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Management of oropharyngeal cancer in the HPV Era: The prevalence of HPV-positive OPC continues to increase at an epidemic rate
Background: Historically, oropharyngeal cancer (OPC) has been attributed to risk factors such as smoking and alcohol use. The increased incidence of OPC has been driven by human papillomavirus (HPV) infection. Methods: A search of the literature involving HPV infection and OPC was performed, along w...
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Published in: | Cancer control 2016-07, p.197 |
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creator | Naghavi, Arash O Strom, Tobin J Ahmed, Kamran A Echevarria, Michelle I Abuodeh, Yazan A Venkat, Puja S Frakes, Jessica M Harrison, Louis B Trotti, Andy M Caudell, Jimmy J |
description | Background: Historically, oropharyngeal cancer (OPC) has been attributed to risk factors such as smoking and alcohol use. The increased incidence of OPC has been driven by human papillomavirus (HPV) infection. Methods: A search of the literature involving HPV infection and OPC was performed, along with a search of ongoing clinical trials regarding HPV-positive OPC. Results: This review summarizes the differences in epidemiology and prognosis of HPV-positive OPC compared with non-HPV-related OPC. It will also discuss use of de-escalating treatment to minimize toxicity while maintaining excellent outcomes. Disease management is also addressed, including prevention and follow-up recommendations for this cohort of patients. Conclusions: HPV-positive OPC is a distinct disease, and efforts should be made to personalize its management. Preventive measures and vaccinations, along with de-escalation of treatment, may help optimize outcomes in this population. |
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The increased incidence of OPC has been driven by human papillomavirus (HPV) infection. Methods: A search of the literature involving HPV infection and OPC was performed, along with a search of ongoing clinical trials regarding HPV-positive OPC. Results: This review summarizes the differences in epidemiology and prognosis of HPV-positive OPC compared with non-HPV-related OPC. It will also discuss use of de-escalating treatment to minimize toxicity while maintaining excellent outcomes. Disease management is also addressed, including prevention and follow-up recommendations for this cohort of patients. Conclusions: HPV-positive OPC is a distinct disease, and efforts should be made to personalize its management. Preventive measures and vaccinations, along with de-escalation of treatment, may help optimize outcomes in this population.</description><identifier>ISSN: 1073-2748</identifier><identifier>EISSN: 1526-2359</identifier><language>eng</language><publisher>H. Lee Moffitt Cancer Center and Research Institute</publisher><subject>Care and treatment ; Development and progression ; Papillomavirus infections ; Throat cancer</subject><ispartof>Cancer control, 2016-07, p.197</ispartof><rights>COPYRIGHT 2016 H. Lee Moffitt Cancer Center and Research Institute</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790</link.rule.ids></links><search><creatorcontrib>Naghavi, Arash O</creatorcontrib><creatorcontrib>Strom, Tobin J</creatorcontrib><creatorcontrib>Ahmed, Kamran A</creatorcontrib><creatorcontrib>Echevarria, Michelle I</creatorcontrib><creatorcontrib>Abuodeh, Yazan A</creatorcontrib><creatorcontrib>Venkat, Puja S</creatorcontrib><creatorcontrib>Frakes, Jessica M</creatorcontrib><creatorcontrib>Harrison, Louis B</creatorcontrib><creatorcontrib>Trotti, Andy M</creatorcontrib><creatorcontrib>Caudell, Jimmy J</creatorcontrib><title>Management of oropharyngeal cancer in the HPV Era: The prevalence of HPV-positive OPC continues to increase at an epidemic rate</title><title>Cancer control</title><description>Background: Historically, oropharyngeal cancer (OPC) has been attributed to risk factors such as smoking and alcohol use. The increased incidence of OPC has been driven by human papillomavirus (HPV) infection. Methods: A search of the literature involving HPV infection and OPC was performed, along with a search of ongoing clinical trials regarding HPV-positive OPC. Results: This review summarizes the differences in epidemiology and prognosis of HPV-positive OPC compared with non-HPV-related OPC. It will also discuss use of de-escalating treatment to minimize toxicity while maintaining excellent outcomes. Disease management is also addressed, including prevention and follow-up recommendations for this cohort of patients. Conclusions: HPV-positive OPC is a distinct disease, and efforts should be made to personalize its management. Preventive measures and vaccinations, along with de-escalation of treatment, may help optimize outcomes in this population.</description><subject>Care and treatment</subject><subject>Development and progression</subject><subject>Papillomavirus infections</subject><subject>Throat cancer</subject><issn>1073-2748</issn><issn>1526-2359</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptUE1Lw0AQDaJgrf6HAcFbZLObZBtvpVQrVNpD8Vom29lkJd0N2W3Bk3_d9eNQQeYwX-8N781ZMsoKXqZcFNV5rJkUKZf55DK58v6NMc5ykY-Sjxe02NCebACnwQ2ub3F4tw1hBwqtogGMhdASLNavMB_wATax6Qc6Ykdx_0WLq7R33gRzJFitZ6CcDcYeyENwka8GQk-AAdAC9WZHe6NgwEDXyYXGztPNbx4nm8f5ZrZIl6un59l0mTbVJJqoWKGRSymQF1jWudQ1q4pooqZMIQkiYiWr-E6oXV4KyXVdS42ZErXkLBPj5PbnbBNFb43VLgyo9sar7TTiS5EXkzKi7v9BxfjW6yxpE-d_CHcnhDb-LLTedYdgnPWnwE_toHf-</recordid><startdate>20160701</startdate><enddate>20160701</enddate><creator>Naghavi, Arash O</creator><creator>Strom, Tobin J</creator><creator>Ahmed, Kamran A</creator><creator>Echevarria, Michelle I</creator><creator>Abuodeh, Yazan A</creator><creator>Venkat, Puja S</creator><creator>Frakes, Jessica M</creator><creator>Harrison, Louis B</creator><creator>Trotti, Andy M</creator><creator>Caudell, Jimmy J</creator><general>H. 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source | Sage Journals GOLD Open Access 2024 |
subjects | Care and treatment Development and progression Papillomavirus infections Throat cancer |
title | Management of oropharyngeal cancer in the HPV Era: The prevalence of HPV-positive OPC continues to increase at an epidemic rate |
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