Determinants of enlarged perivascular spaces (ePVS) on MRI: The Florida Vascular Imaging Phenotypes (FL‐VIP) Study of AD risk

Background PVS are fluid filled compartments surrounding small intracerebral vessels. They are conduits for fluid transport, exchange, and waste clearance. Their relationship to cardiovascular markers is unknown. We tested whether ePVS counts are affected by vascular risk factors and comorbidities....

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Bibliographic Details
Published in:Alzheimer's & dementia 2021-12, Vol.17 (S4), p.n/a
Main Authors: Rundek, Tatjana, Brutto, Victor Del, Goryawala, Mohammed, Saporta, Anita Seixas Dias, Merritt, Stacy S., Camargo, Christian, Agudelo, Christian, Ariko, Taylor, Dong, Chuanhui, Loewenstein, David, Duara, Ranjan, Haq, Ihtsham U.
Format: Article
Language:English
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Summary:Background PVS are fluid filled compartments surrounding small intracerebral vessels. They are conduits for fluid transport, exchange, and waste clearance. Their relationship to cardiovascular markers is unknown. We tested whether ePVS counts are affected by vascular risk factors and comorbidities. Method We analyzed nondemented subjects’ brains from the FL‐VIP (comprised of 1Florida ADRC participants with available high quality 3T MRI). ePVS were defined as parenchymal hypo/hyperintensities of
ISSN:1552-5260
1552-5279
DOI:10.1002/alz.054617