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Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields
Shortening spin-lattice relaxation rates (1/T 1 ) or spin-spin relaxation rates (1/T 2 ) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe 3 O 4 s...
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| Published in: | Journal of applied physics 2011-12, Vol.110 (12), p.123911-123911-6 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c385t-a0a8146717a7a21fedf219d5bf958283acd9aec577a8480e7c201008985753f83 |
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| cites | cdi_FETCH-LOGICAL-c385t-a0a8146717a7a21fedf219d5bf958283acd9aec577a8480e7c201008985753f83 |
| container_end_page | 123911-6 |
| container_issue | 12 |
| container_start_page | 123911 |
| container_title | Journal of applied physics |
| container_volume | 110 |
| creator | Chen, Ming-Jye Liao, Shu-Hsien Yang, Hong-Chang Lee, Hsin-Yi Liu, Yi-Jia Chen, Hsin-Hsien Horng, Herng-Er Yang, Shieh-Yueh |
| description | Shortening spin-lattice relaxation rates (1/T
1
) or spin-spin relaxation rates (1/T
2
) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe
3
O
4
superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T
1
and 1/T
2
increase linearly when the magnetic susceptibility χ of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T
1
-contrast image is demonstrated, using SPIO as the contrast agent and high-T
c
superconducting quantum interference devices as the detector. T
1
-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer. |
| doi_str_mv | 10.1063/1.3671420 |
| format | article |
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1
) or spin-spin relaxation rates (1/T
2
) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe
3
O
4
superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T
1
and 1/T
2
increase linearly when the magnetic susceptibility χ of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T
1
-contrast image is demonstrated, using SPIO as the contrast agent and high-T
c
superconducting quantum interference devices as the detector. T
1
-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer.</description><identifier>ISSN: 0021-8979</identifier><identifier>EISSN: 1089-7550</identifier><identifier>DOI: 10.1063/1.3671420</identifier><identifier>CODEN: JAPIAU</identifier><language>eng</language><publisher>American Institute of Physics</publisher><ispartof>Journal of applied physics, 2011-12, Vol.110 (12), p.123911-123911-6</ispartof><rights>2011 American Institute of Physics</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-a0a8146717a7a21fedf219d5bf958283acd9aec577a8480e7c201008985753f83</citedby><cites>FETCH-LOGICAL-c385t-a0a8146717a7a21fedf219d5bf958283acd9aec577a8480e7c201008985753f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Chen, Ming-Jye</creatorcontrib><creatorcontrib>Liao, Shu-Hsien</creatorcontrib><creatorcontrib>Yang, Hong-Chang</creatorcontrib><creatorcontrib>Lee, Hsin-Yi</creatorcontrib><creatorcontrib>Liu, Yi-Jia</creatorcontrib><creatorcontrib>Chen, Hsin-Hsien</creatorcontrib><creatorcontrib>Horng, Herng-Er</creatorcontrib><creatorcontrib>Yang, Shieh-Yueh</creatorcontrib><title>Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields</title><title>Journal of applied physics</title><description>Shortening spin-lattice relaxation rates (1/T
1
) or spin-spin relaxation rates (1/T
2
) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe
3
O
4
superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T
1
and 1/T
2
increase linearly when the magnetic susceptibility χ of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T
1
-contrast image is demonstrated, using SPIO as the contrast agent and high-T
c
superconducting quantum interference devices as the detector. T
1
