on influenza activity worldwide. However, as the pandemic progressed, influenza activity resumed. Here, we describe the influenza epidemic of high intensity of the 2022–2023 season. The epidemic had an early start and peaked in week 51.2022. The extremely high intensity of the epidemic may have been due to a significant decrease in herd immunity. The results of PCR-testing of 220,067 clinical samples revealed that the influenza A(H1N1)pdm09 virus dominated, causing 56.4% of positive cases, while A(H3N2) influenza subtype accounted for only 0.6%, and influenza B of Victoria lineage—for 34.3%. The influenza vaccine was found to be highly effective, with an estimated effectiveness of 92.7% in preventing admission with laboratory-confirmed influenza severe acute respiratory illness (SARI) cases and 54.7% in preventing influenza-like illness/acute respiratory illness (ILI/ARI) cases due to antigenic matching of circulated viruses with influenza vaccine strains for the season. Full genome next-generation sequencing of 1723 influenza A(H1N1)pdm09 viruses showed that all of them fell within clade 6B.1A.5.a2; nine of them possessed H275Y substitution in the NA gene, a genetic marker of oseltamivir resistance. Influenza A(H3N2) viruses belonged to subclade 3C.2a1b.2a.2 with the genetic group 2b being dominant. All 433 influenza B viruses belonged to subclade V1A.3a.2 encoding HA1 substitutions A127T, P144L, and K203R, which could be further divided into two subgroups. None of the influenza A(H3N2) and B viruses sequenced had markers of resistance to NA inhibitors. Thus, despite the continuing circulation of Omicron descendant lineages, influenza activity has resumed in full force, raising concerns about the intensity of fore coming seasonal epidemics.</description><identifier>ISSN: 1999-4915</identifier><identifier>EISSN: 1999-4915</identifier><identifier>DOI: 10.3390/v15081780</identifier><language>eng</language><publisher>MDPI AG</publisher><subject>Causes of ; Epidemics ; Influenza ; Influenza vaccines ; Patient outcomes ; Prevention ; Russia ; Statistics</subject><ispartof>Viruses, 2023-08, Vol.15 (8)</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Sominina, Anna</creatorcontrib><creatorcontrib>Danilenko, Daria</creatorcontrib><creatorcontrib>Komissarov, Andrey B</creatorcontrib><creatorcontrib>Pisareva, Maria</creatorcontrib><creatorcontrib>Fadeev, Artem</creatorcontrib><creatorcontrib>Konovalova, Nadezhda</creatorcontrib><creatorcontrib>Eropkin, Mikhail</creatorcontrib><creatorcontrib>Petrova, Polina</creatorcontrib><creatorcontrib>Zheltukhina, Alyona</creatorcontrib><creatorcontrib>Musaeva, Tamila</creatorcontrib><creatorcontrib>Eder, Veronika</creatorcontrib><creatorcontrib>Ivanova, Anna</creatorcontrib><creatorcontrib>Komissarova, Kseniya</creatorcontrib><creatorcontrib>Stolyarov, Kirill</creatorcontrib><creatorcontrib>Karpova, Ludmila</creatorcontrib><creatorcontrib>Smorodintseva, Elizaveta</creatorcontrib><creatorcontrib>Dorosh, Anna</creatorcontrib><creatorcontrib>Krivitskaya, Vera</creatorcontrib><creatorcontrib>Kuznetzova, Elena</creatorcontrib><creatorcontrib>Majorova, Victoria</creatorcontrib><creatorcontrib>Petrova, Ekaterina</creatorcontrib><creatorcontrib>Boyarintseva, Anastassia</creatorcontrib><creatorcontrib>Ksenafontov, Andrey</creatorcontrib><creatorcontrib>Shtro, Anna</creatorcontrib><creatorcontrib>Nikolaeva, Julia</creatorcontrib><creatorcontrib>Bakaev, Mikhail</creatorcontrib><creatorcontrib>Burtseva, Elena</creatorcontrib><creatorcontrib>Lioznov, Dmitry</creatorcontrib><title>Assessing