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Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity
Obesity is a chronic metabolic disease that is prevalent worldwide, causing complications that affect the quality of life and longevity of humans. Currently, the low bioavailability upon subcutaneous injection of an appetite suppressant, liraglutide, and health problems in the locally injected regio...
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| Published in: | Lab on a chip 2023-05, Vol.23 (1), p.2378-2388 |
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| Main Authors: | , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c337t-d6e6c605d70a5bcf4a5178eae7a004535caea2ff532e275fbd19e93c0b53bd8c3 |
| container_end_page | 2388 |
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| container_title | Lab on a chip |
| container_volume | 23 |
| creator | Juhng, Seorin Song, Jieun You, Jeongyun Park, Jihyun Yang, Huisuk Jang, Mingyu Kang, Geonwoo Shin, Jiwoo Ko, Hyuk Wan Jung, Hyungil |
| description | Obesity is a chronic metabolic disease that is prevalent worldwide, causing complications that affect the quality of life and longevity of humans. Currently, the low bioavailability upon subcutaneous injection of an appetite suppressant, liraglutide, and health problems in the locally injected region remain to be overcome. In this study, we developed a novel hyaluronic acid-based liraglutide-encapsulated triple-layer microneedle (TLM) as a painless and patient-friendly long-term drug delivery system. In contrast to previous anti-obesity microneedle approaches, this TLM is composed of three layers for complete skin insertion, protecting the encapsulated liraglutide from environmental stresses. Daily topical application of the liraglutide-loaded TLM significantly reduced body weight and improved body composition in a mouse model of high-fat diet-induced obesity. Additionally, it ameliorated diet-induced hepatic steatosis in obese mice. This novel TLM could promote a glucagon-like peptide-1 drug release system for long-term daily administration with relatively higher patient compliance compared to subcutaneous injection.
The triple layer system (TLM) is a novel three layer composition dissolving microneedle which enhances drug efficacy and bioavailability, where each layer is designed to maximize the microneedle insertion and drug delivery. |
| doi_str_mv | 10.1039/d2lc01084d |
| format | article |
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The triple layer system (TLM) is a novel three layer composition dissolving microneedle which enhances drug efficacy and bioavailability, where each layer is designed to maximize the microneedle insertion and drug delivery.</description><identifier>ISSN: 1473-0197</identifier><identifier>EISSN: 1473-0189</identifier><identifier>DOI: 10.1039/d2lc01084d</identifier><identifier>PMID: 36919574</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Bioavailability ; Body weight ; Diet ; Diet, High-Fat ; Drug delivery systems ; Encapsulation ; Humans ; Hyaluronic acid ; Hyaluronic Acid - therapeutic use ; Liraglutide - pharmacology ; Liraglutide - therapeutic use ; Metabolic disorders ; Mice ; Needles ; Obesity ; Obesity - drug therapy ; Quality of Life ; Weight reduction</subject><ispartof>Lab on a chip, 2023-05, Vol.23 (1), p.2378-2388</ispartof><rights>Copyright Royal Society of Chemistry 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-d6e6c605d70a5bcf4a5178eae7a004535caea2ff532e275fbd19e93c0b53bd8c3</citedby><cites>FETCH-LOGICAL-c337t-d6e6c605d70a5bcf4a5178eae7a004535caea2ff532e275fbd19e93c0b53bd8c3</cites><orcidid>0000-0002-1946-7300</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36919574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juhng, Seorin</creatorcontrib><creatorcontrib>Song, Jieun</creatorcontrib><creatorcontrib>You, Jeongyun</creatorcontrib><creatorcontrib>Park, Jihyun</creatorcontrib><creatorcontrib>Yang, Huisuk</creatorcontrib><creatorcontrib>Jang, Mingyu</creatorcontrib><creatorcontrib>Kang, Geonwoo</creatorcontrib><creatorcontrib>Shin, Jiwoo</creatorcontrib><creatorcontrib>Ko, Hyuk