Anti-inflammatory and antioxidant activities assessment of an aqueous extract of Ceiba pentandra (L.) Gaertn (Malvaceae)

Abstract Objective In traditional folk medicine, Ceiba pentandra has been used for its anti-diabetic and anti-infective effects. This study investigates the anti-inflammatory and antioxidant activities of the aqueous extract of the plant’s leaves. Methods The anti-oedematous tests with carrageenan a...

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Published in:RPS Pharmacy and Pharmacology Reports 2023-10, Vol.2 (4)
Main Authors: Silué, Gniènèfèrètien Nounaféri Awa, Belemlilga, Mohamed Bonewendé, Djadji, Ayoman Thierry Lenoir, Traoré, Kadiatou Tata, Boly, Gilchrist Abdoul Laurent, Koala, Moumouni, Ouédraogo, Noufou, Traoré, Aristide, Kouakou-Siransy, Gisèle
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creator Silué, Gniènèfèrètien Nounaféri Awa
Belemlilga, Mohamed Bonewendé
Djadji, Ayoman Thierry Lenoir
Traoré, Kadiatou Tata
Boly, Gilchrist Abdoul Laurent
Koala, Moumouni
Ouédraogo, Noufou
Traoré, Aristide
Kouakou-Siransy, Gisèle
description Abstract Objective In traditional folk medicine, Ceiba pentandra has been used for its anti-diabetic and anti-infective effects. This study investigates the anti-inflammatory and antioxidant activities of the aqueous extract of the plant’s leaves. Methods The anti-oedematous tests with carrageenan and lipoxygenase inhibition assay were carried out concerning anti-inflammatory studies. DPPH free radical scavenging, ferric-reducing antioxidant power, ABTS+ free radical scavenging assay, and lipid peroxide determination were investigated for antioxidant activities. Key findings As a result, C. pentandra extract inhibited edema between 3 and 5 h in the order of 83.07% and 94.09% at 200 kg. b.w. and lipoxygenase enzyme with a percentage of 87.11 ± 3.02%. This study used the lipid peroxidation level as a marker. The results of the lipid peroxidation test show a percentage inhibition of 49.60%, close to Trolox 48.11%, and present a good antioxidant activity compare with the free radical scavenging assay. Conclusions The aqueous decoction of C. pentandra leaves has demonstrated anti-inflammatory solid activities as well as lipid peroxidation due to the presence of phytochemical groups of interest such as sterols, polyphenols, quinones, catechin tannins, flavonoids, and saponins.
doi_str_mv 10.1093/rpsppr/rqad037
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Gaertn (Malvaceae)</title><source>Alma/SFX Local Collection</source><creator>Silué, Gniènèfèrètien Nounaféri Awa ; Belemlilga, Mohamed Bonewendé ; Djadji, Ayoman Thierry Lenoir ; Traoré, Kadiatou Tata ; Boly, Gilchrist Abdoul Laurent ; Koala, Moumouni ; Ouédraogo, Noufou ; Traoré, Aristide ; Kouakou-Siransy, Gisèle</creator><creatorcontrib>Silué, Gniènèfèrètien Nounaféri Awa ; Belemlilga, Mohamed Bonewendé ; Djadji, Ayoman Thierry Lenoir ; Traoré, Kadiatou Tata ; Boly, Gilchrist Abdoul Laurent ; Koala, Moumouni ; Ouédraogo, Noufou ; Traoré, Aristide ; Kouakou-Siransy, Gisèle</creatorcontrib><description>Abstract Objective In traditional folk medicine, Ceiba pentandra has been used for its anti-diabetic and anti-infective effects. This study investigates the anti-inflammatory and antioxidant activities of the aqueous extract of the plant’s leaves. Methods The anti-oedematous tests with carrageenan and lipoxygenase inhibition assay were carried out concerning anti-inflammatory studies. DPPH free radical scavenging, ferric-reducing antioxidant power, ABTS+ free radical scavenging assay, and lipid peroxide determination were investigated for antioxidant activities. Key findings As a result, C. pentandra extract inhibited edema between 3 and 5 h in the order of 83.07% and 94.09% at 200 kg. b.w. and lipoxygenase enzyme with a percentage of 87.11 ± 3.02%. This study used the lipid peroxidation level as a marker. The results of the lipid peroxidation test show a percentage inhibition of 49.60%, close to Trolox 48.11%, and present a good antioxidant activity compare with the free radical scavenging assay. Conclusions The aqueous decoction of C. pentandra leaves has demonstrated anti-inflammatory solid activities as well as lipid peroxidation due to the presence of phytochemical groups of interest such as sterols, polyphenols, quinones, catechin tannins, flavonoids, and saponins.</description><identifier>ISSN: 2754-5849</identifier><identifier>EISSN: 2754-5849</identifier><identifier>DOI: 10.1093/rpsppr/rqad037</identifier><language>eng</language><ispartof>RPS Pharmacy and Pharmacology Reports, 2023-10, Vol.2 (4)</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c797-c5fc879374d805e2ab68ec5daa29de0fb4bb7ccd6659b36ddcc028044d2e59a43</cites><orcidid>0000-0003-0593-3267</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Silué, Gniènèfèrètien Nounaféri Awa</creatorcontrib><creatorcontrib>Belemlilga, Mohamed Bonewendé</creatorcontrib><creatorcontrib>Djadji, Ayoman Thierry Lenoir</creatorcontrib><creatorcontrib>Traoré, Kadiatou Tata</creatorcontrib><creatorcontrib>Boly, Gilchrist Abdoul Laurent</creatorcontrib><creatorcontrib>Koala, Moumouni</creatorcontrib><creatorcontrib>Ouédraogo, Noufou</creatorcontrib><creatorcontrib>Traoré, Aristide</creatorcontrib><creatorcontrib>Kouakou-Siransy, Gisèle</creatorcontrib><title>Anti-inflammatory and antioxidant activities assessment of an aqueous extract of Ceiba pentandra (L.) Gaertn (Malvaceae)</title><title>RPS Pharmacy and Pharmacology Reports</title><description>Abstract Objective In traditional folk medicine, Ceiba pentandra has been used for its anti-diabetic and anti-infective effects. This study investigates the anti-inflammatory and antioxidant activities of the aqueous extract of the plant’s leaves. Methods The anti-oedematous tests with carrageenan and lipoxygenase inhibition assay were carried out concerning anti-inflammatory studies. DPPH free radical scavenging, ferric-reducing antioxidant power, ABTS+ free radical scavenging assay, and lipid peroxide determination were investigated for antioxidant activities. Key findings As a result, C. pentandra extract inhibited edema between 3 and 5 h in the order of 83.07% and 94.09% at 200 kg. b.w. and lipoxygenase enzyme with a percentage of 87.11 ± 3.02%. This study used the lipid peroxidation level as a marker. The results of the lipid peroxidation test show a percentage inhibition of 49.60%, close to Trolox 48.11%, and present a good antioxidant activity compare with the free radical scavenging assay. 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