A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice

by de Alwis, Ruklanthi, Gan, Esther S., Chen, Shiwei, Leong, Yan Shan, Tan, Hwee Cheng, Zhang, Summer L., Yau, Clement, Low, Jenny G.H., Kalimuddin, Shirin, Matsuda, Daiki, Allen, Elizabeth C., Hartman, Paula, Park, Kyoung-Joo Jenny, Alayyoubi, Maher, Bhaskaran, Hari, Dukanovic, Adrian, Bao, Yanjie, Clemente, Brenda, Vega, Jerel, Roberts, Scott, Gonzalez, Jose A., Sablad, Marciano, Yelin, Rodrigo, Taylor, Wendy, Tachikawa, Kiyoshi, Parker, Suezanne, Karmali, Priya, Davis, Jared, Sullivan, Brian M., Sullivan, Sean M., Hughes, Steve G., Chivukula, Pad, Ooi, Eng Eong
Published in Molecular therapy

A systematic approach to the development of a safe live attenuated Zika vaccine

by Kwek, Swee Sen, Watanabe, Satoru, Chan, Kuan Rong, Ong, Eugenia Z, Tan, Hwee Cheng, Ng, Wy Ching, Nguyen, Mien T X, Gan, Esther S, Zhang, Summer L, Chan, Kitti W K, Tan, Jun Hao, Sessions, October M, Manuel, Menchie, Pompon, Julien, Chua, Camillus, Hazirah, Sharifah, Tryggvason, Karl, Vasudevan, Subhash G, Ooi, Eng Eong
Published in Nature communications

Dengue virus neutralization in cells expressing Fc gamma receptors

by Chawla, Tanu, Chan, Kuan Rong, Zhang, Summer L, Tan, Hwee Cheng, Lim, Angeline P C, Hanson, Brendon J, Ooi, Eng Eong
Published in PloS one

Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution

by Ong, Eugenia Z, Kalimuddin, Shirin, Chia, Wen Chong, Ooi, Sarah H, Koh, Clara WT, Tan, Hwee Cheng, Zhang, Summer L, Low, Jenny G, Ooi, Eng Eong, Chan, Kuan Rong
Published in EBioMedicine

A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine

by Low, Jenny G, de Alwis, Ruklanthi, Chen, Shiwei, Kalimuddin, Shirin, Leong, Yan Shan, Mah, Tania Ken Lin, Yuen, Natalene, Tan, Hwee Cheng, Zhang, Summer L, Sim, Jean X Y, Chan, Yvonne F Z, Syenina, Ayesa, Yee, Jia Xin, Ong, Eugenia Z, Sekulovich, Rose, Sullivan, Brian B, Lindert, Kelly, Sullivan, Sean M, Chivukula, Pad, Hughes, Steven G, Ooi, Eng Eong
Published in npj vaccines

Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection

by Choy, Milly M, Zhang, Summer L, Costa, Vivian V, Tan, Hwee Cheng, Horrevorts, Sophie, Ooi, Eng Eong
Published in PLoS neglected tropical diseases

Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset

by Kalimuddin, Shirin, Tham, Christine Y.L., Qui, Martin, de Alwis, Ruklanthi, Sim, Jean X.Y., Lim, Joey M.E., Tan, Hwee-Cheng, Syenina, Ayesa, Zhang, Summer L., Le Bert, Nina, Tan, Anthony T., Leong, Yan Shan, Yee, Jia Xin, Ong, Eugenia Z., Ooi, Eng Eong, Bertoletti, Antonio, Low, Jenny G.
Published in Med (New York, N.Y. : Online)

A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection

by Gan, Esther S., Syenina, Ayesa, Linster, Martin, Ng, Benson, Zhang, Summer L., Watanabe, Satoru, Rajarethinam, Ravisankar, Tan, Hwee Cheng, Smith, Gavin JD, Ooi, Eng Eong
Published in Antiviral research

Dengue virus compartmentalization during antibody-enhanced infection

by Ong, Eugenia Z, Zhang, Summer L, Tan, Hwee Cheng, Gan, Esther S, Chan, Kuan Rong, Ooi, Eng Eong
Published in Scientific reports

