Pneumonia and Related Conditions in Critically Ill Patients—Insights from Basic and Experimental Studies

Pneumonia is an acute infectious disease with high morbidity and mortality rates. Pneumonia’s development, severity and outcome depend on age, comorbidities and the host immune response. In this study, we combined theoretical and experimental investigations to characterize pneumonia and its comorbid...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-09, Vol.23 (17), p.9896
Main Authors: Kashatnikova, Darya A., Khadzhieva, Maryam B., Kolobkov, Dmitry S., Belopolskaya, Olesya B., Smelaya, Tamara V., Gracheva, Alesya S., Kalinina, Ekaterina V., Larin, Sergey S., Kuzovlev, Artem N., Salnikova, Lyubov E.
Format: Article
Language:English
Subjects:
acute respiratory distress syndrome (ARDS)
Age
Bone marrow
Cell division
Chronic illnesses
Circulatory system
Columbia Open Health Data (COHD)
comorbidities
Comorbidity
Coronaviruses
COVID-19
Drug resistance
Electronic health records
Electronic medical records
Heart failure
Hospitals
Immune response
Immune system
Infectious diseases
Intensive care units
Lymphocytes
Medical screening
Microorganisms
Morbidity
Mortality
Nosocomial infections
Pathogens
Patients
Pneumonia
Respiratory distress syndrome
Sepsis
Severe acute respiratory syndrome coronavirus 2
Staphylococcus infections
Streptococcus infections
TREC/KREC
Tumors
West Nile virus
Young adults
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pneumonia is an acute infectious disease with high morbidity and mortality rates. Pneumonia’s development, severity and outcome depend on age, comorbidities and the host immune response. In this study, we combined theoretical and experimental investigations to characterize pneumonia and its comorbidities as well as to assess the host immune response measured by TREC/KREC levels in patients with pneumonia. The theoretical study was carried out using the Columbia Open Health Data (COHD) resource, which provides access to clinical concept prevalence and co-occurrence from electronic health records. The experimental study included TREC/KREC assays in young adults (18–40 years) with community-acquired (CAP) (n = 164) or nosocomial (NP) (n = 99) pneumonia and healthy controls (n = 170). Co-occurring rates between pneumonia, sepsis, acute respiratory distress syndrome (ARDS) and some other related conditions common in intensive care units were the top among 4170, 3382 and 963 comorbidities in pneumonia, sepsis and ARDS, respectively. CAP patients had higher TREC levels, while NP patients had lower TREC/KREC levels compared to controls. Low TREC and KREC levels were predictive for the development of NP, ARDS, sepsis and lethal outcome (AUCTREC in the range 0.71–0.82, AUCKREC in the range 0.67–0.74). TREC/KREC analysis can be considered as a potential prognostic test in patients with pneumonia.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23179896