Estimation of plasma apolipoprotein B concentration using routinely measured lipid biochemical tests in apparently healthy Asian adults

Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotei...

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Bibliographic Details
Published in:Cardiovascular diabetology 2012-05, Vol.11 (1), p.55-55, Article 55
Main Authors: Cho, Dong-Sik, Woo, Sookyoung, Kim, Seonwoo, Byrne, Christopher D, Kong, Joon-Hyuk, Sung, Ki-Chul
Format: Article
Language:English
Subjects:
Adult
Algorithms
Apolipoprotein
Apolipoprotein B-100 - blood
Asian Continental Ancestry Group
Biomarkers - blood
Blood Chemical Analysis
Body Mass Index
Cardiovascular disease
Cholesterol
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Female
Formula
Humans
Hypercholesterolemia
Linear Models
Lipid
Low density lipoprotein
Male
Medical research
Middle Aged
Models, Biological
Multivariate Analysis
Original Investigation
Predictive Value of Tests
Reference Values
Reproducibility of Results
Republic of Korea
Triglycerides - blood
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Summary:Increased low-density lipoprotein cholesterol (LDL) concentration is associated with increased risk of coronary heart disease (CHD) but a substantial risk of cardiovascular disease often remains after LDL concentrations have been treated to target. Apolipoprotein B (apo B) is the major apolipoprotein contained within atherogenic lipoproteins such as LDL, and apo B is a more reliable indicator of cardiovascular risk than LDL concentration. Our aim was to develop a formula for calculating apo B using lipid biochemistry measurements that are commonly available in clinical practice. We examined the clinical and laboratory data from 73,047 Koreans who underwent a medical health check that included apolipoprotein B concentration. The study sample was randomly divided into a training set for prediction model building and a validation set of equal size. Multivariable linear regression analysis was used to develop a prediction model equation for estimating apo B and to validate the developed model. The best results for estimating apo B were derived from an equation utilising LDL and triglyceride (TG) concentrations [ApoB = -33.12 + 0.675*LDL + 11.95*ln(tg)]. This equation predicted the apo B result with a concordance correlation coefficient (CCC and 95%CIs) = 0.936 (0.935,0.937)). Our equation for predicting apo B concentrations from routine analytical lipid biochemistry provides a simple method for obtaining precise information about an important cardiovascular risk marker.
ISSN:1475-2840
1475-2840
DOI:10.1186/1475-2840-11-55