Biochemical and hemodynamic effects of ascorbic acid and alpha-tocopherol in coronary artery surgery

This study was undertaken to evaluate the effects of alpha-tocopherol and ascorbic acid on markers of myocardial reperfusion injury and myocardial contractile function after coronary artery surgery. Forty-eight patients were divided into 4 groups; 300 mg/day alpha-tocopherol was given orally to the...

Full description

Saved in:
Bibliographic Details
Published in:Scandinavian journal of clinical and laboratory investigation 2001, Vol.61 (8), p.621-629
Main Authors: Oktar, G. L., Sinci, V., Kalaycio lu, S., Soncul, H., Gökgöz, L., Halit, V., Ersöz, A.
Format: Article
Language:English
Subjects:
Aged
alpha-Tocopherol - administration & dosage
alpha-Tocopherol - blood
Alpha-TOCOPHEROL Ascorbic Acid Coronary Bypass Ischaemia-REPERFUSION Injury
Antioxidants - administration & dosage
Antioxidants - metabolism
Ascorbic Acid - administration & dosage
Ascorbic Acid - blood
Biological and medical sciences
Biomarkers - blood
Cardioplegic Solutions - administration & dosage
Cardiopulmonary Bypass
Coronary Artery Disease - drug therapy
Coronary Artery Disease - surgery
Creatine Kinase - blood
Creatine Kinase, MB Form
Female
General and cellular metabolism. Vitamins
Humans
Injections, Intravenous
Isoenzymes - blood
Male
Malondialdehyde - blood
Medical sciences
Middle Aged
Myocardial Reperfusion Injury - blood
Pharmacology. Drug treatments
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the heart
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was undertaken to evaluate the effects of alpha-tocopherol and ascorbic acid on markers of myocardial reperfusion injury and myocardial contractile function after coronary artery surgery. Forty-eight patients were divided into 4 groups; 300 mg/day alpha-tocopherol was given orally to the patients in group I for 14 days. In groups II and III, 4 g of ascorbic acid was administered intravenously prior to induction and in the cardioplegic solution, respectively. Group IV was the control group. Blood samples were taken to determine the concentrations of creatine phosphokinase MB isoenzyme, malondialdehyde, uric acid, ascorbic acid and alpha-tocopherol in the perioperative period. Left ventricular functions were determined by means of MUGA scans and echocardiography preoperatively and on the 3rd and 7th days, postoperatively. The changes in serum creatine phosphokinase MB and malondialdehyde were significantly lower in study groups, when compared with the control group. We observed no significant changes in ventricular function, requirement for (+) inotropic agents and the incidence of ventricular arrhythmias among the groups, postoperatively. Biochemical findings are consistent with the free radical hypothesis. But we could not confirm these data with hemodynamic findings. This is probably due to the population of low-risk elective coronary surgery patients in this study.
ISSN:0036-5513
1502-7686
DOI:10.1080/003655101753267982