Wan</creatorcontrib><creatorcontrib>Jung, Hyungil</creatorcontrib><title>Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity</title><title>Lab on a chip</title><addtitle>Lab Chip</addtitle><description>Obesity is a chronic metabolic disease that is prevalent worldwide, causing complications that affect the quality of life and longevity of humans. Currently, the low bioavailability upon subcutaneous injection of an appetite suppressant, liraglutide, and health problems in the locally injected region remain to be overcome. In this study, we developed a novel hyaluronic acid-based liraglutide-encapsulated triple-layer microneedle (TLM) as a painless and patient-friendly long-term drug delivery system. In contrast to previous anti-obesity microneedle approaches, this TLM is composed of three layers for complete skin insertion, protecting the encapsulated liraglutide from environmental stresses. Daily topical application of the liraglutide-loaded TLM significantly reduced body weight and improved body composition in a mouse model of high-fat diet-induced obesity. Additionally, it ameliorated diet-induced hepatic steatosis in obese mice. This novel TLM could promote a glucagon-like peptide-1 drug release system for long-term daily administration with relatively higher patient compliance compared to subcutaneous injection.
The triple layer system (TLM) is a novel three layer composition dissolving microneedle which enhances drug efficacy and bioavailability, where each layer is designed to maximize the microneedle insertion and drug delivery.</description><subject>Animals</subject><subject>Bioavailability</subject><subject>Body weight</subject><subject>Diet</subject><subject>Diet, High-Fat</subject><subject>Drug delivery systems</subject><subject>Encapsulation</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - therapeutic use</subject><subject>Liraglutide - pharmacology</subject><subject>Liraglutide - therapeutic use</subject><subject>Metabolic disorders</subject><subject>Mice</subject><subject>Needles</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Quality of Life</subject><subject>Weight reduction</subject><issn>1473-0197</issn><issn>1473-0189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkUtP7DAMhSMEAi6wYQ-KxGYuUiGPpmmXaLg8pEFsYF25iQtBaTsk6WL-PYXhDhIr2_LnI9uHkGPOLjiT1aUV3jDOytxukX2ea5kxXlbbm7zSe-RPjG-McZUX5S7Zk0XFK6XzfTLeQBOcgeSGng4t9S7Aix-Ts5hhb2AZRw8JLU3BLT1SDysM9HUFfgxD7wwF4yztnJkqROsx0tnT4iH-pe0QaHrFaRAhddinT_mhwejS6pDstOAjHn3HA_J88-9pfpctHm_v51eLzEipU2YLLEzBlNUMVGPaHBTXJQJqYCxXUhlAEG2rpEChVdtYXmElDWuUbGxp5AGZrXWXYXgfMaa6c9Gg99DjMMZa6FILLgRTE3r2C30bxtBP29Wi5LKUhSrERJ2vqeneGAO29TK4DsKq5qz-NKO-Fov5lxnXE3z6LTk2HdoN-v_7E3CyBkI0m-6Pm_ID9m2P-g</recordid><startdate>20230516</startdate><enddate>20230516</enddate><creator>Juhng, Seorin</creator><creator>Song, Jieun</creator><creator>You, Jeongyun</creator><creator>Park, Jihyun</creator><creator>Yang, Huisuk</creator><creator>Jang, Mingyu</creator><creator>Kang, Geonwoo</creator><creator>Shin, Jiwoo</creator><creator>Ko, Hyuk Wan</creator><creator>Jung, Hyungil</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1946-7300</orcidid></search><sort><creationdate>20230516</creationdate><title>Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity</title><author>Juhng, Seorin ; Song, Jieun ; You, Jeongyun ; Park, Jihyun ; Yang, Huisuk ; Jang, Mingyu ; Kang, Geonwoo ; Shin, Jiwoo ; Ko, Hyuk Wan ; Jung, Hyungil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-d6e6c605d70a5bcf4a5178eae7a004535caea2ff532e275fbd19e93c0b53bd8c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Animals</topic><topic>Bioavailability</topic><topic>Body