Predictors of major adverse events and complications after ventricular septal defects surgical closure in children less than 10 kg
Abstract Background Ventricular septal defect (VSD) is the most common congenital cardiac defect for which outcomes are not uniform. There is a lack of consensus on the risk factors for the unfavorable outcomes following surgical VSD closure. Aim The aim of this study was to determine the risk facto...
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| Published in: | Journal of cardiothoracic surgery 2022-09, Vol.17 (1), p.1-232, Article 232 |
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Predictors of major adverse events and complications after ventricular septal defects surgical closure in children less than 10 kg |
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Abdelrehim, Ayman R Al-Muhaya, Mustafa Alkodami, Alassal A Baangood, Luna S Al-Mutairi, Mansour Quadeer, Abdul Alabsi, Fath A Alashwal, M Morsy, Mohamed Mofeed F Alnajjar, Abdulhameed A Salem, Sherif S |
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Age Analysis Anomalies Cardiac patients Cardiovascular diseases Children Children's furniture Complications Complications and side effects Congenital diseases Coronary artery disease Coronary vessels Defects Genetic disorders Heart Heart diseases Hospitals Infections Major adverse events Males Medical records Medical research Medicine, Experimental Mortality Pacemakers Patients Pediatrics Peritoneal dialysis Pulmonary arteries Pulmonary artery Pulmonary hypertension Regression analysis Risk analysis Risk factors Sex Sex ratio Statistical analysis Surgical closure Surgical outcomes Sutures Trisomy Veins & arteries Ventilation Ventilators Ventricle Ventricular septal defect Ventricular septal defects |
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Journal of cardiothoracic surgery, 2022-09, Vol.17 (1), p.1-232, Article 232 |
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Abstract
Background
Ventricular septal defect (VSD) is the most common congenital cardiac defect for which outcomes are not uniform. There is a lack of consensus on the risk factors for the unfavorable outcomes following surgical VSD closure.
Aim
The aim of this study was to determine the risk factors and the predictors of major adverse events (MAEs) and complications following surgical closure of VSD in children weighing less than 10 kg.
Methods
This retrospective cohort study included children less than 10 kg who underwent surgical closure of congenital VSD of any type with or without associated congenital heart diseases. Patients with associated major cardiac anomalies were excluded. Preoperative, operative and postoperative data were collected from medical records.
Results
This study included 127 patients 52.8% were males, the median age was 8.0 months (IQR = 6.0–11.0 months), and their median weight was 5.7 kg (IQR = 4.8–7.0). Mortality was in one patient (0.8%) Multivariable logistic regression analysis revealed that male sex group (observational data), previous pulmonary artery banding (PAB), and significant intraoperative residual VSD were significant risk factors for the development of MAEs (odds ratios were 3.398, 14.282, and 8.634, respectively). Trisomy 21 syndrome (odds ratio: 5.678) contributed significantly to prolonged ventilation. Pulmonary artery banding (odds ratio: 14.415), significant intraoperative (3 mm) residual VSD (odds ratio: 11.262), and long cross-clamp time (odds ratio: 1.064) were significant predictors of prolonged ICU stay, whereas prolonged hospital stay was observed significantly in male sex group (odds ratio: 12.8281), PAB (odds ratio: 2.669), and significant intraoperative (3 mm) residual VSD (odds ratio: 19.551).
