One Biocatalyst-Many Applications: The Use of Candida Antarctica B-Lipase in Organic Synthesis

The application of the B-component lipase from the yeast Candida antarctica in organic synthesis is reviewed. This enzyme has been found to be a particularly efficient and robust lipase catalyzing a surprising diversity of reactions including many different regio- and enantio-selec-tive syntheses. F...

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Bibliographic Details
Published in:Biocatalysis and biotransformation 1998, Vol.16 (3), p.181-204
Main Authors: Anderson, Emily M., Larsson, Karin M., Kirk, Ole
Format: Article
Language:English
Subjects:
Amides
Bioconversions. Hemisynthesis
Biological and medical sciences
Biotechnology
Candida antarctica B-lipase
Enantio-selectivity
Esters
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Peroxycarboxylic acids
Predicted specificity
Regio-selectivity
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Summary:The application of the B-component lipase from the yeast Candida antarctica in organic synthesis is reviewed. This enzyme has been found to be a particularly efficient and robust lipase catalyzing a surprising diversity of reactions including many different regio- and enantio-selec-tive syntheses. Furthermore, the C. antarctica B-lipase is an example of an enzyme for which its specificity has been predicted based on the crystal structure and modeling of the active site region. This prediction is compared to experimental observations and a very close correlation is found.
ISSN:1024-2422
1029-2446
DOI:10.3109/10242429809003198