Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy

by Yossef, Rami, Tran, Eric, Deniger, Drew C, Gros, Alena, Pasetto, Anna, Parkhurst, Maria R, Gartner, Jared J, Prickett, Todd D, Cafri, Gal, Robbins, Paul F, Rosenberg, Steven A
Published in JCI insight

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging

by Dorronsoro, Akaitz, Santiago, Fernando E., Grassi, Diego, Zhang, Tianpeng, Lai, Ruenn Chai, McGowan, Sara J., Angelini, Luise, Lavasani, Mitra, Corbo, Lana, Lu, Aiping, Brooks, Robert W., Garcia‐Contreras, Marta, Stolz, Donna B., Amelio, Antonio, Boregowda, Siddaraju V., Fallahi, Mohammad, Reich, Adrian, Ricordi, Camillo, Phinney, Donald G., Huard, Johnny, Lim, Sai Kiang, Niedernhofer, Laura J., Robbins, Paul D.
Published in Aging cell

Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

by Lo, Winifred, Parkhurst, Maria, Robbins, Paul F, Tran, Eric, Lu, Yong-Chen, Jia, Li, Gartner, Jared J, Pasetto, Anna, Deniger, Drew, Malekzadeh, Parisa, Shelton, Thomas E, Prickett, Todd, Ray, Satyajit, Kivitz, Scott, Paria, Biman C, Kriley, Isaac, Schrump, David S, Rosenberg, Steven A
Published in Cancer immunology research

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

by Parkhurst, Maria R, Yang, James C, Langan, Russell C, Dudley, Mark E, Nathan, Debbie-Ann N, Feldman, Steven A, Davis, Jeremy L, Morgan, Richard A, Merino, Maria J, Sherry, Richard M, Hughes, Marybeth S, Kammula, Udai S, Phan, Giao Q, Lim, Ramona M, Wank, Stephen A, Restifo, Nicholas P, Robbins, Paul F, Laurencot, Carolyn M, Rosenberg, Steven A
Published in Molecular therapy

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice

by Proto, Jonathan D, Lu, Aiping, Dorronsoro, Akaitz, Scibetta, Alex, Robbins, Paul D, Niedernhofer, Laura J, Huard, Johnny
Published in PloS one

Expansion of myeloid‐derived suppressor cells with aging in the bone marrow of mice through a NF‐κB‐dependent mechanism

by Flores, Rafael R., Clauson, Cheryl L., Cho, Joonseok, Lee, Byeong‐Chel, McGowan, Sara J., Baker, Darren J., Niedernhofer, Laura J., Robbins, Paul D.
Published in Aging cell

NY-ESO-1 expression in synovial sarcoma and other mesenchymal tumors: significance for NY-ESO-1-based targeted therapy and differential diagnosis

by Lai, Jin-Ping, Robbins, Paul F, Raffeld, Mark, Aung, Phyu Phyu, Tsokos, Maria, Rosenberg, Steven A, Miettinen, Markku M, Lee, Chyi-Chia Richard
Published in Modern pathology

Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

by Liu, Lei, Yue, Xianlin, Sun, Zewei, Hambright, William S., Feng, Qi, Cui, Yan, Huard, Johnny, Robbins, Paul D., Wang, Zhihui, Mu, Xiaodong
Published in Aging (Albany, NY.)

Heterochronic parabiosis: a valuable tool to investigate cellular senescence and other hallmarks of aging

by Yousefzadeh, Matthew J, Robbins, Paul D, Huffman, Derek M
Published in Aging (Albany, NY.)

