PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment

by Collins, Natalie B, Al Abosy, Rose, Miller, Brian C, Bi, Kevin, Zhao, Qihong, Quigley, Michael, Ishizuka, Jeffrey J, Yates, Kathleen B, Pope, Hans W, Manguso, Robert T, Shrestha, Yashaswi, Wadsworth, Marc, Hughes, Travis, Shalek, Alex K, Boehm, Jesse S, Hahn, William C, Doench, John G, Haining, W Nicholas
Published in Journal for immunotherapy of cancer

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

by Manguso, Robert T, Pope, Hans W, Zimmer, Margaret D, Brown, Flavian D, Yates, Kathleen B, Miller, Brian C, Collins, Natalie B, Bi, Kevin, LaFleur, Martin W, Juneja, Vikram R, Weiss, Sarah A, Lo, Jennifer, Fisher, David E, Miao, Diana, Van Allen, Eliezer, Root, David E, Sharpe, Arlene H, Doench, John G, Haining, W Nicholas
Published in Nature (London)

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

by Ishizuka, Jeffrey J, Manguso, Robert T, Cheruiyot, Collins K, Bi, Kevin, Panda, Arpit, Iracheta-Vellve, Arvin, Miller, Brian C, Du, Peter P, Yates, Kathleen B, Dubrot, Juan, Buchumenski, Ilana, Comstock, Dawn E, Brown, Flavian D, Ayer, Austin, Kohnle, Ian C, Pope, Hans W, Zimmer, Margaret D, Sen, Debattama R, Lane-Reticker, Sarah K, Robitschek, Emily J, Griffin, Gabriel K, Collins, Natalie B, Long, Adrienne H, Doench, John G, Kozono, David, Levanon, Erez Y, Haining, W Nicholas
Published in Nature (London)

In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma

by Dubrot, Juan, Lane-Reticker, Sarah Kate, Kessler, Emily A., Ayer, Austin, Mishra, Gargi, Wolfe, Clara H., Zimmer, Margaret D., Du, Peter P., Mahapatra, Animesh, Ockerman, Kyle M., Davis, Thomas G.R., Kohnle, Ian C., Pope, Hans W., Allen, Peter M., Olander, Kira E., Iracheta-Vellve, Arvin, Doench, John G., Haining, W. Nicholas, Yates, Kathleen B., Manguso, Robert T.
Published in Immunity (Cambridge, Mass.)

Abstract 1019: In vivo CRISPR screening identifies Ptpn2 as a target for cancer immunotherapy

by Manguso, Robert T., Pope, Hans W., Zimmer, Margaret D., Brown, Flavian D., Yates, Kathleen B., Miller, Brian C., Collins, Natalie B., Bi, Kevin, Lafleur, Martin W., Juneja, Vikram R., Weiss, Sarah A., Fisher, David E., Root, David E., Sharpe, Arlene H., Doench, John G., Haining, W Nicholas
Published in Cancer research (Chicago, Ill.)

Abstract 3610: In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

by Dubrot, Juan, Du, Peter P., Lane-Reticker, Sarah Kate, Kessler, Emily A., Muscato, Audrey J., Mehta, Arnav, Freeman, Samuel S., Allen, Peter M., Olander, Kira E., Ockerman, Kyle M., Wolfe, Clara H., Wiesmann, Fabius, Knudsen, Nelson H., Tsao, Hsiao-Wei, Iracheta-Vellve, Arvin, Schneider, Emily M., Rivera-Rosario, Andrea N., Kohnle, Ian C., Pope, Hans W., Ayer, Austin, Mishra, Gargi, Zimmer, Margaret D., Kim, Sarah Y., Mahapatra, Animesh, Ebrahimi-Nik, Hakimeh, Frederick, Dennie T., Boland, Genevieve M., Haining, W. Nicholas, Root, David E., Doench, John G., Hacohen, Nir, Yates, Kathleen B., Manguso, Robert T.
Published in Cancer research (Chicago, Ill.)

Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter

by Burnett, Richard, Chen, Hong, Szyszkowicz, Mieczysław, Fann, Neal, Hubbell, Bryan, Pope, C. Arden, Apte, Joshua S., Brauer, Michael, Cohen, Aaron, Weichenthal, Scott, Coggins, Jay, Di, Qian, Brunekreef, Bert, Frostad, Joseph, Lim, Stephen S., Kan, Haidong, Walker, Katherine D., Thurston, George D., Hayes, Richard B., Lim, Chris C., Turner, Michelle C., Jerrett, Michael, Krewski, Daniel, Gapstur, Susan M., Diver, W. Ryan, Ostro, Bart, Goldberg, Debbie, Crouse, Daniel L., Martin, Randall V., Peters, Paul, Pinault, Lauren, Tjepkema, Michael, van Donkelaar, Aaron, Villeneuve, Paul J., Miller, Anthony B., Yin, Peng, Zhou, Maigeng, Wang, Lijun, Janssen, Nicole A. H., Marra, Marten, Atkinson, Richard W., Tsang, Hilda, Thach, Thuan Quoc, Cannon, John B., Allen, Ryan T., Hart, Jaime E., Laden, Francine, Cesaroni, Giulia, Forastiere, Francesco, Weinmayr, Gudrun, Jaensch, Andrea, Nagel, Gabriele, Concin, Hans, Spadaro, Joseph V.
Published in Proceedings of the National Academy of Sciences - PNAS

The contribution of frailty, cognition, activity of daily life and comorbidities on outcome in acutely admitted patients over 80 years in European ICUs: the VIP2 study

by Guidet, Bertrand, de Lange, Dylan W., Boumendil, Ariane, Leaver, Susannah, Watson, Ximena, Boulanger, Carol, Szczeklik, Wojciech, Artigas, Antonio, Morandi, Alessandro, Andersen, Finn, Zafeiridis, Tilemachos, Jung, Christian, Moreno, Rui, Walther, Sten, Oeyen, Sandra, Schefold, Joerg C., Cecconi, Maurizio, Marsh, Brian, Joannidis, Michael, Nalapko, Yuriy, Elhadi, Muhammed, Fjølner, Jesper, Flaatten, Hans
Published in Intensive care medicine

Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old: results from an observational study in 241 European ICUs

by Haas, Lenneke E M, Boumendil, Ariane, Flaatten, Hans, Guidet, Bertrand, Ibarz, Mercedes, Jung, Christian, Moreno, Rui, Morandi, Alessandro, Andersen, Finn H, Zafeiridis, Tilemachos, Walther, Sten, Oeyen, Sandra, Leaver, Susannah, Watson, Ximena, Boulanger, Carole, Szczeklik, Wojciech, Schefold, Joerg C, Cecconi, Maurizio, Marsh, Brian, Joannidis, Michael, Nalapko, Yuriy, Elhadi, Muhammed, Fjølner, Jesper, Artigas, Antonio, de Lange, Dylan W
Published in Age and ageing

The association of premorbid conditions with 6-month mortality in acutely admitted ICU patients over 80 years

by de Lange, Dylan W., Soliman, Ivo W., Leaver, Susannah, Boumendil, Ariane, Haas, Lenneke E. M., Watson, Ximena, Boulanger, Carol, Szczeklik, Wojciech, Artigas, Antonio, Morandi, Alessandro, Andersen, Finn, Jung, Christian, Moreno, Rui, Walther, Sten, Oeyen, Sandra, Schefold, Joerg C., Cecconi, Maurizio, Marsh, Brian, Joannidis, Michael, Nalapko, Yuriy, Elhadi, Muhammed, Fjølner, Jesper, Guidet, Bertrand, Flaatten, Hans
Published in Annals of intensive care

Abstract A16: Defining molecular mechanisms of resistance to tumor immunity

by Collins, Natalie B., Manguso, Robert, Pope, Hans, Haining, W. Nicholas
Published in Cancer immunology research

Timing of Introduction to Solid Food, Growth, and Nutrition Risk in Later Childhood