Conclusions
Surgical VSD repair is considered a safe procedure with very low mortality. Trisomy 21 was a significant risk factor for prolonged ventilation. Further, PAB, significant intraoperative residual of 3 mm or more that required a second pulmonary bypass, and a greater cross-clamp time were significant predictors of MAE and associated complications with prolonged ICU and hospital stay. |
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ISSN: 1749-8090 |
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<record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_824874b94a474b97a27022464a70fe64</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A716520543</galeid><doaj_id>oai_doaj_org_article_824874b94a474b97a27022464a70fe64</doaj_id><sourcerecordid>A716520543</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-daf171fcb963622da2a90cb7e1b2f5a3a7c4cd7f8cefe71327c31fd3ac066c1d3</originalsourceid><addsrcrecordid>eNptUstuFDEQHCEQCYEf4GSJC5cJfo09c0GKIh6RIsEBzlav3d714hkv9uxKnPkRvoUvw5ONgEXIh25VV5fd5W6a54xeMtarV4UJyoaWct7W2HetetCcMy2HtqcDffhXftY8KWVLqewE7R43Z0JRzTquzpvvHzO6YOeUC0mejLBNmYA7YC5I8IDTXAhMjtg07mKwMIc0VcTPmMlSzcHuI2RScDdDJA492tpS9nld2ZHYmGqOJEzEbkJ0GScSsRQyb2AijP788WX9tHnkIRZ8dh8vms9v33y6ft_efnh3c31121o5sLl14Jlm3q4GJRTnDjgM1K40shX3HQjQVlqnfW_rIzQTXFvBvBNgqVKWOXHR3Bx1XYKt2eUwQv5mEgRzB6S8NpDnYCOanstey9UgQS5BA9fVZqkkaOpRyar1-qi1269GdHaxAuKJ6GllChuzTgczyI7yoasCL-8Fcvq6xzKbMRSLMcKEaV8M1_WPJZdyob74h7pN-zxVqxZWJ_TQMfmHtYY6QJh8qvfaRdRcaaY6TjspKuvyP6x6HI7Bpgl9qPhJAz822JxKyeh_z8ioWdbQHNfQVH_M3RoaJX4BPATQRA</addsrcrecordid><sourcetype>Open Website</sourcetype><isCDI>true</isCDI><recordtype>article</recordtype><pqid>2715379514</pqid></control><display><type>article</type><title>Predictors of major adverse events and complications after ventricular septal defects surgical closure in children less than 10 kg</title><source>SpringerOpen</source><source>Publicly Available Content Database</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>Scholars Portal Open Access Journals</source><creator>Abdelrehim, Ayman R ; Al-Muhaya, Mustafa ; Alkodami, Alassal A ; Baangood, Luna S ; Al-Mutairi, Mansour ; Quadeer, Abdul ; Alabsi, Fath A ; Alashwal, M ; Morsy, Mohamed Mofeed F ; Alnajjar, Abdulhameed A ; Salem, Sherif S</creator><creatorcontrib>Abdelrehim, Ayman R ; Al-Muhaya, Mustafa ; Alkodami, Alassal A ; Baangood, Luna S ; Al-Mutairi, Mansour ; Quadeer, Abdul ; Alabsi, Fath A ; Alashwal, M ; Morsy, Mohamed Mofeed F ; Alnajjar, Abdulhameed A ; Salem, Sherif S</creatorcontrib><description>Abstract
Background
Ventricular septal defect (VSD) is the most common congenital cardiac defect for which outcomes are not uniform. There is a lack of consensus on the risk factors for the unfavorable outcomes following surgical VSD closure.
Aim
The aim of this study was to determine the risk factors and the predictors of major adverse events (MAEs) and complications following surgical closure of VSD in children weighing less than 10 kg.
Methods
This retrospective cohort study included children less than 10 kg who underwent surgical closure of congenital VSD of any type with or without associated congenital heart diseases. Patients with associated major cardiac anomalies were excluded. Preoperative, operative and postoperative data were collected from medical records.
Results
This study included 127 patients 52.8% were males, the median age was 8.0 months (IQR = 6.0–11.0 months), and their median weight was 5.7 kg (IQR = 4.8–7.0). Mortality was in one patient (0.8%) Multivariable logistic regression analysis revealed that male sex group (observational data), previous pulmonary artery banding (PAB), and significant intraoperative residual VSD were significant risk factors for the development of MAEs (odds ratios were 3.398, 14.282, and 8.634, respectively). Trisomy 21 syndrome (odds ratio: 5.678) contributed significantly to prolonged ventilation. Pulmonary artery banding (odds ratio: 14.415), significant intraoperative (3 mm) residual VSD (odds ratio: 11.262), and long cross-clamp time (odds ratio: 1.064) were significant predictors of prolonged ICU stay, whereas prolonged hospital stay was observed significantly in male sex group (odds ratio: 12.8281), PAB (odds ratio: 2.669), and significant intraoperative (3 mm) residual VSD (odds ratio: 19.551).
