JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

by Lu, Ben, Antoine, Daniel J., Kwan, Kevin, Lundbäck, Peter, Wähämaa, Heidi, Schierbeck, Hanna, Robinson, Melissa, Van Zoelen, Marieke A. D., Yang, Huan, Li, Jianhua, Erlandsson-Harris, Helena, Chavan, Sangeeta S., Wang, Haichao, Andersson, Ulf, Tracey, Kevin J.
Published in Proceedings of the National Academy of Sciences - PNAS

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

by Najm, Fadi J, Madhavan, Mayur, Zaremba, Anita, Shick, Elizabeth, Karl, Robert T, Factor, Daniel C, Miller, Tyler E, Nevin, Zachary S, Kantor, Christopher, Sargent, Alex, Quick, Kevin L, Schlatzer, Daniela M, Tang, Hong, Papoian, Ruben, Brimacombe, Kyle R, Shen, Min, Boxer, Matthew B, Jadhav, Ajit, Robinson, Andrew P, Podojil, Joseph R, Miller, Stephen D, Miller, Robert H, Tesar, Paul J
Published in Nature (London)

Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

by Ashrafian, Houman, Czibik, Gabor, Bellahcene, Mohamed, Aksentijević, Dunja, Smith, Anthony C., Mitchell, Sarah J., Dodd, Michael S., Kirwan, Jennifer, Byrne, Jonathan J., Ludwig, Christian, Isackson, Henrik, Yavari, Arash, Støttrup, Nicolaj B., Contractor, Hussain, Cahill, Thomas J., Sahgal, Natasha, Ball, Daniel R., Birkler, Rune I.D., Hargreaves, Iain, Tennant, Daniel A., Land, John, Lygate, Craig A., Johannsen, Mogens, Kharbanda, Rajesh K., Neubauer, Stefan, Redwood, Charles, de Cabo, Rafael, Ahmet, Ismayil, Talan, Mark, Günther, Ulrich L., Robinson, Alan J., Viant, Mark R., Pollard, Patrick J., Tyler, Damian J., Watkins, Hugh
Published in Cell metabolism

Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease

by Hill, Rebecca M., Kuijper, Sanne, Lindsey, Janet C., Petrie, Kevin, Schwalbe, Ed C., Barker, Karen, Boult, Jessica K.R., Williamson, Daniel, Ahmad, Zai, Hallsworth, Albert, Ryan, Sarra L., Poon, Evon, Robinson, Simon P., Ruddle, Ruth, Raynaud, Florence I., Howell, Louise, Kwok, Colin, Joshi, Abhijit, Nicholson, Sarah Leigh, Crosier, Stephen, Ellison, David W., Wharton, Stephen B., Robson, Keith, Michalski, Antony, Hargrave, Darren, Jacques, Thomas S., Pizer, Barry, Bailey, Simon, Swartling, Fredrik J., Weiss, William A., Chesler, Louis, Clifford, Steven C.
Published in Cancer cell

A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins

by Keysar, Stephen B., Astling, David P., Anderson, Ryan T., Vogler, Brian W., Bowles, Daniel W., Morton, J. Jason, Paylor, Jeramiah J., Glogowska, Magdalena J., Le, Phuong N., Eagles-Soukup, Justin R., Kako, Severine L., Takimoto, Sarah M., Sehrt, Daniel B., Umpierrez, Adrian, Pittman, Morgan A., Macfadden, Sarah M., Helber, Ryan M., Peterson, Scott, Hausman, Diana F., Said, Sherif, Leem, Ted H., Goddard, Julie A., Arcaroli, John J., Messersmith, Wells A., Robinson, William A., Hirsch, Fred R., Varella-Garcia, Marileila, Raben, David, Wang, Xiao-Jing, Song, John I., Tan, Aik-Choon, Jimeno, Antonio
Published in Molecular oncology

A recessive PRDM13 mutation results in congenital hypogonadotropic hypogonadism and cerebellar hypoplasia

by Whittaker, Danielle E, Oleari, Roberto, Gregory, Louise C, Le Quesne-Stabej, Polona, Williams, Hywel J, Torpiano, John G, Formosa, Nancy, Cachia, Mario J, Field, Daniel, Lettieri, Antonella, Ocaka, Louise A, Paganoni, Alyssa Jj, Rajabali, Sakina H, Riegman, Kimberley Lh, De Martini, Lisa B, Chaya, Taro, Robinson, Iain Caf, Furukawa, Takahisa, Cariboni, Anna, Basson, M Albert, Dattani, Mehul T
Published in The Journal of clinical investigation

