Pembrolizumab versus chemotherapy for microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer (KEYNOTE-177): final analysis of a randomised, open-...

by Diaz, Luis A, Shiu, Kai-Keen, Kim, Tae-Won, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis, Smith, Denis, Garcia-Carbonero, Rocio, Benavides, Manuel, Gibbs, Peter, de la Fourchardiere, Christelle, Rivera, Fernando, Elez, Elena, Le, Dung T, Yoshino, Takayuki, Zhong, Wen Yan, Fogelman, David, Marinello, Patricia, Andre, Thierry
Published in The lancet oncology

Health-related quality of life in patients with microsatellite instability-high or mismatch repair deficient metastatic colorectal cancer treated with first-line pembrolizumab vers...

by Andre, Thierry, Amonkar, Mayur, Norquist, Josephine M, Shiu, Kai-Keen, Kim, Tae Won, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis J A, Smith, Denis, Garcia-Carbonero, Rocio, Sevilla, Isabel, De La Fouchardiere, Christelle, Rivera, Fernando, Elez, Elena, Diaz, Luis A, Yoshino, Takayuki, Van Cutsem, Eric, Yang, Ping, Farooqui, Mohammed, Le, Dung T
Published in The lancet oncology

The immunomodulatory role of IDO1-Kynurenine-NAD + pathway in switching cold tumor microenvironment in PDAC

by Anu, R I, Shiu, Kai-Keen, Khan, Khurum Hayat
Published in Frontiers in oncology

Biomarkers of systemic inflammation provide additional prognostic stratification in cancers of unknown primary

by Harvey, Svenja, Stares, Mark, Scott, Julie‐Anne, Thottiyil, Tharun Joseph Vattam, Conway, Alicia‐Marie, Haigh, Rachel, Brown, Jackie, Knowles, Gillian, Dasgupta, Sonali, Shiu, Kai‐Keen, Mitchell, Claire, Barrie, Colin, Cook, Natalie, Clive, Sally
Published in Cancer medicine (Malden, MA)

Pembrolizumab in Asian patients with microsatellite‐instability‐high/mismatch‐repair‐deficient colorectal cancer

by Yoshino, Takayuki, Andre, Thierry, Kim, Tae Won, Yong, Wei Peng, Shiu, Kai‐Keen, Jensen, Benny Vittrup, Jensen, Lars Henrik, Punt, Cornelis J. A., Smith, Denis, Garcia‐Carbonero, Rocio, Alcaide‐Garcia, Julia, Gibbs, Peter, Fouchardiere, Christelle, Rivera, Fernando, Elez, Elena, Le, Dung T., Adachi, Noriaki, Fogelman, David, Marinello, Patricia, Diaz, Luis A.
Published in Cancer science

Review of metastatic colorectal cancer treatment pathways and early clinical experience of trifluridine/tipiracil in the UK named patient programme

by Iveson, Timothy, Carter, Angela M, Shiu, Kai-Keen, Spooner, Clare, Stevens, Daniel, Mullamitha, Saifee
Published in BMC cancer

Comprehensive Examination of Cholangiocarcinoma Patients Treated with Novel Targeted Therapies after Extended Molecular Profiling on Liquid Biopsies

by Mahmood, Umair, Muhamad Faizul, Elisya, Howlett, Sarah, Amin, Zahir, Hochhauser, Daniel, Shiu, Kai-Keen, Bridgewater, John, Khan, Khurum
Published in Cancers

Immunotherapy in gastrointestinal cancer: The current scenario and future perspectives

by Abdul-Latif, Mohammed, Townsend, Katherine, Dearman, Charles, Shiu, Kai-Keen, Khan, Khurum
Published in Cancer treatment reviews

Gastric Inflammatory Prognostic Index (GIPI) in Patients with Metastatic Gastro-Esophageal Junction/Gastric Cancer Treated with PD-1/PD-L1 Immune Checkpoint Inhibitors

by Formica, Vincenzo, Morelli, Cristina, Patrikidou, Anna, Murias, Carmen, Butt, Sabeeh, Nardecchia, Antonella, Lucchetti, Jessica, Renzi, Nicola, Shiu, Kai-Keen, Roselli, Mario, Arkenau, Hendrik-Tobias
Published in Targeted oncology

COVID-19 in cancer patients on systemic anti-cancer therapies: outcomes from the CAPITOL (COVID-19 Cancer PatIenT Outcomes in North London) cohort study

by Crolley, Valerie E., Hanna, Daire, Joharatnam-Hogan, Nalinie, Chopra, Neha, Bamac, Ekin, Desai, Meera, Lam, Yuk-Chun, Dipro, Sabiq, Kanani, Ruhi, Benson, Jack, Wilson, William, Fox, Thomas A., Shiu, Kai-Keen, Forster, Martin, Bridgewater, John, Hochhauser, Daniel, Khan, Khurum
Published in Therapeutic advances in medical oncology

