MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential

Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-07, Vol.12 (7), p.1610
Main Authors: Wani, Javaid Ahmad, Majid, Sabhiya, Imtiyaz, Zuha, Rehman, Muneeb U, Alsaffar, Rana M, Shah, Naveed Nazir, Alshehri, Sultan, Ghoneim, Mohammed M, Imam, Syed Sarim
Format: Article
Language:English
Subjects:
Binding sites
Biomarkers
Biosynthesis
Bronchoscopy
Cancer
Cancer therapies
Cell growth
Chromosomes
Cytotoxicity
Diagnosis
diagnostics
DNA methylation
Epigenetics
Gene expression
Genetic aspects
Health aspects
Immune system
Immunology
Immunotherapy
Kinases
Lung cancer
Medical prognosis
Metastasis
MicroRNA
miRNA
Molecular diagnostic techniques
Molecular targeted therapy
Mutation
Oncology, Experimental
Prognosis
Review
therapeutics
Tomography
Transcription factors
Tumors
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Summary:Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20–24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12071610