Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation

by Xie, Wensheng, Pariollaud, Marie, Wixted, William E, Chitnis, Nilesh, Fornwald, James, Truong, Maggie, Pao, Christina, Liu, Yan, Ames, Robert S, Callahan, James, Solari, Roberto, Sanchez, Yolanda, Diehl, Alan, Li, Hu
Published in PloS one

Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction with High Cell Potency Identi...

by Davies, Thomas G, Wixted, William E, Coyle, Joseph E, Griffiths-Jones, Charlotte, Hearn, Keisha, McMenamin, Rachel, Norton, David, Rich, Sharna J, Richardson, Caroline, Saxty, Gordon, Willems, Henriëtte M. G, Woolford, Alison J.-A, Cottom, Joshua E, Kou, Jen-Pyng, Yonchuk, John G, Feldser, Heidi G, Sanchez, Yolanda, Foley, Joseph P, Bolognese, Brian J, Logan, Gregory, Podolin, Patricia L, Yan, Hongxing, Callahan, James F, Heightman, Tom D, Kerns, Jeffrey K
Published in Journal of medicinal chemistry

In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

by Kamola, Piotr J, Kitson, Jeremy D A, Turner, Gemma, Maratou, Klio, Eriksson, Sofie, Panjwani, Aliza, Warnock, Linda C, Douillard Guilloux, Gaelle A, Moores, Kitty, Koppe, Emma L, Wixted, William E, Wilson, Paul A, Gooderham, Nigel J, Gant, Timothy W, Clark, Kenneth L, Hughes, Stephen A, Edbrooke, Mark R, Parry, Joel D
Published in Nucleic acids research

Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein−Protei...

by Norton, David, Bonnette, William G, Callahan, James F, Carr, Maria G, Griffiths-Jones, Charlotte M, Heightman, Tom D, Kerns, Jeffrey K, Nie, Hong, Rich, Sharna J, Richardson, Caroline, Rumsey, William, Sanchez, Yolanda, Verdonk, Marcel L, Willems, Henriëtte M. G, Wixted, William E, Woolford, Alison J.-A, Wu, Zining, Davies, Thomas G
Published in Journal of medicinal chemistry

Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stres...

by Yonchuk, John G, Foley, Joseph P, Bolognese, Brian J, Logan, Gregory, Wixted, William E, Kou, Jen-Pyng, Chalupowicz, Diana G, Feldser, Heidi G, Sanchez, Yolanda, Nie, Hong, Callahan, James F, Kerns, Jeffrey K, Podolin, Patricia L
Published in The Journal of pharmacology and experimental therapeutics

Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2 H -Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Str...

by Yonchuk, John G, Foley, Joseph P, Bolognese, Brian J, Logan, Gregory, Wixted, William E, Kou, Jen-Pyng, Chalupowicz, Diana G, Feldser, Heidi G, Sanchez, Yolanda, Nie, Hong, Callahan, James F, Kerns, Jeffrey K, Podolin, Patricia L
Published in The Journal of pharmacology and experimental therapeutics

Nonpeptidic urotensin‐II receptor antagonists I: in vitro pharmacological characterization of SB‐706375

by Douglas, Stephen A, Behm, David J, Aiyar, Nambi V, Naselsky, Diane, Disa, Jyoti, Brooks, David P, Ohlstein, Eliot H, Gleason, John G, Sarau, Henry M, Foley, James J, Buckley, Peter T, Schmidt, Dulcie B, Wixted, William E, Widdowson, Katherine, Riley, Graham, Jin, Jian, Gallagher, Timothy F, Schmidt, Stanley J, Ridgers, Lance, Christmann, Lisa T, Keenan, Richard M, Knight, Steven D, Dhanak, Dashyant
Published in British journal of pharmacology

The neuromedin B receptor antagonist, BIM‐23127, is a potent antagonist at human and rat urotensin‐II receptors

by Herold, Christopher L, Behm, David J, Buckley, Peter T, Foley, James J, Wixted, William E, Sarau, Henry M, Douglas, Stephen A
Published in British journal of pharmacology

A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference

by Wixted, William E., Kitson, Chris, Colebrook, Jayne C., Roberts, Emma J., Fox, Steven M., Kou, Jen P., Li, Jun U., López-Boado, Yolanda S.
Published in Toxicology in vitro

Estimating the reliability of eyewitness identifications from police lineups

by Wixted, John T., Mickes, Laura, Dunn, John C., Clark, Steven E., Wells, William
Published in Proceedings of the National Academy of Sciences - PNAS