Outcomes of the 2019 novel coronavirus in patients with or without a history of cancer: a multi-centre North London experience

by Joharatnam-Hogan, Nalinie, Hochhauser, Daniel, Shiu, Kai-Keen, Rush, Hannah, Crolley, Valerie, Wilson, William, Sharma, Anand, Muhammad, Aun, Anwar, Muhammad, Vasdev, Nikhil, Goldstein, Robert, Kantser, Ganna, Saha, Aramita, Raja, Fharat, Bridgewater, John, Khan, Khurum
Published in Therapeutic advances in medical oncology

Crossing survival curves of KEYNOTE-177 illustrate the rationale behind combining immune checkpoint inhibition with chemotherapy – Authors' reply

by André, Thierry, Diaz, Luis A, Shiu, Kai-Keen
Published in The lancet oncology

Transarterial Chemoembolisation of Colorectal Liver Metastases with Irinotecan-Loaded Beads: A Bi-institutional Analysis of 125 Treatments in 53 Patients

by Ngo, An, von Stempel, Conrad, Corbo, Beniamino, Bandula, Steve, Shiu, Kai Keen, Raja, Jowad, Hague, Julian, Evans, Jonathan, Kibrya, Nabil
Published in Cardiovascular and interventional radiology

Trifluridine/Tipiracil in Metastatic Colorectal Cancer: A UK Multicenter Real-world Analysis on Efficacy, Safety, Predictive and Prognostic Factors

by Stavraka, Chara, Pouptsis, Athanasios, Synowiec, Alicja, Angelis, Vasileios, Satterthwaite, Liyana, Khan, Sam, Chauhan, Meera, Holden, Chloe, Young, Sally, Karampera, Christina, Martinou, Maria, Mills-Baldock, Tina, Baxter, Mark, Barry, Ainsley, Eccles, Bryony, Iveson, Timothy, Shiu, Kai-Keen, Hill, Mark, Abdel-Raouf, Sherif, Graham, Janet Shirley, Thomas, Anne, Ross, Paul J.
Published in Clinical colorectal cancer

Functional viability profiles of breast cancer

by Brough, Rachel, Frankum, Jessica R, Sims, David, Mackay, Alan, Mendes-Pereira, Ana M, Bajrami, Ilirjana, Costa-Cabral, Sara, Rafiq, Rumana, Ahmad, Amar S, Cerone, Maria Antonietta, Natrajan, Rachael, Sharpe, Rachel, Shiu, Kai-Keen, Wetterskog, Daniel, Dedes, Konstantine J, Lambros, Maryou B, Rawjee, Teeara, Linardopoulos, Spiros, Reis-Filho, Jorge S, Turner, Nicholas C, Lord, Christopher J, Ashworth, Alan
Published in Cancer discovery

Multimodal Treatment in Metastatic Colorectal Cancer (mCRC) Improves Outcomes-The University College London Hospital (UCLH) Experience

by Joharatnam-Hogan, Nalinie, Wilson, William, Shiu, Kai Keen, Fusai, Giuseppe Kito, Davidson, Brian, Hochhauser, Daniel, Bridgewater, John, Khan, Khurum
Published in Cancers

Functional characterization of the 19q12 amplicon in grade III breast cancers

by Natrajan, Rachael, Mackay, Alan, Wilkerson, Paul M, Lambros, Maryou B, Wetterskog, Daniel, Arnedos, Monica, Shiu, Kai-Keen, Geyer, Felipe C, Langerød, Anita, Kreike, Bas, Reyal, Fabien, Horlings, Hugo M, van de Vijver, Marc J, Palacios, Jose, Weigelt, Britta, Reis-Filho, Jorge S
Published in Breast cancer research : BCR

Challenges in the treatment of gastric cancer in the older patient

by Joharatnam-Hogan, Nalinie, Shiu, Kai Keen, Khan, Khurum
Published in Cancer treatment reviews

