Chemical composition and antinociceptive activity of volatile fractions of the aerial parts of Solidago chilensis (Compositae)

Abstract Thirty-six compounds were identified from aerial parts of Solidago chilensis cultivated at PAF/FIOCRUZ campus in Rio de Janeiro city (RJ) using solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) analysis. These compounds are mainly non-oxygenated mono and...

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Published in:Rodriguésia 2020, Vol.71
Main Authors: Valverde, Simone Sacramento, Souza, Stefânia Priscilla de, Oliveira, Temistocles Barroso de, Kelly, Andressa Maia, Costa, Nathalia Ferreira, Calheiros, Andrea Surrage, Lima, Keila dos Santos Cople, Frutuoso, Valber da Silva, Lima, Antônio Luís dos Santos
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Language:English
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antinociceptive activity
essential oil
Germacrene D
Solidago chilensis
SPME
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Souza, Stefânia Priscilla de
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Lima, Keila dos Santos Cople
Frutuoso, Valber da Silva
Lima, Antônio Luís dos Santos
description Abstract Thirty-six compounds were identified from aerial parts of Solidago chilensis cultivated at PAF/FIOCRUZ campus in Rio de Janeiro city (RJ) using solid-phase microextraction (HS-SPME) and gas chromatography-mass spectrometry (GC-MS) analysis. These compounds are mainly non-oxygenated mono and sesquiterpenes. Germacrene D is the major compound of two the essential oil analyzed samples (12 to 23%) and of two of the volatiles samples analyzed by SPME (central stems and dry inflorescences samples). Limonene is the major compound in the fresh inflorescences sample (about 21%). The bornil acetate is present in both volatile fractions (16%) and essential oils (7-8%). All the essential oils samples evaluated shown a great antinociceptive activity, considering the used dose of the samples (1 mg/kg) and the standard substance (50 mg/kg). Solidago chilensis is one of Brazil arnicas and it is a medicinal plant widely used by the brazilian population. Other plants of the genus Solidago are also used in traditional medicine in North America and Europe. This is the first report of SPME analysis from Solidago genus and of the antinociceptive effect from Solidago chilensis essential oil. Resumo Trinta e seis compostos foram identificados à partir de partes aéreas de Solidago chilensis cultivadas na PAF/FIOCRUZ, na cidade do Rio de Janeiro, usando microextração em fase sólida (MEFS) e analisados por cromatografia gasosa-espectrometria de massa (CG-EM). Estes compostos são principalmente mono terpenos não oxigenados e sesquiterpenos. O Germacreno D é o composto majoritário de duas amostras de óleo essencial analisadas (12 a 23%) e de duas amostras voláteis analisadas por MEFS. Limoneno é o composto majoritário da amostra de inflorescências frescas (cerca de 21%). O acetato de bornila está presente em ambas as frações, voláteis (16%) e óleos essenciais (7-8%). Todas as amostras de óleos essenciais avaliadas apresentaram boa atividade antinociceptiva, considerando a dose utilizada das amostras (1 mg/kg) e a substância padrão (50 mg/kg). Solidago chilensis é uma das arnicas brasileiras e é uma planta medicinal amplamente utilizada pela população brasileira. Outras plantas do gênero Solidago também são utilizadas na medicina tradicional na América do Norte e na Europa. Este é o primeiro relato da análise de MEFS do gênero Soligado e do efeito antinociceptivo do óleo essencial de Solidago chilensis.
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These compounds are mainly non-oxygenated mono and sesquiterpenes. Germacrene D is the major compound of two the essential oil analyzed samples (12 to 23%) and of two of the volatiles samples analyzed by SPME (central stems and dry inflorescences samples). Limonene is the major compound in the fresh inflorescences sample (about 21%). The bornil acetate is present in both volatile fractions (16%) and essential oils (7-8%). All the essential oils samples evaluated shown a great antinociceptive activity, considering the used dose of the samples (1 mg/kg) and the standard substance (50 mg/kg). Solidago chilensis is one of Brazil arnicas and it is a medicinal plant widely used by the brazilian population. Other plants of the genus Solidago are also used in traditional medicine in North America and Europe. This is the first report of SPME analysis from Solidago genus and of the antinociceptive effect from Solidago chilensis essential oil. Resumo Trinta e seis compostos foram identificados à partir de partes aéreas de Solidago chilensis cultivadas na PAF/FIOCRUZ, na cidade do Rio de Janeiro, usando microextração em fase sólida (MEFS) e analisados por cromatografia gasosa-espectrometria de massa (CG-EM). Estes compostos são principalmente mono terpenos não oxigenados e sesquiterpenos. O Germacreno D é o composto majoritário de duas amostras de óleo essencial analisadas (12 a 23%) e de duas amostras voláteis analisadas por MEFS. Limoneno é o composto majoritário da amostra de inflorescências frescas (cerca de 21%). O acetato de bornila está presente em ambas as frações, voláteis (16%) e óleos essenciais (7-8%). Todas as amostras de óleos essenciais avaliadas apresentaram boa atividade antinociceptiva, considerando a dose utilizada das amostras (1 mg/kg) e a substância padrão (50 mg/kg). Solidago chilensis é uma das arnicas brasileiras e é uma planta medicinal amplamente utilizada pela população brasileira. Outras plantas do gênero Solidago também são utilizadas na medicina tradicional na América do Norte e na Europa. 