Trifunctionalization of Allenes via Cobalt-Catalyzed MHP-Assisted C–H Bond Functionalization and Molecular Oxygen Activation

We have developed an approach for the cobalt-catalyzed trifunctionalization of allenes to form versatile 3-acylquinolines in the presence of molecular oxygen with moderate to good yields in high regioselectivity. C–H bond functionalization of benzoic hydrazides assisted by the 2-(1′-methylhydrazinyl...

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Bibliographic Details
Published in:ACS catalysis 2018-07, Vol.8 (7), p.6645-6649
Main Authors: Zhai, Shengxian, Qiu, Shuxian, Chen, Xiaoming, Tao, Cheng, Li, Yun, Cheng, Bin, Wang, Huifei, Zhai, Hongbin
Format: Article
Language:English
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Summary:We have developed an approach for the cobalt-catalyzed trifunctionalization of allenes to form versatile 3-acylquinolines in the presence of molecular oxygen with moderate to good yields in high regioselectivity. C–H bond functionalization of benzoic hydrazides assisted by the 2-(1′-methylhydrazinyl)­pyridine (MHP) acted as a key step in the cascade reaction. The reaction shows broad functional group tolerance of both allenes and hydrazides. Moreover, relevant experiments have been performed to probe the reaction mechanism.
ISSN:2155-5435
2155-5435
DOI:10.1021/acscatal.8b01720