Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

by Mitew, Stanislaw, Gobius, Ilan, Fenlon, Laura R, McDougall, Stuart J, Hawkes, David, Xing, Yao Lulu, Bujalka, Helena, Gundlach, Andrew L, Richards, Linda J, Kilpatrick, Trevor J, Merson, Tobias D, Emery, Ben
Published in Nature communications

CD8 + T cell landscape in Indigenous and non-Indigenous people restricted by influenza mortality-associated HLA-A24:02 allomorph

by Hensen, Luca, Illing, Patricia T, Bridie Clemens, E, Nguyen, Thi H O, Koutsakos, Marios, van de Sandt, Carolien E, Mifsud, Nicole A, Nguyen, Andrea T, Szeto, Christopher, Chua, Brendon Y, Halim, Hanim, Rizzetto, Simone, Luciani, Fabio, Loh, Liyen, Grant, Emma J, Saunders, Phillipa M, Brooks, Andrew G, Rockman, Steve, Kotsimbos, Tom C, Cheng, Allen C, Richards, Michael, Westall, Glen P, Wakim, Linda M, Loudovaris, Thomas, Mannering, Stuart I, Elliott, Michael, Tangye, Stuart G, Jackson, David C, Flanagan, Katie L, Rossjohn, Jamie, Gras, Stephanie, Davies, Jane, Miller, Adrian, Tong, Steven Y C, Purcell, Anthony W, Kedzierska, Katherine
Published in Nature communications

Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

by Charles Coombes, R, Howell, Sacha, Lord, Simon R, Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I, Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O'Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D, Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G
Published in Nature communications

Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process

by Springelkamp, Henriët, Höhn, René, Mishra, Aniket, Hysi, Pirro G, Khor, Chiea-Chuen, Loomis, Stephanie J, Bailey, Jessica N Cooke, Gibson, Jane, Thorleifsson, Gudmar, Janssen, Sarah F, Luo, Xiaoyan, Ramdas, Wishal D, Vithana, Eranga, Nongpiur, Monisha E, Montgomery, Grant W, Xu, Liang, Mountain, Jenny E, Gharahkhani, Puya, Lu, Yi, Amin, Najaf, Karssen, Lennart C, Sim, Kar-Seng, van Leeuwen, Elisabeth M, Iglesias, Adriana I, Verhoeven, Virginie J M, Hauser, Michael A, Loon, Seng-Chee, Despriet, Dominiek D G, Nag, Abhishek, Venturini, Cristina, Sanfilippo, Paul G, Schillert, Arne, Kang, Jae H, Landers, John, Jonasson, Fridbert, Cree, Angela J, van Koolwijk, Leonieke M E, Rivadeneira, Fernando, Souzeau, Emmanuelle, Jonsson, Vesteinn, Menon, Geeta, Weinreb, Robert N, de Jong, Paulus T V M, Oostra, Ben A, Uitterlinden, André G, Hofman, Albert, Ennis, Sarah, Thorsteinsdottir, Unnur, Burdon, Kathryn P, Spector, Timothy D, Mirshahi, Alireza, Saw, Seang-Mei, Vingerling, Johannes R, Teo, Yik-Ying, Haines, Jonathan L, Wolfs, Roger C W, Lemij, Hans G, Tai, E-Shyong, Jansonius, Nomdo M, Jonas, Jost B, Cheng, Ching-Yu, Aung, Tin, Viswanathan, Ananth C, Klaver, Caroline C W, Craig, Jamie E, Macgregor, Stuart, Mackey, David A, Lotery, Andrew J, Stefansson, Kari, Bergen, Arthur A B, Young, Terri L, Wiggs, Janey L, Pfeiffer, Norbert, Wong, Tien-Yin, Pasquale, Louis R, Hewitt, Alex W, van Duijn, Cornelia M, Hammond, Christopher J
Published in Nature communications

Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

by Coombes, R C, Howell, Sacha, Lord, Simon R, Kenny, Laura, Mansi, Janine, Mitri, Zahi, Palmieri, Carlo, Chap, Linnea I, Richards, Paul, Gradishar, William, Sardesai, Sagar, Melear, Jason, O'Shaughnessy, Joyce, Ward, Patrick, Chalasani, Pavani, Arkenau, Tobias, Baird, Richard D, Jeselsohn, Rinath, Ali, Simak, Clack, Glen, Bahl, Ashwani, McIntosh, Stuart, Krebs, Matthew G
Published in Nature communications