NF-κB inhibition delays DNA damage-induced senescence and aging in mice

by Tilstra, Jeremy S, Robinson, Andria R, Wang, Jin, Gregg, Siobhán Q, Clauson, Cheryl L, Reay, Daniel P, Nasto, Luigi A, St Croix, Claudette M, Usas, Arvydas, Vo, Nam, Huard, Johnny, Clemens, Paula R, Stolz, Donna B, Guttridge, Denis C, Watkins, Simon C, Garinis, George A, Wang, Yinsheng, Niedernhofer, Laura J, Robbins, Paul D
Published in The Journal of clinical investigation

CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic Malignancies

by Rodriguez-Garcia, Alba, Sharma, Prannda, Poussin, Mathilde, Boesteanu, Alina C., Minutolo, Nicholas G., Gitto, Sarah B., Omran, Dalia K., Robinson, Matthew K., Adams, Gregory P., Simpkins, Fiona, Powell, Daniel J.
Published in Molecular therapy

Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM

by Lanz, Tobias V, Brewer, R Camille, Ho, Peggy P, Moon, Jae-Seung, Jude, Kevin M, Fernandez, Daniel, Fernandes, Ricardo A, Gomez, Alejandro M, Nadj, Gabriel-Stefan, Bartley, Christopher M, Schubert, Ryan D, Hawes, Isobel A, Vazquez, Sara E, Iyer, Manasi, Zuchero, J Bradley, Teegen, Bianca, Dunn, Jeffrey E, Lock, Christopher B, Kipp, Lucas B, Cotham, Victoria C, Ueberheide, Beatrix M, Aftab, Blake T, Anderson, Mark S, DeRisi, Joseph L, Wilson, Michael R, Bashford-Rogers, Rachael J M, Platten, Michael, Garcia, K Christopher, Steinman, Lawrence, Robinson, William H
Published in Nature (London)

Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1

by Tardif, Keith D, Rogers, Aaron, Cassiano, Jared, Roth, Bruce L, Cimbora, Daniel M, McKinnon, Rena, Peterson, Ashley, Douce, Thomas B, Robinson, Rosann, Dorweiler, Irene, Davis, Thaylon, Hess, Mark A, Ostanin, Kirill, Papac, Damon I, Baichwal, Vijay, McAlexander, Ian, Willardsen, J Adam, Saunders, Michael, Christophe, Hoarau, Kumar, D Vijay, Wettstein, Daniel A, Carlson, Robert O, Williams, Brandi L
Published in Molecular cancer therapeutics

Proteogenomic Characterization of Endometrial Carcinoma

by Kawaler, Emily A., Cui Zhou, Daniel, Huang, Chen, Blumenberg, Lili, Karpova, Alla, Petyuk, Vladislav A., Wen, Bo, Li, Zhi, Cao, Song, Moon, Jamie, Shi, Zhiao, Cornwell, MacIntosh, Wyczalkowski, Matthew A., Chu, Rosalie K., Gao, Qingsong, Moore, Ronald J., Li, Kai, Zhao, Rui, Clauser, Karl, Maruvka, Yosef, Pico, Alexander R., Beecroft, Sean J.I., Adams, David W., Liao, Yuxing, Rykunov, Dmitry, Czekański, Andrzej, Jędryka, Marcin, Kinsinger, Christopher R., Mesri, Mehdi, Ellis, Matthew J., Thiagarajan, Mathangi, Noble, Michael, Wang, Pei, Anderson, Matthew L., Levine, Douglas A., Rodland, Karin D., Liu, Tao, Birger, Chet, Birrer, Michael J., Bocik, William E., Borate, Uma, Cai, Shuang, Carter, Sonya, Castro, Patricia, Chaikin, Michelle, Chen, Jin, Chesla, David, Chheda, Milan G., Culpepper, Houston, Demir, Emek, Dhir, Rajiv, Domagalski, Marcin J., Edwards, Robert, Elburn, Kim, Field, Jayson B., Gabriel, Stacey, Godwin, Andrew K., Grady, Pamela, Hariharan, Pushpa, Hoadley, Katherine A., Hostetter, Galen, Hu, Yingwei, Jaehnig, Eric, Jewell, Scott D., Ji, Jiayi, Jones, Corbin D., Karabon, Renee, Ketchum, Karen A., Krubit, Tanya, Leprevost, Felipe D., Lewis, Michael, Ma, Weiping, Madan, Rashna, Markey, Sanford P., McDermott, Jason, McGarvey, Peter B., Modugno, Francesmary, Montgomery, Rebecca, Piehowski, Paul, Polonskaya, Larisa, Qi, Liqun, Schadt, Eric E., Shi, Yan, Skelly, Tara, Stein, Stephen E., Tan, Donghui, Teo, Guo Ci, Thangudu, Ratna R., Valley, Dana R., Vernon, Michael, Wang, Ying, Webster, Alex, Westbrook, Thomas, Wheeler, David, Wilson, George D., Zelt, Robert, Zhang, Hui, Zhang, Yuping, Zhang, Zhen, Zhao, Grace
Published in Cell

Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational Derepression of HIF2α

by Ghosh, Manik C., Zhang, De-Liang, Jeong, Suh Young, Kovtunovych, Gennadiy, Ollivierre-Wilson, Hayden, Noguchi, Audrey, Tu, Tiffany, Senecal, Thomas, Robinson, Gabrielle, Crooks, Daniel R., Tong, Wing-Hang, Ramaswamy, Kavitha, Singh, Anamika, Graham, Brian B., Tuder, Rubin M., Yu, Zu-Xi, Eckhaus, Michael, Lee, Jaekwon, Springer, Danielle A., Rouault, Tracey A.
Published in Cell metabolism

The Lin28/let-7 Axis Regulates Glucose Metabolism

by Zhu, Hao, Shyh-Chang, Ng, Segrè, Ayellet V., Shinoda, Gen, Shah, Samar P., Einhorn, William S., Takeuchi, Ayumu, Engreitz, Jesse M., Hagan, John P., Kharas, Michael G., Urbach, Achia, Thornton, James E., Triboulet, Robinson, Gregory, Richard I., Altshuler, David, Daley, George Q.
Published in Cell

Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer

by Greene, Michelle K, Chen, Ting, Robinson, Eifion, Straubinger, Ninfa L, Minx, Charlene, Chan, Darren K W, Wang, Jun, Burrows, James F, Van Schaeybroeck, Sandra, Baker, James R, Caddick, Stephen, Longley, Daniel B, Mager, Donald E, Straubinger, Robert M, Chudasama, Vijay, Scott, Christopher J
Published in British journal of cancer

Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity

by Ascough, Stephanie, Ingram, Rebecca J, Chu, Karen K, Reynolds, Catherine J, Musson, Julie A, Doganay, Mehmet, Metan, Gökhan, Ozkul, Yusuf, Baillie, Les, Sriskandan, Shiranee, Moore, Stephen J, Gallagher, Theresa B, Dyson, Hugh, Williamson, E Diane, Robinson, John H, Maillere, Bernard, Boyton, Rosemary J, Altmann, Daniel M
Published in PLoS pathogens

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context

by Kerk, Samuel A, Lin, Lin, Myers, Amy L, Sutton, Damien J, Andren, Anthony, Sajjakulnukit, Peter, Zhang, Li, Zhang, Yaqing, Jiménez, Jennifer A, Nelson, Barbara S, Chen, Brandon, Robinson, Anthony, Thurston, Galloway, Kemp, Samantha B, Steele, Nina G, Hoffman, Megan T, Wen, Hui-Ju, Long, Daniel, Ackenhusen, Sarah E, Ramos, Johanna, Gao, Xiaohua, Nwosu, Zeribe C, Galban, Stefanie, Halbrook, Christopher J, Lombard, David B, Piwnica-Worms, David R, Ying, Haoqiang, Pasca di Magliano, Marina, Crawford, Howard C, Shah, Yatrik M, Lyssiotis, Costas A
Published in eLife

Cytoskeletal defects in Bmpr2-associated pulmonary arterial hypertension

by Johnson, Jennifer A, Hemnes, Anna R, Perrien, Daniel S, Schuster, Manfred, Robinson, Linda J, Gladson, Santhi, Loibner, Hans, Bai, Susan, Blackwell, Tom R, Tada, Yuji, Harral, Julie W, Talati, Megha, Lane, Kirk B, Fagan, Karen A, West, James
Published in American journal of physiology. Lung cellular and molecular physiology

The molecular genetics of Marfan syndrome and related disorders

by Robinson, P N, Arteaga-Solis, E, Baldock, C, Collod-Béroud, G, Booms, P, De Paepe, A, Dietz, H C, Guo, G, Handford, P A, Judge, D P, Kielty, C M, Loeys, B, Milewicz, D M, Ney, A, Ramirez, F, Reinhardt, D P, Tiedemann, K, Whiteman, P, Godfrey, M
Published in Journal of Medical Genetics

The genome architecture of the Collaborative Cross mouse genetic reference population

by Cross Consortium, Collaborative
Published in Genetics (Austin)

Effectiveness and Relationship between Biased and Unbiased Measures of Dopamine Release and Clearance

by Everett, Anna C., Graul, Ben E., Ronström, Joakim W., Robinson, J. Kayden, Watts, Daniel B., España, Rodrigo A., Siciliano, Cody A., Yorgason, Jordan T.
Published in ACS chemical neuroscience