Retinoblastoma Inactivation Induces a Protumoral Microenvironment via Enhanced CCL2 Secretion

by Li, Fengkai, Kitajima, Shunsuke, Kohno, Susumu, Yoshida, Akiyo, Tange, Shoichiro, Sasaki, Soichiro, Okada, Nobuhiro, Nishimoto, Yuuki, Muranaka, Hayato, Nagatani, Naoko, Suzuki, Misa, Masuda, Sayuri, Thai, Tran C, Nishiuchi, Takumi, Tanaka, Tomoaki, Barbie, David A, Mukaida, Naofumi, Takahashi, Chiaki
Published in Cancer research (Chicago, Ill.)

ER Stress Signaling Promotes the Survival of Cancer "Persister Cells" Tolerant to EGFR Tyrosine Kinase Inhibitors

by Terai, Hideki, Kitajima, Shunsuke, Potter, Danielle S, Matsui, Yusuke, Quiceno, Laura Gutierrez, Chen, Ting, Kim, Tae-Jung, Rusan, Maria, Thai, Tran C, Piccioni, Federica, Donovan, Katherine A, Kwiatkowski, Nicholas, Hinohara, Kunihiko, Wei, Guo, Gray, Nathanael S, Fischer, Eric S, Wong, Kwok-Kin, Shimamura, Teppei, Letai, Anthony, Hammerman, Peter S, Barbie, David A
Published in Cancer research (Chicago, Ill.)

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

by Barbie, Thanh U, Alexe, Gabriela, Aref, Amir R, Li, Shunqiang, Zhu, Zehua, Zhang, Xiuli, Imamura, Yu, Thai, Tran C, Huang, Ying, Bowden, Michaela, Herndon, John, Cohoon, Travis J, Fleming, Timothy, Tamayo, Pablo, Mesirov, Jill P, Ogino, Shuji, Wong, Kwok-Kin, Ellis, Matthew J, Hahn, William C, Barbie, David A, Gillanders, William E
Published in The Journal of clinical investigation

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

by Kitajima, Shunsuke, Asahina, Hajime, Chen, Ting, Guo, Sujuan, Quiceno, Laura Gutierrez, Cavanaugh, Jillian D., Merlino, Ashley A., Tange, Shoichiro, Terai, Hideki, Kim, Jong Wook, Wang, Xiaoen, Zhou, Shan, Xu, Man, Wang, Stephen, Zhu, Zehua, Thai, Tran C., Takahashi, Chiaki, Wang, Yujin, Neve, Richard, Stinson, Susanna, Tamayo, Pablo, Watanabe, Hideo, Kirschmeier, Paul T., Wong, Kwok-Kin, Barbie, David A.
Published in Cancer cell

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit

by Zhu, Zehua, Aref, Amir R, Cohoon, Travis J, Barbie, Thanh U, Imamura, Yu, Yang, Shenghong, Moody, Susan E, Shen, Rhine R, Schinzel, Anna C, Thai, Tran C, Reibel, Jacob B, Tamayo, Pablo, Godfrey, Jason T, Qian, Zhi Rong, Page, Asher N, Maciag, Karolina, Chan, Edmond M, Silkworth, Whitney, Labowsky, Mary T, Rozhansky, Lior, Mesirov, Jill P, Gillanders, William E, Ogino, Shuji, Hacohen, Nir, Gaudet, Suzanne, Eck, Michael J, Engelman, Jeffrey A, Corcoran, Ryan B, Wong, Kwok-Kin, Hahn, William C, Barbie, David A
Published in Cancer discovery

MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer

by Yoshida, Ryohei, Saigi, Maria, Tani, Tetsuo, Springer, Benjamin F, Shibata, Hirofumi, Kitajima, Shunsuke, Mahadevan, Navin R, Campisi, Marco, Kim, William, Kobayashi, Yoshihisa, Thai, Tran C, Haratani, Koji, Yamamoto, Yurie, Sundararaman, Shriram K, Knelson, Erik H, Vajdi, Amir, Canadas, Israel, Uppaluri, Ravindra, Paweletz, Cloud P, Miret, Juan J, Lizotte, Patrick H, Gokhale, Prafulla C, Jänne, Pasi A, Barbie, David A
Published in Cancer research (Chicago, Ill.)

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

by Noyes, Christopher, Kitajima, Shunsuke, Li, Fengkai, Suita, Yusuke, Miriyala, Saradha, Isaac, Shakson, Ahsan, Nagib, Knelson, Erik, Vajdi, Amir, Tani, Tetsuo, Thai, Tran C, Xu, Derek, Murai, Junko, Tapinos, Nikos, Takahashi, Chiaki, Barbie, David A, Yajima, Mamiko
Published in Communications biology

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

by Kitajima, Shunsuke, Ivanova, Elena, Guo, Sujuan, Yoshida, Ryohei, Campisi, Marco, Sundararaman, Shriram K, Tange, Shoichiro, Mitsuishi, Yoichiro, Thai, Tran C, Masuda, Sayuri, Piel, Brandon P, Sholl, Lynette M, Kirschmeier, Paul T, Paweletz, Cloud P, Watanabe, Hideo, Yajima, Mamiko, Barbie, David A
Published in Cancer discovery

