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3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity, Selective, and Orally Bioavailable h5-HT2A Receptor Antagonists
by
Rowley, Michael
,
Hallett, David J
,
Goodacre, Simon
,
Moyes, Christopher
,
Crawforth, James
,
Sparey, Timothy J
,
Patel, Smita
,
Marwood, Rose
,
Patel, Shil
,
Thomas, Steven
,
Hitzel, Laure
,
O'Connor, Desmond
,
Szeto, Nicola
,
Castro, Jose L
,
Hutson, Peter H
,
MacLeod, Angus M
Published in
Journal of medicinal chemistry
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Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selectiv...
by
Jones, Philip
,
Atack, John R.
,
Braun, Matthew P.
,
Cato, Brian P.
,
Chambers, Mark S.
,
O’Connor, Desmond
,
Cook, Susan M.
,
Hobbs, Sarah C.
,
Maxey, Robert
,
Szekeres, Helen J.
,
Szeto, Nicola
,
Wafford, Keith A.
,
MacLeod, Angus M.
Published in
Bioorganic & medicinal chemistry letters
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Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selectiv...
by
Jones, Philip
,
Atack, John R
,
Braun, Matthew P
,
Cato, Brian P
,
Chambers, Mark S
,
O'Connor, Desmond
,
Cook, Susan M
,
Hobbs, Sarah C
,
Maxey, Robert
,
Szekeres, Helen J
,
Szeto, Nicola
,
Wafford, Keith A
,
MacLeod, Angus M
Published in
Bioorganic & medicinal chemistry letters
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Article
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Pharmacokinetics and metabolism studies on (3-tert-butyl-7-(5-methylisoxazol-3-yl)-2- (1-methyl-1H-1,2,4-triazol-5-ylme thoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally select...
by
Jones, Philip
,
Atack, John R
,
Braun, Matthew P
,
Cato, Brian P
,
Chambers, Mark S
,
O'Connor, Desmond
,
Cook, Susan M
,
Hobbs, Sarah C
,
Maxey, Robert
,
Szekeres, Helen J
,
Szeto, Nicola
,
Wafford, Keith A
,
MacLeod, Angus M
Published in
Bioorganic & medicinal chemistry letters
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Article
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5
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Pharmacokinetics and metabolism studies on (3- tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1 H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5- d][1,2,4]triazine, a functionally selec...
by
Jones, Philip
,
Atack, John R.
,
Braun, Matthew P.
,
Cato, Brian P.
,
Chambers, Mark S.
,
O’Connor, Desmond
,
Cook, Susan M.
,
Hobbs, Sarah C.
,
Maxey, Robert
,
Szekeres, Helen J.
,
Szeto, Nicola
,
Wafford, Keith A.
,
MacLeod, Angus M.
Published in
Bioorganic & medicinal chemistry letters
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Article
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6
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Pharmacokinetics and metabolism studies on 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy) pyrazolo[1,5-d][1,2,4]triazine, a functionally selective...
by
JONES, Philip
,
ATACK, John R
,
SZETO, Nicola
,
WAFFORD, Keith A
,
MACLEOD, Angus M
,
BRAUN, Matthew P
,
CATO, Brian P
,
CHAMBERS, Mark S
,
O'CONNOR, Desmond
,
COOK, Susan M
,
HOBBS, Sarah C
,
MAXEY, Robert
,
SZEKERES, Helen J
Published in
Bioorganic & medicinal chemistry letters
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2-aryl indole NK1 antagonists : Optimisation of the amide substituent
by
SHAW, Duncan
,
CHICCHI, Gary G
,
ELLIOTT, Jason M
,
KURTZ, Marc
,
MORRISON, Denise
,
RIDGILL, Mark P
,
SZETO, Nicola
,
WATT, Alan P
,
WILLIAMS, Angela R
,
SWAIN, Christopher J
Published in
Bioorganic & medicinal chemistry letters
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8
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3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity, Selective, and Orally Bioavailable h5-HT 2A Receptor Antagonists
by
Rowley, Michael
,
Hallett, David J.
,
Goodacre, Simon
,
Moyes, Christopher
,
Crawforth, James
,
Sparey, Timothy J.
,
Patel, Smita
,
Marwood, Rose
,
Patel, Shil
,
Thomas, Steven
,
Hitzel, Laure
,
O'Connor, Desmond
,
Szeto, Nicola
,
Castro, Jose L.
,
Hutson, Peter H.
,
MacLeod, Angus M.
Published in
Journal of medicinal chemistry
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2-Aryl indole NK 1 antagonists: optimisation of the amide substituent
by
Shaw, Duncan
,
Chicchi, Gary G
,
Elliott, Jason M
,
Kurtz, Marc
,
Morrison, Denise
,
Ridgill, Mark P
,
Szeto, Nicola
,
Watt, Alan P
,
Williams, Angela R
,
Swain, Christopher J
Published in
Bioorganic & medicinal chemistry letters
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