Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

by Finlay, M. Raymond V, Anderton, Mark, Ashton, Susan, Ballard, Peter, Bethel, Paul A, Box, Matthew R, Bradbury, Robert H, Brown, Simon J, Butterworth, Sam, Campbell, Andrew, Chorley, Christopher, Colclough, Nicola, Cross, Darren A. E, Currie, Gordon S, Grist, Matthew, Hassall, Lorraine, Hill, George B, James, Daniel, James, Michael, Kemmitt, Paul, Klinowska, Teresa, Lamont, Gillian, Lamont, Scott G, Martin, Nathaniel, McFarland, Heather L, Mellor, Martine J, Orme, Jonathon P, Perkins, David, Perkins, Paula, Richmond, Graham, Smith, Peter, Ward, Richard A, Waring, Michael J, Whittaker, David, Wells, Stuart, Wrigley, Gail L
Published in Journal of medicinal chemistry

Acquired Resistance to the Mutant-Selective EGFR Inhibitor AZD9291 Is Associated with Increased Dependence on RAS Signaling in Preclinical Models

by Eberlein, Catherine A, Stetson, Daniel, Markovets, Aleksandra A, Al-Kadhimi, Katherine J, Lai, Zhongwu, Fisher, Paul R, Meador, Catherine B, Spitzler, Paula, Ichihara, Eiki, Ross, Sarah J, Ahdesmaki, Miika J, Ahmed, Ambar, Ratcliffe, Laura E, O'Brien, Elizabeth L Christey, Barnes, Claire H, Brown, Henry, Smith, Paul D, Dry, Jonathan R, Beran, Garry, Thress, Kenneth S, Dougherty, Brian, Pao, William, Cross, Darren A E
Published in Cancer research (Chicago, Ill.)

Preclinical Comparison of the Blood-brain barrier Permeability of Osimertinib with Other EGFR TKIs

by Colclough, Nicola, Chen, Kan, Johnström, Peter, Strittmatter, Nicole, Yan, Yumei, Wrigley, Gail L, Schou, Magnus, Goodwin, Richard, Varnäs, Katarina, Adua, Sally J, Zhao, Minghui, Nguyen, Don X, Maglennon, Gareth, Barton, Peter, Atkinson, James, Zhang, Lin, Janefeldt, Annika, Wilson, Joanne, Smith, Aaron, Takano, Akihiro, Arakawa, Ryosuke, Kondrashov, Mikhail, Malmquist, Jonas, Revunov, Evgeny, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Windhorst, Albert D, Karp, Natasha A, Finlay, M Raymond V, Ward, Richard A, Yates, James W T, Smith, Paul D, Farde, Lars, Cheng, Zack, Cross, Darren A E
Published in Clinical cancer research

Conserved cell types with divergent features in human versus mouse cortex

by Hodge, Rebecca D, Bakken, Trygve E, Miller, Jeremy A, Smith, Kimberly A, Barkan, Eliza R, Graybuck, Lucas T, Close, Jennie L, Long, Brian, Johansen, Nelson, Penn, Osnat, Yao, Zizhen, Eggermont, Jeroen, Höllt, Thomas, Levi, Boaz P, Shehata, Soraya I, Aevermann, Brian, Beller, Allison, Bertagnolli, Darren, Brouner, Krissy, Casper, Tamara, Cobbs, Charles, Dalley, Rachel, Dee, Nick, Ding, Song-Lin, Ellenbogen, Richard G, Fong, Olivia, Garren, Emma, Goldy, Jeff, Gwinn, Ryder P, Hirschstein, Daniel, Keene, C Dirk, Keshk, Mohamed, Ko, Andrew L, Lathia, Kanan, Mahfouz, Ahmed, Maltzer, Zoe, McGraw, Medea, Nguyen, Thuc Nghi, Nyhus, Julie, Ojemann, Jeffrey G, Oldre, Aaron, Parry, Sheana, Reynolds, Shannon, Rimorin, Christine, Shapovalova, Nadiya V, Somasundaram, Saroja, Szafer, Aaron, Thomsen, Elliot R, Tieu, Michael, Quon, Gerald, Scheuermann, Richard H, Yuste, Rafael, Sunkin, Susan M, Lelieveldt, Boudewijn, Feng, David, Ng, Lydia, Bernard, Amy, Hawrylycz, Michael, Phillips, John W, Tasic, Bosiljka, Zeng, Hongkui, Jones, Allan R, Koch, Christof, Lein, Ed S
Published in Nature (London)