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

by Jenkins, Russell W, Aref, Amir R, Lizotte, Patrick H, Ivanova, Elena, Stinson, Susanna, Zhou, Chensheng W, Bowden, Michaela, Deng, Jiehui, Liu, Hongye, Miao, Diana, He, Meng Xiao, Walker, William, Zhang, Gao, Tian, Tian, Cheng, Chaoran, Wei, Zhi, Palakurthi, Sangeetha, Bittinger, Mark, Vitzthum, Hans, Kim, Jong Wook, Merlino, Ashley, Quinn, Max, Venkataramani, Chandrasekar, Kaplan, Joshua A, Portell, Andrew, Gokhale, Prafulla C, Phillips, Bart, Smart, Alicia, Rotem, Asaf, Jones, Robert E, Keogh, Lauren, Anguiano, Maria, Stapleton, Lance, Jia, Zhiheng, Barzily-Rokni, Michal, Cañadas, Israel, Thai, Tran C, Hammond, Marc R, Vlahos, Raven, Wang, Eric S, Zhang, Hua, Li, Shuai, Hanna, Glenn J, Huang, Wei, Hoang, Mai P, Piris, Adriano, Eliane, Jean-Pierre, Stemmer-Rachamimov, Anat O, Cameron, Lisa, Su, Mei-Ju, Shah, Parin, Izar, Benjamin, Thakuria, Manisha, LeBoeuf, Nicole R, Rabinowits, Guilherme, Gunda, Viswanath, Parangi, Sareh, Cleary, James M, Miller, Brian C, Kitajima, Shunsuke, Thummalapalli, Rohit, Miao, Benchun, Barbie, Thanh U, Sivathanu, Vivek, Wong, Joshua, Richards, William G, Bueno, Raphael, Yoon, Charles H, Miret, Juan, Herlyn, Meenhard, Garraway, Levi A, Van Allen, Eliezer M, Freeman, Gordon J, Kirschmeier, Paul T, Lorch, Jochen H, Ott, Patrick A, Hodi, F Stephen, Flaherty, Keith T, Kamm, Roger D, Boland, Genevieve M, Wong, Kwok-Kin, Dornan, David, Paweletz, Cloud Peter, Barbie, David A
Published in Cancer discovery

MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

by Kitajima, Shunsuke, Tani, Tetsuo, Springer, Benjamin F., Campisi, Marco, Osaki, Tatsuya, Haratani, Koji, Chen, Minyue, Knelson, Erik H., Mahadevan, Navin R., Ritter, Jessica, Yoshida, Ryohei, Köhler, Jens, Ogino, Atsuko, Nozawa, Ryu-Suke, Sundararaman, Shriram K., Thai, Tran C., Homme, Mizuki, Piel, Brandon, Kivlehan, Sophie, Obua, Bonje N., Purcell, Connor, Yajima, Mamiko, Barbie, Thanh U., Lizotte, Patrick H., Jänne, Pasi A., Paweletz, Cloud P., Gokhale, Prafulla C., Barbie, David A.
Published in Cancer cell

Phosphorylation of RAB7 by TBK1/IKKε Regulates Innate Immune Signaling in Triple-Negative Breast Cancer

by Ritter, Jessica L, Zhu, Zehua, Thai, Tran C, Mahadevan, Navin R, Mertins, Philipp, Knelson, Erik H, Piel, Brandon P, Han, Saemi, Jaffe, Jacob D, Carr, Steven A, Barbie, David A, Barbie, Thanh U
Published in Cancer research (Chicago, Ill.)

Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity

by Mahadevan, Navin R, Knelson, Erik H, Wolff, Jacquelyn O, Vajdi, Amir, Saigí, Maria, Campisi, Marco, Hong, Deli, Thai, Tran C, Piel, Brandon, Han, Saemi, Reinhold, Bruce B, Duke-Cohan, Jonathan S, Poitras, Michael J, Taus, Luke J, Lizotte, Patrick H, Portell, Andrew, Quadros, Victor, Santucci, Alison D, Murayama, Takahiko, Cañadas, Israel, Kitajima, Shunsuke, Akitsu, Aoi, Fridrikh, Maya, Watanabe, Hideo, Reardon, Brendan, Gokhale, Prafulla C, Paweletz, Cloud P, Awad, Mark M, Van Allen, Eliezer M, Lako, Ana, Wang, Xi-Tao, Chen, Benjamin, Hong, Fangxin, Sholl, Lynette M, Tolstorukov, Michael Y, Pfaff, Kathleen, Jänne, Pasi A, Gjini, Evisa, Edwards, Robin, Rodig, Scott, Reinherz, Ellis L, Oser, Matthew G, Barbie, David A
Published in Cancer discovery