by Birken, Catherine S., O'Connor, Deborah L., Maguire, Jonathon L., Cohn, Ronald, Lau, Eddy, Laupacis, Andreas, Parkin, Patricia C., Salter, Michael, Anderson, Laura N., Borkhoff, Cornelia M., Kowal, Christine, Abdurrahman, Murtala, Anderson, Kelly, Baker, Jillian, Barozzino, Tony, Bergeron, Sylvie, Bhagat, Dimple, Bonifacio, Joey, Calpin, Caroline, Campbell, Douglas, Cheng, Elaine, Constantin, Evelyn, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Egger, Anne, Farber, Allison, Freedman, Amy, Freeman, Sloane, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Harrington, Leah, Jansz, Gwen, Kadar, Paul, Kim, Florence, Kiran, Tara, Knowles, Holly, Lakhoo, Sheila, Lam-Antoniades, Margarita, Leduc, Denis, Malach, Jessica, Male, Roy, Mascoll, Vashti, Mok, Elise, Moodie, Rosemary, Nader, Maya, Naymark, Sharon, Peer, Michael, Pena, Kifi, Perlmutar, Marty, Persaud, Navindra, Pinto, Andrew, Porepa, Michelle, Qi, Vikky, Ramji, Nasreen, Ramji, Noor, Rosenthal, Alana, Rouleau, Katherine, Ruderman, Caroline, Saunderson, Janet, Schiralli, Vanna, Sgro, Michael, Smiltnieks, Barbara, Srikanthan, Cinntha, Taylor, Carolyn, Uddin, Fatima, van den Heuvel, Meta, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Young, Elizabeth, Zajdman, Michael, Bazeghi, Farnaz, Bouchard, Vincent, Bustos, Marivic, Koroshegyi, Christine, Malhi, Tarandeep, Thadani, Sharon, Thompson, Julia, Thompson, Laurie, Aglipay, Mary, Bayoumi, Imaan, Carsley, Sarah, Cost, Katherine, Eny, Karen, Kim, Theresa, Omand, Jessica, Vanderhout, Shelley, Chan, Olivia, Dai, David W.H., Hall, Judith, Lebovic, Gerald, Pope, Karen, Thorpe, Kevin, Kandel, Rita, Rodrigues, Michelle
Published in The Journal of pediatrics

Reliability of routinely collected anthropometric measurements in primary care

by Carsley, Sarah, Parkin, Patricia C, Tu, Karen, Pullenayegum, Eleanor, Persaud, Nav, Maguire, Jonathon L, Birken, Catherine S
Published in BMC medical research methodology

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

by Saya, Sibel, Vertosick, Emily, Dadaev, Tokhir, Brendler, Charles, Page, Elizabeth, Dias, Alexander, Evans, D Gareth, Rothwell, Jeanette, Maehle, Lovise, Axcrona, Karol, Richardson, Kate, Eccles, Diana, Jensen, Thomas, Osther, Palle J, van Asperen, Christi J, Vasen, Hans, Ringelberg, Janneke, Cybulski, Cezary, Wokolorczyk, Dominika, Hart, Rachel, Glover, Wayne, Lam, Jimmy, Taylor, Louise, Salinas, Monica, Feliubadaló, Lidia, Oldenburg, Rogier, Cremers, Ruben, Verhaegh, Gerald, van Zelst-Stams, Wendy A, Oosterwijk, Jan C, Cook, Jackie, Rosario, Derek J, Buys, Saundra S, Powers, Jacquelyn, Ausems, Margreet Gem, Maia, Sofia, Izatt, Louise, Schmutzler, Rita, Rhiem, Kerstin, Foulkes, William D, Boshari, Talia, Davidson, Rosemarie, Ruijs, Marielle, Helderman-van den Enden, Apollonia Tjm, Andrews, Lesley, Walker, Lisa, Snape, Katie, Henderson, Alex, Jobson, Irene, Lindeman, Geoffrey J, Liljegren, Annelie, Harris, Marion, Adank, Muriel A, Kirk, Judy, Taylor, Amy, Susman, Rachel, Chen-Shtoyerman, Rakefet, Pachter, Nicholas, Spigelman, Allan, Zgajnar, Janez, Mora, Josefina, Brewer, Carole, Brady, Angela F, van Os, Theo, Stefansdottir, Vigdis, James, Paul A, Murphy, Declan, Friedman, Eitan, Greenhalgh, Lynn, Obeid, Elias, Murthy, Vedang, Copakova, Lucia, McGrath, John, Strom, Sara, Chamberlain, Anthony, Pope, Jenny, Aaronson, Neil, Ardern-Jones, Audrey, Eyfjord, Jorunn, Falconer, Alison, Foster, Christopher S, Gronberg, Henrik, Hamdy, Freddie C, Johannsson, Oskar, Khoo, Vincent, Lubinski, Jan, Grindedal, Eli Marie, McKinley, Joanne, Shackleton, Kylie, Mitra, Anita V, Moynihan, Clare, Rennert, Gad, Suri, Mohnish, Tricker, Karen, Moss, Sue, Kote-Jarai, Zsofia, Vickers, Andrew, Lilja, Hans, Helfand, Brian T, Eeles, Rosalind A
Published in British journal of cancer