Protection against SARS-CoV-2 Omicron BA.4/5 variant following booster vaccination or breakthrough infection in the UK

by Wei, Jia, Matthews, Philippa C, Stoesser, Nicole, Newton, John N, Diamond, Ian, Studley, Ruth, Taylor, Nick, Bell, John I, Farrar, Jeremy, Kolenchery, Jaison, Marsden, Brian D, Hoosdally, Sarah, Jones, E Yvonne, Stuart, David I, Crook, Derrick W, Peto, Tim E A, Walker, A Sarah, Pouwels, Koen B, Eyre, David W
Published in Nature communications

Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

by Chintalapudi, Sumana R, Maria, Doaa, Di Wang, Xiang, Bailey, Jessica N Cooke, Hysi, Pirro G, Wiggs, Janey L, Williams, Robert W, Jablonski, Monica M
Published in Nature communications

Risk of SARS-CoV-2 reinfection during multiple Omicron variant waves in the UK general population

by Wei, Jia, Stoesser, Nicole, Matthews, Philippa C, Khera, Tarnjit, Gethings, Owen, Diamond, Ian, Studley, Ruth, Taylor, Nick, Peto, Tim E A, Walker, A Sarah, Pouwels, Koen B, Eyre, David W
Published in Nature communications

SARS-CoV-2 antibody trajectories after a single COVID-19 vaccination with and without prior infection

by Wei, Jia, Matthews, Philippa C, Stoesser, Nicole, Diamond, Ian, Studley, Ruth, Rourke, Emma, Cook, Duncan, Bell, John I, Newton, John N, Farrar, Jeremy, Howarth, Alison, Marsden, Brian D, Hoosdally, Sarah, Jones, E Yvonne, Stuart, David I, Crook, Derrick W, Peto, Tim E A, Walker, A Sarah, Eyre, David W, Pouwels, Koen B
Published in Nature communications

Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation

by Gellert, Pascal, Segal, Corrinne V, Gao, Qiong, López-Knowles, Elena, Martin, Lesley-Ann, Dodson, Andrew, Li, Tiandao, Miller, Christopher A, Lu, Charles, Mardis, Elaine R, Gillman, Alexa, Morden, James, Graf, Manuela, Sidhu, Kally, Evans, Abigail, Shere, Michael, Holcombe, Christopher, McIntosh, Stuart A, Bundred, Nigel, Skene, Anthony, Maxwell, William, Robertson, John, Bliss, Judith M, Smith, Ian, Dowsett, Mitch
Published in Nature communications

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer

by Song, Honglin, Lawrenson, Kate, Ramus, Susan J, Cicek, Mine S, Tyrer, Jonathan, Stram, Douglas, Wozniak, Eva L, Wik, Elisabeth, Whittemore, Alice S, Weber, Rachel Palmieri, Vitonis, Allison F, Vergote, Ignace, Van Den Berg, David, Van Altena, Anne M, Tworoger, Shelley S, Thompson, Pamela J, Tessier, Daniel C, Teo, Soo-Hwang, Templeman, Claire, Stram, Daniel O, Southey, Melissa C, Siddiqui, Nadeem, Shu, Xiao-Ou, Shridhar, Viji, Severi, Gianluca, Schwaab, Ira, Rzepecka, Iwona K, Runnebaum, Ingo B, Rossing, Mary Anne, Rodriguez-Rodriguez, Lorna, Renner, Stefan P, Poole, Elizabeth M, Pike, Malcolm C, Pelttari, Liisa M, Pejovic, Tanja, Paul, James, Orlow, Irene, Odunsi, Kunle, Nevanlinna, Heli, Ness, Roberta B, Nakanishi, Toru, Moysich, Kirsten B, Monteiro, Alvaro N A, Moes-Sosnowska, Joanna, Modugno, Francesmary, Menon, Usha, Massuger, Leon F A G, Lundvall, Lene, Lissowska, Jolanta, Kupryjanczyk, Jolanta, Krakstad, Camilla, Konecny, Gottfried E, Kjaer, Susanne Krüger, Kiemeney, Lambertus A, Karlan, Beth Y, Karevan, Rod, Kalli, Kimberly R, Kajiyama, Hiroaki, Ji, Bu-Tian, Høgdall, Claus K, Hoatlin, Maureen, Hein, Rebecca, Hall, Per, Gronwald, Jacek, Gore, Martin, Goodman, Marc T, Giles, Graham G, Gentry-Maharaj, Aleksandra, Garcia-Closas, Montserrat, Flanagan, James M, Fasching, Peter A, Ekici, Arif B, Edwards, Robert, Eccles, Diana, Easton, Douglas F, Dürst, Matthias, du Bois, Andreas, Dörk, Thilo, Despierre, Evelyn, Cramer, Daniel W, Cook, Linda S, Chen, Xiaoqing, Charbonneau, Bridget, Chang-Claude, Jenny, Bunker, Clareann H, Brueggmann, Doerthe, Brown, Robert, Brooks-Wilson, Angela, Brinton, Louise A, Bogdanova, Natalia, Beesley, Jonathan, Beckmann, Matthias W, Baglietto, Laura, Bacot, François, Armasu, Sebastian M, Antonenkova, Natalia, Wu, Xifeng, Hildebrandt, Michelle A T, Sellers, Thomas A, Pearce, Celeste Leigh
Published in Nature communications

