A Hierarchical Combination of Factors Shapes the Genome-wide Topography of Yeast Meiotic Recombination Initiation by Pan, Jing, Sasaki, Mariko, Kniewel, Ryan, Murakami, Hajime, Blitzblau, Hannah G., Tischfield, Sam E., Zhu, Xuan, Neale, Matthew J., Jasin, Maria, Socci, Nicholas D., Hochwagen, Andreas, Keeney, Scott

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The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair by Lange, Julian, Yamada, Shintaro, Tischfield, Sam E., Pan, Jing, Kim, Seoyoung, Zhu, Xuan, Socci, Nicholas D., Jasin, Maria, Keeney, Scott

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Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts by Caeser, Rebecca, Egger, Jacklynn V, Chavan, Shweta, Socci, Nicholas D, Jones, Caitlin Byrne, Kombak, Faruk Erdem, Asher, Marina, Roehrl, Michael H, Shah, Nisargbhai S, Allaj, Viola, Manoj, Parvathy, Tischfield, Sam E, Kulick, Amanda, Meneses, Maximiliano, Iacobuzio-Donahue, Christine A, Lai, W Victoria, Bhanot, Umeshkumar, Baine, Marina K, Rekhtman, Natasha, Hollmann, Travis J, de Stanchina, Elisa, Poirier, John T, Rudin, Charles M, Sen, Triparna

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Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation by Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A, Hasan, Maysun M, Chavan, Shweta S, Meng, Fanli, Uddin, Fathema, Manoj, Parvathy, Donoghue, Mark T A, Won, Helen H, Chan, Joseph M, Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Chang, Jason C, Ray-Kirton, Jordana, Tischfield, Sam E, Egger, Jacklynn, Bhanot, Umesh K, Linkov, Irina, Asher, Marina, Sinha, Sonali, Silber, Joachim, Iacobuzio-Donahue, Christine A, Roehrl, Michael H, Hollmann, Travis J, Yu, Helena A, Qiu, Juan, de Stanchina, Elisa, Baine, Marina K, Rekhtman, Natasha, Poirier, John T, Loomis, Brian, Koche, Richard P, Rudin, Charles M, Sen, Triparna

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Genomic and chromatin features shaping meiotic double-strand break formation and repair in mice by Yamada, Shintaro, Kim, Seoyoung, Tischfield, Sam E., Jasin, Maria, Lange, Julian, Keeney, Scott

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Scale matters: The spatial correlation of yeast meiotic DNA breaks with histone H3 trimethylation is driven largely by independent colocalization at promoters by Tischfield, Sam E., Keeney, Scott

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Meiotic recombination initiation in and around retrotransposable elements in Saccharomyces cerevisiae by Sasaki, Mariko, Tischfield, Sam E, van Overbeek, Megan, Keeney, Scott

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Genomic and transcriptomic analysis of a diffuse pleural mesothelioma patient-derived xenograft library by Offin, Michael, Sauter, Jennifer L, Tischfield, Sam E, Egger, Jacklynn V, Chavan, Shweta, Shah, Nisargbhai S, Manoj, Parvathy, Ventura, Katia, Allaj, Viola, de Stanchina, Elisa, Travis, William, Ladanyi, Marc, Rimner, Andreas, Rusch, Valerie W, Adusumilli, Prasad S, Poirier, John T, Zauderer, Marjorie G, Rudin, Charles M, Sen, Triparna

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Developmental chromatin programs determine oncogenic competence in melanoma by Baggiolini, Arianna, Callahan, Scott J, Montal, Emily, Weiss, Joshua M, Trieu, Tuan, Tagore, Mohita M, Tischfield, Sam E, Walsh, Ryan M, Suresh, Shruthy, Fan, Yujie, Campbell, Nathaniel R, Perlee, Sarah C, Saurat, Nathalie, Hunter, Miranda V, Simon-Vermot, Theresa, Huang, Ting-Hsiang, Ma, Yilun, Hollmann, Travis, Tickoo, Satish K, Taylor, Barry S, Khurana, Ekta, Koche, Richard P, Studer, Lorenz, White, Richard M

