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A Hemoglobin-based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC-201) Versus Hetastarch (HEX) in a Moderate Severity Hemorrhagic Shock Swine Model with Delayed Evacuation
Objective: To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. Methods: A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untrea...
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| creator | Philbin, Nora Rice, Jennifer Gurney, Jennifer McGwin, Gerald Arnaud, Francoise Dong, Feng Johnson, Todd Flourncy, W S Ahlers, Stephen Pearce, L B McCarron, Richard Freilich, Daniel |
| description | Objective: To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. Methods: A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated with HBOC-201 or 6% hetastarch (HEX) at 20 min. Invasive hemodynamics and clinical variables were monitored for 4 h (pre-hospital phase) and subsequent fluid infusions were administered for severe hypotension or tachycardia. Animals were recovered from anesthesia and monitored non-invasively to 72 h (hospital phase). Results: 100% (8/8) of HBOC-201-, 88% (7/8) of HEX-, and 63% (5/8) of non-resuscitated pigs, survived to 72 h (p = 0.27). Mean arterial pressure, mean pulmonary arterial pressure and systemic vascular resistance index were higher in HBOC-201 pigs. By 90 min, cardiac index was restored to baseline in the HBOC-201 group and was 1.4-fold greater than baseline in the HEX group. HBOC-201 pigs had lower fluid requirements than HEX pigs (18.8 1.8 and 29.9 1.1 ml/kg, p 0.001) in the pre-hospital phase and required fewer blood transfusions (1.3 1.3 and 9.4 0.6 ml/kg, respectively, p 0.001) in the hospital phase. Urine output and blood creatinine were comparable in HBOC-201 and HEX pigs. Tissue oxygenation levels were highest in the HBOC-201 group. Conclusions: As HBOC-201 restored hemodynamics and tissue oxygenation and decreased fluid requirements, in comparison with HEX, HBOC-201 was at least as efficacious and possibly a superior resuscitative fluid in a military-relevant delayed evacuation hemorrhagic shock swine model.
The original document contains color images. Pub. in Resuscitation, v66, p367-378, 2005. |
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The original document contains color images. Pub. in Resuscitation, v66, p367-378, 2005.</description><language>eng</language><subject>ANESTHESIA ; ANIMALS ; Biochemistry ; BLOOD CIRCULATION ; BLOOD PRESSURE ; BLOOD TRANSFUSION ; BOVINE ; CARDIOVASCULAR SYSTEM ; CLINICAL MEDICINE ; CREATININE ; FLUID THERAPY HYPOVOLEMIA ; HBOC(HEMOGLOBIN BASED OXYGEN CARRIERS) ; HEART ; HEMOGLOBIN ; HEMOGLOBIN BASED OXYGEN CARRIERS ; HEMORRHAGIC SHOCK ; HEX(HETASTARCH) ; HOSPITALS ; INFUSIONS ; LUNG ; Medicine and Medical Research ; MUSCLES ; OUTPUT ; OXYGEN ; PERFUSION ; REPRINTS ; RESUSCITATION ; SOFT TISSUES ; SWINE ; TACHYCARDIA ; TISSUES(BIOLOGY) ; URINE ; WOUNDS AND INJURIES</subject><creationdate>2005</creationdate><rights>Approved for public release; distribution is unlimited.