Conclusions
Surgical VSD repair is considered a safe procedure with very low mortality. Trisomy 21 was a significant risk factor for prolonged ventilation. Further, PAB, significant intraoperative residual of 3 mm or more that required a second pulmonary bypass, and a greater cross-clamp time were significant predictors of MAE and associated complications with prolonged ICU and hospital stay.</description><identifier>ISSN: 1749-8090</identifier><identifier>EISSN: 1749-8090</identifier><identifier>DOI: 10.1186/s13019-022-01985-6</identifier><identifier>PMID: 36071526</identifier><language>eng</language><publisher>London: BioMed Central Ltd</publisher><subject>Age ; Analysis ; Anomalies ; Cardiac patients ; Cardiovascular diseases ; Children ; Children's furniture ; Complications ; Complications and side effects ; Congenital diseases ; Coronary artery disease ; Coronary vessels ; Defects ; Genetic disorders ; Heart ; Heart diseases ; Hospitals ; Infections ; Major adverse events ; Males ; Medical records ; Medical research ; Medicine, Experimental ; Mortality ; Pacemakers ; Patients ; Pediatrics ; Peritoneal dialysis ; Pulmonary arteries ; Pulmonary artery ; Pulmonary hypertension ; Regression analysis ; Risk analysis ; Risk factors ; Sex ; Sex ratio ; Statistical analysis ; Surgical closure ; Surgical outcomes ; Sutures ; Trisomy ; Veins & arteries ; Ventilation ; Ventilators ; Ventricle ; Ventricular septal defect ; Ventricular septal defects</subject><ispartof>Journal of cardiothoracic surgery, 2022-09, Vol.17 (1), p.1-232, Article 232</ispartof><rights>COPYRIGHT 2022 BioMed Central Ltd.</rights><rights>2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c491t-daf171fcb963622da2a90cb7e1b2f5a3a7c4cd7f8cefe71327c31fd3ac066c1d3</cites><orcidid>0000-0002-4254-4204 ; 0000-0002-7120-7813 ; 0000-0002-0134-6244 ; 0000-0002-8905-0148 ; 0000-0001-5104-6517 ; 0000-0003-1738-4154 ; 0000-0003-3170-1574 ; 0000-0002-4682-9303 ; 0000-0002-1947-2839 ; 0000-0001-9897-1574</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9450295/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2715379514?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,734,787,791,871,892,2116,24362,25799,27985,27986,37077,37078,44955,54176,54178</link.rule.ids></links><search><creatorcontrib>Abdelrehim, Ayman R</creatorcontrib><creatorcontrib>Al-Muhaya, Mustafa</creatorcontrib><creatorcontrib>Alkodami, Alassal A</creatorcontrib><creatorcontrib>Baangood, Luna S</creatorcontrib><creatorcontrib>Al-Mutairi, Mansour</creatorcontrib><creatorcontrib>Quadeer, Abdul</creatorcontrib><creatorcontrib>Alabsi, Fath A</creatorcontrib><creatorcontrib>Alashwal, M</creatorcontrib><creatorcontrib>Morsy, Mohamed Mofeed F</creatorcontrib><creatorcontrib>Alnajjar, Abdulhameed A</creatorcontrib><creatorcontrib>Salem, Sherif S</creatorcontrib><title>Predictors of major adverse events and complications after ventricular septal defects surgical closure in children less than 10 kg</title><title>Journal of cardiothoracic surgery</title><description>Abstract
Background
Ventricular septal defect (VSD) is the most common congenital cardiac defect for which outcomes are not uniform. There is a lack of consensus on the risk factors for the unfavorable outcomes following surgical VSD closure.
Aim
The aim of this study was to determine the risk factors and the predictors of major adverse events (MAEs) and complications following surgical closure of VSD in children weighing less than 10 kg.
Methods
This retrospective cohort study included children less than 10 kg who underwent surgical closure of congenital VSD of any type with or without associated congenital heart diseases. Patients with associated major cardiac anomalies were excluded. Preoperative, operative and postoperative data were collected from medical records.
Results
This study included 127 patients 52.8% were males, the median age was 8.0 months (IQR = 6.0–11.0 months), and their median weight was 5.7 kg (IQR = 4.8–7.0). Mortality was in one patient (0.8%) Multivariable logistic regression analysis revealed that male sex group (observational data), previous pulmonary artery banding (PAB), and significant intraoperative residual VSD were significant risk factors for the development of MAEs (odds ratios were 3.398, 14.282, and 8.634, respectively). Trisomy 21 syndrome (odds ratio: 5.678) contributed significantly to prolonged ventilation. Pulmonary artery banding (odds ratio: 14.415), significant intraoperative (3 mm) residual VSD (odds ratio: 11.262), and long cross-clamp time (odds ratio: 1.064) were significant predictors of prolonged ICU stay, whereas prolonged hospital stay was observed significantly in male sex group (odds ratio: 12.8281), PAB (odds ratio: 2.669), and significant intraoperative (3 mm) residual VSD (odds ratio: 19.551).