-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer.</description><issn>0021-8979</issn><issn>1089-7550</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kE1LAzEQQIMoWKsH_0GuHrZONk2TXAQpWoWCFz0vYz7aSJqVJBX117u2vXjwNId5DPMeIZcMJgxm_JpN-EyyaQtHZMRA6UYKAcdkBNCyRmmpT8lZKW8AjCmuR2Q9X2NGU10O3yGtaOzTKtStDQkjxWRpzZjKh8vF0ewifmINfaIZqyu099S7nHsft8EWGhLdBJP7YRWRbnCVXA2G-uCiLefkxGMs7uIwx-Tl_u55_tAsnxaP89tlY7gStUFAxaaDgkSJLfPO-pZpK169FqpVHI3V6IyQEtVUgZOmBQaDqBJScK_4mFzt7w6PlJKd795z2GD-6hh0v4k61h0SDezNni0m1J3Y__DfTt2uE_8B-1lwZg</recordid><startdate>20111215</startdate><enddate>20111215</enddate><creator>Chen, Ming-Jye</creator><creator>Liao, Shu-Hsien</creator><creator>Yang, Hong-Chang</creator><creator>Lee, Hsin-Yi</creator><creator>Liu, Yi-Jia</creator><creator>Chen, Hsin-Hsien</creator><creator>Horng, Herng-Er</creator><creator>Yang, Shieh-Yueh</creator><general>American Institute of Physics</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20111215</creationdate><title>Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields</title><author>Chen, Ming-Jye ; Liao, Shu-Hsien ; Yang, Hong-Chang ; Lee, Hsin-Yi ; Liu, Yi-Jia ; Chen, Hsin-Hsien ; Horng, Herng-Er ; Yang, Shieh-Yueh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-a0a8146717a7a21fedf219d5bf958283acd9aec577a8480e7c201008985753f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ming-Jye</creatorcontrib><creatorcontrib>Liao, Shu-Hsien</creatorcontrib><creatorcontrib>Yang, Hong-Chang</creatorcontrib><creatorcontrib>Lee, Hsin-Yi</creatorcontrib><creatorcontrib>Liu, Yi-Jia</creatorcontrib><creatorcontrib>Chen, Hsin-Hsien</creatorcontrib><creatorcontrib>Horng, Herng-Er</creatorcontrib><creatorcontrib>Yang, Shieh-Yueh</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of applied physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ming-Jye</au><au>Liao, Shu-Hsien</au><au>Yang, Hong-Chang</au><au>Lee, Hsin-Yi</au><au>Liu, Yi-Jia</au><au>Chen, Hsin-Hsien</au><au>Horng, Herng-Er</au><au>Yang, Shieh-Yueh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields</atitle><jtitle>Journal of applied physics</jtitle><date>2011-12-15</date><risdate>2011</risdate><volume>110</volume><issue>12</issue><spage>123911</spage><epage>123911-6</epage><pages>123911-123911-6</pages><issn>0021-8979</issn><eissn>1089-7550</eissn><coden>JAPIAU</coden><abstract>Shortening spin-lattice relaxation rates (1/T
1
) or spin-spin relaxation rates (1/T
2
) is the purpose of magnetic resonance imaging contrast agents. In this work, an ultralow field nuclear magnetic resonance spectrometer and imager are set up to characterize the spin relaxation rates of Fe
3
O
4
superparamagnetic iron oxide (SPIO) for image contrast. It was found that both 1/T
1
and 1/T
2
increase linearly when the magnetic susceptibility χ of SPIO increases by increasing the concentration of SPIO dispersed in water. In an applied field, magnetic moments of SPIO generate microscopic field gradients that weaken the field homogeneity, in turn de-phasing the proton's nuclear spin and enhancing the relaxation rates. A T
1
-contrast image is demonstrated, using SPIO as the contrast agent and high-T
c
superconducting quantum interference devices as the detector. T
1
-contrast imaging in microtesla fields might provide a potential modality for discriminating cancer.</abstract><pub>American Institute of Physics</pub><doi>10.1063/1.3671420</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of applied physics, 2011-12, Vol.110 (12), p.123911-123911-6 |
| issn | 0021-8979 1089-7550 |
| language | eng |
| recordid | cdi_crossref_primary_10_1063_1_3671420 |
| source | American Institute of Physics:Jisc Collections:Transitional Journals Agreement 2021-23 (Reading list) |
| title | Characterizing longitudinal and transverse relaxation rates of ferrofluids in microtesla magnetic fields |
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