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,786,891,27600,27601</link.rule.ids><linktorsrc>$$Uhttps://apps.dtic.mil/sti/citations/ADA469050$$EView_record_in_DTIC$$FView_record_in_$$GDTIC$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Philbin, Nora</creatorcontrib><creatorcontrib>Rice, Jennifer</creatorcontrib><creatorcontrib>Gurney, Jennifer</creatorcontrib><creatorcontrib>McGwin, Gerald</creatorcontrib><creatorcontrib>Arnaud, Francoise</creatorcontrib><creatorcontrib>Dong, Feng</creatorcontrib><creatorcontrib>Johnson, Todd</creatorcontrib><creatorcontrib>Flourncy, W S</creatorcontrib><creatorcontrib>Ahlers, Stephen</creatorcontrib><creatorcontrib>Pearce, L B</creatorcontrib><creatorcontrib>McCarron, Richard</creatorcontrib><creatorcontrib>Freilich, Daniel</creatorcontrib><creatorcontrib>NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD</creatorcontrib><title>A Hemoglobin-based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC-201) Versus Hetastarch (HEX) in a Moderate Severity Hemorrhagic Shock Swine Model with Delayed Evacuation</title><description>Objective: To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. Methods: A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated with HBOC-201 or 6% hetastarch (HEX) at 20 min. Invasive hemodynamics and clinical variables were monitored for 4 h (pre-hospital phase) and subsequent fluid infusions were administered for severe hypotension or tachycardia. Animals were recovered from anesthesia and monitored non-invasively to 72 h (hospital phase). Results: 100% (8/8) of HBOC-201-, 88% (7/8) of HEX-, and 63% (5/8) of non-resuscitated pigs, survived to 72 h (p = 0.27). Mean arterial pressure, mean pulmonary arterial pressure and systemic vascular resistance index were higher in HBOC-201 pigs. By 90 min, cardiac index was restored to baseline in the HBOC-201 group and was 1.4-fold greater than baseline in the HEX group. HBOC-201 pigs had lower fluid requirements than HEX pigs (18.8 1.8 and 29.9 1.1 ml/kg, p 0.001) in the pre-hospital phase and required fewer blood transfusions (1.3 1.3 and 9.4 0.6 ml/kg, respectively, p 0.001) in the hospital phase. Urine output and blood creatinine were comparable in HBOC-201 and HEX pigs. Tissue oxygenation levels were highest in the HBOC-201 group. Conclusions: As HBOC-201 restored hemodynamics and tissue oxygenation and decreased fluid requirements, in comparison with HEX, HBOC-201 was at least as efficacious and possibly a superior resuscitative fluid in a military-relevant delayed evacuation hemorrhagic shock swine model.
The original document contains color images. Pub. in Resuscitation, v66, p367-378, 2005.</description><subject>ANESTHESIA</subject><subject>ANIMALS</subject><subject>Biochemistry</subject><subject>BLOOD CIRCULATION</subject><subject>BLOOD PRESSURE</subject><subject>BLOOD TRANSFUSION</subject><subject>BOVINE</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>CLINICAL MEDICINE</subject><subject>CREATININE</subject><subject>FLUID THERAPY HYPOVOLEMIA</subject><subject>HBOC(HEMOGLOBIN BASED OXYGEN CARRIERS)</subject><subject>HEART</subject><subject>HEMOGLOBIN</subject><subject>HEMOGLOBIN BASED OXYGEN CARRIERS</subject><subject>HEMORRHAGIC SHOCK</subject><subject>HEX(HETASTARCH)</subject><subject>HOSPITALS</subject><subject>INFUSIONS</subject><subject>LUNG</subject><subject>Medicine and Medical Research</subject><subject>MUSCLES</subject><subject>OUTPUT</subject><subject>OXYGEN</subject><subject>PERFUSION</subject><subject>REPRINTS</subject><subject>RESUSCITATION</subject><subject>SOFT