Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff

Background. For the treatment of visceral leishmaniasis in Bangladesh, single dose liposomal amphotericin B (ambisome) is supposed to be the safest and most effective treatment. Specific needs for application and storage raise questions about feasibility of its implementation and acceptance by patie...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Tropical Medicine 2014-01, Vol.2014 (2014), p.92-98
Main Authors: Mondal, Dinesh, Arana, Byron, Alim, Abdul, Hossain, Md. Shakhawat, Ghosh, Debashis, Huda, M. Mamun, Hasan, M., Maintz, Eva-Maria, Kroeger, Axel
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-a670t-bc3f0052efd165d03ca5e501a348a55a2b2f099b8e9ae0326f53fe1474917f7b3
cites cdi_FETCH-LOGICAL-a670t-bc3f0052efd165d03ca5e501a348a55a2b2f099b8e9ae0326f53fe1474917f7b3
container_end_page 98
container_issue 2014
container_start_page 92
container_title Journal of Tropical Medicine
container_volume 2014
creator Mondal, Dinesh
Arana, Byron
Alim, Abdul
Hossain, Md. Shakhawat
Ghosh, Debashis
Huda, M. Mamun
Hasan, M.
Maintz, Eva-Maria
Kroeger, Axel
description Background. For the treatment of visceral leishmaniasis in Bangladesh, single dose liposomal amphotericin B (ambisome) is supposed to be the safest and most effective treatment. Specific needs for application and storage raise questions about feasibility of its implementation and acceptance by patients and health staff. Methods. The study was carried out in the most endemic district of Bangladesh. Study population includes patients treated with ambisome or miltefosine, hospital staff, and a director of the national visceral leishmaniasis program. Study methods include direct observation (subdistrict hospitals), open interviews (heath staff and program personnel), structured questionnaires, and focus group discussions (patients). Results. Politicalcommitment for ambisome is strong; the general hospital infrastructure favours implementation but further strengthening is required, particularly for drug storage below 25°C (refrigerators), back-up energy (fuel for generators), and supplies for ambisome administration (like 5% dextrose solution). Ambisome created high satisfaction in patients and hospital staff, less adverse events, and less income loss for patients compared to miltefosine. Conclusions. High political commitment, general capacities of subdistrict hospitals, and high acceptability favour the implementation of ambisome treatment in Bangladesh. However, strengthening of the infrastructure and uninterrupted supplies of essential accessories is mandatory before introducing sLAB in Bangladesh.
doi_str_mv 10.1155/2014/676817
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_61d8745d0cf643b0912136a54d662188</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A421524707</galeid><airiti_id>P20151222003_201412_201512220003_201512220003_92_98</airiti_id><doaj_id>oai_doaj_org_article_61d8745d0cf643b0912136a54d662188</doaj_id><sourcerecordid>A421524707</sourcerecordid><originalsourceid>FETCH-LOGICAL-a670t-bc3f0052efd165d03ca5e501a348a55a2b2f099b8e9ae0326f53fe1474917f7b3</originalsourceid><addsrcrecordid>eNqNkktv1DAQgCMEoqVw4o4sISEE2taPOA8OSNtC6aKVqGjhak2S8cZVEi-2A-pP4l_i3ZS2K3FAkRJn5psv8XiS5Dmjh4xJecQpS4-yPCtY_iDZZ1mRz8qsTB_erotsL3ni_RWlWV4W9HGyx1OZFzmj-8nvxRCcbcbaDCtyEW8dkg_WI1matfW2h47M-3VrAzoTGXJMtHUktEguHULocQjEavLd-BpdhJdofNvDYMAbT2LB13ETPoZohgZ9-46cYsxVpjPhmsDQkHld4zrAUCMJlpxDMFHqt6kzhC605CKA1k-TRxo6j89ungfJt9OPlydns-WXT4uT-XIGWU7DrKqFplRy1A3LZENFDRIlZSDSAqQEXnFNy7IqsASkgmdaCo0szdOS5TqvxEGymLyNhSu1dqYHd60sGLUNWLdS4IKpO1QZa4o8jR-pdZaKipaMM5GBTJss46woouv95FqPVY9NHTcWu7Ej3c0MplUr-1OJkhVCiih4fSNw9seIPqh-0-mugwHt6BWTVEjJ4llG9OWEriD-mhm0jcZ6g6t5ypnkaU7zSB3-g4pXg72p7YDaxPhOwat7Be32QLztxmDs4HfBtxNYO-u9Q327TUbVZlDVZlDVNKiRfnG_M7fs38mMwJsJaM3QwC_zfzaMCGq4B6eCpzwCnycAjDPBqCs7uiFOkTqPGsk455SKrZJxdReaYncvJVdlIf4ANXgNIw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503551871</pqid></control><display><type>article</type><title>Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff</title><source>Wiley Online Library Open Access</source><source>PubMed Central</source><creator>Mondal, Dinesh ; Arana, Byron ; Alim, Abdul ; Hossain, Md. Shakhawat ; Ghosh, Debashis ; Huda, M. Mamun ; Hasan, M. ; Maintz, Eva-Maria ; Kroeger, Axel</creator><contributor>Elhassan, Ibrahim M.