Genome-wide atlas of gene expression in the adult mouse brain

by Sunkin, Susan M, Ng, Lydia L, Bensinger, Amy, Pak, Tu H, Wood, Matthew, Dougherty, Jennifer G, Fields, Rick, Desaki, Aimee L, Diep, Ellen, Sarno, Nadia R, Bernard, Amy, Chen, Tsuey-Ming, Sutram, Madhavi, Gates, Sabrina N, Dolbeare, Tim A, Luong, Lon T, Zhang, Bin, Parry, Sheana E, Rockett, Hannah R, Smith, Kimberly A, Jones, Allan R, Crook, Brian E, Stumpf, Kenda-Ruth, Teemer, Carey D, Byrnes, Emi J, Czaplinska, Aneta, Laramee, Annabel R, Young, Rob C, Chong, Jimmy, Youngstrom, Brian L, Smith, Bryan I, Howell, Maureen P, Sodt, Andy J, Riley, Zackery L, Smith, Simon C, Ayres, Mikael, Feng Yuan, Xu, Wohnoutka, Paul E, Hohmann, John G, Ng, Randy, Zwingman, Theresa A, Liu, Ying, Puchalski, Ralph B, Faber, Casey, Mosqueda, Nerick F, Rowland, Stephen A, Overly, Caroline C, Mortrud, Marty T, Liang, Agnes J, Wong, Victoria Y, Dong, Hong-Wei, Wolkey, Crissa K, Boguski, Mark S, Thompson, Carol L, Duncan, Ben J, Morgan, Judith J, Stewart, Nick N, Whitlock, Ray M, Estin, Lili K, Orta, Geralyn J, Jeung, Darren P, Larsen, Kirk D, Lein, Ed S, Desta, Tsega, Kidney, Jolene M, Schaffnit, Katherine, Lau, Christopher, Karr, Patrick T, Facer, Benjamin A, Morgan, Rebecca J, Eichele, Gregor, Shapovalova, Nadiya V, Kawal, Reena, Datta, Suvro, Glattfelder, Katie J, Kuan, Chihchau L, Sivisay, Taz, Thaller, Christina, Chi Chin, Mei, Royall, Joshua J, Lake, James H, Visel, Axel, Fliss, Tim P, Fischer, Shanna R, Halverson, Kevin R, Yaylaoglu, Murat B, Hawrylycz, Michael J, Ao, Nancy, Pearson, Owen C, Varnam, Lee R, Johnson, Rebecca A, Michaels, Jesse, Hart, Matthew R, Dee, Nick R, Slaughterbeck, Clifford R, Brockway, Kevin S, Frensley, Cliff, Chen, Li, Chen, Lin, Dang, Chinh N
Published in Nature

Novel antiinflammatory biologics shaped by parasite-host coevolution

by Ryan, Stephanie M, Ruscher, Roland, Johnston, Wayne A, Pickering, Darren A, Kennedy, Malcolm W, Smith, Brian O, Jones, Linda, Buitrago, Geraldine, Field, Matt A, Esterman, Adrian J, McHugh, Connor P, Browne, Daniel J, Cooper, Martha M, Ryan, Rachael Y M, Doolan, Denise L, Engwerda, Christian R, Miles, Kim, Mitreva, Makedonka, Croese, John, Rahman, Tony, Alexandrov, Kirill, Giacomin, Paul R, Loukas, Alex
Published in Proceedings of the National Academy of Sciences - PNAS

Efavirenz promotes β-secretase expression and increased Aβ1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders...

by Brown, Lecia A M, Jin, Jingji, Ferrell, Darren, Sadic, Edin, Obregon, Demian, Smith, Adam J, Tan, Jun, Giunta, Brian
Published in PloS one

The Recycling Endosome Protein Rab17 Regulates Melanocytic Filopodia Formation and Melanosome Trafficking

by Beaumont, Kimberley A., Hamilton, Nicholas A., Moores, Matthew T., Brown, Darren L., Ohbayashi, Norihiko, Cairncross, Oliver, Cook, Anthony L., Smith, Aaron G., Misaki, Ryo, Fukuda, Mitsunori, Taguchi, Tomohiko, Sturm, Richard A., Stow, Jennifer L.
Published in Traffic (Copenhagen, Denmark)

CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

by Ko, Han Seok, Bailey, Rachel, Smith, Wanli W, Liu, Zhaohui, Shin, Joo-Ho, Lee, Yun-Il, Zhang, Yong-Jie, Jiang, Haibing, Ross, Christopher A, Moore, Darren J, Patterson, Cam, Petrucelli, Leonard, Dawson, Ted M, Dawson, Valina L
Published in Proceedings of the National Academy of Sciences - PNAS

Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors

by Phillips, Darren C, Buchanan, Fritz G, Cheng, Dong, Solomon, Larry R, Xiao, Yu, Xue, John, Tahir, Stephen K, Smith, Morey L, Zhang, Haichao, Widomski, Deborah, Abraham, Vivek C, Xu, Nan, Liu, Zhihong, Zhou, Li, DiGiammarino, Enrico, Lu, Xin, Rudra-Ganguly, Nandini, Trela, Bruce, Morgan-Lappe, Susan E
Published in Cancer research (Chicago, Ill.)

Genomic analyses identify molecular subtypes of pancreatic cancer

by Bailey, Peter, Nones, Katia, Johns, Amber L, Patch, Ann-Marie, Gingras, Marie-Claude, Miller, David K, Christ, Angelika N, Bruxner, Tim J C, Quinn, Michael C, Nourse, Craig, Murtaugh, L Charles, Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourbakhsh, Ehsan, Wani, Shivangi, Fink, Lynn, Holmes, Oliver, Chin, Venessa, Anderson, Matthew J, Kazakoff, Stephen, Leonard, Conrad, Newell, Felicity, Waddell, Nick, Wood, Scott, Xu, Qinying, Wilson, Peter J, Cloonan, Nicole, Kassahn, Karin S, Taylor, Darrin, Quek, Kelly, Robertson, Alan, Pantano, Lorena, Mincarelli, Laura, Sanchez, Luis N, Evers, Lisa, Wu, Jianmin, Pinese, Mark, Cowley, Mark J, Jones, Marc D, Colvin, Emily K, Nagrial, Adnan M, Humphrey, Emily S, Mawson, Amanda, Humphris, Jeremy, Chou, Angela, Pajic, Marina, Scarlett, Christopher J, Pinho, Andreia V, Giry-Laterriere, Marc, Rooman, Ilse, Samra, Jaswinder S, Kench, James G, Lovell, Jessica A, Merrett, Neil D, Toon, Christopher W, Epari, Krishna, Nguyen, Nam Q, Barbour, Andrew, Zeps, Nikolajs, Moran-Jones, Kim, Jamieson, Nigel B, Graham, Janet S, Duthie, Fraser, Oien, Karin, Hair, Jane, Grützmann, Robert, Maitra, Anirban, Iacobuzio-Donahue, Christine A, Wolfgang, Christopher L, Morgan, Richard A, Lawlor, Rita T, Corbo, Vincenzo, Bassi, Claudio, Rusev, Borislav, Capelli, Paola, Salvia, Roberto, Tortora, Giampaolo, Mukhopadhyay, Debabrata, Petersen, Gloria M, Munzy, Donna M, Fisher, William E, Karim, Saadia A, Eshleman, James R, Hruban, Ralph H, Pilarsky, Christian, Morton, Jennifer P, Sansom, Owen J, Scarpa, Aldo, Musgrove, Elizabeth A, Bailey, Ulla-Maja Hagbo, Hofmann, Oliver, Sutherland, Robert L, Wheeler, David A, Gill, Anthony J, Gibbs, Richard A, Pearson, John V, Waddell, Nicola, Biankin, Andrew V, Grimmond, Sean M
Published in Nature (London)

Comparison of Carbon Nutrition for Pathogenic and Commensal Escherichia coli Strains in the Mouse Intestine

by FABICH, Andrew J, JONES, Shari A, LEATHAM, Mary P, LINS, Jeremy J, ALLEN, Regina L, LAUX, David C, COHEN, Paul S, CONWAY, Tyrrell, CHOWDHURY, Fatema Z, CERNOSEK, Amanda, ANDERSON, April, SMALLEY, Darren, MCHARGUE, J. Wesley, HIGHTOWER, G. Aaron, SMITH, Joel T, AUTIERI, Steven M
Published in Infection and Immunity