A Non-structural 1 Protein G53D Substitution Attenuates a Clinically Tested Live Dengue Vaccine

by Choy, Milly M., Ng, Dorothy H.L., Siriphanitchakorn, Tanamas, Ng, Wy Ching, Sundstrom, Karin B., Tan, Hwee Cheng, Zhang, Summer L., Chan, Kitti W.K., Manuel, Menchie, Kini, R. Manjunatha, Chan, Kuan Rong, Vasudevan, Subhash G., Ooi, Eng Eong
Published in Cell reports (Cambridge)

Early peripheral blood MCEMP1 and HLA-DRA expression predicts COVID-19 prognosis

by Chan, Kuan Rong, Koh, Clara W.T., Ng, Dorothy H.L., Qin, Shijie, Ooi, Justin S.G., Ong, Eugenia Z., Zhang, Summer L.X., Sam, Huizhen, Kalimuddin, Shirin, Low, Jenny G.H., Ooi, Eng Eong
Published in EBioMedicine

A protocol to assess cellular bioenergetics in flavivirus-infected cells

by Low, John Z.H., Yau, Clement, Zhang, Summer L.X., Tan, Hwee Cheng, Ooi, Eng Eong, Chan, Kuan Rong
Published in STAR protocols

Electron transport chain capacity expands yellow fever vaccine immunogenicity

by Mok, Darren Zl, Tng, Danny Jh, Yee, Jia Xin, Chew, Valerie Sy, Tham, Christine Yl, Ooi, Justin Sg, Tan, Hwee Cheng, Zhang, Summer L, Lin, Lowell Z, Ng, Wy Ching, Jeeva, Lavanya Lakshmi, Murugayee, Ramya, Goh, Kelvin K-K, Lim, Tze-Peng, Cui, Liang, Cheung, Yin Bun, Ong, Eugenia Z, Chan, Kuan Rong, Ooi, Eng Eong, Low, Jenny G
Published in EMBO molecular medicine

Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection: e0004058

by Choy, Milly M, Zhang, Summer L, Costa, Vivian V, Tan, Hwee Cheng, Horrevorts, Sophie, Ooi, Eng Eong
Published in PLoS neglected tropical diseases

Dengue Virus Neutralization in Cells Expressing Fc Gamma Receptors. e65231

by Chawla, Tanu, Chan, Kuan Rong, Zhang, Summer L, Tan, Hwee Cheng, Lim, Angeline PC, Hanson, Brendon J, Ooi, Eng Eong
Published in PloS one

A Single Dose of Self-Transcribing and Replicating RNA Based SARS-CoV-2 Vaccine Produces Protective Adaptive Immunity In Mice

by De Alwis, Ruklanthi, Gan, Esther S, Chen, Shiwei, Leong, Yan Shan, Hwee Cheng Tan, Zhang, Summer L, Yau, Clement, Matsuda, Daiki, Allen, Elizabeth, Hartman, Paula, Park, Jenny, Alayyoubi, Maher, Bhaskaran, Hari, Dukanovic, Adrian, Bao, Belle, Clemente, Brenda, Vega, Jerel, Roberts, Scott, Gonzalez, Jose A, Marciano Sablad, Yelin, Rodrigo, Taylor, Wendy, Tachikawa, Kiyoshi, Parker, Suezanne, Karmali, Priya, Davis, Jared, Sullivan, Sean M, Hughes, Steve G, Chivukula, Pad, Ooi, Eng Eong
Published in bioRxiv

Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue

by Chan, Kuan Rong, Ong, Eugenia Z., Tan, Hwee Cheng, Zhang, Summer Li-Xin, Zhang, Qian, Tang, Kin Fai, Kaliaperumal, Nivashini, Pei Chiew Lim, Angeline, Hibberd, Martin L., Chan, Soh Ha, Connolly, John E., Krishnan, Manoj N., Lok, Shee Mei, Hanson, Brendon J., Lin, Chao-Nan, Ooi, Eng Eong
Published in Proceedings of the National Academy of Sciences - PNAS