</contributor><creatorcontrib>Mondal, Dinesh ; Arana, Byron ; Alim, Abdul ; Hossain, Md. Shakhawat ; Ghosh, Debashis ; Huda, M. Mamun ; Hasan, M. ; Maintz, Eva-Maria ; Kroeger, Axel ; Elhassan, Ibrahim M.</creatorcontrib><description>Background. For the treatment of visceral leishmaniasis in Bangladesh, single dose liposomal amphotericin B (ambisome) is supposed to be the safest and most effective treatment. Specific needs for application and storage raise questions about feasibility of its implementation and acceptance by patients and health staff. Methods. The study was carried out in the most endemic district of Bangladesh. Study population includes patients treated with ambisome or miltefosine, hospital staff, and a director of the national visceral leishmaniasis program. Study methods include direct observation (subdistrict hospitals), open interviews (heath staff and program personnel), structured questionnaires, and focus group discussions (patients). Results. Politicalcommitment for ambisome is strong; the general hospital infrastructure favours implementation but further strengthening is required, particularly for drug storage below 25°C (refrigerators), back-up energy (fuel for generators), and supplies for ambisome administration (like 5% dextrose solution). Ambisome created high satisfaction in patients and hospital staff, less adverse events, and less income loss for patients compared to miltefosine. Conclusions. High political commitment, general capacities of subdistrict hospitals, and high acceptability favour the implementation of ambisome treatment in Bangladesh. However, strengthening of the infrastructure and uninterrupted supplies of essential accessories is mandatory before introducing sLAB in Bangladesh.</description><identifier>ISSN: 1687-9686</identifier><identifier>EISSN: 1687-9694</identifier><identifier>DOI: 10.1155/2014/676817</identifier><identifier>PMID: 24578710</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Limiteds</publisher><ispartof>Journal of Tropical Medicine, 2014-01, Vol.2014 (2014), p.92-98</ispartof><rights>Copyright © 2014 Eva-Maria Maintz et al.</rights><rights>COPYRIGHT 2014 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2014 Eva-Maria Maintz et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a670t-bc3f0052efd165d03ca5e501a348a55a2b2f099b8e9ae0326f53fe1474917f7b3</citedby><cites>FETCH-LOGICAL-a670t-bc3f0052efd165d03ca5e501a348a55a2b2f099b8e9ae0326f53fe1474917f7b3</cites><orcidid>0000-0003-1236-0970</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918353/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918353/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,730,783,787,888,27938,27939,53806,53808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24578710$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Elhassan, Ibrahim M.</contributor><creatorcontrib>Mondal, Dinesh</creatorcontrib><creatorcontrib>Arana, Byron</creatorcontrib><creatorcontrib>Alim, Abdul</creatorcontrib><creatorcontrib>Hossain, Md. Shakhawat</creatorcontrib><creatorcontrib>Ghosh, Debashis</creatorcontrib><creatorcontrib>Huda, M. Mamun</creatorcontrib><creatorcontrib>Hasan, M.