the Intense Influenza Apdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation</title><title>Viruses</title><description>The COVID-19 pandemic had a profound impact on influenza activity worldwide. However, as the pandemic progressed, influenza activity resumed. Here, we describe the influenza epidemic of high intensity of the 2022–2023 season. The epidemic had an early start and peaked in week 51.2022. The extremely high intensity of the epidemic may have been due to a significant decrease in herd immunity. The results of PCR-testing of 220,067 clinical samples revealed that the influenza A(H1N1)pdm09 virus dominated, causing 56.4% of positive cases, while A(H3N2) influenza subtype accounted for only 0.6%, and influenza B of Victoria lineage—for 34.3%. The influenza vaccine was found to be highly effective, with an estimated effectiveness of 92.7% in preventing admission with laboratory-confirmed influenza severe acute respiratory illness (SARI) cases and 54.7% in preventing influenza-like illness/acute respiratory illness (ILI/ARI) cases due to antigenic matching of circulated viruses with influenza vaccine strains for the season. Full genome next-generation sequencing of 1723 influenza A(H1N1)pdm09 viruses showed that all of them fell within clade 6B.1A.5.a2; nine of them possessed H275Y substitution in the NA gene, a genetic marker of oseltamivir resistance. Influenza A(H3N2) viruses belonged to subclade 3C.2a1b.2a.2 with the genetic group 2b being dominant. All 433 influenza B viruses belonged to subclade V1A.3a.2 encoding HA1 substitutions A127T, P144L, and K203R, which could be further divided into two subgroups. None of the influenza A(H3N2) and B viruses sequenced had markers of resistance to NA inhibitors. Thus, despite the continuing circulation of Omicron descendant lineages, influenza activity has resumed in full force, raising concerns about the intensity of fore coming seasonal epidemics.</description><subject>Causes of</subject><subject>Epidemics</subject><subject>Influenza</subject><subject>Influenza vaccines</subject><subject>Patient outcomes</subject><subject>Prevention</subject><subject>Russia</subject><subject>Statistics</subject><issn>1999-4915</issn><issn>1999-4915</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptT8FKAzEUDKJgrR78g4DnrclmN2mOS211oVDR0mvJvrzUSJstzbYH8eONVaEHmcM85s2b4RFyy9lACM3uD7xkQ66G7Iz0uNY6KzQvz0_mS3IV4ztjUmqmeuSzihFj9GFFuzekdegwxG926z2GD0Orrd0wTcdbb3HjgZpg6cIA-IB07BxC5w8YUgT14Rjx3MYuG80W9QN9RRPb8Ld42aceE-gELe5M59twTS6cWUe8-eU-mU_G89FTNp091qNqmq2kKjJuC8jBuqbRmjMGrGysULkwMBRSOZEgHS-TkjcGcsGVsgxKVwBopZpS9MndT-zKrHHpg2u7nYGNj7CslMzLQktZJNfgH1fC8e82oPNJPzn4AtUbbgU</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Sominina, Anna</creator><creator>Danilenko, Daria</creator><creator>Komissarov, Andrey B</creator><creator>Pisareva, Maria</creator><creator>Fadeev, Artem</creator><creator>Konovalova, Nadezhda</creator><creator>Eropkin, Mikhail</creator><creator>Petrova, Polina</creator><creator>Zheltukhina, Alyona</creator><creator>Musaeva, Tamila</creator><creator>Eder, Veronika</creator><creator>Ivanova, Anna</creator><creator>Komissarova, Kseniya</creator><creator>Stolyarov, Kirill</creator><creator>Karpova, Ludmila</creator><creator>Smorodintseva, Elizaveta</creator><creator>Dorosh, Anna</creator><creator>Krivitskaya, Vera</creator><creator>Kuznetzova, Elena</creator><creator>Majorova, Victoria</creator><creator>Petrova, Ekaterina</creator><creator>Boyarintseva, Anastassia</creator><creator>Ksenafontov, Andrey</creator><creator>Shtro, Anna</creator><creator>Nikolaeva, Julia</creator><creator>Bakaev, Mikhail</creator><creator>Burtseva, Elena</creator><creator>Lioznov, Dmitry</creator><general>MDPI