Conclusions
Surgical VSD repair is considered a safe procedure with very low mortality. Trisomy 21 was a significant risk factor for prolonged ventilation. Further, PAB, significant intraoperative residual of 3 mm or more that required a second pulmonary bypass, and a greater cross-clamp time were significant predictors of MAE and associated complications with prolonged ICU and hospital stay.</description><subject>Age</subject><subject>Analysis</subject><subject>Anomalies</subject><subject>Cardiac patients</subject><subject>Cardiovascular diseases</subject><subject>Children</subject><subject>Children's furniture</subject><subject>Complications</subject><subject>Complications and side effects</subject><subject>Congenital diseases</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Defects</subject><subject>Genetic disorders</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Hospitals</subject><subject>Infections</subject><subject>Major adverse events</subject><subject>Males</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Pacemakers</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Peritoneal dialysis</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Pulmonary hypertension</subject><subject>Regression analysis</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sex</subject><subject>Sex ratio</subject><subject>Statistical analysis</subject><subject>Surgical closure</subject><subject>Surgical outcomes</subject><subject>Sutures</subject><subject>Trisomy</subject><subject>Veins & arteries</subject><subject>Ventilation</subject><subject>Ventilators</subject><subject>Ventricle</subject><subject>Ventricular septal defect</subject><subject>Ventricular septal defects</subject><issn>1749-8090</issn><issn>1749-8090</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUstuFDEQHCEQCYEf4GSJC5cJfo09c0GKIh6RIsEBzlav3d714hkv9uxKnPkRvoUvw5ONgEXIh25VV5fd5W6a54xeMtarV4UJyoaWct7W2HetetCcMy2HtqcDffhXftY8KWVLqewE7R43Z0JRzTquzpvvHzO6YOeUC0mejLBNmYA7YC5I8IDTXAhMjtg07mKwMIc0VcTPmMlSzcHuI2RScDdDJA492tpS9nld2ZHYmGqOJEzEbkJ0GScSsRQyb2AijP788WX9tHnkIRZ8dh8vms9v33y6ft_efnh3c31121o5sLl14Jlm3q4GJRTnDjgM1K40shX3HQjQVlqnfW_rIzQTXFvBvBNgqVKWOXHR3Bx1XYKt2eUwQv5mEgRzB6S8NpDnYCOanstey9UgQS5BA9fVZqkkaOpRyar1-qi1269GdHaxAuKJ6GllChuzTgczyI7yoasCL-8Fcvq6xzKbMRSLMcKEaV8M1_WPJZdyob74h7pN-zxVqxZWJ_TQMfmHtYY6QJh8qvfaRdRcaaY6TjspKuvyP6x6HI7Bpgl9qPhJAz822JxKyeh_z8ioWdbQHNfQVH_M3RoaJX4BPATQRA</recordid><startdate>20220907</startdate><enddate>20220907</enddate><creator>Abdelrehim, Ayman R</creator><creator>Al-Muhaya, Mustafa</creator><creator>Alkodami, Alassal A</creator><creator>Baangood, Luna S</creator><creator>Al-Mutairi, Mansour</creator><creator>Quadeer, Abdul</creator><creator>Alabsi, Fath A</creator><creator>Alashwal, M</creator><creator>Morsy, Mohamed Mofeed F</creator><creator>Alnajjar, Abdulhameed A</creator><creator>Salem, Sherif S</creator><general>BioMed Central Ltd</general><general>BioMed 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of major adverse events and complications after ventricular septal defects surgical closure in children less than 10 kg</title><author>Abdelrehim, Ayman R ; Al-Muhaya, Mustafa ; Alkodami, Alassal A ; Baangood, Luna S ; Al-Mutairi, Mansour ; Quadeer, Abdul ; Alabsi, Fath A ; Alashwal, M ; Morsy, Mohamed Mofeed F ; Alnajjar, Abdulhameed A ; Salem, Sherif S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-daf171fcb963622da2a90cb7e1b2f5a3a7c4cd7f8cefe71327c31fd3ac066c1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Analysis</topic><topic>Anomalies</topic><topic>Cardiac patients</topic><topic>Cardiovascular diseases</topic><topic>Children</topic><topic>Children's furniture</topic><topic>Complications</topic><topic>Complications and side effects</topic><topic>Congenital diseases</topic><topic>Coronary artery disease</topic><topic>Coronary vessels</topic><topic>Defects</topic><topic>Genetic disorders</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Hospitals</topic><topic>Infections</topic><topic>Major adverse events</topic><topic>Males</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mortality</topic><topic>Pacemakers</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Peritoneal dialysis</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Pulmonary hypertension</topic><topic>Regression