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The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer by Chow, Andrew, Uddin, Fathema Z., Liu, Michael, Dobrin, Anton, Nabet, Barzin Y., Mangarin, Levi, Lavin, Yonit, Rizvi, Hira, Tischfield, Sam E., Quintanal-Villalonga, Alvaro, Chan, Joseph M., Shah, Nisargbhai, Allaj, Viola, Manoj, Parvathy, Mattar, Marissa, Meneses, Maximiliano, Landau, Rebecca, Ward, Mariana, Kulick, Amanda, Kwong, Charlene, Wierzbicki, Matthew, Yavner, Jessica, Egger, Jacklynn, Chavan, Shweta S., Farillas, Abigail, Holland, Aliya, Sridhar, Harsha, Ciampricotti, Metamia, Hirschhorn, Daniel, Guan, Xiangnan, Richards, Allison L., Heller, Glenn, Mansilla-Soto, Jorge, Sadelain, Michel, Klebanoff, Christopher A., Hellmann, Matthew D., Sen, Triparna, de Stanchina, Elisa, Wolchok, Jedd D., Merghoub, Taha, Rudin, Charles M.

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MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer by Caeser, Rebecca, Hulton, Christopher, Costa, Emily, Durani, Vidushi, Little, Megan, Chen, Xiaoping, Tischfield, Sam E., Asher, Marina, Kombak, Faruk Erdem, Chavan, Shweta S., Shah, Nisargbhai S., Ciampricotti, Metamia, de Stanchina, Elisa, Poirier, John T., Rudin, Charles M., Sen, Triparna

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Combination Therapy With MDM2 and MEK Inhibitors Is Effective in Patient-Derived Models of Lung Adenocarcinoma With Concurrent Oncogenic Drivers and MDM2 Amplification by Elkrief, Arielle, Odintsov, Igor, Markov, Vladimir, Caeser, Rebecca, Sobczuk, Pawel, Tischfield, Sam E., Bhanot, Umesh, Vanderbilt, Chad M., Cheng, Emily H., Drilon, Alexander, Riely, Gregory J., Lockwood, William W., de Stanchina, Elisa, Tirunagaru, Vijaya G., Doebele, Robert C., Quintanal-Villalonga, Álvaro, Rudin, Charles M., Somwar, Romel, Ladanyi, Marc

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Meiotic Recombination Initiation in and around Retrotransposable Elements in Saccharomyces cerevisiae: e1003732 by Sasaki, Mariko, Tischfield, Sam E, Overbeek, Megan van, Keeney, Scott

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Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation by Quintanal-Villalonga, Alvaro, Taniguchi, Hirokazu, Zhan, Yingqian A., Hasan, Maysun M., Chavan, Shweta S., Meng, Fanli, Uddin, Fathema, Manoj, Parvathy, Donoghue, Mark T.A., Won, Helen H., Chan, Joseph M., Ciampricotti, Metamia, Chow, Andrew, Offin, Michael, Chang, Jason C., Ray-Kirton, Jordana, Tischfield, Sam E., Egger, Jacklynn, Bhanot, Umesh K., Linkov, Irina, Asher, Marina, Sinha, Sonali, Silber, Joachim, Iacobuzio-Donahue, Christine A., Roehrl, Michael H., Hollmann, Travis J., Yu, Helena A., Qiu, Juan, de Stanchina, Elisa, Baine, Marina K., Rekhtman, Natasha, Poirier, John T., Loomis, Brian, Koche, Richard P., Rudin, Charles M., Sen, Triparna

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Abstract 3858: Exploring Exportin-1 as a therapeutic vulnerability in squamous cell carcinoma by Durani, Vidushi, Caeser, Rebecca, Rudin, Charles M., Quintanal-Villalonga, Alvaro, Sridhar, Harsha, Manoj, Parvathy, Tischfield, Sam E., Asher, Marina, Bhanot, Umeshkumar, Egger, Jacklynn V., Socci, Nicholas D. Socci D., Shah, Nisargbhai S S., de Stanchina, Elisa, Rekhtman, Natasha

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Abstract 90: STAT3-driven MAPK activation represents a therapeutic vulnerability in ASCL1 high SCLC by Caeser, Rebecca, Hulton, Christopher, Costa, Emily, Durani, Vidushi, Little, Megan, Chen, Xiaoping, Tischfield, Sam E., Asher, Marina, Kombak, Faruk Erdem, Chavan, Shweta S., Shah, Nisargbhai S., Ciampricotti, Metamia, de Stanchina, Elisa, Poirier, John T., Rudin, Charles M., Sen, Triparna

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Common biological networks underlie genetic risk for alcoholism in African‐ and European‐American populations by Kos, M. Z., Yan, J., Dick, D. M., Agrawal, A., Bucholz, K. K., Rice, J. P., Johnson, E. O., Schuckit, M., Kuperman, S., Kramer, J., Goate, A. M., Tischfield, J. A., Foroud, T., Nurnberger, J., Hesselbrock, V., Porjesz, B., Bierut, L. J., Edenberg, H. J., Almasy, L.

