Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface

by Weight, Caroline M, Venturini, Cristina, Pojar, Sherin, Jochems, Simon P, Reiné, Jesús, Nikolaou, Elissavet, Solórzano, Carla, Noursadeghi, Mahdad, Brown, Jeremy S, Ferreira, Daniela M, Heyderman, Robert S
Published in Nature communications

Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination

by Mitsi, Elena, Diniz, Mariana O, Reiné, Jesús, Collins, Andrea M, Robinson, Ryan E, Hyder-Wright, Angela, Farrar, Madlen, Liatsikos, Konstantinos, Hamilton, Josh, Onyema, Onyia, Urban, Britta C, Solórzano, Carla, Belij-Rammerstorfer, Sandra, Sheehan, Emma, Lambe, Teresa, Draper, Simon J, Weiskopf, Daniela, Sette, Alessandro, Maini, Mala K, Ferreira, Daniela M
Published in Nature communications

Human alveolar macrophages predominately express combined classical M1 and M2 surface markers in steady state

by Mitsi, Elena, Kamng'ona, Raphael, Rylance, Jamie, Solórzano, Carla, Jesus Reiné, J, Mwandumba, Henry C, Ferreira, Daniela M, Jambo, Kondwani C
Published in Respiratory research

Detection of SARS-CoV-2 infection by saliva and nasopharyngeal sampling in frontline healthcare workers: An observational cohort study

by Walker, Naomi F, Byrne, Rachel L, Howard, Ashleigh, Nikolaou, Elissavet, Farrar, Madlen, Glynn, Sharon, Cheliotis, Katerina S, Cubas Atienzar, Ana I, Davies, Kelly, Reiné, Jesús, Rashid-Gardner, Zalina, German, Esther L, Solórzano, Carla, Blandamer, Tess, Hitchins, Lisa, Myerscough, Christopher, Gessner, Bradford D, Begier, Elizabeth, Collins, Andrea M, Beadsworth, Mike, Todd, Stacy, Hill, Helen, Houlihan, Catherine F, Nastouli, Eleni, Adams, Emily R, Mitsi, Elena, Ferreira, Daniela M
Published in PloS one

Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage

by Pennington, Shaun H, Pojar, Sherin, Mitsi, Elena, Gritzfeld, Jenna F, Nikolaou, Elissavet, Solórzano, Carla, Owugha, Jessica T, Masood, Qasim, Gordon, Melita A, Wright, Angela D, Collins, Andrea M, Miyaji, Eliane N, Gordon, Stephen B, Ferreira, Daniela M
Published in American journal of respiratory and critical care medicine

Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash

by Jochems, Simon P, Piddock, Katherine, Rylance, Jamie, Adler, Hugh, Carniel, Beatriz F, Collins, Andrea, Gritzfeld, Jenna F, Hancock, Carole, Hill, Helen, Reiné, Jesus, Seddon, Alexandra, Solórzano, Carla, Sunny, Syba, Trimble, Ashleigh, Wright, Angela D, Zaidi, Seher, Gordon, Stephen B, Ferreira, Daniela M
Published in PloS one

Evaluation of polymer choice on immunogenicity of chitosan coated PLGA NPs with surface-adsorbed pneumococcal protein antigen PspA4Pro

by Kaneko, Kan, Miyaji, Eliane N., Gonçalves, Viviane M., Ferreira, Daniela M., Solórzano, Carla, MacLoughlin, Ronan, Saleem, Imran
Published in International journal of pharmaceutics