Transcriptional landscape of the prenatal human brain

by Miller, Jeremy A, Ding, Song-Lin, Sunkin, Susan M, Smith, Kimberly A, Ng, Lydia, Szafer, Aaron, Ebbert, Amanda, Riley, Zackery L, Royall, Joshua J, Aiona, Kaylynn, Arnold, James M, Bennet, Crissa, Bertagnolli, Darren, Brouner, Krissy, Butler, Stephanie, Caldejon, Shiella, Carey, Anita, Cuhaciyan, Christine, Dalley, Rachel A, Dee, Nick, Dolbeare, Tim A, Facer, Benjamin A C, Feng, David, Fliss, Tim P, Gee, Garrett, Goldy, Jeff, Gourley, Lindsey, Gregor, Benjamin W, Gu, Guangyu, Howard, Robert E, Jochim, Jayson M, Kuan, Chihchau L, Lau, Christopher, Lee, Chang-Kyu, Lee, Felix, Lemon, Tracy A, Lesnar, Phil, McMurray, Bergen, Mastan, Naveed, Mosqueda, Nerick, Naluai-Cecchini, Theresa, Ngo, Nhan-Kiet, Nyhus, Julie, Oldre, Aaron, Olson, Eric, Parente, Jody, Parker, Patrick D, Parry, Sheana E, Stevens, Allison, Pletikos, Mihovil, Reding, Melissa, Roll, Kate, Sandman, David, Sarreal, Melaine, Shapouri, Sheila, Shapovalova, Nadiya V, Shen, Elaine H, Sjoquist, Nathan, Slaughterbeck, Clifford R, Smith, Michael, Sodt, Andy J, Williams, Derric, Zöllei, Lilla, Fischl, Bruce, Gerstein, Mark B, Geschwind, Daniel H, Glass, Ian A, Hawrylycz, Michael J, Hevner, Robert F, Huang, Hao, Jones, Allan R, Knowles, James A, Levitt, Pat, Phillips, John W, Sestan, Nenad, Wohnoutka, Paul, Dang, Chinh, Bernard, Amy, Hohmann, John G, Lein, Ed S
Published in Nature (London)

Salmonella enterica Serovar Typhimurium Can Detect Acyl Homoserine Lactone Production by Yersinia enterocolitica in Mice

by DYSZEL, Jessica L, SMITH, Jenee N, LUCAS, Darren E, SOARES, Jitesh A, SWEARINGEN, Matthew C, VROSS, Mathew A, YOUNG, Glenn M, AHMER, Brian M. M
Published in Journal of Bacteriology

A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex

by Yao, Zizhen, Liu, Hanqing, Xie, Fangming, Fischer, Stephan, Adkins, Ricky S, Aldridge, Andrew I, Ament, Seth A, Bartlett, Anna, Behrens, M Margarita, Van den Berge, Koen, Bertagnolli, Darren, de Bézieux, Hector Roux, Biancalani, Tommaso, Booeshaghi, A Sina, Bravo, Héctor Corrada, Casper, Tamara, Colantuoni, Carlo, Crabtree, Jonathan, Creasy, Heather, Crichton, Kirsten, Crow, Megan, Dee, Nick, Dougherty, Elizabeth L, Doyle, Wayne I, Dudoit, Sandrine, Fang, Rongxin, Felix, Victor, Fong, Olivia, Giglio, Michelle, Goldy, Jeff, Hawrylycz, Mike, Herb, Brian R, Hertzano, Ronna, Hou, Xiaomeng, Hu, Qiwen, Kancherla, Jayaram, Kroll, Matthew, Lathia, Kanan, Li, Yang Eric, Lucero, Jacinta D, Luo, Chongyuan, Mahurkar, Anup, McMillen, Delissa, Nadaf, Naeem M, Nery, Joseph R, Nguyen, Thuc Nghi, Niu, Sheng-Yong, Ntranos, Vasilis, Orvis, Joshua, Osteen, Julia K, Pham, Thanh, Pinto-Duarte, Antonio, Poirion, Olivier, Preissl, Sebastian, Purdom, Elizabeth, Rimorin, Christine, Risso, Davide, Rivkin, Angeline C, Smith, Kimberly, Street, Kelly, Sulc, Josef, Svensson, Valentine, Tieu, Michael, Torkelson, Amy, Tung, Herman, Vaishnav, Eeshit Dhaval, Vanderburg, Charles R, van Velthoven, Cindy, Wang, Xinxin, White, Owen R, Huang, Z Josh, Kharchenko, Peter V, Pachter, Lior, Ngai, John, Regev, Aviv, Tasic, Bosiljka, Welch, Joshua D, Gillis, Jesse, Macosko, Evan Z, Ren, Bing, Ecker, Joseph R, Zeng, Hongkui, Mukamel, Eran A
Published in Nature (London)