Avelumab in Combination with Axitinib as First-Line Treatment in Patients with Advanced Hepatocellular Carcinoma: Results from the Phase 1b VEGF Liver 100 Trial

by Kudo, Masatoshi, Motomura, Kenta, Wada, Yoshiyuki, Inaba, Yoshitaka, Sakamoto, Yasunari, Kurosaki, Masayuki, Umeyama, Yoshiko, Kamei, Yoichi, Yoshimitsu, Junichiro, Fujii, Yosuke, Aizawa, Mana, Robbins, Paul B., Furuse, Junji
Published in Liver cancer (Basel )

Safety and efficacy of durvalumab in patients with head and neck squamous cell carcinoma: results from a phase I/II expansion cohort

by Segal, Neil H., Ou, Sai-Hong I., Balmanoukian, Ani, Fury, Matthew G., Massarelli, Erminia, Brahmer, Julie R., Weiss, Jared, Schöffski, Patrick, Antonia, Scott J., Massard, Christophe, Zandberg, Dan P., Khleif, Samir N., Xiao, Feng, Rebelatto, Marlon C., Steele, Keith E., Robbins, Paul B., Angra, Natasha, Song, Xuyang, Abdullah, Shaad, Butler, Marcus
Published in European journal of cancer (1990)

A TCR targeting the HLA-A0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in several types of cancer

by Chinnasamy, Nachimuthu, Wargo, Jennifer A, Yu, Zhiya, Rao, Mahadev, Frankel, Timothy L, Riley, John P, Hong, Jenny J, Parkhurst, Maria R, Feldman, Steven A, Schrump, David S, Restifo, Nicholas P, Robbins, Paul F, Rosenberg, Steven A, Morgan, Richard A
Published in The Journal of immunology (1950)

Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression

by Lu, Yong-Chen, Yao, Xin, Li, Yong F, El-Gamil, Mona, Dudley, Mark E, Yang, James C, Almeida, Jorge R, Douek, Daniel C, Samuels, Yardena, Rosenberg, Steven A, Robbins, Paul F
Published in The Journal of immunology (1950)

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

by Pasetto, Anna, Gros, Alena, Robbins, Paul F, Deniger, Drew C, Prickett, Todd D, Matus-Nicodemos, Rodrigo, Douek, Daniel C, Howie, Bryan, Robins, Harlan, Parkhurst, Maria R, Gartner, Jared, Trebska-McGowan, Katarzyna, Crystal, Jessica S, Rosenberg, Steven A
Published in Cancer immunology research

Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans

by Yousefzadeh, Matthew J., Schafer, Marissa J., Noren Hooten, Nicole, Atkinson, Elizabeth J., Evans, Michele K., Baker, Darren J., Quarles, Ellen K., Robbins, Paul D., Ladiges, Warren C., LeBrasseur, Nathan K., Niedernhofer, Laura J.
Published in Aging cell

Levels of peripheral CD4+FoxP3+ regulatory T cells are negatively associated with clinical response to adoptive immunotherapy of human cancer

by Yao, Xin, Ahmadzadeh, Mojgan, Lu, Yong-Chen, Liewehr, David J., Dudley, Mark E., Liu, Fang, Schrump, David S., Steinberg, Seth M., Rosenberg, Steven A., Robbins, Paul F.
Published in Blood

Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing

by Lu, Yong-Chen, Zheng, Zhili, Lowery, Frank J, Gartner, Jared J, Prickett, Todd D, Robbins, Paul F, Rosenberg, Steven A
Published in Journal for immunotherapy of cancer

Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities

by Silwal, Prashanta, Nguyen-Thai, Allison M, Mohammad, Haneef Ahamed, Wang, Yanshan, Robbins, Paul D, Lee, Joon Y, Vo, Nam V
Published in Biomolecules (Basel, Switzerland)

Novel small molecule inhibition of IKK/NF‐κB activation reduces markers of senescence and improves healthspan in mouse models of aging

by Zhang, Lei, Zhao, Jing, Mu, Xiaodong, McGowan, Sara J., Angelini, Luise, O'Kelly, Ryan D., Yousefzadeh, Matthew J., Sakamoto, Ayumi, Aversa, Zaira, LeBrasseur, Nathan K., Suh, Yousin, Huard, Johnny, Kamenecka, Theodore M., Niedernhofer, Laura J., Robbins, Paul D.
Published in Aging cell

Immunosuppressive Exosomes: A New Approach for Treating Arthritis

by Yang, Chenjie, Robbins, Paul D.
Published in International Journal of Rheumatology