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

by Voysey, Merryn, Weckx, Lily Y, Collins, Andrea M, Hill, Helen, Lazarus, Rajeka, Lawrie, Alison M, McGregor, Alastair, Villafana, Tonya L, Gilbert, Sarah C, Aban, Marites, Aboagye, Jeremy, Adam, Matthew, Adams, Kirsty, Alves, Mariana P.S., Barnes, Eleanor, Berrie, Eleanor, Bewley, Kevin R., Bletchly, Heather, Borthwick, Nicola, Brown, Phillip, Buttigieg, Karen R., Cashen, Paul, Castro, Lucia Carratala, Chadwick, Jim, Chapman, David, Charlton, Sue, Clark, Matthew, Clutterbuck, Elizabeth A., Cooper, Cushla, Cooper, Rachel, Darroch, Paula, Dearlove, David, Drake-Brockman, Rachael, van Eck, Samual, Farrar, Madi, Fraiman, Pedro H.A., Gracie, Lara, Grossi, Leonardo, Hanrath, Aidan T., Harris, Tara, Hassan, Shadin, Hay, Jodie, Head, Ian, Hodges, Gina, Horne, Elizea, Hou, Mimi M., Humphries, Holly E., Hyder-Wright, Angela, Jeffers, Helen, Karampatsas, Konstantinos, Keen, Jade, Khan, Liaquat, King, Thomas B., Klenerman, Paul, Lees, Emily A., Li, Yuanyuan, Loew, Lisa, Marques, Gabriela N., Masilela, Mduduzi, Mathew, Moncy, Meijs, Wilma, Morris, Susan, Mpelembue, Mushiya, Noal, Helena, Nugent, Fay L., O'Connor, Daniel, Olchawski, Victoria, O'Reilly, Paula, Phillips, Daniel J., Pickup, Lorinda, Du Plessis, Joan, Pollard, Samuel, Poulton, Ian, Pulido, David, Reiné, Jesús, Resuello-Dauti, Mila, Richter, Alex, Roche, Sophie, Rollier, Christine, Ruiz, Sarah, Sala, Claudia, Sanchez-Gonzalez, Amada, Sharpe, Hannah E., Smith, Daniel C., Smith, Holly E., Soares, Tiago, Souza, Cinthia M.C.D.L., Spina, Fernanda, Steven, Jill, Stockdale, Lisa, Stockwell, Lisa V., Sturdy, Ann, Tarr, Alexander W., Taylor, Ursula, Themistocleous, Andreas, Tsheko, Betty Lebogang, Turabi, Aadil, Waddington, Claire S., Wallis, Erica, Webb, Stewart
Published in The Lancet (British edition)

Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults

by Nikolaou, Elissavet, Jochems, Simon P, Mitsi, Elena, Pojar, Sherin, Blizard, Annie, Reiné, Jesus, Solórzano, Carla, Negera, Edessa, Carniel, Beatriz, Soares-Schanoski, Alessandra, Connor, Victoria, Adler, Hugh, Zaidi, Seher R, Hales, Caz, Hill, Helen, Hyder-Wright, Angie, Gordon, Stephen B, Rylance, Jamie, Ferreira, Daniela M
Published in mBio

Safety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-i...

by Liu, Xinxue, Shaw, Robert H, Stuart, Arabella S V, Greenland, Melanie, Aley, Parvinder K, Andrews, Nick J, Cameron, J Claire, Charlton, Sue, Clutterbuck, Elizabeth A, Collins, Andrea M, Dinesh, Tanya, England, Anna, Faust, Saul N, Ferreira, Daniela M, Finn, Adam, Green, Christopher A, Hallis, Bassam, Heath, Paul T, Hill, Helen, Lambe, Teresa, Lazarus, Rajeka, Libri, Vincenzo, Long, Fei, Mujadidi, Yama F, Plested, Emma L, Provstgaard-Morys, Samuel, Ramasamy, Maheshi N, Ramsay, Mary, Read, Robert C, Robinson, Hannah, Singh, Nisha, Turner, David P J, Turner, Paul J, Walker, Laura L, White, Rachel, Nguyen-Van-Tam, Jonathan S, Snape, Matthew D, Munro, Alasdair P S, Bartholomew, Jazz, Presland, Laura, Horswill, Sarah, Warren, Sarah, Varkonyi-Clifford, Sophie, Saich, Stephen, Adams, Kirsty, Ricamara, Marivic, Turner, Nicola, Yee Ting, Nicole Y, Whittley, Sarah, Rampling, Tommy, Desai, Amisha, Brown, Claire H, Qureshi, Ehsaan, Gokani, Karishma, Naker, Kush, Kellett Wright, Johanna K, Williams, Rachel L, Riaz, Tawassal, Penciu, Florentina D, Di Maso, Claudio, Howe, Elizabeth G, Vichos, Iason, Ghulam Farooq, Mujtaba, Noristani, Rabiullah, Yao, Xin L, Oldfield, Neil J, Hammersley, Daniel, Belton, Sue, Royal, Simon, San Francisco Ramos, Alberto, Hultin, Cecilia, Galiza, Eva P, Shiham, Farah, Solórzano, Carla, Sainsbury, Hannah, Davies, Kelly, Ambrose, Pauline, Hitchins, Lisa, Baker, Natalie, Leung, Stephanie, Fothergill, Ross, Godwin, Kerry, Buttigieg, Karen, Shaik, Imam, Brown, Phill, Knight, Chanice, Lall, Paminder, Allen, Lauren
Published in The Lancet (British edition)

