Solvent‐Free Dehydrogenative C‒H Chalcogenations of Pyrazolones Using Mechanochemistry

A mechanochemical cross‐dehydrogenative coupling reaction of pyrazolones with thiols using ball milling is described. Benzeneselenol and dichalcogenide substrates are also compatible under mild reaction conditions, yielding up to 99%. Notable features of this reaction include its metal‐ and solvent‐...

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Bibliographic Details
Published in:Asian journal of organic chemistry 2024-09
Main Authors: Ma, Wenbo, Zheng, Tao, Yu, Zihan, Li, Junlong, Gu, Qilin, Gu, Linghui, Li, Zheyu
Format: Article
Language:English
Online Access:Get full text
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Summary:A mechanochemical cross‐dehydrogenative coupling reaction of pyrazolones with thiols using ball milling is described. Benzeneselenol and dichalcogenide substrates are also compatible under mild reaction conditions, yielding up to 99%. Notable features of this reaction include its metal‐ and solvent‐free, wide substrate scope and good functional group tolerance. Preliminary mechanistic investigations suggest that a radical pathway is likely involved in this C‒H chalcogenation reaction
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.202400353