Superenhancer Analysis Defines Novel Epigenomic Subtypes of Non-APL AML, Including an RARα Dependency Targetable by SY-1425, a Potent and Selective RARα Agonist

by McKeown, Michael R, Corces, M Ryan, Eaton, Matthew L, Fiore, Chris, Lee, Emily, Lopez, Jeremy T, Chen, Mei Wei, Smith, Darren, Chan, Steven M, Koenig, Julie L, Austgen, Kathryn, Guenther, Matthew G, Orlando, David A, Lovén, Jakob, Fritz, Christian C, Majeti, Ravindra
Published in Cancer discovery

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

by PEREZ-MANCERA, Pedro A, RUST, Alistair G, KNÖSEL, Thomas, HERD, Colin, STEMPLE, Derek L, KETTLEBOROUGH, Ross, BROSNAN, Jacqueline A, ANG LI, MORGAN, Richard, KNIGHT, Spencer, JUN YU, STEGEMAN, Shane, DER WEYDEN, Louise Van, COLLIER, Lara S, HOEVE, Jelle J. Ten, RIDDER, Jeroen De, KLEIN, Alison P, GOGGINS, Michael, HRUBAN, Ralph H, CHANG, David K, BIANKIN, Andrew V, GRIMMOND, Sean M, GENOME INITIATIVE, Australian Pancreatic Cancer, KRISTIANSEN, Glen, WESSELS, LodewykF A, WOOD, StephenA, IACOBUZIO-DONAHUE, Christine A, PILARSKY, Christian, LARGAESPADA, David A, ADAMS, David J, TUVESON, David A, ALLEN LI, SARVER, Aaron L, SILVERSTEIN, Kevin A. T, GRÜTZMANN, Robert, AUST, Daniela, RÜMMELE, Petra
Published in Nature (London)

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter

by Hannigan, Adèle, Smith, Paul, Kalna, Gabriela, Lo Nigro, Cristiana, Orange, Clare, O'Brien, Darren I, Shah, Reshma, Syed, Nelofer, Spender, Lindsay C, Herrera, Blanca, Thurlow, Johanna K, Lattanzio, Laura, Monteverde, Martino, Maurer, Meghan E, Buffa, Francesca M, Mann, Jelena, Chu, David C K, West, Catharine M L, Patridge, Max, Oien, Karin A, Cooper, Jonathan A, Frame, Margaret C, Harris, Adrian L, Hiller, Louise, Nicholson, Linda J, Gasco, Milena, Crook, Tim, Inman, Gareth J
Published in The Journal of clinical investigation

Lineage-specific biology revealed by a finished genome assembly of the mouse

by Church, Deanna M, Goodstadt, Leo, Hillier, Ladeana W, Zody, Michael C, Goldstein, Steve, She, Xinwe, Bult, Carol J, Agarwala, Richa, Cherry, Joshua L, DiCuccio, Michael, Hlavina, Wratko, Kapustin, Yuri, Meric, Peter, Maglott, Donna, Birtle, Zoë, Marques, Ana C, Graves, Tina, Zhou, Shiguo, Teague, Brian, Potamousis, Konstantinos, Churas, Christopher, Place, Michael, Herschleb, Jill, Runnheim, Ron, Forrest, Daniel, Amos-Landgraf, James, Schwartz, David C, Cheng, Ze, Lindblad-Toh, Kerstin, Eichler, Evan E, Ponting, Chris P
Published in PLoS biology

Functional enhancer elements drive subclass-selective expression from mouse to primate neocortex

by Mich, John K., Graybuck, Lucas T., Hess, Erik E., Mahoney, Joseph T., Kojima, Yoshiko, Ding, Yi, Somasundaram, Saroja, Miller, Jeremy A., Kalmbach, Brian E., Radaelli, Cristina, Gore, Bryan B., Weed, Natalie, Omstead, Victoria, Bishaw, Yemeserach, Shapovalova, Nadiya V., Martinez, Refugio A., Fong, Olivia, Yao, Shenqin, Mortrud, Marty, Chong, Peter, Loftus, Luke, Bertagnolli, Darren, Goldy, Jeff, Casper, Tamara, Dee, Nick, Opitz-Araya, Ximena, Cetin, Ali, Smith, Kimberly A., Gwinn, Ryder P., Cobbs, Charles, Ko, Andrew L., Ojemann, Jeffrey G., Keene, C. Dirk, Silbergeld, Daniel L., Sunkin, Susan M., Gradinaru, Viviana, Horwitz, Gregory D., Zeng, Hongkui, Tasic, Bosiljka, Lein, Ed S., Ting, Jonathan T., Levi, Boaz P.
Published in Cell reports (Cambridge)