AG</general><scope/></search><sort><creationdate>20230801</creationdate><title>Assessing the Intense Influenza Apdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation</title><author>Sominina, Anna ; Danilenko, Daria ; Komissarov, Andrey B ; Pisareva, Maria ; Fadeev, Artem ; Konovalova, Nadezhda ; Eropkin, Mikhail ; Petrova, Polina ; Zheltukhina, Alyona ; Musaeva, Tamila ; Eder, Veronika ; Ivanova, Anna ; Komissarova, Kseniya ; Stolyarov, Kirill ; Karpova, Ludmila ; Smorodintseva, Elizaveta ; Dorosh, Anna ; Krivitskaya, Vera ; Kuznetzova, Elena ; Majorova, Victoria ; Petrova, Ekaterina ; Boyarintseva, Anastassia ; Ksenafontov, Andrey ; Shtro, Anna ; Nikolaeva, Julia ; Bakaev, Mikhail ; Burtseva, Elena ; Lioznov, Dmitry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g674-1d4c2cdfbb99100c05bd3723ac8367f3f3f6f157232bac23177d0c5f4cc977b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Causes of</topic><topic>Epidemics</topic><topic>Influenza</topic><topic>Influenza vaccines</topic><topic>Patient outcomes</topic><topic>Prevention</topic><topic>Russia</topic><topic>Statistics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sominina, Anna</creatorcontrib><creatorcontrib>Danilenko, Daria</creatorcontrib><creatorcontrib>Komissarov, Andrey B</creatorcontrib><creatorcontrib>Pisareva, Maria</creatorcontrib><creatorcontrib>Fadeev, Artem</creatorcontrib><creatorcontrib>Konovalova, Nadezhda</creatorcontrib><creatorcontrib>Eropkin, Mikhail</creatorcontrib><creatorcontrib>Petrova, Polina</creatorcontrib><creatorcontrib>Zheltukhina, Alyona</creatorcontrib><creatorcontrib>Musaeva, Tamila</creatorcontrib><creatorcontrib>Eder, Veronika</creatorcontrib><creatorcontrib>Ivanova, Anna</creatorcontrib><creatorcontrib>Komissarova, Kseniya</creatorcontrib><creatorcontrib>Stolyarov, Kirill</creatorcontrib><creatorcontrib>Karpova, Ludmila</creatorcontrib><creatorcontrib>Smorodintseva, Elizaveta</creatorcontrib><creatorcontrib>Dorosh, Anna</creatorcontrib><creatorcontrib>Krivitskaya, Vera</creatorcontrib><creatorcontrib>Kuznetzova, Elena</creatorcontrib><creatorcontrib>Majorova, Victoria</creatorcontrib><creatorcontrib>Petrova, Ekaterina</creatorcontrib><creatorcontrib>Boyarintseva, Anastassia</creatorcontrib><creatorcontrib>Ksenafontov, Andrey</creatorcontrib><creatorcontrib>Shtro, Anna</creatorcontrib><creatorcontrib>Nikolaeva, Julia</creatorcontrib><creatorcontrib>Bakaev, Mikhail</creatorcontrib><creatorcontrib>Burtseva, Elena</creatorcontrib><creatorcontrib>Lioznov, Dmitry</creatorcontrib><jtitle>Viruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sominina, Anna</au><au>Danilenko, Daria</au><au>Komissarov, Andrey B</au><au>Pisareva, Maria</au><au>Fadeev, Artem</au><au>Konovalova, Nadezhda</au><au>Eropkin, Mikhail</au><au>Petrova, Polina</au><au>Zheltukhina, Alyona</au><au>Musaeva, Tamila</au><au>Eder, Veronika</au><au>Ivanova, Anna</au><au>Komissarova, Kseniya</au><au>Stolyarov, Kirill</au><au>Karpova, Ludmila</au><au>Smorodintseva, Elizaveta</au><au>Dorosh, Anna</au><au>Krivitskaya, Vera</au><au>Kuznetzova, Elena</au><au>Majorova, Victoria</au><au>Petrova, Ekaterina</au><au>Boyarintseva, Anastassia</au><au>Ksenafontov, Andrey</au><au>Shtro, Anna</au><au>Nikolaeva, Julia</au><au>Bakaev, Mikhail</au><au>Burtseva, Elena</au><au>Lioznov, Dmitry</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the