</creatorcontrib><creatorcontrib>Maintz, Eva-Maria</creatorcontrib><creatorcontrib>Kroeger, Axel</creatorcontrib><title>Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff</title><title>Journal of Tropical Medicine</title><addtitle>J Trop Med</addtitle><description>Background. For the treatment of visceral leishmaniasis in Bangladesh, single dose liposomal amphotericin B (ambisome) is supposed to be the safest and most effective treatment. Specific needs for application and storage raise questions about feasibility of its implementation and acceptance by patients and health staff. Methods. The study was carried out in the most endemic district of Bangladesh. Study population includes patients treated with ambisome or miltefosine, hospital staff, and a director of the national visceral leishmaniasis program. Study methods include direct observation (subdistrict hospitals), open interviews (heath staff and program personnel), structured questionnaires, and focus group discussions (patients). Results. Politicalcommitment for ambisome is strong; the general hospital infrastructure favours implementation but further strengthening is required, particularly for drug storage below 25°C (refrigerators), back-up energy (fuel for generators), and supplies for ambisome administration (like 5% dextrose solution). Ambisome created high satisfaction in patients and hospital staff, less adverse events, and less income loss for patients compared to miltefosine. Conclusions. High political commitment, general capacities of subdistrict hospitals, and high acceptability favour the implementation of ambisome treatment in Bangladesh. However, strengthening of the infrastructure and uninterrupted supplies of essential accessories is mandatory before introducing sLAB in Bangladesh.</description><issn>1687-9686</issn><issn>1687-9694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqNkktv1DAQgCMEoqVw4o4sISEE2taPOA8OSNtC6aKVqGjhak2S8cZVEi-2A-pP4l_i3ZS2K3FAkRJn5psv8XiS5Dmjh4xJecQpS4-yPCtY_iDZZ1mRz8qsTB_erotsL3ni_RWlWV4W9HGyx1OZFzmj-8nvxRCcbcbaDCtyEW8dkg_WI1matfW2h47M-3VrAzoTGXJMtHUktEguHULocQjEavLd-BpdhJdofNvDYMAbT2LB13ETPoZohgZ9-46cYsxVpjPhmsDQkHld4zrAUCMJlpxDMFHqt6kzhC605CKA1k-TRxo6j89ungfJt9OPlydns-WXT4uT-XIGWU7DrKqFplRy1A3LZENFDRIlZSDSAqQEXnFNy7IqsASkgmdaCo0szdOS5TqvxEGymLyNhSu1dqYHd60sGLUNWLdS4IKpO1QZa4o8jR-pdZaKipaMM5GBTJss46woouv95FqPVY9NHTcWu7Ej3c0MplUr-1OJkhVCiih4fSNw9seIPqh-0-mugwHt6BWTVEjJ4llG9OWEriD-mhm0jcZ6g6t5ypnkaU7zSB3-g4pXg72p7YDaxPhOwat7Be32QLztxmDs4HfBtxNYO-u9Q327TUbVZlDVZlDVNKiRfnG_M7fs38mMwJsJaM3QwC_zfzaMCGq4B6eCpzwCnycAjDPBqCs7uiFOkTqPGsk455SKrZJxdReaYncvJVdlIf4ANXgNIw</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Mondal, Dinesh</creator><creator>Arana, Byron</creator><creator>Alim, Abdul</creator><creator>Hossain, Md. Shakhawat</creator><creator>Ghosh, Debashis</creator><creator>Huda, M. Mamun</creator><creator>Hasan, M.</creator><creator>Maintz, Eva-Maria</creator><creator>Kroeger, Axel</creator><general>Hindawi Limiteds</general><general>Hindawi Publishing Corporation</general><general>John Wiley &amp; Sons, Inc</general><general>Wiley</general><scope>188</scope><scope>ADJCN</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1236-0970</orcidid></search><sort><creationdate>20140101</creationdate><title>Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff</title><author>Mondal, Dinesh ; Arana, Byron ; Alim, Abdul ; Hossain, Md. Shakhawat ; Ghosh, Debashis ; Huda, M. Mamun ; Hasan, M. ; Maintz, Eva-Maria ; Kroeger, Axel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a670t-bc3f0052efd165d03ca5e501a348a55a2b2f099b8e9ae0326f53fe1474917f7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mondal, Dinesh</creatorcontrib><creatorcontrib>Arana, Byron</creatorcontrib><creatorcontrib>Alim, Abdul</creatorcontrib><creatorcontrib>Hossain, Md. Shakhawat</creatorcontrib><creatorcontrib>Ghosh, Debashis</creatorcontrib><creatorcontrib>Huda, M. Mamun</creatorcontrib><creatorcontrib>Hasan, M.