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Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review
In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth. To be concise, among all the various shapes of nanocarriers, rods and tubes with a narrow cross-section are the most preferred shapes for the pen...
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Published in: | RSC advances 2022-12, Vol.13 (1), p.8-114 |
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creator | Zhang, Wenjie Taheri-Ledari, Reza Ganjali, Fatemeh Mirmohammadi, Seyedeh Shadi Qazi, Fateme Sadat Saeidirad, Mahdi KashtiAray, Amir Zarei-Shokat, Simindokht Tian, Ye Maleki, Ali |
description | In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth. To be concise, among all the various shapes of nanocarriers, rods and tubes with a narrow cross-section are the most preferred shapes for the penetration of a cell membrane. In this regard, several studies have focused on methods to produce nanorods and nanotubes with controlled optimized size and aspect ratio (AR). Additionally, a non-spherical orientation could affect the cellular uptake process while a tangent angle of less than 45 is better at penetrating the membrane, and
= 90 is beneficial. Moreover, these nanocarriers show different behaviors when confronting diverse cells whose fields should be investigated in future studies. In this survey, a comprehensive classification based on carrier shape is first submitted. Then, the most commonly used methods for control over the size and shape of the carriers are reviewed. Finally, influential factors on the cellular uptake and internalization processes and related analytical methods for evaluating this process are discussed.
In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth. |
doi_str_mv | 10.1039/d2ra06888e |
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= 90 is beneficial. Moreover, these nanocarriers show different behaviors when confronting diverse cells whose fields should be investigated in future studies. In this survey, a comprehensive classification based on carrier shape is first submitted. Then, the most commonly used methods for control over the size and shape of the carriers are reviewed. Finally, influential factors on the cellular uptake and internalization processes and related analytical methods for evaluating this process are discussed.
In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth.</description><identifier>ISSN: 2046-2069</identifier><identifier>EISSN: 2046-2069</identifier><identifier>DOI: 10.1039/d2ra06888e</identifier><identifier>PMID: 36605676</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aspect ratio ; Cell membranes ; Chemistry ; Drug carriers ; Morphology ; Nanorods ; Production methods ; Tubes</subject><ispartof>RSC advances, 2022-12, Vol.13 (1), p.8-114</ispartof><rights>This journal is © The Royal Society of Chemistry.</rights><rights>Copyright Royal Society of Chemistry 2023</rights><rights>This journal is © The Royal Society of Chemistry 2023 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-fdb4bff8684e5e4ba5e3a92f89bf807210bcd487b252c4a52a7a78d1ac2466cf3</citedby><cites>FETCH-LOGICAL-c428t-fdb4bff8684e5e4ba5e3a92f89bf807210bcd487b252c4a52a7a78d1ac2466cf3</cites><orcidid>0000-0001-5490-3350 ; 0000-0002-6511-9411</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764328/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9764328/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36605676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Wenjie</creatorcontrib><creatorcontrib>Taheri-Ledari, Reza</creatorcontrib><creatorcontrib>Ganjali, Fatemeh</creatorcontrib><creatorcontrib>Mirmohammadi, Seyedeh Shadi</creatorcontrib><creatorcontrib>Qazi, Fateme Sadat</creatorcontrib><creatorcontrib>Saeidirad, Mahdi</creatorcontrib><creatorcontrib>KashtiAray, Amir</creatorcontrib><creatorcontrib>Zarei-Shokat, Simindokht</creatorcontrib><creatorcontrib>Tian, Ye</creatorcontrib><creatorcontrib>Maleki, Ali</creatorcontrib><title>Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review</title><title>RSC advances</title><addtitle>RSC Adv</addtitle><description>In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth. To be concise, among all the various shapes of nanocarriers, rods and tubes with a narrow cross-section are the most preferred shapes for the penetration of a cell membrane. In this regard, several studies have focused on methods to produce nanorods and nanotubes with controlled optimized size and aspect ratio (AR). Additionally, a non-spherical orientation could affect the cellular uptake process while a tangent angle of less than 45 is better at penetrating the membrane, and
= 90 is beneficial. Moreover, these nanocarriers show different behaviors when confronting diverse cells whose fields should be investigated in future studies. In this survey, a comprehensive classification based on carrier shape is first submitted. Then, the most commonly used methods for control over the size and shape of the carriers are reviewed. Finally, influential factors on the cellular uptake and internalization processes and related analytical methods for evaluating this process are discussed.
