Lactobacilli with superoxide dismutase-like or catalase activity are more effective in alleviating inflammation in an inflammatory bowel disease mouse model

Some lactobacilli, which possess superoxide dismutase-like activity and catalase activity naturally, have strong antioxidative properties. The aim of this study was to identify such strains and check which of them play a crucial role in alleviating intestinal inflammation. We selected two strains fo...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2018-01, Vol.12, p.3221-3233
Main Authors: Tomusiak-Plebanek, Anna, Heczko, Piotr, Skowron, Beata, Baranowska, Agnieszka, Okoń, Krzysztof, Thor, Piotr J, Strus, Magdalena
Format: Article
Language:English
Subjects:
Abscess
Abscesses
Analysis
Animals
antioxidative enzymes
Bacteria
Body mass
Body Mass Index
Body temperature
Catalase
Catalase - metabolism
Colon
Colon - metabolism
Colon - microbiology
Colon - pathology
Colorectal cancer
Cytokines
Disease Models, Animal
Enzymes
Gastrointestinal diseases
Hydrogen peroxide
Inflammation
Inflammation - metabolism
Inflammation - microbiology
Inflammation - pathology
Inflammation - therapy
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - metabolism
Inflammatory Bowel Diseases - microbiology
Inflammatory Bowel Diseases - pathology
Inflammatory Bowel Diseases - therapy
Interleukin-10 - deficiency
Interleukin-10 - genetics
Interleukin-10 - metabolism
Intestine
Intestines
Lactobacilli
Lactobacillus
Lactobacillus - enzymology
Lactobacillus - isolation & purification
Lactobacillus - metabolism
Medical research
Methods
Mice
Mice, Inbred C57BL
Mice, Knockout
Microbiology
Microbiota
mouse model
Original Research
Oxidation
probiotic strains
Probiotics
Researchers
Superoxide dismutase
Superoxide Dismutase - metabolism
Superoxides
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Summary:Some lactobacilli, which possess superoxide dismutase-like activity and catalase activity naturally, have strong antioxidative properties. The aim of this study was to identify such strains and check which of them play a crucial role in alleviating intestinal inflammation. We selected two strains for use in animal studies: 30B (which has the highest catalase activity) and 900 (which has the highest dismutase-like activity). Forty mice (C57B1/6J) were divided into four experimental groups with ten mice in each group. Group I (control group) was not supplemented with , group II (catalase group) was orally supplemented with 30B, group III (dismutase-like group) was supplemented with 900, and group IV (mixed group) was supplemented with both strains. For 23 days, the temperature and body mass of each mouse were recorded and fecal samples for microbiological examination were collected. On day 23, the animals were sacrificed, and their intestines were removed for microbiological and histopathological studies. Compared to the control group, the highest drop in the body temperature was observed in groups II (
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S164559