weight</topic><topic>Diet</topic><topic>Diet, High-Fat</topic><topic>Drug delivery systems</topic><topic>Encapsulation</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - therapeutic use</topic><topic>Liraglutide - pharmacology</topic><topic>Liraglutide - therapeutic use</topic><topic>Metabolic disorders</topic><topic>Mice</topic><topic>Needles</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Quality of Life</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juhng, Seorin</creatorcontrib><creatorcontrib>Song, Jieun</creatorcontrib><creatorcontrib>You, Jeongyun</creatorcontrib><creatorcontrib>Park, Jihyun</creatorcontrib><creatorcontrib>Yang, Huisuk</creatorcontrib><creatorcontrib>Jang, Mingyu</creatorcontrib><creatorcontrib>Kang, Geonwoo</creatorcontrib><creatorcontrib>Shin, Jiwoo</creatorcontrib><creatorcontrib>Ko, Hyuk Wan</creatorcontrib><creatorcontrib>Jung, Hyungil</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Lab on a chip</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juhng, Seorin</au><au>Song, Jieun</au><au>You, Jeongyun</au><au>Park, Jihyun</au><au>Yang, Huisuk</au><au>Jang, Mingyu</au><au>Kang, Geonwoo</au><au>Shin, Jiwoo</au><au>Ko, Hyuk Wan</au><au>Jung, Hyungil</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity</atitle><jtitle>Lab on a chip</jtitle><addtitle>Lab Chip</addtitle><date>2023-05-16</date><risdate>2023</risdate><volume>23</volume><issue>1</issue><spage>2378</spage><epage>2388</epage><pages>2378-2388</pages><issn>1473-0197</issn><eissn>1473-0189</eissn><notes>https://doi.org/10.1039/d2lc01084d</notes><notes>Electronic supplementary information (ESI) available. See DOI</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Obesity is a chronic metabolic disease that is prevalent worldwide, causing complications that affect the quality of life and longevity of humans. Currently, the low bioavailability upon subcutaneous injection of an appetite suppressant, liraglutide, and health problems in the locally injected region remain to be overcome. In this study, we developed a novel hyaluronic acid-based liraglutide-encapsulated triple-layer microneedle (TLM) as a painless and patient-friendly long-term drug delivery system. In contrast to previous anti-obesity microneedle approaches, this TLM is composed of three layers for complete skin insertion, protecting the encapsulated liraglutide from environmental stresses. Daily topical application of the liraglutide-loaded TLM significantly reduced body weight and improved body composition in a mouse model of high-fat diet-induced obesity. Additionally, it ameliorated diet-induced hepatic steatosis in obese mice. This novel TLM could promote a glucagon-like peptide-1 drug release system for long-term daily administration with relatively higher patient compliance compared to subcutaneous injection.
The triple layer system (TLM) is a novel three layer composition dissolving microneedle which enhances drug efficacy and bioavailability, where each layer is designed to maximize the microneedle insertion and drug delivery.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>36919574</pmid><doi>10.1039/d2lc01084d</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1946-7300</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1473-0197 |
| ispartof | Lab on a chip, 2023-05, Vol.23 (1), p.2378-2388 |
| issn | 1473-0197 1473-0189 |
| language | eng |
| recordid | cdi_crossref_primary_10_1039_D2LC01084D |
| source | Royal Society of Chemistry |
| subjects | Animals Bioavailability Body weight Diet Diet, High-Fat Drug delivery systems Encapsulation Humans Hyaluronic acid Hyaluronic Acid - therapeutic use Liraglutide - pharmacology Liraglutide - therapeutic use Metabolic disorders Mice Needles Obesity Obesity - drug therapy Quality of Life Weight reduction |
| title | Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity |
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