Focused HLA analysis in Caucasians with myositis identifies significant associations with autoantibody subgroups

by Rothwell, Simon, Chinoy, Hector, Lamb, Janine A, Miller, Frederick W, Rider, Lisa G, Wedderburn, Lucy R, McHugh, Neil J, Mammen, Andrew L, Betteridge, Zoë E, Tansley, Sarah L, Bowes, John, Vencovsky, Jiří, Deakin, Claire T, Dankó, Katalin, Vidya, Limaye, Selva-O'Callaghan, Albert, Pachman, Lauren M, Reed, Ann M, Molberg, Øyvind, Benveniste, Olivier, Mathiesen, Pernille R, Radstake, Timothy R.D.J, Doria, Andrea, De Bleecker, Jan, Lee, Annette T, Hanna, Michael G, Machado, Pedro M, Ollier, William E, Gregersen, Peter K, Padyukov, Leonid, O'Hanlon, Terrance P, Cooper, Robert G, Lundberg, Ingrid E
Published in Annals of the rheumatic diseases

Autoantigen TRIM21/Ro52 is expressed on the surface of antigen-presenting cells and its enhanced expression in Sjögren’s syndrome is associated with B cell hyperactivity and type I...

by Hillen, Maarten R, Urso, Katia, Koppe, Emma, Lopes, Ana Pinheiro, Blokland, Sofie L M, Pandit, Aridaman, Slocombe, Tom, van Maurik, André, van Roon, Joel A G, Radstake, Timothy R D J
Published in Rheumatic & musculoskeletal diseases open

Comparison of the Heel Enthesitis MRI Scoring System (HEMRIS) with clinical enthesitis and local metabolic activity on PET-CT

by Kleinrensink, Nienke J, Foppen, Wouter, Ten Katen, Iris, van der Veen, Pieternella H, de Klerk, Bo, Diepstraten, Suzanne C E, Radstake, Timothy R D J, Lafeber, Floris P J G, de Jong, Pim A, Leijten, Emmerik F A
Published in Rheumatic & musculoskeletal diseases open

Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis

by Alizadeh, Behrooz Z., Valdigem, Gustavo, Coenen, Marieke J.H., Zhernakova, Alexandra, Franke, Barbara, Monsuur, Alienke, van Riel, Piet L.C.M., Barrera, Pilar, Radstake, Timothy R.D.J., Roep, Bart O., Wijmenga, Cisca, Koeleman, Bobby P.C.
Published in Human molecular genetics

CXCL4 drives fibrosis by promoting several key cellular and molecular processes

by Affandi, Alsya J, Carvalheiro, Tiago, Ottria, Andrea, de Haan, Judith J, Brans, Maike A D, Brandt, Maarten M, Tieland, Ralph G, Lopes, Ana P, Fernández, Beatriz Malvar, Bekker, Cornelis P J, van der Linden, Maarten, Zimmermann, Maili, Giovannone, Barbara, Wichers, Catharina G K, Garcia, Samuel, de Kok, Michael, Stifano, Giuseppina, Xu, Yan Juan, Kowalska, M Anna, Waasdorp, Maaike, Cheng, Caroline, Gibbs, Susan, de Jager, Saskia C A, van Roon, Joel A G, Radstake, Timothy R D J, Marut, Wioleta
Published in Cell reports (Cambridge)

The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis

by ROELOFS, Mieke F, WENINK, Mark H, TOONEN, Erik J. M, COENEN, Marieke J. H, JOOSTEN, Leo A. B, VAN DEN BERG, Wim B, VAN RIEL, Piet L. C. M, RADSTAKE, Timothy R. D. J
Published in Journal of rheumatology

Dendritic cells in systemic sclerosis: Advances from human and mice studies

by Affandi, Alsya J., Carvalheiro, Tiago, Radstake, Timothy R.D.J., Marut, Wioleta
Published in Immunology letters

Delineating the deranged immune system in the antiphospholipid syndrome

by van den Hoogen, Lucas L, van Roon, Joël A.G, Radstake, Timothy R.D.J, Fritsch-Stork, Ruth D.E, Derksen, Ronald H.W.M
Published in Autoimmunity reviews

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis

by Kuiper, Jonas J W, Setten, Jessica van, Devall, Matthew, Cretu-Stancu, Mircea, Hiddingh, Sanne, Ophoff, Roel A, Missotten, Tom O A R, Velthoven, Mirjam van, Den Hollander, Anneke I, Hoyng, Carel B, James, Edward, Reeves, Emma, Cordero-Coma, Miguel, Fonollosa, Alejandro, Adán, Alfredo, Martín, Javier, Koeleman, Bobby P C, Boer, Joke H de, Pulit, Sara L, Márquez, Ana, Radstake, Timothy R D J
Published in Human molecular genetics

Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopath...

by Blokland, Sofie L M, van Vliet-Moret, Fréderique M, Hillen, Maarten R, Pandit, Aridaman, Goldschmeding, Roel, Kruize, Aike A, Bouma, Gerben, van Maurik, André, Olek, Sven, Hoffmueller, Ulrich, van Roon, Joel A G, Radstake, Timothy R D J
Published in Rheumatology (Oxford, England)

Increased mTORC1 activation in salivary gland B cells and T cells from patients with Sjögren’s syndrome: mTOR inhibition as a novel therapeutic strategy to halt immunopathology?

by Blokland, Sofie L M, Hillen, Maarten R, Wichers, Catharina G K, Zimmermann, Maili, Kruize, Aike A, Radstake, Timothy R D J, Broen, Jasper C A, van Roon, Joel A G
Published in Rheumatic & musculoskeletal diseases open

Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis

by Chouri, Eleni, Servaas, Nila H., Bekker, Cornelis P.J., Affandi, Alsya J., Cossu, Marta, Hillen, Maarten R., Angiolilli, Chiara, Mertens, Jorre S., van den Hoogen, Lucas L., Silva-Cardoso, Sandra, van der Kroef, Maarten, Vazirpanah, Nadia, Wichers, Catharina G.K., Carvalheiro, Tiago, Blokland, Sofie L.M., Giovannone, Barbara, Porretti, Laura, Marut, Wioleta, Vigone, Barbara, van Roon, Joel A.G., Beretta, Lorenzo, Rossato, Marzia, Radstake, Timothy R.D.J.
Published in Journal of autoimmunity

Increased B-cell activating factor (BAFF)/B-lymphocyte stimulator (BLyS) in primary antiphospholipid syndrome is associated with higher adjusted global antiphospholipid syndrome sc...

by van den Hoogen, Lucas L, Palla, Giovanni, Bekker, Cornelis P J, Fritsch-Stork, Ruth D E, Radstake, Timothy R D J, van Roon, Joel A G
Published in Rheumatic & musculoskeletal diseases open

Increased expression of Fas on group 2 and 3 innate lymphoid cells is associated with an interferon signature in systemic lupus erythematosus and Sjögren’s syndrome

by Blokland, Sofie L M, van den Hoogen, Lucas L, Leijten, Emmerik F A, Hartgring, Sarita A Y, Fritsch, Ruth, Kruize, Aike A, van Roon, Joel A G, Radstake, Timothy R D J
Published in Rheumatology (Oxford, England)

Immune checkpoint inhibitor–associated sarcoidosis: A usually benign disease that does not require immunotherapy discontinuation

by Chanson, Noémie, Ramos-Casals, Manuel, Pundole, Xerxes, Suijkerbuijk, Karijn, José de Barros e Silva, Milton, Lidar, Merav, Benesova, Karolina, Leipe, Jan, Acar-Denizli, Nihan, Pradère, Pauline, Michot, Jean-Marie, Voisin, Anne- Laure, Suárez-Almazor, Maria E., Radstake, Timothy R.D., Fernandes Moça Trevisani, Virginia, Schulze-Koops, Hendrik, Melin, Audrey, Robert, Caroline, Mariette, Xavier, Baughman, Robert P., Lambotte, Olivier, Ramos-Casals, Manuel, Mariette, Xavier, Lambotte, Olivier, Kostine, Marie, Khamashta, Munther A., Calabrese, Leonard, Suárez-Almazor, Maria, Baldini, Chiara, Bingham, Clifton O., Gottenberg, Jacques-Eric, Radstake, Timothy R.D., Schaeverbeke, Thierry, Schulze-Koops, Hendrik, Brito-Zerón, Pilar, Flores-Chávez, Alejandra, Acar-Denizli, Nihan
Published in European journal of cancer (1990)

Poly(I:C) Drives Type I IFN- and TGFβ-Mediated Inflammation and Dermal Fibrosis Simulating Altered Gene Expression in Systemic Sclerosis

by Farina, Giuseppina A., York, Michael R., Di Marzio, Michael, Collins, Cindy A., Meller, Stephan, Homey, Bernhard, Rifkin, Ian R., Marshak-Rothstein, Ann, Radstake, Timothy R.D.J., Lafyatis, Robert
Published in Journal of investigative dermatology

Evidence for PTPN22 R620W Polymorphism As the Sole Common Risk Variant for Rheumatoid Arthritis in the 1p13.2 Region

by MARTIN, Jose-Ezequiel, ALIZADEH, Behrooz Z, VAN RIEL, Piet, RADSTAKE, Timothy R. D. J, KVIEN, Tore K, VIKEN, Marte K, LIE, Benedicte A, KOELEMAN, Bobby P. C, MARTIN, Javier, GONZALEZ-GAY, Miguel A, BALSA, Alejandro, PASCUAL-SALCEDO, Dora, GONZALEZ-ESCRIBANO, Maria F, RODRIGUEZ-RODRIGUEZ, Luis, FERNANDEZ-GUTIERREZ, Benjamin, RAYA, Enrique, COENEN, Marieke J. H
Published in Journal of rheumatology

Genetic variants in toll-like receptors are not associated with rheumatoid arthritis susceptibility or anti-tumour necrosis factor treatment outcome

by Coenen, Marieke J H, Enevold, Christian, Barrera, Pilar, Schijvenaars, Mascha M V A P, Toonen, Erik J M, Scheffer, Hans, Padyukov, Leonid, Kastbom, Alf, Klareskog, Lars, Barton, Anne, Kievit, Wietske, Rood, Maarten J, Jansen, Tim L, Swinkels, Dorine, van Riel, Piet L C M, Franke, Barbara, Bendtzen, Klaus, Radstake, Timothy R D J
Published in PloS one

CXCL4 is a driver of cytokine mRNA stability in monocyte-derived dendritic cells

by Silva-Cardoso, Sandra C., Bekker, Cornelis P.J., Boes, Marianne, Radstake, Timothy R.D.J., Angiolilli, Chiara
Published in Molecular immunology

The Pronounced Th17 Profile in Systemic Sclerosis (SSc) Together with Intracellular Expression of TGFβ and IFNγ Distinguishes SSc Phenotypes

by Radstake, Timothy R. D. J., van Bon, Lenny, Broen, Jasper, Hussiani, Anila, Hesselstrand, Roger, Wuttge, Dirk M., Deng, Yanhui, Simms, Robbert, Lubberts, Erik, Lafyatis, Robert
Published in PloS one