Oncogenic RAS Networks Suppression: Reversibly Ionic Oligonucleotide‐Based Nanoparticles Caged microRNA‐143 Inhibit KRAS‐Mutated Colon Cancer Growth in Tumor‐Bearing Mice (Adv. Therap. 2/2023)

This back cover shows a novel delivery vehicle of RNA nanoparticle (named RIONmiR‐143) for RAS‐mutated intractable cancers. Tumor‐suppressor microRNA‐143 (miR‐143) silences oncogenic KRAS networks, but it lacks a nucleic acid delivery vehicle for clinical application. This research creates the RIONm...

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Bibliographic Details
Published in:Advanced therapeutics 2023-02, Vol.6 (2), p.n/a
Main Authors: Miyamoto, Noriko, Kawasaki, Riku, Sakuragi, Mina, Yamana, Keita, Isozaki, Hinata, Kawamura, Shogo, Akiba, Isamu, Kitade, Yukio
Format: Article
Language:English
Online Access:Get full text
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Summary:This back cover shows a novel delivery vehicle of RNA nanoparticle (named RIONmiR‐143) for RAS‐mutated intractable cancers. Tumor‐suppressor microRNA‐143 (miR‐143) silences oncogenic KRAS networks, but it lacks a nucleic acid delivery vehicle for clinical application. This research creates the RIONmiR‐143 by self‐assembly of miR‐143s and demonstrates delivery functions.
ISSN:2366-3987
2366-3987
DOI:10.1002/adtp.202370008