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31

by Permuth-Wey, Jennifer, Shen, Howard C, Tyrer, Jonathan P, Chen, Zhihua, Lin, Hui-Yi, Chen, Y Ann, Ramus, Susan J, Karevan, Rod, Larson, Melissa C, Anton-Culver, Hoda, Armasu, Sebastian M, Bacot, François, Bandera, Elisa V, Barnholtz-Sloan, Jill, Bloom, Greg, Brooks-Wilson, Angela, Brown, Robert, Butzow, Ralf, Cai, Qiuyin, Campbell, Ian, Chenevix-Trench, Georgia, Coetzee, Gerhard A, Cook, Linda S, Couch, Fergus J, Cramer, Daniel W, Cunningham, Julie M, Despierre, Evelyn, Doherty, Jennifer A, du Bois, Andreas, Dürst, Matthias, Easton, Douglas F, Edwards, Robert, Ekici, Arif B, Fenstermacher, David A, Flanagan, James M, Garcia-Closas, Montserrat, Goodman, Marc T, Gore, Martin, Gronwald, Jacek, Halle, Mari K, Harter, Philipp, Hillemanns, Peter, Høgdall, Claus K, Hosono, Satoyo, Jakubowska, Anna, Jensen, Allan, Jim, Heather, Kalli, Kimberly R, Kaye, Stanley B, Kelemen, Linda E, Kikkawa, Fumitaka, Konecny, Gottfried E, Krakstad, Camilla, Kjaer, Susanne Krüger, Kupryjanczyk, Jolanta, Lancaster, Johnathan M, Le, Nhu D, Liang, Dong, Lim, Boon Kiong, Lin, Jie, Lissowska, Jolanta, Lu, Karen H, Matsuo, Keitaro, Moysich, Kirsten B, Ness, Roberta B, Nevanlinna, Heli, Odunsi, Kunle, Orlow, Irene, Pejovic, Tanja, Pike, Malcolm C, Poole, Elizabeth M, Renner, Stefan P, Rodriguez-Rodriguez, Lorna, Rossing, Mary Anne, Rzepecka, Iwona K, Salvesen, Helga B, Severi, Gianluca, Shu, Xiao-Ou, Shvetsov, Yurii B, Song, Honglin, Spiewankiewicz, Beata, Stram, Daniel, Sutphen, Rebecca, Teo, Soo-Hwang, Terry, Kathryn L, Thompson, Pamela J, van Altena, Anne M, Vergote, Ignace, Vierkant, Robert A, Wang-Gohrke, Shan, Palmieri Weber, Rachel, Wik, Elisabeth, Wilkens, Lynne R, Woo, Yin Ling, Ziogas, Argyrios, Phelan, Catherine M, Berchuck, Andrew, Fridley, Brooke L, Pharoah, Paul D P, Sellers, Thomas A
Published in Nature communications