TISSUES</subject><subject>SWINE</subject><subject>TACHYCARDIA</subject><subject>TISSUES(BIOLOGY)</subject><subject>URINE</subject><subject>WOUNDS AND INJURIES</subject><fulltext>true</fulltext><rsrctype>report</rsrctype><creationdate>2005</creationdate><recordtype>report</recordtype><sourceid>1RU</sourceid><recordid>eNqFjU9rwkAQR3PxINVv4GGOFRqI9g_0mMRILqIQKb3JuJkmSzdZmB2j6afqR3QVwaOnObw37zcM_mPIqbGVsXvdhnt0VML61FfUQorMmvgFEtvplmBjTd8Q6z-v3H_gOU_WaTiPZlP4InYH56GgE2RVe5h9T8FbCCtbEqMQFNT5ivTXCHONlVZQ1Fb9QnG8DF1MA0ctNSzIYO_3sg7VAUXbdhQMftA4Gt_uUzBZZts0D0vRaufEB2QXL-K3j8_oPXp9gM82rFTO</recordid><startdate>20050323</startdate><enddate>20050323</enddate><creator>Philbin, Nora</creator><creator>Rice, Jennifer</creator><creator>Gurney, Jennifer</creator><creator>McGwin, Gerald</creator><creator>Arnaud, Francoise</creator><creator>Dong, Feng</creator><creator>Johnson, Todd</creator><creator>Flourncy, W S</creator><creator>Ahlers, Stephen</creator><creator>Pearce, L B</creator><creator>McCarron, Richard</creator><creator>Freilich, Daniel</creator><scope>1RU</scope><scope>BHM</scope></search><sort><creationdate>20050323</creationdate><title>A Hemoglobin-based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC-201) Versus Hetastarch (HEX) in a Moderate Severity Hemorrhagic Shock Swine Model with Delayed Evacuation</title><author>Philbin, Nora ; Rice, Jennifer ; Gurney, Jennifer ; McGwin, Gerald ; Arnaud, Francoise ; Dong, Feng ; Johnson, Todd ; Flourncy, W S ; Ahlers, Stephen ; Pearce, L B ; McCarron, Richard ; Freilich, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-dtic_stinet_ADA4690503</frbrgroupid><rsrctype>reports</rsrctype><prefilter>reports</prefilter><language>eng</language><creationdate>2005</creationdate><topic>ANESTHESIA</topic><topic>ANIMALS</topic><topic>Biochemistry</topic><topic>BLOOD CIRCULATION</topic><topic>BLOOD PRESSURE</topic><topic>BLOOD TRANSFUSION</topic><topic>BOVINE</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>CLINICAL MEDICINE</topic><topic>CREATININE</topic><topic>FLUID THERAPY HYPOVOLEMIA</topic><topic>HBOC(HEMOGLOBIN BASED OXYGEN CARRIERS)</topic><topic>HEART</topic><topic>HEMOGLOBIN</topic><topic>HEMOGLOBIN BASED OXYGEN CARRIERS</topic><topic>HEMORRHAGIC SHOCK</topic><topic>HEX(HETASTARCH)</topic><topic>HOSPITALS</topic><topic>INFUSIONS</topic><topic>LUNG</topic><topic>Medicine and Medical Research</topic><topic>MUSCLES</topic><topic>OUTPUT</topic><topic>OXYGEN</topic><topic>PERFUSION</topic><topic>REPRINTS</topic><topic>RESUSCITATION</topic><topic>SOFT TISSUES</topic><topic>SWINE</topic><topic>TACHYCARDIA</topic><topic>TISSUES(BIOLOGY)</topic><topic>URINE</topic><topic>WOUNDS AND INJURIES</topic><toplevel>online_resources</toplevel><creatorcontrib>Philbin, Nora</creatorcontrib><creatorcontrib>Rice, Jennifer</creatorcontrib><creatorcontrib>Gurney, Jennifer</creatorcontrib><creatorcontrib>McGwin, Gerald</creatorcontrib><creatorcontrib>Arnaud, Francoise</creatorcontrib><creatorcontrib>Dong, Feng</creatorcontrib><creatorcontrib>Johnson, Todd</creatorcontrib><creatorcontrib>Flourncy, W S</creatorcontrib><creatorcontrib>Ahlers, Stephen</creatorcontrib><creatorcontrib>Pearce, L B</creatorcontrib><creatorcontrib>McCarron, Richard</creatorcontrib><creatorcontrib>Freilich, Daniel</creatorcontrib><creatorcontrib>NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD</creatorcontrib><collection>DTIC