Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

by Kremer, Jeff Charles, Prudner, Bethany Cheree, Lange, Sara Elaine Stubbs, Bean, Gregory Richard, Schultze, Matthew Bailey, Brashears, Caitlyn Brook, Radyk, Megan DeAnna, Redlich, Nathan, Tzeng, Shin-Cheng, Kami, Kenjiro, Shelton, Laura, Li, Aixiao, Morgan, Zack, Bomalaski, John Stephen, Tsukamoto, Takashi, McConathy, Jon, Michel, Loren Scott, Held, Jason Matthew, Van Tine, Brian Andrew
Published in Cell reports (Cambridge)

Facts and Hopes in Immunotherapy of Soft-Tissue Sarcomas

by Martín-Broto, Javier, Moura, David S, Van Tine, Brian A
Published in Clinical cancer research

Management of localized extremity and retroperitoneal soft tissue sarcoma

by Abaricia, Sarah, Van Tine, Brian Andrew
Published in Current problems in cancer

A randomised phase II trial of a trivalent ganglioside vaccine targeting GM2, GD2 and GD3 combined with immunological adjuvant OPT-821 versus OPT-821 alone in metastatic sarcoma pa...

by Rosenbaum, Evan, Chugh, Rashmi, Ryan, Christopher W., Agulnik, Mark, Milhem, Mohammed M., George, Suzanne, Jones, Robin L., Chmielowski, Bartosz, Van Tine, Brian A., Tawbi, Hussein, Elias, Anthony D., Read, William L., Budd, G. Thomas, Qin, Li-Xuan, Rodler, Eve T., Hirman, Joe, Weiden, Paul, Bennett, Cathryn M., Livingston, Philip O., Ragupathi, Govind, Hansen, David, D'Angelo, Sandra P., Tap, William D., Schwartz, Gary K., Maki, Robert G., Carvajal, Richard D.
Published in European journal of cancer (1990)

Amino Acid Uptake Measured by [ 18 F]AFETP Increases in Response to Arginine Starvation in ASS1-Deficient Sarcomas

by Prudner, Bethany Cheree, Sun, Fangdi, Kremer, Jeffrey Charles, Xu, Jinbin, Huang, Chaofeng, Sai, Kiran Kumar Solingapuram, Morgan, Zachary, Leeds, Hayden, McConathy, Jonathan, Van Tine, Brian Andrew
Published in Theranostics

Effect of Doxorubicin Plus Olaratumab vs Doxorubicin Plus Placebo on Survival in Patients With Advanced Soft Tissue Sarcomas: The ANNOUNCE Randomized Clinical Trial

by Tap, William D, Wagner, Andrew J, Schöffski, Patrick, Martin-Broto, Javier, Krarup-Hansen, Anders, Ganjoo, Kristen N, Yen, Chueh-Chuan, Abdul Razak, Albiruni R, Spira, Alexander, Kawai, Akira, Le Cesne, Axel, Van Tine, Brian A, Naito, Yoichi, Park, Se Hoon, Fedenko, Alexander, Pápai, Zsuzsanna, Soldatenkova, Victoria, Shahir, Ashwin, Mo, Gary, Wright, Jennifer, Jones, Robin L
Published in JAMA : the journal of the American Medical Association

Cixutumumab and temsirolimus for patients with bone and soft-tissue sarcoma: a multicentre, open-label, phase 2 trial

by Schwartz, Gary K, Prof, Tap, William D, MD, Qin, Li-Xuan, PhD, Livingston, Michael B, Prof, Undevia, Samir D, MD, Chmielowski, Bartosz, MD, Agulnik, Mark, MD, Schuetze, Scott M, MD, Reed, Damon R, MD, Okuno, Scott H, Prof, Ludwig, Joseph A, MD, Keedy, Vicki, MD, Rietschel, Petra, MD, Kraft, Andrew S, Prof, Adkins, Douglas, Prof, Van Tine, Brian A, MD, Brockstein, Bruce, MD, Yim, Vincent, BA, Bitas, Christiana, BA, Abdullah, Abdul, BA, Antonescu, Cristina R, Prof, Condy, Mercedes, RN, Dickson, Mark A, MD, Vasudeva, Shyamprasad Deraje, MA, Ho, Alan L, MD, Doyle, L Austin, Prof, Chen, Helen X, Prof, Maki, Robert G, Prof
Published in The lancet oncology

Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma

by Rathore, Richa, Caldwell, Katharine E., Schutt, Charles, Brashears, Caitlyn B., Prudner, Bethany C., Ehrhardt, William R., Leung, Cheuk Hong, Lin, Heather, Daw, Najat C., Beird, Hannah C., Giles, Abigail, Wang, Wei-Lien, Lazar, Alexander J., Chrisinger, John S.A., Livingston, J. Andrew, Van Tine, Brian A.
Published in Cell reports (Cambridge)

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

by Abeshouse, Adam, Armenia, Joshua, Auman, J. Todd, Bailey, Matthew H., Baker, Laurence, Balasundaram, Miruna, Balu, Saianand, Baylin, Stephen B., Behera, Madhusmita, Benz, Christopher, Bocklage, Thèrése, Boice, Lori, Bootwalla, Moiz S., Bowlby, Reanne, Boyd, Jeff, Castro, Patricia, Cherniack, Andrew D., Chudamani, Sudha, Cooper, Lee A.D., Davis, Ian J., Demetri, George D., Demicco, Elizabeth G., Ding, Li, DiSaia, Phil, Dottino, Peter, Eschbacher, Jennifer, Fedosenko, Konstantin, Ferguson, Martin L., Gao, Qingsong, Gastier-Foster, Julie M., Gerken, Mark, Godwin, Eryn M., Gordienko, Elena, Grilley-Olson, Juneko E., Gutman, David A., Hegde, Apurva M., Heiman, David I., Helsel, Carmen, Hoadley, Katherine A., Hobensack, Shital, Hornick, Jason L., Hoyle, Alan P., Iacocca, Mary, Ittmann, Michael, Jones, Steven J.M., Kim, Jaegil, Ladanyi, Marc, Lai, Phillip H., Larsson, Erik, Lee, Sanghoon, Lehmann, Kjong-Van, Levine, Douglas A., Liu, Jia, Liu, Wenbin, Liu, Eric Minwei, Lu, Yiling, Madan, Rashna, Magliocco, Anthony, Maki, Robert G., Martinez, Cathleen, Mayo, Michael, McLellan, Michael D., Mozgovoy, Evgeny, Mungall, Andrew J., Mungall, Karen, Noble, Michael S., Olvera, Narciso, Paklina, Oxana, Paulauskis, Joseph, Penny, Robert, Perou, Charles M., Perou, Amy H., Pollock, Raphael E., Ramalingam, Suresh S., Reilly, Colleen, Reynolds, Sheila M., Roach, Jeffrey, Roszik, Jason, Sadeghi, Sara, Saksena, Gordon, Sanchez-Vega, Francisco, Sander, Chris, Schein, Jacqueline E., Shelton, Candace, Shelton, Troy, Shi, Yan, Shmulevich, Ilya, Sipahimalani, Payal, Swanson, Patricia, Tarnuzzer, Roy, Thiessen, Nina, Thorne, Leigh B., Van Tine, Brian A., Verhaak, Roel, Voronina, Olga, Wang, Jing, Wise, Lisa, Wyczalkowski, Matthew, Yau, Christina, Yellapantula, Venkata
Published in Cell

A Phase I Study of the Combination of Pexidartinib and Sirolimus to Target Tumor-Associated Macrophages in Unresectable Sarcoma and Malignant Peripheral Nerve Sheath Tumors

by Manji, Gulam A, Van Tine, Brian A, Lee, Shing M, Raufi, Alexander G, Pellicciotta, Ilenia, Hirbe, Angela C, Pradhan, Jaya, Chen, Andrew, Rabadan, Raul, Schwartz, Gary K
Published in Clinical cancer research

Prospective Evaluation of Doxorubicin Cardiotoxicity in Patients with Advanced Soft-tissue Sarcoma Treated in the ANNOUNCE Phase III Randomized Trial

by Jones, Robin L, Wagner, Andrew J, Kawai, Akira, Tamura, Kazuo, Shahir, Ashwin, Van Tine, Brian A, Martín-Broto, Javier, Peterson, Patrick M, Wright, Jennifer, Tap, William D
Published in Clinical cancer research