Correction: Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial

by Del Fabbro, Gina, McKay, Paula, Thabane, Lehana, McCabe, Randi E, Nowakowski, Matilda, Shibu, Christy, Fleming, Natalie, Johal, Herman, Slobogean, Gerard, Natoli, Roman M, Gitajn, I. Leah, Schneider, Prism, Devereaux, P. J, Schemitsch, Emil H, Bhandari, Mohit, Guyatt, Gordon H, Hapidou, Eleni, Chiaramonte, Delia, Kehlet, Henrick, Khan, James, Johnson, Aaron, Heels-Ansdell, Diane, Bzovsky, Sofia, Petrisor, Brad A, Williams, Dale, Ristevski, Bill, Al-Asiri, Jamal, Denkers, Matthew, Rajaratnam, Kris, Gallant, Jodi L, MacRae, Sarah, Pusztai, Kaitlyn, Renaud, Sara, Johal, Nicki, Papp, Steven, Lalonde, Karl-Andre, Meulenkamp, Bradley, Liew, Allan, Mistry, Manisha, Gammon, Braden, Gofton, Wade, Wilkin, Geoffrey, Dodd-Moher, Melanie, Puskas, David, Marion, Travis, Lefrancois, Tina, Payandeh, Jubin, Cullinan, Claude, Wilson, Tracy, Droll, Kurt, Riediger, Michael, Siddiqui, Rabail, Littlefield, Shalyn, Chahal, Simrun, Wagar, Paige, Schneider, Prism S, Ogunleye, Tosin, Cherppukaran, Tanya, Lienhard, Karin, Smith, Nicholas, Anthony, Sarah, Butt, Krista, Selby, La Shann, Kovvur, Murali, Lawrence, Joshua, Sampson, Skyler, Turner, Kristin, Jaeblon, Todd, Demyanovich, Haley K, Talwar, Sneh, Benzel, Caroline, Chockbengboun, Theresa, Mullin, Devin, Bateman, Logan, Christian, Melanie, DePalo, Peter, Appleton, Paul J, Wixted, John J, Rodriguez, Edward K, McTague, Michael F, Wagner, Katiri, Brackpool, Kristina, Hegermiller, Kate, Nguyen, Nhi, Fentz, Courteney, Diaz, Maricela, Niceley, Jill, Jeray, Kyle J, Schaller, Thomas M, Sridhar, Michael S, Adams, John D, Gurich, Richard W, Tanner, Stephanie L, Adams, Kyle, Donohue, Michelle, Bray, Emily, Brignull, Calleigh, Sprouse, Harper
Published in Trials

In-person cognitive behavioural therapy vs. usual care after surgical management of extremity fractures: an unsuccessful feasibility trial

by Gouveia, Kyle, Sprague, Sheila, Gallant, Jodi, Del Fabbro, Gina, Leonard, Jordan, Bzovsky, Sofia, McKay, Paula, Busse, Jason W
Published in Pilot and feasibility studies

Cognitive Behavioural Therapy to Optimize Post-Operative Fracture Recovery (COPE): protocol for a randomized controlled trial

by Busse, Jason W., Sprague, Sheila, Del Fabbro, Gina, McKay, Paula, Thabane, Lehana, McCabe, Randi E., Nowakowski, Matilda, Shibu, Christy, Fleming, Natalie, Johal, Herman, Slobogean, Gerard, Natoli, Roman M., Gitajn, I. Leah, Schneider, Prism, Devereaux, P. J., Schemitsch, Emil H., Bhandari, Mohit, Guyatt, Gordon H., Hapidou, Eleni, Chiaramonte, Delia, Kehlet, Henrick, Khan, James, Johnson, Aaron, Heels-Ansdell, Diane, Bzovsky, Sofia, Petrisor, Brad A., Williams, Dale, Ristevski, Bill, Al-Asiri, Jamal, Denkers, Matthew, Rajaratnam, Kris, Gallant, Jodi L., MacRae, Sarah, Pusztai, Kaitlyn, Renaud, Sara, Johal, Nicki, Papp, Steven, Lalonde, Karl-Andre, Meulenkamp, Bradley, Liew, Allan, Mistry, Manisha, Gammon, Braden, Gofton, Wade, Wilkin, Geoffrey, Dodd-Moher, Melanie, Puskas, David, Marion, Travis, Lefrancois, Tina, Payandeh, Jubin, Cullinan, Claude, Wilson, Tracy, Droll, Kurt, Riediger, Michael, Siddiqui, Rabail, Littlefield, Shalyn, Chahal, Simrun, Wagar, Paige, Schneider, Prism S., Ogunleye, Tosin, Cherppukaran, Tanya, Lienhard, Karin, Smith, Nicholas, Anthony, Sarah, Butt, Krista, Selby, LaShann, Kovvur, Murali, Lawrence, Joshua, Sampson, Skyler, Turner, Kristin, Jaeblon, Todd, Demyanovich, Haley K., Talwar, Sneh, Benzel, Caroline, Chockbengboun, Theresa, Mullin, Devin, Bateman, Logan, Christian, Melanie, DePalo, Peter, Appleton, Paul J., Wixted, John J., Rodriguez, Edward K., McTague, Michael F., Wagner, Katiri, Brackpool, Kristina, Hegermiller, Kate, Nguyen, Nhi, Fentz, Courteney, Diaz, Maricela, Niceley, Jill, Jeray, Kyle J., Schaller, Thomas M., Sridhar, Michael S., Adams, John D., Gurich, Richard W., Tanner, Stephanie L., Adams, Kyle, Donohue, Michelle, Bray, Emily, Brignull, Calleigh, Sprouse, Harper
Published in Trials