Effect of the probiotic Lactobacillus plantarum IS-10506 on BDNF and 5HT stimulation: role of intestinal microbiota on the gut-brain axis

Microbial communities residing in the gut play a major role in the communication between the gut and the brain through neural, immune, and hormonal routes. Changes in abundance of beneficial intestinal bacteria can affect health of individuals. Conversely, drugs, disease, diet and other factors can...

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Bibliographic Details
Published in:Iranian journal of microbiology 2019-04, Vol.11 (2), p.145-150
Main Authors: Ranuh, Reza, Athiyyah, Alpha Fardah, Darma, Andy, Risky, Vitria Prasetyo, Riawan, Wibi, Surono, Ingrid S, Sudarmo, Subijanto Marto
Format: Article
Language:English
Subjects:
Brain-derived neurotrophic factor
Gut–brain axis
Original
Probiotic Lactobacillus plantarum IS 10506
Serotonin
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Summary:Microbial communities residing in the gut play a major role in the communication between the gut and the brain through neural, immune, and hormonal routes. Changes in abundance of beneficial intestinal bacteria can affect health of individuals. Conversely, drugs, disease, diet and other factors can alter the gut microbiome. However, there is limited information on the effect of exogenous factors on gut microbiota. In this study, we investigated whether a beneficial bacterium, the probiotic IS-10506, can stimulate the gut-brain axis using Wistar rats. The animals were divided into two groups: one received IS strain 10506 supplementation, while the control group received no treatment. Activation of the gut-brain axis was evaluated by immunohistochemical analysis of intestinal and brain serotonin (5-HT) and brain neurotrophin (NT), serotonin transporter (5-HTT), and brain-derived neurotrophic factor (BDNF) levels. The results showed that BDNF ( < 0.000), NT ( < 0.000007), and 5-HTT ( < 0.000007) expression was upregulated in the brain along with intestinal 5-HT ( < 0.000) level in rats treated with strain IS-10506 relative to the control group. The probiotic IS-10506 stimulates the gut-brain axis and can potentially promote brain development and function.
ISSN:2008-3289
2008-4447
DOI:10.18502/ijm.v11i2.1077