analysis</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>Sex</topic><topic>Sex ratio</topic><topic>Statistical analysis</topic><topic>Surgical closure</topic><topic>Surgical outcomes</topic><topic>Sutures</topic><topic>Trisomy</topic><topic>Veins & arteries</topic><topic>Ventilation</topic><topic>Ventilators</topic><topic>Ventricle</topic><topic>Ventricular septal defect</topic><topic>Ventricular septal defects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdelrehim, Ayman R</creatorcontrib><creatorcontrib>Al-Muhaya, Mustafa</creatorcontrib><creatorcontrib>Alkodami, Alassal A</creatorcontrib><creatorcontrib>Baangood, Luna S</creatorcontrib><creatorcontrib>Al-Mutairi, Mansour</creatorcontrib><creatorcontrib>Quadeer, Abdul</creatorcontrib><creatorcontrib>Alabsi, Fath A</creatorcontrib><creatorcontrib>Alashwal, M</creatorcontrib><creatorcontrib>Morsy, Mohamed Mofeed F</creatorcontrib><creatorcontrib>Alnajjar, Abdulhameed A</creatorcontrib><creatorcontrib>Salem, Sherif S</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research 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closure in children less than 10 kg</atitle><jtitle>Journal of cardiothoracic surgery</jtitle><date>2022-09-07</date><risdate>2022</risdate><volume>17</volume><issue>1</issue><spage>1</spage><epage>232</epage><pages>1-232</pages><artnum>232</artnum><issn>1749-8090</issn><eissn>1749-8090</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Abstract
Background
Ventricular septal defect (VSD) is the most common congenital cardiac defect for which outcomes are not uniform. There is a lack of consensus on the risk factors for the unfavorable outcomes following surgical VSD closure.
Aim
The aim of this study was to determine the risk factors and the predictors of major adverse events (MAEs) and complications following surgical closure of VSD in children weighing less than 10 kg.
Methods
This retrospective cohort study included children less than 10 kg who underwent surgical closure of congenital VSD of any type with or without associated congenital heart diseases. Patients with associated major cardiac anomalies were excluded. Preoperative, operative and postoperative data were collected from medical records.
Results
This study included 127 patients 52.8% were males, the median age was 8.0 months (IQR = 6.0–11.0 months), and their median weight was 5.7 kg (IQR = 4.8–7.0). Mortality was in one patient (0.8%) Multivariable logistic regression analysis revealed that male sex group (observational data), previous pulmonary artery banding (PAB), and significant intraoperative residual VSD were significant risk factors for the development of MAEs (odds ratios were 3.398, 14.282, and 8.634, respectively). Trisomy 21 syndrome (odds ratio: 5.678) contributed significantly to prolonged ventilation. Pulmonary artery banding (odds ratio: 14.415), significant intraoperative (3 mm) residual VSD (odds ratio: 11.262), and long cross-clamp time (odds ratio: 1.064) were significant predictors of prolonged ICU stay, whereas prolonged hospital stay was observed significantly in male sex group (odds ratio: 12.8281), PAB (odds ratio: 2.669), and significant intraoperative (3 mm) residual VSD (odds ratio: 19.551).
Conclusions
Surgical VSD repair is considered a safe procedure with very low mortality. Trisomy 21 was a significant risk factor for prolonged ventilation. Further, PAB, significant intraoperative residual of 3 mm or more that required a second pulmonary bypass, and a greater cross-clamp time were significant predictors of MAE and associated complications with prolonged ICU and hospital stay.</abstract><cop>London</cop><pub>BioMed Central Ltd</pub><pmid>36071526</pmid><doi>10.1186/s13019-022-01985-6</doi><orcidid>https://orcid.org/0000-0002-4254-4204</orcidid><orcidid>https://orcid.org/0000-0002-7120-7813</orcidid><orcidid>https://orcid.org/0000-0002-0134-6244</orcidid><orcidid>https://orcid.org/0000-0002-8905-0148</orcidid><orcidid>https://orcid.org/0000-0001-5104-6517</orcidid><orcidid>https://orcid.org/0000-0003-1738-4154</orcidid><orcidid>https://orcid.org/0000-0003-3170-1574</orcidid><orcidid>https://orcid.org/0000-0002-4682-9303</orcidid><orcidid>https://orcid.org/0000-0002-1947-2839</orcidid><orcidid>https://orcid.org/0000-0001-9897-1574</orcidid><oa>free_for_read</oa></addata></record> |