Assessment of metabolite quantitation reproducibility in serial 3D‐ 1 H‐MR spectroscopic imaging of human brain using stereotactic repositioning

Abstract Intrasubject reproducibility of metabolite quantitation in three‐dimensional proton magnetic resonance spectroscopic imaging (3D‐MRSI) was investigated in 10 healthy volunteers over five separate sessions using two echo times (TEs): 144 and 30 ms. The use of a Gill‐Thomas‐Cosman (GTC) stere...

Full description

Saved in:
Bibliographic Details
Published in:Magnetic resonance in medicine 2007-10, Vol.58 (4), p.666-673
Main Authors: Langer, Deanna L., Rakaric, Peter, Kirilova, Anna, Jaffray, David A., Damyanovich, Andrei Z.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c741-4d939cbf81d0dffc13373b79304f69a189f992e66a41d19552d68595b16e14f23
cites cdi_FETCH-LOGICAL-c741-4d939cbf81d0dffc13373b79304f69a189f992e66a41d19552d68595b16e14f23
container_end_page 673
container_issue 4
container_start_page 666
container_title Magnetic resonance in medicine
container_volume 58
creator Langer, Deanna L.
Rakaric, Peter
Kirilova, Anna
Jaffray, David A.
Damyanovich, Andrei Z.
description Abstract Intrasubject reproducibility of metabolite quantitation in three‐dimensional proton magnetic resonance spectroscopic imaging (3D‐MRSI) was investigated in 10 healthy volunteers over five separate sessions using two echo times (TEs): 144 and 30 ms. The use of a Gill‐Thomas‐Cosman (GTC) stereotactic head frame enabled precise subject repositioning and immobilization. Metabolite levels from each voxel in the volume of interest (VOI) were quantified using the Linear Combination of Model spectra (LCModel) analysis algorithm, and coefficients of variation (CVs) were calculated. Standard error estimates (%SD or Cramer‐Rao lower bounds) generated by LCModel were used as a confidence filter. The 95% confidence interval (CI) was found for each metabolite, providing an indication of the normal fluctuation expected for 3D‐MRSI. In vivo, median CVs at the %SD ≤ 20 level were found to be (%CV for TE = 144 and 30 ms, respectively): N‐acetyl‐aspartate plus N‐acetyl‐aspartyl‐glutamate (NAA): 10.2% and 13.5%; creatine plus phosphocreatine (Cr), 14.4% and 21.7%; and choline‐containing compounds (Cho), 15.2% and 18.4%. Relaxing the statistical filtering criteria to %SD ≤ 30 increased median CVs by less than 5% and permitted in vivo quantitation reproducibility to be evaluated for glutamine plus glutamate (Glx) and myoinositol (Ins) for TE = 30 ms, yielding CVs of 24.0% and 21.0%, respectively. Magn Reson Med 58:666–673, 2007. © 2007 Wiley‐Liss, Inc.
doi_str_mv 10.1002/mrm.21351
format article
fullrecord <record><control><sourceid>crossref</sourceid><recordid>TN_cdi_crossref_primary_10_1002_mrm_21351</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>10_1002_mrm_21351</sourcerecordid><originalsourceid>FETCH-LOGICAL-c741-4d939cbf81d0dffc13373b79304f69a189f992e66a41d19552d68595b16e14f23</originalsourceid><addsrcrecordid>eNotUEtOwzAUtBBIlMKCG3jLIsXPn6ReVuUrFSGh7iPHsYtREwfbWXTHEVhwQk6CA6xGejNvZjQIXQJZACH0ugvdggITcIRmICgtqJD8GM1IxUnBQPJTdBbjGyFEyorP0NcqRhNjZ_qEvcWdSarxe5cMfh9Vn1xSyfkeBzME347aNS6TB-x6HE1wao_ZzffHJwb8kOHpBcfB6BR81H5wGrtO7Vy_m5xfx071uAkqv45xOsZkgvFJ6ZSVOcBHN2Vl6hydWLWP5uIf52h7d7tdPxSb5_vH9WpT6IpDwVvJpG7sElrSWquBsYo1lWSE21IqWEorJTVlqTi0IIWgbbkUUjRQGuCWsjm6-rPVuXAMxtZDyI3DoQZST2vWec36d032AxkIbQM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Assessment of metabolite quantitation reproducibility in serial 3D‐ 1 H‐MR spectroscopic imaging of human brain using stereotactic repositioning</title><source>Wiley-Blackwell Journals</source><creator>Langer, Deanna L. ; Rakaric, Peter ; Kirilova, Anna ; Jaffray, David A. ; Damyanovich, Andrei Z.</creator><creatorcontrib>Langer, Deanna L. ; Rakaric, Peter ; Kirilova, Anna ; Jaffray, David A. ; Damyanovich, Andrei Z.