A review on medicinally important heterocyclic compounds and importance of biophysical approach of underlying the insight mechanism in biological environment

Heterocyclic derivatives have more interesting biological properties which hold a remarkable place in pharmaceutical industries due to their unique physiochemical properties and ease of adaption in various biological environments. Of many, the above-said derivatives have been recently examined for t...

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Published in:Journal of biomolecular structure & dynamics 2023, Vol.41 (23), p.14599-14619
Main Authors: Karthikeyan, Subramani, Grishina, Maria, Kandasamy, Saravanan, Mangaiyarkarasi, Rajendiran, Ramamoorthi, Anitha, Chinnathambi, Shanmugavel, Pandian, Ganesh N, John Kennedy, L
Format: Article
Language:English
Subjects:
Biophysics
computational studies
fluorescence spectroscopy
Heterocyclic Compounds - pharmacology
Heterocyclic derivatives
Molecular Docking Simulation
protein/DNA-drug interaction
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creator Karthikeyan, Subramani
Grishina, Maria
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Pandian, Ganesh N
John Kennedy, L
description Heterocyclic derivatives have more interesting biological properties which hold a remarkable place in pharmaceutical industries due to their unique physiochemical properties and ease of adaption in various biological environments. Of many, the above-said derivatives have been recently examined for their promising action against a few malignancies. Specifically, anti-cancer research has benefited from these derivatives' natural flexibility and dynamic core scaffold. In any case, concerning some other promising anti-cancer drugs, heterocyclic derivative doesn't come without deficiencies. To be a successful drug candidate it should poses Absorption, Distribution, Metabolism and Eliminations (ADME) parameter, and must also have good binding interaction towards carrier protein as well as DNA and less in toxic nature, economically feasible. In this review, we described the overview of biologically important heterocyclic derivatives and their main application in medicine. Further, we focus types of biophysical techniques to understand the binding interaction mechanism. Communicated by Ramaswamy H. Sarma
doi_str_mv 10.1080/07391102.2023.2187640
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Science and Technology Collection (Reading list)
subjects Biophysics
computational studies
fluorescence spectroscopy
Heterocyclic Compounds - pharmacology
Heterocyclic derivatives
Molecular Docking Simulation
protein/DNA-drug interaction
title A review on medicinally important heterocyclic compounds and importance of biophysical approach of underlying the insight mechanism in biological environment
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