Effect of Polyol Chain Length on Proton Relaxivity of Gadolinium Oxide Nanoparticles for Enhanced Magnetic Resonance Imaging Contrast

We present the impact of surface modifications on the magnetic resonance imaging (MRI) contrast enhancement abilities of gadolinium oxide nanoparticles. A series of gadolinium oxide nanoparticles surface-coated with polyols of different reductive abilities such as diethylene glycol (DEG), triethylen...

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Published in:Journal of physical chemistry. C 2019-07, Vol.123 (29), p.18061-18070
Main Authors: Guleria, Anupam, Pranjali, Pranjali, Meher, Mukesh Kumar, Chaturvedi, Anamika, Chakraborti, Sreemoyee, Raj, Ritu, Poluri, Krishna Mohan, Kumar, Dinesh
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cited_by cdi_FETCH-LOGICAL-a383t-cb995d68bf84756d6ab6b4c878cfd6cfd7a8a16159209126c3c7051180bc5f643
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container_end_page 18070
container_issue 29
container_start_page 18061
container_title Journal of physical chemistry. C
container_volume 123
creator Guleria, Anupam
Pranjali, Pranjali
Meher, Mukesh Kumar
Chaturvedi, Anamika
Chakraborti, Sreemoyee
Raj, Ritu
Poluri, Krishna Mohan
Kumar, Dinesh
description We present the impact of surface modifications on the magnetic resonance imaging (MRI) contrast enhancement abilities of gadolinium oxide nanoparticles. A series of gadolinium oxide nanoparticles surface-coated with polyols of different reductive abilities such as diethylene glycol (DEG), triethylene glycol (TEG), tetraethylene glycol (TeEG), and polyethylene glycol (PEG 200) were synthesized. Particle sizes of synthesized Gd2O3 nanoparticles were found to be in correlation with the chain length of glycol. An enhancement in the in vitro and ex vivo relaxivity of Gd2O3 nanoparticles was revealed with the increase in glycol chain length. Among the various nanosystems, PEG-Gd2O3 has the highest in vitro and ex vivo relaxivities and excellent biocompatibility as revealed from cellular cytotoxicity experiments. The enhancement in MR contrast with glycol chain length can be attributed to the increase in surface hydrophilicity, and its modulation can be exploited as a novel strategy for enhancing the MRI contrast of gadolinium-based contrast agents.
doi_str_mv 10.1021/acs.jpcc.9b04089
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title Effect of Polyol Chain Length on Proton Relaxivity of Gadolinium Oxide Nanoparticles for Enhanced Magnetic Resonance Imaging Contrast
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