</creatorcontrib><description>Abstract Intrasubject reproducibility of metabolite quantitation in three‐dimensional proton magnetic resonance spectroscopic imaging (3D‐MRSI) was investigated in 10 healthy volunteers over five separate sessions using two echo times (TEs): 144 and 30 ms. The use of a Gill‐Thomas‐Cosman (GTC) stereotactic head frame enabled precise subject repositioning and immobilization. Metabolite levels from each voxel in the volume of interest (VOI) were quantified using the Linear Combination of Model spectra (LCModel) analysis algorithm, and coefficients of variation (CVs) were calculated. Standard error estimates (%SD or Cramer‐Rao lower bounds) generated by LCModel were used as a confidence filter. The 95% confidence interval (CI) was found for each metabolite, providing an indication of the normal fluctuation expected for 3D‐MRSI. In vivo, median CVs at the %SD ≤ 20 level were found to be (%CV for TE = 144 and 30 ms, respectively): N‐acetyl‐aspartate plus N‐acetyl‐aspartyl‐glutamate (NAA): 10.2% and 13.5%; creatine plus phosphocreatine (Cr), 14.4% and 21.7%; and choline‐containing compounds (Cho), 15.2% and 18.4%. Relaxing the statistical filtering criteria to %SD ≤ 30 increased median CVs by less than 5% and permitted in vivo quantitation reproducibility to be evaluated for glutamine plus glutamate (Glx) and myoinositol (Ins) for TE = 30 ms, yielding CVs of 24.0% and 21.0%, respectively. Magn Reson Med 58:666–673, 2007. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.21351</identifier><language>eng</language><ispartof>Magnetic resonance in medicine, 2007-10, Vol.58 (4), p.666-673</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c741-4d939cbf81d0dffc13373b79304f69a189f992e66a41d19552d68595b16e14f23</citedby><cites>FETCH-LOGICAL-c741-4d939cbf81d0dffc13373b79304f69a189f992e66a41d19552d68595b16e14f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Langer, Deanna L.</creatorcontrib><creatorcontrib>Rakaric, Peter</creatorcontrib><creatorcontrib>Kirilova, Anna</creatorcontrib><creatorcontrib>Jaffray, David A.</creatorcontrib><creatorcontrib>Damyanovich, Andrei Z.</creatorcontrib><title>Assessment of metabolite quantitation reproducibility in serial 3D‐ 1 H‐MR spectroscopic imaging of human brain using stereotactic repositioning</title><title>Magnetic resonance in medicine</title><description>Abstract Intrasubject reproducibility of metabolite quantitation in three‐dimensional proton magnetic resonance spectroscopic imaging (3D‐MRSI) was investigated in 10 healthy volunteers over five separate sessions using two echo times (TEs): 144 and 30 ms. The use of a Gill‐Thomas‐Cosman (GTC) stereotactic head frame enabled precise subject repositioning and immobilization. Metabolite levels from each voxel in the volume of interest (VOI) were quantified using the Linear Combination of Model spectra (LCModel) analysis algorithm, and coefficients of variation (CVs) were calculated. Standard error estimates (%SD or Cramer‐Rao lower bounds) generated by LCModel were used as a confidence filter. The 95% confidence interval (CI) was found for each metabolite, providing an indication of the normal fluctuation expected for 3D‐MRSI. In vivo, median CVs at the %SD ≤ 20 level were found to be (%CV for TE = 144 and 30 ms, respectively): N‐acetyl‐aspartate plus N‐acetyl‐aspartyl‐glutamate (NAA): 10.2% and 13.5%; creatine plus phosphocreatine (Cr), 14.4% and 21.7%; and choline‐containing compounds (Cho), 15.2% and 18.4%. Relaxing the statistical filtering criteria to %SD ≤ 30 increased median CVs by less than 5% and permitted in vivo quantitation reproducibility to be evaluated for glutamine plus glutamate (Glx) and myoinositol (Ins) for TE = 30 ms, yielding CVs of 24.0% and 21.0%, respectively. Magn Reson Med 58:666–673, 2007. © 2007 Wiley‐Liss, Inc.</description><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNotUEtOwzAUtBBIlMKCG3jLIsXPn6ReVuUrFSGh7iPHsYtREwfbWXTHEVhwQk6CA6xGejNvZjQIXQJZACH0ugvdggITcIRmICgtqJD8GM1IxUnBQPJTdBbjGyFEyorP0NcqRhNjZ_qEvcWdSarxe5cMfh9Vn1xSyfkeBzME347aNS6TB-x6HE1wao_ZzffHJwb8kOHpBcfB6BR81H5wGrtO7Vy_m5xfx071uAkqv45xOsZkgvFJ6ZSVOcBHN2Vl6hydWLWP5uIf52h7d7tdPxSb5_vH9WpT6IpDwVvJpG7sElrSWquBsYo1lWSE21IqWEorJTVlqTi0IIWgbbkUUjRQGuCWsjm6-rPVuXAMxtZDyI3DoQZST2vWec36d032AxkIbQM</recordid><startdate>200710</startdate><enddate>200710</enddate><creator>Langer, Deanna L.</creator><creator>Rakaric, Peter</creator><creator>Kirilova, Anna</creator><creator>Jaffray, David A.