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These compounds are mainly non-oxygenated mono and sesquiterpenes. Germacrene D is the major compound of two the essential oil analyzed samples (12 to 23%) and of two of the volatiles samples analyzed by SPME (central stems and dry inflorescences samples). Limonene is the major compound in the fresh inflorescences sample (about 21%). The bornil acetate is present in both volatile fractions (16%) and essential oils (7-8%). All the essential oils samples evaluated shown a great antinociceptive activity, considering the used dose of the samples (1 mg/kg) and the standard substance (50 mg/kg). Solidago chilensis is one of Brazil arnicas and it is a medicinal plant widely used by the brazilian population. Other plants of the genus Solidago are also used in traditional medicine in North America and Europe. This is the first report of SPME analysis from Solidago genus and of the antinociceptive effect from Solidago chilensis essential oil. Resumo Trinta e seis compostos foram identificados à partir de partes aéreas de Solidago chilensis cultivadas na PAF/FIOCRUZ, na cidade do Rio de Janeiro, usando microextração em fase sólida (MEFS) e analisados por cromatografia gasosa-espectrometria de massa (CG-EM). Estes compostos são principalmente mono terpenos não oxigenados e sesquiterpenos. O Germacreno D é o composto majoritário de duas amostras de óleo essencial analisadas (12 a 23%) e de duas amostras voláteis analisadas por MEFS. Limoneno é o composto majoritário da amostra de inflorescências frescas (cerca de 21%). O acetato de bornila está presente em ambas as frações, voláteis (16%) e óleos essenciais (7-8%). Todas as amostras de óleos essenciais avaliadas apresentaram boa atividade antinociceptiva, considerando a dose utilizada das amostras (1 mg/kg) e a substância padrão (50 mg/kg). Solidago chilensis é uma das arnicas brasileiras e é uma planta medicinal amplamente utilizada pela população brasileira. Outras plantas do gênero Solidago também são utilizadas na medicina tradicional na América do Norte e na Europa. 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These compounds are mainly non-oxygenated mono and sesquiterpenes. Germacrene D is the major compound of two the essential oil analyzed samples (12 to 23%) and of two of the volatiles samples analyzed by SPME (central stems and dry inflorescences samples). Limonene is the major compound in the fresh inflorescences sample (about 21%). The bornil acetate is present in both volatile fractions (16%) and essential oils (7-8%). All the essential oils samples evaluated shown a great antinociceptive activity, considering the used dose of the samples (1 mg/kg) and the standard substance (50 mg/kg). Solidago chilensis is one of Brazil arnicas and it is a medicinal plant widely used by the brazilian population. Other plants of the genus Solidago are also used in traditional medicine in North America and Europe. This is the first report of SPME analysis from Solidago genus and of the antinociceptive effect from Solidago chilensis essential oil. Resumo Trinta e seis compostos foram identificados à partir de partes aéreas de Solidago chilensis cultivadas na PAF/FIOCRUZ, na cidade do Rio de Janeiro, usando microextração em fase sólida (MEFS) e analisados por cromatografia gasosa-espectrometria de massa (CG-EM). Estes compostos são principalmente mono terpenos não oxigenados e sesquiterpenos. O Germacreno D é o composto majoritário de duas amostras de óleo essencial analisadas (12 a 23%) e de duas amostras voláteis analisadas por MEFS. Limoneno é o composto majoritário da amostra de inflorescências frescas (cerca de 21%). O acetato de bornila está presente em ambas as frações, voláteis (16%) e óleos essenciais (7-8%). Todas as amostras de óleos essenciais avaliadas apresentaram boa atividade antinociceptiva, considerando a dose utilizada das amostras (1 mg/kg) e a substância padrão (50 mg/kg). Solidago chilensis é uma das arnicas brasileiras e é uma planta medicinal amplamente utilizada pela população brasileira. Outras plantas do gênero Solidago também são utilizadas na medicina tradicional na América do Norte e na Europa. Este é o primeiro relato da análise de MEFS do gênero Soligado e do efeito antinociceptivo do óleo essencial de Solidago chilensis.</abstract><pub>Instituto de Pesquisas Jardim Botânico do Rio de Janeiro</pub><doi>10.1590/2175-7860202071053</doi><orcidid>https://orcid.org/0000-0001-9043-3739</orcidid><oa>free_for_read</oa></addata></record>
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subjects antinociceptive activity
essential oil
Germacrene D
Solidago chilensis
SPME
title Chemical composition and antinociceptive activity of volatile fractions of the aerial parts of Solidago chilensis (Compositae)
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