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

by Au, Lewis, Hatipoglu, Emine, Litchfield, Kevin, Beattie, Gordon, Horswell, Stuart, Nicol, David, Mason, Robert, Del Rosario, Lyra, Edmonds, Kim, Lingard, Karla, Sarker, Sarah, Carlyle, Eleanor, Attig, Jan, Becker, Pablo D., Puccio, Ignazio, Lund, Tom, Ghorani, Ehsan, Xu, Hang, Mitchison, Miriam, Moore, David A., Proctor, Ian, Falzon, Mary, Furness, Andrew J.S., Reading, James L., Marafioti, Teresa, Abbosh, Chris, Bridgewater, John, Hochhauser, Daniel, Forster, Martin, Enfield, Katey, Huebner, Ariana, Enver, Tariq, Sinclair, Ron, Rhodes, Zoe, Moore, David, Khiroya, Reena, Ellery, Peter, Veeriah, Selvaraju, Shaw, Heather, Attard, Gert, Akther, Mita Afroza, Naceur-Lombardelli, Cristina, Manzano, Lizi, Summan, Simranpreet, Kanu, Nnenna, Ward, Sophie, Stone, Paddy, Stirling, Caroline, Spain, Lavinia, Shum, Ben, Carlyle, Eleanor, Korteweg, Justine, Chandra, Ashish, Stewart, Ruby, Iredale, Lara-Rose, Enting, Debra, Ghosh, Sharmistha, Karapagniotou, Lena, Pintus, Elias, Tutt, Andrew, Howlett, Sarah, Michalarea, Vasiliki, Caldas, Carlos, Fitzgerald, Rebecca, Provenzano, Elena, Cluroe, Alison, McDermott, Ultan, Tavare, Simon, Roxburgh, Patricia, Chalmers, Anthony, Fraser, Sioban, Oien, Karin, Krebs, Matt, Blackhall, Fiona, Dransfield, Jo, Le Quesne, John, Tanchel, Bruce, Langman, Gerald, Robinson, Andrew, Kerr, Amy, Middleton, Gary, Webb, Joanne, Ottensmeier, Christian, Harrison, David, Hackshaw, Allan, Ledermann, Jonathan, Sharp, Abby, Farrelly, Laura, Bridger, Hayley, Kassiotis, George, Chain, Benny, Larkin, James, Swanton, Charles, Quezada, Sergio A., Turajlic, Samra, Drake, William, Fernando, Archana, Hazell, Steve, Hill, Peter, O'Brien, Tim
Published in Cancer cell

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial

by Rha, Sun Young, Oh, Do-Youn, Ryu, Min-Hee, Lee, Jeeyun, Shiu, Kai-Keen, Fernández, Manuel González, Li, Jin, Lowery, Maeve A, Cruz, Felipe Melo, Qin, Shukui, Luo, Suxia, Wainberg, Zev A, Wyrwicz, Lucjan S, O'Connor, Juan Manuel, Cundom, Juan, Ng, Weng, Peressoni, Mauricio, Andrade, Carlos, Alves, Gustavo, Vianna, Karina, Monteiro, Maria Marcela, Tan, Ann, Asselah, Jamil, Mahave, Mauricio, Zhang, Xiaochun, Yang, Jianwei, Li, Wei, Qu, Yanli, Yang, Lin, Zhao, Lin, Liang, Xinjun, Zhao, Qun, Ling, Yang, Li, Shouguo, Guerrero, Alvaro, Rubiano, Juan, Guzman Ramirez, Adrian, Gonzalez Herrera, Ileana, Melichar, Bohuslav, Vrana, David, Pfeiffer, Per, Baeksgaard, Lene, Yilmaz, Mette, Boige, Valerie, Lopez-Trabada, Daniel, Pannier, Diane, Hiret, Sandrine, Arnold, Dirk, Martens, Uwe, Lopez, Karla, Ramirez, Julio, Chivalan, Marco, Chan, Wendy, Horvath, Zsolt, Man, Sofia, Pelles Avraham, Sharon, Di Bartolomeo, Maria, Lonardi, Sara, Garufi, Carlo, Iwagami, Shiro, Yasui, Hisateru, Shoji, Hirokazu, Shibata, Nobuhiro, Choda, Yasuhiro, Tsuji, Akihito, Kawakami, Hisato, Ishido, Kenji, Martinez Rodriguez, Jorge, Herrera Martinez, Marytere, Huitzil Melendez, Fidel, Ramirez Godinez, Francisco, Balancan, Paola, Castro Oliden, Victor, Grados, Julio, Hajac, Lukasz, Karaszewska, Boguslawa, Fadeeva, Natalia, Makarycheva, Yulia, Nosov, Dmitry, Smagina, Maria, Jacobs, Conrad, Kraus, Peter, Diez Garcia, Marc, Jimenez Fonseca, Paula, Miranda Poma, Jesus, Fritsch, Ralph, Bastian, Sara, Winterhalder, Ralph, Yeh, Kun-Huei, Chen, Yen-Yang, Lin, Johnson, Ozguroglu, Mustafa, Cil, Timucin, Oksuzoglu, Berna, Karaoglu, Aziz, Erdogan, Bulent, Adamchuk, Hryhoriy, Bondarenko, Igor, Young, Anna-Mary, Dayyani, Farshid
Published in The lancet oncology