The Placental Gene PEG10 Promotes Progression of Neuroendocrine Prostate Cancer

by Akamatsu, Shusuke, Wyatt, Alexander W., Lin, Dong, Lysakowski, Summer, Zhang, Fan, Kim, Soojin, Tse, Charan, Wang, Kendric, Mo, Fan, Haegert, Anne, Brahmbhatt, Sonal, Bell, Robert, Adomat, Hans, Kawai, Yoshihisa, Xue, Hui, Dong, Xin, Fazli, Ladan, Tsai, Harrison, Lotan, Tamara L., Kossai, Myriam, Mosquera, Juan Miguel, Rubin, Mark A., Beltran, Himisha, Zoubeidi, Amina, Wang, Yuzhuo, Gleave, Martin E., Collins, Colin C.
Published in Cell reports (Cambridge)

The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation

by Rayamajhi, Dheeraj, Ege, Mert, Ukhanov, Kirill, Ringers, Christa, Zhang, Yiliu, Jung, Inyoung, D'Gama, Percival P, Li, Summer Shijia, Cosacak, Mehmet Ilyas, Kizil, Caghan, Park, Hae-Chul, Yaksi, Emre, Martens, Jeffrey R, Brody, Steven L, Jurisch-Yaksi, Nathalie, Roy, Sudipto
Published in PLoS biology

SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

by Wang, Beibei, Skelly, Donal, Pan, Daniel, Omo-Dare, Nicola, Koeckerling, David, Jenkin, Daniel, Fernandes da Costa, Cristiano, Malik, Tariq, Baillie, J. Kenneth, Klenerman, Paul, Pollard, Andrew J., Conlon, Christopher, Jeffery, Katie, Stafford, Lizzie, Chand, Meera, Green, Christoper A., Harrison, Ewen M., Wai Ho, Antonia Ying, Palmarini, Massimo, Price, Nicholas, Robertson, David L., Sigfrid, Louise, Sriskandan, Shiranee, Stuart, David, Swann, Olivia V., Tedder, Richard S., Turtle, Lance CW, Zambon, Maria, Pius, Riinu, Knight, Stephen R., Harrison, Janet, Jackson, Clare, Gamble, Carrol, Plotkin, Daniel, Lee, James, Wham, Murray, Shaw, Victoria, McDonald, Sarah E., Armstrong, Jane A., Ashworth, Milton, Barlow, Samantha L., Bullock, Katie, Davis, Christopher, Dunn, Chris, King, Katharine, Kiy, Robyn T., Lant, Suzannah, Latawiec, Diane, Mancini, Maria, Metelmann, Soeren, Penrice-Randal, Rebekah, Pilgrim, Jack, van Tonder, Libby, Murphy, Lee, Morrice, Kirstie, Gilchrist, Tammy, Aldera, Erin L., Barnass, Stella, Bernatoniene, Jolanta, Bothma, Pieter, Brittain-Long, Robin, Caruth, Vikki, Collini, Paul, Dawson, Chris, Dervisevic, Samir, Dushianthan, Ahilanadan, Evans, Cariad, Harvey, Daniel, Hawcutt, Daniel B., Hodgson, Luke, Hormis, Anil, Kerrison, Caroline, Larkin, Susan, Little, Jeff, Meda, Manjula, Moon, James, Mortimore, Katherine, Murphy, Michael, O’Shea, Matthew K., Otahal, Igor, Panchatsharam, Selva, Patel, Brij, Pepperell, Justin, Peters, Mark, Price, David, Reschreiter, Henrik, Ruge, Bobby, Saluja, Taranprit, Sizer, Jeremy, Shankar-Hari, Manu, Snelson, Catherine, Staines, Nikki, Twagira, Mary, Vincent-Smith, Lisa, Visuvanathan, Shico, Welters, Ingeborg, Wolverson, Adam, Yates, Bryan, Fry, Elizabeth E., Ren, Jingshan
Published in Cell