Centralization of Major Trauma Influences Liver Availability for Transplantation in Northern Italy: Lesson Learned from COVID-19 Pandemic

Background: During the COVID-19 pandemic, the centralization of patients allowed trauma and transplants referral centers to continue their routine activity, ensuring the best access to health care. This study aims to analyze how the centralization of trauma is linked with liver allocation in Norther...

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Published in:	Journal of clinical medicine 2022-06, Vol.11 (13), p.3658
Main Authors:	Altomare, Michele, Chierici, Andrea, Virdis, Francesco, Spota, Andrea, Cioffi, Stefano Piero Bernardo, Bekhor, Shir Sara, Del Prete, Luca, Reitano, Elisa, Sacchi, Marco, Ambrogi, Federico, Chiara, Osvaldo, Cimbanassi, Stefania
Format:	Article
Language:	eng
Subjects:	Blood & organ donations Body mass index Clinical medicine Cluster analysis Coronaviruses COVID-19 Damage Control Strategy Injuries Liver liver donation liver transplant Liver transplants Metropolitan areas organ donation Ostomy Pandemics Patients Severe acute respiratory syndrome coronavirus 2 Surgery Transplants & implants Trauma Trauma centers trauma donors
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Summary:	Background: During the COVID-19 pandemic, the centralization of patients allowed trauma and transplants referral centers to continue their routine activity, ensuring the best access to health care. This study aims to analyze how the centralization of trauma is linked with liver allocation in Northern Italy. Methods: Cluster analysis was performed to generate patient phenotype according to trauma-related variables. Comparison between clusters was performed to evaluate differences in damage control strategy procedures (DCS) performed and the 30-day graft dysfunction. Results: During the pandemic period, the centralization of major trauma has deeply impaired the liver procurement and allocation between the transplant centers in the metropolitan area of Milan (Niguarda: 22 liver procurement; other transplant centers: 2 organ procurement). Two clusters were identified the in Niguarda’s series: cluster 1 is represented by 17 (27.4%) trauma donors, of which 13 (76.5%) were treated with DCS procedures, and 4 (23.5%) did not; cluster 2 is represented by 45 trauma donors (72.6%), of which 22 (48.8%) underwent DCS procedures. A significant difference was found in the number of DCS procedures performed between clusters (3.18 ± 2.255 vs. 1.11 ± 1.05, p = 0.0001). Comparative analysis did not significantly differ in the number of transplanted livers (cluster1/cluster2 94.1%/95.6% p = 0.84) and the 30-day graft dysfunction rate (cluster1/cluster2 0.0%/4.8% p = 0.34). Conclusions: The high level of care guaranteed by first-level trauma centers could reduce the loss of organs suitable for donation, maintaining the good outcomes of transplanted ones, even in case of multiple organ injuries. The pandemic period underlined that the centralization of major trauma impairs the liver allocation between transplant centers.
ISSN:	2077-0383 2077-0383