</creatorcontrib><creatorcontrib>Maintz, Eva-Maria</creatorcontrib><creatorcontrib>Kroeger, Axel</creatorcontrib><collection>Airiti Library</collection><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Tropical Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mondal, Dinesh</au><au>Arana, Byron</au><au>Alim, Abdul</au><au>Hossain, Md. Shakhawat</au><au>Ghosh, Debashis</au><au>Huda, M. Mamun</au><au>Hasan, M.</au><au>Maintz, Eva-Maria</au><au>Kroeger, Axel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff</atitle><jtitle>Journal of Tropical Medicine</jtitle><addtitle>J Trop Med</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>92</spage><epage>98</epage><pages>92-98</pages><issn>1687-9686</issn><eissn>1687-9694</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Academic Editor: Ibrahim M. Elhassan</notes><abstract>Background. For the treatment of visceral leishmaniasis in Bangladesh, single dose liposomal amphotericin B (ambisome) is supposed to be the safest and most effective treatment. Specific needs for application and storage raise questions about feasibility of its implementation and acceptance by patients and health staff. Methods. The study was carried out in the most endemic district of Bangladesh. Study population includes patients treated with ambisome or miltefosine, hospital staff, and a director of the national visceral leishmaniasis program. Study methods include direct observation (subdistrict hospitals), open interviews (heath staff and program personnel), structured questionnaires, and focus group discussions (patients). Results. Politicalcommitment for ambisome is strong; the general hospital infrastructure favours implementation but further strengthening is required, particularly for drug storage below 25°C (refrigerators), back-up energy (fuel for generators), and supplies for ambisome administration (like 5% dextrose solution). Ambisome created high satisfaction in patients and hospital staff, less adverse events, and less income loss for patients compared to miltefosine. Conclusions. High political commitment, general capacities of subdistrict hospitals, and high acceptability favour the implementation of ambisome treatment in Bangladesh. However, strengthening of the infrastructure and uninterrupted supplies of essential accessories is mandatory before introducing sLAB in Bangladesh.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Limiteds</pub><pmid>24578710</pmid><doi>10.1155/2014/676817</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1236-0970</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1687-9686
ispartof Journal of Tropical Medicine, 2014-01, Vol.2014 (2014), p.92-98
issn 1687-9686
1687-9694
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_61d8745d0cf643b0912136a54d662188
source Wiley Online Library Open Access; PubMed Central
title Introducing Single Dose Liposomal Amphotericin B for the Treatment of Visceral Leishmaniasis in Rural Bangladesh: Feasibility and Acceptance to Patients and Health Staff
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-01T23%3A25%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Introducing%20Single%20Dose%20Liposomal%20Amphotericin%20B%20for%20the%20Treatment%20of%20Visceral%20Leishmaniasis%20in%20Rural%20Bangladesh:%20Feasibility%20and%20Acceptance%20to%20Patients%20and%20Health%20Staff&rft.jtitle=Journal%20of%20Tropical%20Medicine&rft.au=Mondal,%20Dinesh&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=92&rft.epage=98&rft.pages=92-98&rft.issn=1687-9686&rft.eissn=1687-9694&rft_id=info:doi/10.1155/2014/676817&rft_dat=%3Cgale_doaj_%3EA421524707%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-a670t-bc3f0052efd165d03ca5e501a348a55a2b2f099b8e9ae0326f53fe1474917f7b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1503551871&rft_id=info:pmid/24578710&rft_galeid=A421524707&rft_airiti_id=P20151222003_201412_201512220003_201512220003_92_98&rfr_iscdi=true