Intense Influenza Apdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation</atitle><jtitle>Viruses</jtitle><date>2023-08-01</date><risdate>2023</risdate><volume>15</volume><issue>8</issue><issn>1999-4915</issn><eissn>1999-4915</eissn><abstract>The COVID-19 pandemic had a profound impact on influenza activity worldwide. However, as the pandemic progressed, influenza activity resumed. Here, we describe the influenza epidemic of high intensity of the 2022–2023 season. The epidemic had an early start and peaked in week 51.2022. The extremely high intensity of the epidemic may have been due to a significant decrease in herd immunity. The results of PCR-testing of 220,067 clinical samples revealed that the influenza A(H1N1)pdm09 virus dominated, causing 56.4% of positive cases, while A(H3N2) influenza subtype accounted for only 0.6%, and influenza B of Victoria lineage—for 34.3%. The influenza vaccine was found to be highly effective, with an estimated effectiveness of 92.7% in preventing admission with laboratory-confirmed influenza severe acute respiratory illness (SARI) cases and 54.7% in preventing influenza-like illness/acute respiratory illness (ILI/ARI) cases due to antigenic matching of circulated viruses with influenza vaccine strains for the season. Full genome next-generation sequencing of 1723 influenza A(H1N1)pdm09 viruses showed that all of them fell within clade 6B.1A.5.a2; nine of them possessed H275Y substitution in the NA gene, a genetic marker of oseltamivir resistance. Influenza A(H3N2) viruses belonged to subclade 3C.2a1b.2a.2 with the genetic group 2b being dominant. All 433 influenza B viruses belonged to subclade V1A.3a.2 encoding HA1 substitutions A127T, P144L, and K203R, which could be further divided into two subgroups. None of the influenza A(H3N2) and B viruses sequenced had markers of resistance to NA inhibitors. Thus, despite the continuing circulation of Omicron descendant lineages, influenza activity has resumed in full force, raising concerns about the intensity of fore coming seasonal epidemics.</abstract><pub>MDPI AG</pub><doi>10.3390/v15081780</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1999-4915 |
| ispartof | Viruses, 2023-08, Vol.15 (8) |
| issn | 1999-4915 1999-4915 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A762549664 |
| source | PubMed Central（OA）; ProQuest Publicly Available Content database |
| subjects | Causes of Epidemics Influenza Influenza vaccines Patient outcomes Prevention Russia Statistics |
| title | Assessing the Intense Influenza Apdm09 Epidemic and Vaccine Effectiveness in the Post-COVID Season in the Russian Federation |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T12%3A35%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessing%20the%20Intense%20Influenza%20Apdm09%20Epidemic%20and%20Vaccine%20Effectiveness%20in%20the%20Post-COVID%20Season%20in%20the%20Russian%20Federation&rft.jtitle=Viruses&rft.au=Sominina,%20Anna&rft.date=2023-08-01&rft.volume=15&rft.issue=8&rft.issn=1999-4915&rft.eissn=1999-4915&rft_id=info:doi/10.3390/v15081780&rft_dat=%3Cgale%3EA762549664%3C/gale%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-g674-1d4c2cdfbb99100c05bd3723ac8367f3f3f6f157232bac23177d0c5f4cc977b53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A762549664&rfr_iscdi=true |