Endocannabinoids and heart rate variability alterations after exposure to prolonged intensive physical exercise of the Hellenic Navy SEALs

Abstract Background Recent research indicates that endocanabinoids (eCB) and heart rate variability (HRV) are associated with stress-induced experiences. However, these underlying mechanisms have not been elucidated. Purpose The aim of the present study is to investigate if exposure to acute and chr...

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Published in:European heart journal 2021-10, Vol.42 (Supplement_1)
Main Authors: Mourtakos, S, Vassiliou, G, Kontoangelos, K, Philippou, A, Bersimis, F, Geladas, N, Koutsilieris, M, Sidossis, L, Papageorgiou, C H, Papageorgiou, C
Format: Article
Language:English
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Summary:Abstract Background Recent research indicates that endocanabinoids (eCB) and heart rate variability (HRV) are associated with stress-induced experiences. However, these underlying mechanisms have not been elucidated. Purpose The aim of the present study is to investigate if exposure to acute and chronic stress promotes measurable changes concurrently to the peripheral eCB ligands and the HRV. Methods 13 candidates under intense preparation for their enlistment in the Hellenic Navy SEALs (H.N.S.) participated in the study. All subjects underwent mental state examination, while HRV variables in time and frequency domains recordings were acquired. Furthermore, at baseline and 30 days after prolonged and intensive physical exercise hair were collected in order to measure eCB ligands, such as anandamide (AEA), 2-arachidonoylglycerol (2-AG), and the N-acyl ethanolamine (NAE) molecules: palmitoylethanolamide (PEA) and oleoylethanolamide (OEA). Results Comparing basal hair concentrations of eCB ligands before and after intensive physical exercise, we found that AEA, PEA and OEA were notably increased (p
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehab724.2751