Anti-Trop2 blockade enhances the therapeutic efficacy of ErbB3 inhibition in head and neck squamous cell carcinoma

by Redlich, Nathan, Robinson, Anthony M, Nickel, Kwangok P, Stein, Andrew P, Wheeler, Deric L, Adkins, Douglas R, Uppaluri, Ravindra, Kimple, Randall J, Van Tine, Brian A, Michel, Loren S
Published in Cell death & disease

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

by Foltz, Steven M., Yu, Lihua, Ferguson, Martin L., Liu, Jia, Heiman, David I., Lawrence, Michael S., Saksena, Gordon, Dhankani, Varsha, Hegde, Apurva M., Li, Jun, Liu, Wenbin, Nissan, Moriah G., Sander, Chris, Wong, Christopher K., Ally, Adrian, Kasaian, Katayoon, Moore, Richard A., Cherniack, Andrew D., Meyerson, Matthew, Baylin, Stephen, Bootwalla, Moiz S., Hoadley, Katherine A., Mose, Lisle E., Hale, Walker, Morton, Donna, Santibanez, Jireh, Wheeler, David A., Fulton, Robert S., Wilson, Richard K., Penny, Robert, Gerken, Mark, Leraas, Kristen M., Huntsman, David, Duffy, Elizabeth R., Berkowitz, Ross, Malykh, Andrei, Iacocca, Mary, Roman-Roman, Sergio, Stern, Marc-Henri, Lipp, Eric, Sharp, Alexis, Delman, Keith, Owonikoko, Taofeek, Gillis, Ad, Korpershoek, Esther, Looijenga, Leendert, DiMeco, Francesco, Chen, Chu, Stoehr, Robert, Bubley, Glenn, Campo, Elias, Martignetti, John A., Breggia, Anne, Kocher, Jean-Pierre, Petersen, Gloria, Smyrk, Thomas, Ajani, Jaffer A., Esmaeli, Bita, Logothetis, Christopher, Rice, David, Sood, Anil, Kefford, Richard, Al-Ahmadie, Hikmat, Miller, Judy, Schiffman, Mark, Wentzensen, Nicolas, Caraman, Irina, Clipca, Adrian, Doruc, Serghei, Stancul, Irina, Albert, Monique, Arnaout, Angel, Bartlett, John, Engel, Jay, Urba, Walter, Marino, Mirella, Barnett, Gene, Farver, Carol, Abdel-Rahman, Mohamed H., Cebulla, Colleen M., Kumar, Bahavna, Rai, Karan, Lechan, Ronald, Graefen, Markus, Simon, Ronald, Tennstedt, Pierre, Glenn, Pat, Simko, Jeffry, Steele, Ruth, Campos, Benito, Rosenthal, Howard G., Adebamowo, Sally N., Giordano, Thomas, Moore, Kathleen, Moxley, Katherine, Shipman, Cassaundra, Wolf, Gregory, Ley, Timothy, Van Tine, Brian, Shmulevich, Ilya
Published in Cell reports (Cambridge)

Circulating Tumor Cells and Biomarker Modulation with Olaratumab Monotherapy Followed by Olaratumab plus Doxorubicin: Phase Ib Study in Patients with Soft-Tissue Sarcoma

by Martín-Broto, Javier, Pousa, Antonio López, Brohl, Andrew S, Van Tine, Brian A, Powers, Benjamin, Stacchiotti, Silvia, Blay, Jean-Yves, Hu, James S, Oakley, 3rd, Gerard J, Wang, Hong, Szpurka, Anna M, Levy, Donna E, Mo, Gary, Ceccarelli, Matteo, Jones, Robin L
Published in Molecular cancer therapeutics

