SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

by Mlcochova, Petra, Kemp, Steven A, Dhar, Mahesh Shanker, Papa, Guido, Meng, Bo, Ferreira, Isabella A T M, Datir, Rawlings, Collier, Dami A, Albecka, Anna, Singh, Sujeet, Pandey, Rajesh, Brown, Jonathan, Zhou, Jie, Goonawardane, Niluka, Mishra, Swapnil, Whittaker, Charles, Mellan, Thomas, Marwal, Robin, Datta, Meena, Sengupta, Shantanu, Ponnusamy, Kalaiarasan, Radhakrishnan, Venkatraman Srinivasan, Abdullahi, Adam, Charles, Oscar, Chattopadhyay, Partha, Devi, Priti, Caputo, Daniela, Peacock, Tom, Wattal, Chand, Goel, Neeraj, Satwik, Ambrish, Vaishya, Raju, Agarwal, Meenakshi, Mavousian, Antranik, Lee, Joo Hyeon, Bassi, Jessica, Silacci-Fegni, Chiara, Saliba, Christian, Pinto, Dora, Irie, Takashi, Yoshida, Isao, Hamilton, William L, Sato, Kei, Bhatt, Samir, Flaxman, Seth, James, Leo C, Corti, Davide, Piccoli, Luca, Barclay, Wendy S, Rakshit, Partha, Agrawal, Anurag, Gupta, Ravindra K
Published in Nature (London)

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

by Meng, Bo, Abdullahi, Adam, Ferreira, Isabella A T M, Goonawardane, Niluka, Saito, Akatsuki, Kimura, Izumi, Yamasoba, Daichi, Gerber, Pehuén Pereyra, Fatihi, Saman, Rathore, Surabhi, Zepeda, Samantha K, Papa, Guido, Kemp, Steven A, Ikeda, Terumasa, Toyoda, Mako, Tan, Toong Seng, Kuramochi, Jin, Mitsunaga, Shigeki, Ueno, Takamasa, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Brevini, Teresa, Mallery, Donna L, Charles, Oscar J, Bowen, John E, Joshi, Anshu, Walls, Alexandra C, Jackson, Laurelle, Martin, Darren, Smith, Kenneth G C, Bradley, John, Briggs, John A G, Choi, Jinwook, Madissoon, Elo, Meyer, Kerstin B, Mlcochova, Petra, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Teichmann, Sarah A, Fisher, Andrew J, Pizzuto, Matteo S, de Marco, Anna, Corti, Davide, Hosmillo, Myra, Lee, Joo Hyeon, James, Leo C, Thukral, Lipi, Veesler, David, Sigal, Alex, Sampaziotis, Fotios, Goodfellow, Ian G, Matheson, Nicholas J, Sato, Kei, Gupta, Ravindra K
Published in Nature (London)

Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

by Collier, Dami A, Ferreira, Isabella A T M, Kotagiri, Prasanti, Datir, Rawlings P, Lim, Eleanor Y, Touizer, Emma, Meng, Bo, Abdullahi, Adam, Elmer, Anne, Kingston, Nathalie, Graves, Barbara, Le Gresley, Emma, Caputo, Daniela, Bergamaschi, Laura, Smith, Kenneth G C, Bradley, John R, Ceron-Gutierrez, Lourdes, Cortes-Acevedo, Paulina, Barcenas-Morales, Gabriela, Linterman, Michelle A, McCoy, Laura E, Davis, Chris, Thomson, Emma, Lyons, Paul A, McKinney, Eoin, Doffinger, Rainer, Wills, Mark, Gupta, Ravindra K
Published in Nature (London)

Definitions and pathophysiology of vasoplegic shock

by Lambden, Simon, Creagh-Brown, Ben C, Hunt, Julie, Summers, Charlotte, Forni, Lui G
Published in Critical care (London, England)

The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities

by Millar, Fraser R, Summers, Charlotte, Griffiths, Mark J, Toshner, Mark R, Proudfoot, Alastair G
Published in Thorax

Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study

by Hamilton, Fergus W, Thomas, Matt, Arnold, David, Palmer, Tom, Moran, Ed, Mentzer, Alexander J, Maskell, Nick, Baillie, Kenneth, Summers, Charlotte, Hingorani, Aroon, MacGowan, Alasdair, Khandaker, Golam M, Mitchell, Ruth, Davey Smith, George, Ghazal, Peter, Timpson, Nicholas J
Published in PLoS medicine

We need medical leadership built on trust

by Summers, Charlotte
Published in BMJ (Online)

Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities

by Mehta, Puja, Porter, Joanna C, Manson, Jessica J, Isaacs, John D, Openshaw, Peter J M, McInnes, Iain B, Summers, Charlotte, Chambers, Rachel C
Published in The Lancet Respiratory Medicine

Supervised machine learning for the early prediction of acute respiratory distress syndrome (ARDS)

by Le, Sidney, Pellegrini, Emily, Green-Saxena, Abigail, Summers, Charlotte, Hoffman, Jana, Calvert, Jacob, Das, Ritankar
Published in Journal of critical care

Associate Principal Investigators and the HEAL-COVID trial: good for trainees, good for trials

by Newman, Joseph, Wild, Philip, Summers, Charlotte, Toshner, Mark
Published in Current controlled trials in cardiovascular medicine

Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition

by Juss, Jatinder K, House, David, Amour, Augustin, Begg, Malcolm, Herre, Jurgen, Storisteanu, Daniel M L, Hoenderdos, Kim, Bradley, Glyn, Lennon, Mark, Summers, Charlotte, Hessel, Edith M, Condliffe, Alison, Chilvers, Edwin R
Published in American journal of respiratory and critical care medicine

The Sequential Organ Failure Assessment (SOFA) Score: has the time come for an update?

by Moreno, Rui, Rhodes, Andrew, Piquilloud, Lise, Hernandez, Glenn, Takala, Jukka, Gershengorn, Hayley B, Tavares, Miguel, Coopersmith, Craig M, Myatra, Sheila N, Singer, Mervyn, Rezende, Ederlon, Prescott, Hallie C, Soares, Márcio, Timsit, Jean-François, de Lange, Dylan W, Jung, Christian, De Waele, Jan J, Martin, Greg S, Summers, Charlotte, Azoulay, Elie, Fujii, Tomoko, McLean, Anthony S, Vincent, Jean-Louis
Published in Critical care (London, England)

Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice

by Li, Wei, Long, Lu, Yang, Xudong, Tong, Zhen, Southwood, Mark, King, Ross, Caruso, Paola, Upton, Paul D, Yang, Peiran, Bocobo, Geoffrey A, Nikolic, Ivana, Higuera, Angelica, Salmon, Richard M, Jiang, He, Lodge, Katharine M, Hoenderdos, Kim, Baron, Rebecca M, Yu, Paul B, Condliffe, Alison M, Summers, Charlotte, Nourshargh, Sussan, Chilvers, Edwin R, Morrell, Nicholas W
Published in American journal of respiratory and critical care medicine

Chasing the 'Holy Grail' - Modulating Neutrophils in Inflammatory Lung Disease

by Summers, Charlotte
Published in American journal of respiratory and critical care medicine

ACCORD: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID-19 in Hospi...

by Wilkinson, Tom, Dixon, Rupert, Page, Clive, Carroll, Miles, Griffiths, Gareth, Ho, Ling-Pei, De Soyza, Anthony, Felton, Timothy, Lewis, Keir E, Phekoo, Karen, Chalmers, James D, Gordon, Anthony, McGarvey, Lorcan, Doherty, Jillian, Read, Robert C, Shankar-Hari, Manu, Martinez-Alier, Nuria, O'Kelly, Michael, Duncan, Graeme, Walles, Roelize, Sykes, James, Summers, Charlotte, Singh, Dave
Published in Current controlled trials in cardiovascular medicine

Understanding the Security and Privacy Concerns About the Use of Identifiable Health Data in the Context of the COVID-19 Pandemic: Survey Study of Public Attitudes Toward COVID-19...

by Summers, Charlotte, Griffiths, Frances, Cave, Jonathan, Panesar, Arjun
Published in JMIR formative research

