276 An X-ray crystal structure-based understanding of the inhibition of the MDM2–p53 protein–protein interaction by isoindolinones by Anil, B, Blackburn, E, Blackburn, T, Cully, S, Liu, J, Drummond, C.J, Endicott, J.A, Golding, B.T, Griffin, R.J, Haggerty, K, Lunec, J, Newell, D.R, Revill, C.H, Riedinger, C, Watson, A.F, Xu, Q, Zhao, Y, Hardcastle, I.R, Noble, M.E.M

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