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Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies by Keating, Brendan J, Tischfield, Sam, Murray, Sarah S, Bhangale, Tushar, Price, Thomas S, Glessner, Joseph T, Galver, Luana, Barrett, Jeffrey C, Grant, Struan F A, Farlow, Deborah N, Chandrupatla, Hareesh R, Hansen, Mark, Ajmal, Saad, Papanicolaou, George J, Guo, Yiran, Li, Mingyao, Derohannessian, Stephanie, de Bakker, Paul I W, Bailey, Swneke D, Montpetit, Alexandre, Edmondson, Andrew C, Taylor, Kent, Gai, Xiaowu, Wang, Susanna S, Fornage, Myriam, Shaikh, Tamim, Groop, Leif, Boehnke, Michael, Hall, Alistair S, Hattersley, Andrew T, Frackelton, Edward, Patterson, Nick, Chiang, Charleston W K, Kim, Cecelia E, Fabsitz, Richard R, Ouwehand, Willem, Price, Alkes L, Munroe, Patricia, Caulfield, Mark, Drake, Thomas, Boerwinkle, Eric, Reich, David, Whitehead, A Stephen, Cappola, Thomas P, Samani, Nilesh J, Lusis, A Jake, Schadt, Eric, Wilson, James G, Koenig, Wolfgang, McCarthy, Mark I, Kathiresan, Sekar, Gabriel, Stacey B, Hakonarson, Hakon, Anand, Sonia S, Reilly, Muredach, Engert, James C, Nickerson, Deborah A, Rader, Daniel J, Hirschhorn, Joel N, Fitzgerald, Garret A

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Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals by Guo, Yiran, Lanktree, Matthew B, Taylor, Kira C, Hakonarson, Hakon, Lange, Leslie A, Keating, Brendan J

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Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height by Lanktree, Matthew B., Guo, Yiran, Murtaza, Muhammed, Onland-Moret, N. Charlotte, Rajagopalan, Ramakrishnan, Johnson, Toby, Nelson, Christopher P., Pankratz, Nathan, Pankow, James S., Shah, Sonia, Barnard, John, Peters, Bas J., Maloney, Cliona M., Zafarmand, M. Hadi, Romaine, Simon P.R., Gong, Yan, Price, Tom S., Smith, Erin N., Kim, Cecilia E., Asselbergs, Folkert W., Bailey, Kristian M., Bauer, Florianne, Behr, Elijah R., Bhangale, Tushar, Boer, Jolanda M.A., Brown, Morris, Burton, Paul R., Chandrupatla, Hareesh R., Connell, John, Elbers, Clara C., Fang, James C., Fox, Caroline S., Fuchs, Barry, Furlong, Clement E., Goel, Anuj, Grobbee, Diederik E., Huang, Guan-Hua, Johnson, W. Craig, Li, Qing, Kleber, Marcus E., Klein, Ronald, Kooperberg, Charles, Ky, Bonnie, LaCroix, Andrea, Lanken, Paul, Lathrop, Mark, Li, Mingyao, Melander, Olle, Mentch, Frank D., Meyer, Nuala J., Onipinla, Abiodun, Rafelt, Suzanne, Patel, Sanjey R., Putt, Mary E., Simpson, Claire, Srinivasan, Sathanur R., Suver, Christine, Swergold, Gary, Sweitzer, Nancy K., Tischfield, Sam, Tobin, Martin, Tomaszewski, Maciej, Zheng, Dongling, Danesh, John, Day, Ian N., Duggan, David, Hirschhorn, Joel N., Hofker, Marten H., Kivimaki, Mika, Kottke-Marchant, Kandice, Mega, Jessica L., Mitchell, Braxton D., Morrow, David A., Palmen, Jutta, Shields, Denis C., Shuldiner, Alan R., Sleiman, Patrick M., Smith, George Davey, Christie, Jason D., Murray, Sarah S., Dorn, Gerald W., Boerwinkle, Eric, Rader, Daniel J., Caulfield, Mark, Talmud, Philippa J., Topol, Eric, Engert, James C., Wang, Kai, Dominiczak, Anna, Curtis, Sean P., Sabatine, Marc S., Saleheen, Danish, Cruickshanks, Karen J., Klungel, Olaf H., Wijmenga, Cisca, Schadt, Eric E., Grant, Struan F.A., Anand, Sonia S., Reiner, Alex, Hakonarson, Hakon

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