Technical Reports</collection><collection>DTIC STINET</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Philbin, Nora</au><au>Rice, Jennifer</au><au>Gurney, Jennifer</au><au>McGwin, Gerald</au><au>Arnaud, Francoise</au><au>Dong, Feng</au><au>Johnson, Todd</au><au>Flourncy, W S</au><au>Ahlers, Stephen</au><au>Pearce, L B</au><au>McCarron, Richard</au><au>Freilich, Daniel</au><aucorp>NAVAL MEDICAL RESEARCH CENTER SILVER SPRING MD</aucorp><format>book</format><genre>unknown</genre><ristype>RPRT</ristype><btitle>A Hemoglobin-based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC-201) Versus Hetastarch (HEX) in a Moderate Severity Hemorrhagic Shock Swine Model with Delayed Evacuation</btitle><date>2005-03-23</date><risdate>2005</risdate><notes>DTIC</notes><abstract>Objective: To evaluate the efficacy of HBOC-201 for resuscitation of hemorrhagic shock in a swine model incorporating soft tissue injury and delayed evacuation. Methods: A muscle crush injury and 40% estimated blood volume controlled hemorrhage was completed in 24 Yucatan mini-pigs. Pigs were untreated or resuscitated with HBOC-201 or 6% hetastarch (HEX) at 20 min. Invasive hemodynamics and clinical variables were monitored for 4 h (pre-hospital phase) and subsequent fluid infusions were administered for severe hypotension or tachycardia. Animals were recovered from anesthesia and monitored non-invasively to 72 h (hospital phase). Results: 100% (8/8) of HBOC-201-, 88% (7/8) of HEX-, and 63% (5/8) of non-resuscitated pigs, survived to 72 h (p = 0.27). Mean arterial pressure, mean pulmonary arterial pressure and systemic vascular resistance index were higher in HBOC-201 pigs. By 90 min, cardiac index was restored to baseline in the HBOC-201 group and was 1.4-fold greater than baseline in the HEX group. HBOC-201 pigs had lower fluid requirements than HEX pigs (18.8 1.8 and 29.9 1.1 ml/kg, p 0.001) in the pre-hospital phase and required fewer blood transfusions (1.3 1.3 and 9.4 0.6 ml/kg, respectively, p 0.001) in the hospital phase. Urine output and blood creatinine were comparable in HBOC-201 and HEX pigs. Tissue oxygenation levels were highest in the HBOC-201 group. Conclusions: As HBOC-201 restored hemodynamics and tissue oxygenation and decreased fluid requirements, in comparison with HEX, HBOC-201 was at least as efficacious and possibly a superior resuscitative fluid in a military-relevant delayed evacuation hemorrhagic shock swine model.
The original document contains color images. Pub. in Resuscitation, v66, p367-378, 2005.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ANESTHESIA ANIMALS Biochemistry BLOOD CIRCULATION BLOOD PRESSURE BLOOD TRANSFUSION BOVINE CARDIOVASCULAR SYSTEM CLINICAL MEDICINE CREATININE FLUID THERAPY HYPOVOLEMIA HBOC(HEMOGLOBIN BASED OXYGEN CARRIERS) HEART HEMOGLOBIN HEMOGLOBIN BASED OXYGEN CARRIERS HEMORRHAGIC SHOCK HEX(HETASTARCH) HOSPITALS INFUSIONS LUNG Medicine and Medical Research MUSCLES OUTPUT OXYGEN PERFUSION REPRINTS RESUSCITATION SOFT TISSUES SWINE TACHYCARDIA TISSUES(BIOLOGY) URINE WOUNDS AND INJURIES |
| title | A Hemoglobin-based Oxygen Carrier, Bovine Polymerized Hemoglobin (HBOC-201) Versus Hetastarch (HEX) in a Moderate Severity Hemorrhagic Shock Swine Model with Delayed Evacuation |
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