</creator><creator>Damyanovich, Andrei Z.</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200710</creationdate><title>Assessment of metabolite quantitation reproducibility in serial 3D‐ 1 H‐MR spectroscopic imaging of human brain using stereotactic repositioning</title><author>Langer, Deanna L. ; Rakaric, Peter ; Kirilova, Anna ; Jaffray, David A. ; Damyanovich, Andrei Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c741-4d939cbf81d0dffc13373b79304f69a189f992e66a41d19552d68595b16e14f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Langer, Deanna L.</creatorcontrib><creatorcontrib>Rakaric, Peter</creatorcontrib><creatorcontrib>Kirilova, Anna</creatorcontrib><creatorcontrib>Jaffray, David A.</creatorcontrib><creatorcontrib>Damyanovich, Andrei Z.</creatorcontrib><collection>CrossRef</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Langer, Deanna L.</au><au>Rakaric, Peter</au><au>Kirilova, Anna</au><au>Jaffray, David A.</au><au>Damyanovich, Andrei Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of metabolite quantitation reproducibility in serial 3D‐ 1 H‐MR spectroscopic imaging of human brain using stereotactic repositioning</atitle><jtitle>Magnetic resonance in medicine</jtitle><date>2007-10</date><risdate>2007</risdate><volume>58</volume><issue>4</issue><spage>666</spage><epage>673</epage><pages>666-673</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Abstract Intrasubject reproducibility of metabolite quantitation in three‐dimensional proton magnetic resonance spectroscopic imaging (3D‐MRSI) was investigated in 10 healthy volunteers over five separate sessions using two echo times (TEs): 144 and 30 ms. The use of a Gill‐Thomas‐Cosman (GTC) stereotactic head frame enabled precise subject repositioning and immobilization. Metabolite levels from each voxel in the volume of interest (VOI) were quantified using the Linear Combination of Model spectra (LCModel) analysis algorithm, and coefficients of variation (CVs) were calculated. Standard error estimates (%SD or Cramer‐Rao lower bounds) generated by LCModel were used as a confidence filter. The 95% confidence interval (CI) was found for each metabolite, providing an indication of the normal fluctuation expected for 3D‐MRSI. In vivo, median CVs at the %SD ≤ 20 level were found to be (%CV for TE = 144 and 30 ms, respectively): N‐acetyl‐aspartate plus N‐acetyl‐aspartyl‐glutamate (NAA): 10.2% and 13.5%; creatine plus phosphocreatine (Cr), 14.4% and 21.7%; and choline‐containing compounds (Cho), 15.2% and 18.4%. Relaxing the statistical filtering criteria to %SD ≤ 30 increased median CVs by less than 5% and permitted in vivo quantitation reproducibility to be evaluated for glutamine plus glutamate (Glx) and myoinositol (Ins) for TE = 30 ms, yielding CVs of 24.0% and 21.0%, respectively. Magn Reson Med 58:666–673, 2007. © 2007 Wiley‐Liss, Inc.</abstract><doi>10.1002/mrm.21351</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0740-3194
ispartof Magnetic resonance in medicine, 2007-10, Vol.58 (4), p.666-673
issn 0740-3194
1522-2594
language eng
recordid cdi_crossref_primary_10_1002_mrm_21351
source Wiley-Blackwell Journals
title Assessment of metabolite quantitation reproducibility in serial 3D‐ 1 H‐MR spectroscopic imaging of human brain using stereotactic repositioning
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T22%3A34%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-crossref&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessment%20of%20metabolite%20quantitation%20reproducibility%20in%20serial%203D%E2%80%90%201%20H%E2%80%90MR%20spectroscopic%20imaging%20of%20human%20brain%20using%20stereotactic%20repositioning&rft.jtitle=Magnetic%20resonance%20in%20medicine&rft.au=Langer,%20Deanna%20L.&rft.date=2007-10&rft.volume=58&rft.issue=4&rft.spage=666&rft.epage=673&rft.pages=666-673&rft.issn=0740-3194&rft.eissn=1522-2594&rft_id=info:doi/10.1002/mrm.21351&rft_dat=%3Ccrossref%3E10_1002_mrm_21351%3C/crossref%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c741-4d939cbf81d0dffc13373b79304f69a189f992e66a41d19552d68595b16e14f23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true