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment

by Sun, Hua, Cao, Song, Mashl, R Jay, Mo, Chia-Kuei, Zaccaria, Simone, Wendl, Michael C, Davies, Sherri R, Bailey, Matthew H, Primeau, Tina M, Hoog, Jeremy, Mudd, Jacqueline L, Dean, 2nd, Dennis A, Patidar, Rajesh, Chen, Li, Wyczalkowski, Matthew A, Jayasinghe, Reyka G, Rodrigues, Fernanda Martins, Terekhanova, Nadezhda V, Li, Yize, Lim, Kian-Huat, Wang-Gillam, Andrea, Van Tine, Brian A, Ma, Cynthia X, Aft, Rebecca, Fuh, Katherine C, Schwarz, Julie K, Zevallos, Jose P, Puram, Sidharth V, Dipersio, John F, Davis-Dusenbery, Brandi, Ellis, Matthew J, Lewis, Michael T, Davies, Michael A, Herlyn, Meenhard, Fang, Bingliang, Roth, Jack A, Welm, Alana L, Welm, Bryan E, Meric-Bernstam, Funda, Chen, Feng, Fields, Ryan C, Li, Shunqiang, Govindan, Ramaswamy, Doroshow, James H, Moscow, Jeffrey A, Evrard, Yvonne A, Chuang, Jeffrey H, Raphael, Benjamin J, Ding, Li
Published in Nature communications

Author Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment

by Sun, Hua, Cao, Song, Mashl, R Jay, Mo, Chia-Kuei, Zaccaria, Simone, Wendl, Michael C, Davies, Sherri R, Bailey, Matthew H, Primeau, Tina M, Hoog, Jeremy, Mudd, Jacqueline L, Dean, 2nd, Dennis A, Patidar, Rajesh, Chen, Li, Wyczalkowski, Matthew A, Jayasinghe, Reyka G, Rodrigues, Fernanda Martins, Terekhanova, Nadezhda V, Li, Yize, Lim, Kian-Huat, Wang-Gillam, Andrea, Van Tine, Brian A, Ma, Cynthia X, Aft, Rebecca, Fuh, Katherine C, Schwarz, Julie K, Zevallos, Jose P, Puram, Sidharth V, Dipersio, John F, Davis-Dusenbery, Brandi, Ellis, Matthew J, Lewis, Michael T, Davies, Michael A, Herlyn, Meenhard, Fang, Bingliang, Roth, Jack A, Welm, Alana L, Welm, Bryan E, Meric-Bernstam, Funda, Chen, Feng, Fields, Ryan C, Li, Shunqiang, Govindan, Ramaswamy, Doroshow, James H, Moscow, Jeffrey A, Evrard, Yvonne A, Chuang, Jeffrey H, Raphael, Benjamin J, Ding, Li
Published in Nature communications

A Phase 1 study of the combination of pexidartinib and sirolimus to target tumor associated macrophages in unresectable sarcoma and malignant peripheral nerve sheath tumors

by Manji, Gulam A., Van Tine, Brian A., Lee, Shing M., Raufi, Alex, Pelliciotta, Ilenia, Hirbe, Angela C., Pradhan, Jaya, Chen, Andrew, Rabadan, Raul, Schwartz, Gary K.
Published in Clinical cancer research

Prospective evaluation of doxorubicin cardiotoxicity in advanced soft tissue sarcoma patients treated in the ANNOUNCE Phase 3 randomized trial

by Jones, Robin L, Wagner, Andrew J, Kawai, Akira, Tamura, Kazuo, Shahir, Ashwin, Van Tine, Brian A, Broto, Javier Martin, Peterson, Patrick M, Wright, Jennifer, Tap, William D
Published in Clinical cancer research

Abstract P2-13-45: Interim results of a phase 1 study of the novel immunotoxin MT-5111 in patients with HER2+tumors

by Van Tine, Brian A., Mita, Monica, Barve, Minal A., Hamilton, Erika P., Brenner, Andrew J., Valdes, Frances, Ahn, Daniel, Hubbard, Joleen, Starr, Jason, Georgy, Angela, Pelham, Joshua, Anand, Banmeet S., Strack, Thomas, Sandri, Andrés Machado, Wainberg, Zev A.
Published in Cancer research (Chicago, Ill.)

Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis

by Evrard, Yvonne A, Srivastava, Anuj, Randjelovic, Jelena, Doroshow, James H, Dean, 2nd, Dennis A, Morris, Jeffrey S, Chuang, Jeffrey H
Published in Cancer research (Chicago, Ill.)