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four random...

by Voysey, Merryn, Weckx, Lily Y, Collins, Andrea M, Feng, Shuo, Marshall, Richard P, Milan, Eveline P, Pollock, Katrina M, Ramasamy, Maheshi N, Robinson, Hannah, Andrade, Claudia Sala, Barker, Debbie, Bates, Louise, Batten, Alexander, Berzenyi, Daniella, Bird, Adam, Blundell, Susannah R., Budd, William, Cabrera Puig, Ingrid, Calvert, Anna, Carvalho, Yasmin de M., Castro, Thais R.Y., Chiplin, Emily, Cifuentes, Liliana, Danos, Zsofia, Dantas, Maria T.D.C., Davies, Sophie, Desai, Amisha, Drake-Brockman, Rachael, Edwards, Mandy, Edwards, Nick J., El Muhanna, Omar M., Ellison-Handley, Branwen, Fedosyuk, Sofiya, Fisher, Richard, Fofie, Hazel, Franco, Marilia M., Fuskova, Michelle, Godwin, Kerry, Gokani, Karishma, Gonçalves, Maria Luisa Freire, Goodall, Jack, Harris-Wright, Tara A., Howell, Nicola, Humphreys, Jonathan, Iyer, Vidyashankara, Jackson, Susan, Jaumdally, Shameem, Jorge, Marianna Rocha, Kellett Wright, Johanna, Kelly, Elizabeth J., Kelly, Dearbhla M., Kidd, Sarah, Larwood, Jessica P.J., Lees, Emily A., Lelliott, Alice, Leung, Stephanie, Manning, Nicola, Mazur, Olga, McGlashan, Joanna, Megson, Clare, Mesquita, Ana Carolina F., Mitton, Celia, Morrison, Hazel, Morselli, Franca, Oliveira, Catarina, Oosthuizen, Angela, Owen, David R.J., Parracho, Helena M. R.T., Perez, Ana Luiza, Perinpanathan, Tanaraj, Perumal, Rubeshan, Plank, Mary, Proud, Pamela C., Rajeswaran, Thurkka, Rees, Byron, Rhead, Sarah, Richards, Alexander, Roberts, Hannah, Robinson, Ryan E., Rudiansyah, Indra, Saunders, Jack E., Screaton, Gavin R., Sorley, Kim, Spencer, Alexandra J., Spoors, Louise, Stein, Ricardo, Strickland, Louise H., Sturdy, Ann, Sutton, Natalina, Taoushanis, Carol, Thomas, Merin, Tinoco, Lygia Accioly, Tomic, Adriana, Truby, Adam, Underwood, Benjamin R., Vichos, Iason, Watkins, Bridget, Wellbelove, Zoe, White, Caroline, Willingham, Silvia
Published in The Lancet (British edition)

Streptococcus pneumoniae colonization associates with impaired adaptive immune responses against SARS-CoV-2

by Mitsi, Elena, Reiné, Jesús, Urban, Britta C, Solórzano, Carla, Nikolaou, Elissavet, Hyder-Wright, Angela D, Pojar, Sherin, Howard, Ashleigh, Hitchins, Lisa, Glynn, Sharon, Farrar, Madlen C, Liatsikos, Konstantinos, Collins, Andrea M, Walker, Naomi F, Hill, Helen C, German, Esther L, Cheliotis, Katerina S, Byrne, Rachel L, Williams, Christopher T, Cubas-Atienzar, Ana I, Fletcher, Tom E, Adams, Emily R, Draper, Simon J, Pulido, David, Beavon, Rohini, Theilacker, Christian, Begier, Elizabeth, Jodar, Luis, Gessner, Bradford D, Ferreira, Daniela M
Published in The Journal of clinical investigation

The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash

by Nikolaou, Elissavet, German, Esther L, Blizard, Annie, Howard, Ashleigh, Hitchins, Lisa, Chen, Tao, Chadwick, Jim, Pojar, Sherin, Mitsi, Elena, Solórzano, Carla, Sunny, Syba, Dunne, Felicity, Gritzfeld, Jenna F, Adler, Hugh, Hinds, Jason, Gould, Katherine A, Rylance, Jamie, Collins, Andrea M, Gordon, Stephen B, Ferreira, Daniela M
Published in Scientific reports

Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization

by Jochems, Simon P, de Ruiter, Karin, Solórzano, Carla, Voskamp, Astrid, Mitsi, Elena, Nikolaou, Elissavet, Carniel, Beatriz F, Pojar, Sherin, German, Esther L, Reiné, Jesús, Soares-Schanoski, Alessandra, Hill, Helen, Robinson, Rachel, Hyder-Wright, Angela D, Weight, Caroline M, Durrenberger, Pascal F, Heyderman, Robert S, Gordon, Stephen B, Smits, Hermelijn H, Urban, Britta C, Rylance, Jamie, Collins, Andrea M, Wilkie, Mark D, Lazarova, Lepa, Leong, Samuel C, Yazdanbakhsh, Maria, Ferreira, Daniela M
Published in The Journal of clinical investigation

Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens

by Mitsi, Elena, Carniel, Beatriz, Reiné, Jesús, Rylance, Jamie, Zaidi, Seher, Soares-Schanoski, Alessandra, Connor, Victoria, Collins, Andrea M, Schlitzer, Andreas, Nikolaou, Elissavet, Solórzano, Carla, Pojar, Sherin, Hill, Helen, Hyder-Wright, Angela D, Jambo, Kondwani C, Oggioni, Marco R, De Ste Croix, Megan, Gordon, Stephen B, Jochems, Simon P, Ferreira, Daniela M
Published in American journal of respiratory and critical care medicine

Human Infection Challenge with Serotype 3 Pneumococcus

by Robinson, Ryan E, Mitsi, Elena, Nikolaou, Elissavet, Pojar, Sherin, Chen, Tao, Reiné, Jesús, Nyazika, Tinashe K, Court, James, Davies, Kelly, Farrar, Madlen, Gonzalez-Dias, Patricia, Hamilton, Josh, Hill, Helen, Hitchins, Lisa, Howard, Ashleigh, Hyder-Wright, Angela, Lesosky, Maia, Liatsikos, Konstantinos, Matope, Agnes, McLenaghan, Daniella, Myerscough, Christopher, Murphy, Annabel, Solórzano, Carla, Wang, Duolao, Burhan, Hassan, Gautam, Manish, Begier, Elizabeth, Theilacker, Christian, Beavon, Rohini, Anderson, Annaliesa S, Gessner, Bradford D, Gordon, Stephen B, Collins, Andrea M, Ferreira, Daniela M
Published in American journal of respiratory and critical care medicine

Two Randomized Trials of the Effect of Live Attenuated Influenza Vaccine on Pneumococcal Colonization

by Rylance, Jamie, de Steenhuijsen Piters, Wouter A A, Mina, Michael J, Bogaert, Debby, French, Neil, Ferreira, Daniela M
Published in American journal of respiratory and critical care medicine

Old World cutaneous leishmaniasis treatment response varies depending on parasite species, geographical location and development of secondary infection

by Al-Salem, Waleed S, Solórzano, Carla, Weedall, Gareth D, Dyer, Naomi A, Kelly-Hope, Louise, Casas-Sánchez, Aitor, Alraey, Yasser, Alyamani, Essam J, Halliday, Alice, Balghonaim, Salah M, Alsohibany, Khalid S, Alzeyadi, Zeyad, Alzahrani, Mohamed H, Al-Shahrani, Ali M, Assiri, Abdullah M, Memish, Ziad, Acosta-Serrano, Álvaro
Published in Parasites & vectors

Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine

by Carniel, Beatriz F, Marcon, Fernando, Rylance, Jamie, German, Esther L, Zaidi, Seher, Reiné, Jesus, Negera, Edessa, Nikolaou, Elissavet, Pojar, Sherin, Solórzano, Carla, Collins, Andrea M, Connor, Victoria, Bogaert, Debbie, Gordon, Stephen B, Nakaya, Helder I, Ferreira, Daniela M, Jochems, Simon P, Mitsi, Elena
Published in JCI insight

Symptoms associated with influenza vaccination and experimental human pneumococcal colonisation of the nasopharynx

by Hales, Caz, Jochems, Simon P., Robinson, Rachel, Solórzano, Carla, Carniel, Beatriz, Pojar, Sherin, Reiné, Jesús, German, Esther L., Nikolaou, Elissavet, Mitsi, Elena, Hyder-Wright, Angela D., Hill, Helen, Adler, Hugh, Connor, Victoria, Zaidi, Seher, Lowe, Catherine, Fan, Xiaojing, Wang, Duolao, Gordon, Stephen B., Rylance, Jamie, Ferreira, Daniela M.
Published in Vaccine