Precision medicine in acute respiratory distress syndrome: workshop report and recommendations for future research

by Bos, Lieuwe D J, Artigas, Antonio, Constantin, Jean-Michel, Hagens, Laura A, Heijnen, Nanon, Laffey, John G, Meyer, Nuala, Papazian, Laurent, Pisani, Lara, Schultz, Marcus J, Shankar-Hari, Manu, Smit, Marry R, Summers, Charlotte, Ware, Lorraine B, Scala, Raffaele, Calfee, Carolyn S
Published in European respiratory review

SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity

by Meng, Bo, Choi, Jinwook, Baker, Stephen, Dougan, Gordon, Hess, Christoph, Kingston, Nathalie, Lehner, Paul J., Lyons, Paul A., Matheson, Nicholas J., Owehand, Willem H., Saunders, Caroline, Summers, Charlotte, Thaventhiran, James E.D., Toshner, Mark, Weekes, Michael P., Maxwell, Patrick, Shaw, Ashley, Calder, Jo, Canna, Laura, Domingo, Jason, Fuller, Stewart, Harris, Julie, Hewitt, Sarah, Kennet, Jane, Jose, Sherly, Kourampa, Jenny, Meadows, Anne, O’Brien, Criona, Price, Jane, Publico, Cherry, Rastall, Rebecca, Ribeiro, Carla, Rowlands, Jane, Ruffolo, Valentina, Tordesillas, Hugo, Dunmore, Benjamin J., Gräf, Stefan, Hodgson, Josh, Huang, Christopher, Hunter, Kelvin, Jones, Emma, Legchenko, Ekaterina, Matara, Cecilia, Martin, Jennifer, O’Donnell, Ciara, Pointon, Linda, Shih, Joy, Sutcliffe, Rachel, Tilly, Tobias, Treacy, Carmen, Tong, Zhen, Wylot, Marta, Betancourt, Ariana, Bower, Georgie, Cossetti, Chiara, De Sa, Aloka, Epping, Madeline, Gleadall, Nick, Hinch, Andrew, Jackson, Sarah, Jarvis, Isobel, Krishna, Ben, Omarjee, Ommar, Perera, Marianne, Potts, Martin, Richoz, Nathan, Romashova, Veronika, Stefanucci, Luca, Strezlecki, Mateusz, Turner, Lori, De Bie, Eckart M.D.D., Bunclark, Katherine, Josipovic, Masa, Mackay, Michael, Allison, John, Butcher, Helen, Caputo, Daniela, Dewhurst, Eleanor, Furlong, Anita, Graves, Barbara, Gray, Jennifer, Ivers, Tasmin, Le Gresley, Emma, Linger, Rachel, Meloy, Sarah, Muldoon, Francesca, Ovington, Nigel, Papadia, Sofia, Stark, Hannah, Stirrups, Kathleen E., Townsend, Paul, Walker, Neil, Webster, Jennifer, Scholtes, Ingrid, Hein, Sabine, King, Rebecca, Bradley, John R., Smith, Kenneth G.C., Lee, Joo Hyeon, Gupta, Ravindra K.
Published in Cell Reports

Evaluation of the Low Carb Program Digital Intervention for the Self-Management of Type 2 Diabetes and Prediabetes in an NHS England General Practice: Single-Arm Prospective Study

by Summers, Charlotte, Tobin, Simon, Unwin, David
Published in JMIR diabetes

In vivo imaging reveals increased eosinophil uptake in the lungs of obese asthmatic patients

by Farahi, Neda, Loutsios, Chrystalla, Tregay, Nicola, Wright, Adam K.A., Berair, Rachid, Lok, Laurence S.C., Gillett, Daniel, Cullum, Ian, Simmonds, Rosalind P., Summers, Charlotte, Wong, Anna, Solanki, Chandra K., Buscombe, John, Pang, Pee Hwee, Thavakumar, Arthikkaa, Peters, A. Michael, Brightling, Christopher E., Condliffe, Alison M., Chilvers, Edwin R.
Published in Journal of allergy and clinical immunology