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

by Sehgal, Kartik, Portell, Andrew, Ivanova, Elena V, Lizotte, Patrick H, Mahadevan, Navin R, Greene, Jonathan R, Vajdi, Amir, Gurjao, Carino, Teceno, Tyler, Taus, Luke J, Thai, Tran C, Kitajima, Shunsuke, Liu, Derek, Tani, Tetsuo, Noureddine, Moataz, Lau, Christie J, Kirschmeier, Paul T, Liu, David, Giannakis, Marios, Jenkins, Russell W, Gokhale, Prafulla C, Goldoni, Silvia, Pinzon-Ortiz, Maria, Hastings, William D, Hammerman, Peter S, Miret, Juan J, Paweletz, Cloud P, Barbie, David A
Published in The Journal of clinical investigation

Activation of Tumor-Cell STING Primes NK-Cell Therapy

by Knelson, Erik H, Ivanova, Elena V, Tarannum, Mubin, Campisi, Marco, Lizotte, Patrick H, Booker, Matthew A, Ozgenc, Ismail, Noureddine, Moataz, Meisenheimer, Brittany, Chen, Minyue, Piel, Brandon, Spicer, Nathaniel, Obua, Bonje, Messier, Cameron M, Shannon, Erin, Mahadevan, Navin R, Tani, Tetsuo, Schol, Pieter J, Lee-Hassett, Anna M, Zlota, Ari, Vo, Ha V, Ha, Minh, Bertram, Arrien A, Han, Saemi, Thai, Tran C, Gustafson, Corinne E, Venugopal, Kartika, Haggerty, Timothy J, Albertson, Thomas P, Hartley, Antja-Voy, Eser, Pinar O, Li, Ze-Hua, Cañadas, Israel, Vivero, Marina, De Rienzo, Assunta, Richards, William G, Abu-Yousif, Adnan O, Appleman, Vicky A, Gregory, Richard C, Parent, Alexander, Lineberry, Neil, Smith, Eric L, Jänne, Pasi A, Miret, Juan J, Tolstorukov, Michael Y, Romee, Rizwan, Paweletz, Cloud P, Bueno, Raphael, Barbie, David A
Published in Cancer immunology research

MicroRNA-140 mediates RB tumor suppressor function to control stem cell-like activity through interleukin-6

by Yoshida, Akiyo, Kitajima, Shunsuke, Li, Fengkai, Cheng, Chaoyang, Takegami, Yujiro, Kohno, Susumu, Wan, Yuan Song, Hayashi, Naoyuki, Muranaka, Hayato, Nishimoto, Yuuki, Nagatani, Naoko, Nishiuchi, Takumi, Thai, Tran C, Suzuki, Sawako, Nakao, Shinji, Tanaka, Tomoaki, Hirose, Osamu, Barbie, David A, Takahashi, Chiaki
Published in Oncotarget

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

by Koyama, Shohei, Akbay, Esra A, Li, Yvonne Y, Aref, Amir R, Skoulidis, Ferdinandos, Herter-Sprie, Grit S, Buczkowski, Kevin A, Liu, Yan, Awad, Mark M, Denning, Warren L, Diao, Lixia, Wang, Jing, Parra-Cuentas, Edwin R, Wistuba, Ignacio I, Soucheray, Margaret, Thai, Tran, Asahina, Hajime, Kitajima, Shunsuke, Altabef, Abigail, Cavanaugh, Jillian D, Rhee, Kevin, Gao, Peng, Zhang, Haikuo, Fecci, Peter E, Shimamura, Takeshi, Hellmann, Matthew D, Heymach, John V, Hodi, F Stephen, Freeman, Gordon J, Barbie, David A, Dranoff, Glenn, Hammerman, Peter S, Wong, Kwok-Kin
Published in Cancer research (Chicago, Ill.)

Abstract 1012: Determinants of immune evasion in MET driven lung cancer

by Saigi, Maria, Yoshida, Ryohei, Knelson, Erik H, Mahadevan, Navin R, Vajdi, Amir, Cañadas, Israel, Thai, Tran C, Awad, Mark M., Sánchez-Céspedes, Montse, Barbie, David A
Published in Cancer research (Chicago, Ill.)

Abstract 6431: Targeting Rab7-mediated STING degradation to amplify therapeutic STING agonism in TNBC

by Zhang, Yuqing, Ritter, Jessica L., Thai, Tran C., Dillon, Deborah A., Barbie, David A., Barbie, Thanh U.
Published in Cancer research (Chicago, Ill.)

Abstract 5727: Identification of synthetic lethal vulnerabilities in cancers with loss of function mutations in NOTCH

by Hong, Deli, Booker, Matthew A., Anjum, Sidrah, Li, Yixiang, Thai, Tran C., Wang, Michelle Y., Barbie, David A., Tolstorukov, Michael Y., Qi, Jun, Oser, Matthew G.
Published in Cancer research (Chicago, Ill.)

Abstract 297: Epigenetic activation of IGF1R signaling promotes resistance to momelotinib and MEK inhibition in KRAS-driven lung cancer

by Kitajima, Shunsuke, Asahina, Hajime, Cavanaugh, Jillian D., Chen, Ting, Merlino, Ashley A., Tran, Thai C., Wong, Kwonk-Kin, Barbie, David A.
Published in Cancer research (Chicago, Ill.)