In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth.</description><subject>Aspect ratio</subject><subject>Cell membranes</subject><subject>Chemistry</subject><subject>Drug carriers</subject><subject>Morphology</subject><subject>Nanorods</subject><subject>Production methods</subject><subject>Tubes</subject><issn>2046-2069</issn><issn>2046-2069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkt9rFDEQx4MottS--K4EfBHhajabTbI-CKVef0BBEH0Os9nJNXVvs052K-1f716vnrV5mTDzmS-TfIex14U4KkRZf2wlgdDWWnzG9qVQeiGFrp8_uu-xw5yvxXx0VUhdvGR7pdai0kbvM1qGgH7MPAW-TjRcpS6tbjn0Lc_xDjfpHvqUPXTIW5pW3ANRRJo7eu6x66YOiE_DCD_xvi32I1IPXbyDMc7MQMljzp84cMKbiL9fsRcBuoyHD_GA_Thdfj85X1x-Pbs4Ob5ceCXtuAhto5oQrLYKK1QNVFhCLYOtm2CFkYVofKusaWQlvYJKggFj2wK8VFr7UB6wz1vdYWrW2HrsR4LODRTXQLcuQXT_V_p45VbpxtVGq1LaWeD9gwClXxPm0a1j3jwZekxTdtLooja1lfWMvnuCXqdp8wtbymplZDlTH7aUp5QzYdgNUwi3cdN9kd-O791czvDbx-Pv0L_ezcCbLUDZ76r_1qH8AyChpwI</recordid><startdate>20221219</startdate><enddate>20221219</enddate><creator>Zhang, Wenjie</creator><creator>Taheri-Ledari, Reza</creator><creator>Ganjali, Fatemeh</creator><creator>Mirmohammadi, Seyedeh Shadi</creator><creator>Qazi, Fateme Sadat</creator><creator>Saeidirad, Mahdi</creator><creator>KashtiAray, Amir</creator><creator>Zarei-Shokat, Simindokht</creator><creator>Tian, Ye</creator><creator>Maleki, Ali</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5490-3350</orcidid><orcidid>https://orcid.org/0000-0002-6511-9411</orcidid></search><sort><creationdate>20221219</creationdate><title>Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review</title><author>Zhang, Wenjie ; Taheri-Ledari, Reza ; Ganjali, Fatemeh ; Mirmohammadi, Seyedeh Shadi ; Qazi, Fateme Sadat ; Saeidirad, Mahdi ; KashtiAray, Amir ; Zarei-Shokat, Simindokht ; Tian, Ye ; Maleki, Ali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-fdb4bff8684e5e4ba5e3a92f89bf807210bcd487b252c4a52a7a78d1ac2466cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Aspect ratio</topic><topic>Cell membranes</topic><topic>Chemistry</topic><topic>Drug carriers</topic><topic>Morphology</topic><topic>Nanorods</topic><topic>Production methods</topic><topic>Tubes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Wenjie</creatorcontrib><creatorcontrib>Taheri-Ledari, Reza</creatorcontrib><creatorcontrib>Ganjali, Fatemeh</creatorcontrib><creatorcontrib>Mirmohammadi, Seyedeh Shadi</creatorcontrib><creatorcontrib>Qazi, Fateme Sadat</creatorcontrib><creatorcontrib>Saeidirad, Mahdi</creatorcontrib><creatorcontrib>KashtiAray, Amir</creatorcontrib><creatorcontrib>Zarei-Shokat, Simindokht</creatorcontrib><creatorcontrib>Tian, Ye</creatorcontrib><creatorcontrib>Maleki, Ali</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RSC advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Wenjie</au><au>Taheri-Ledari, Reza</au><au>Ganjali, Fatemeh</au><au>Mirmohammadi, Seyedeh Shadi</au><au>Qazi, Fateme Sadat</au><au>Saeidirad, Mahdi</au><au>KashtiAray, Amir</au><au>Zarei-Shokat, Simindokht</au><au>Tian, Ye</au><au>Maleki, Ali</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review</atitle><jtitle>RSC advances</jtitle><addtitle>RSC Adv</addtitle><date>2022-12-19</date><risdate>2022</risdate><volume>13</volume><issue>1</issue><spage>8</spage><epage>114</epage><pages>8-114</pages><issn>2046-2069</issn><eissn>2046-2069</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-3</notes><notes>content type line 23</notes><notes>ObjectType-Review-1</notes><abstract>In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth. To be concise, among all the various shapes of nanocarriers, rods and tubes with a narrow cross-section are the most preferred shapes for the penetration of a cell membrane. In this regard, several studies have focused on methods to produce nanorods and nanotubes with controlled optimized size and aspect ratio (AR). Additionally, a non-spherical orientation could affect the cellular uptake process while a tangent angle of less than 45 is better at penetrating the membrane, and
= 90 is beneficial. Moreover, these nanocarriers show different behaviors when confronting diverse cells whose fields should be investigated in future studies. In this survey, a comprehensive classification based on carrier shape is first submitted. Then, the most commonly used methods for control over the size and shape of the carriers are reviewed. Finally, influential factors on the cellular uptake and internalization processes and related analytical methods for evaluating this process are discussed.
In the field of targeted drug delivery, the effects of size and morphology of drug nanocarriers are of great importance and need to be discussed in depth.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36605676</pmid><doi>10.1039/d2ra06888e</doi><tpages>35</tpages><orcidid>https://orcid.org/0000-0001-5490-3350</orcidid><orcidid>https://orcid.org/0000-0002-6511-9411</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Aspect ratio Cell membranes Chemistry Drug carriers Morphology Nanorods Production methods Tubes |
title | Effects of morphology and size of nanoscale drug carriers on cellular uptake and internalization process: a review |
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