A Positive Association Between Dietary Intake of Higher Cow's Milk-Fat Percentage and Non−High-Density Lipoprotein Cholesterol in Young Children

by Wong, Vincent C.H., Maguire, Jonathon L., Dai, David W.H., Lebovic, Gerald, O'Connor, Deborah L., Birken, Catherine S., Maguire, Jonathon L., Cohn, Ronald, Lau, Eddy, Salter, Michael, Anderson, Laura N., Borkhoff, Cornelia M., Kowal, Christine, Abdurrahman, Murtala, Anderson, Kelly, Baker, Jillian, Barozzino, Tony, Bergeron, Sylvie, Bhagat, Dimple, Bonifacio, Joey, Bowry, Ashna, Calpin, Caroline, Campbell, Douglas, Constantin, Evelyn, Danayan, Karoon, Das, Paul, Derocher, Mary Beth, Do, Anh, Doukas, Kathleen, Egger, Anne, Freeman, Sloane, Gazeley, Sharon, Guiang, Charlie, Ha, Dan, Handford, Curtis, Hanson, Laura, Harrington, Leah, Jansz, Gwen, Kim, Florence, Kwok, Bruce, Lakhoo, Sheila, Lam-Antoniades, Margarita, Leduc, Denis, Li, Alan, Malach, Jessica, Male, Roy, Mascoll, Vashti, Moodie, Rosemary, Nader, Maya, Nash, Katherine, Pena, Kifi, Perlmutar, Marty, Persaud, Navindra, Pinto, Andrew, Porepa, Michelle, Qi, Vikky, Ramji, Noor, Raza, Danyaal, Rosenthal, Alana, Rouleau, Katherine, Ruderman, Caroline, Saunderson, Janet, Schiralli, Vanna, Sgro, Michael, Shuja, Hafiz, Smiltnieks, Barbara, Srikanthan, Cinntha, Uddin, Fatima, van den Heuvel, Meta, Vaughan, Joanne, Weisdorf, Thea, Wijayasinghe, Sheila, Yaremko, John, Ying, Ethel, Young, Elizabeth, Zajdman, Michael, Bazeghi, Farnaz, Bouchard, Vincent, Bustos, Marivic, Dalwadi, Dharma, Koroshegyi, Christine, Malhi, Tarandeep, Thadani, Sharon, Thompson, Julia, Thompson, Laurie, Aglipay, Mary, Bayoumi, Imaan, Cost, Katherine, Eny, Karen, Omand, Jessica, Vanderhout, Shelley, Vanderloo, Leigh, Allen, Christopher, Dai, David W.H., Lebovic, Gerald, Pope, Karen, Thorpe, Kevin, Kandel, Rita, Rodrigues, Michelle, Vandenberghe, Hilde
Published in The Journal of pediatrics

Abstract 1768: Multiplexed shRNA cassettes targeting orthogonal pathways (FAS/PTPN2/TGFBR) enhance the potency of integrated circuit T cells (ICTs) in multiple solid tumor models

by Gardner, Thomas J., Litterman, Adam, Singh, Brenal K., Silva, Luisa, Hari, Mukund, Zhou, Stanley, Tang, Colin, Joshi, Sahil, Gagnon, John, Takacsi-Nagy, Oliver, Hall, Jason, Pope, Hans, Zhang, James, Gomez, Alma, Chen, Jeremy, Mohanty, Suchismita, Thomas, Vince, Quant, Nicholas, Millare, Beatriz, Casbon, Amy-Jo, Bezman, Natalie, Gray-Rupp, Levi, Boroughs, Angela C., Haining, W. Nicholas
Published in Cancer research (Chicago, Ill.)

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

by Mikropoulos, Christos, Hutten Selkirk, Christina G, Saya, Sibel, Bancroft, Elizabeth, Vertosick, Emily, Dadaev, Tokhir, Brendler, Charles, Page, Elizabeth, Dias, Alexander, Evans, D Gareth, Rothwell, Jeanette, Maehle, Lovise, Axcrona, Karol, Eccles, Diana, Jensen, Thomas, Osther, Palle J, van Asperen, Christi J, Vasen, Hans, Kiemeney, Lambertus A, Ringelberg, Janneke, Cybulski, Cezary, Hart, Rachel, Glover, Wayne, Lam, Jimmy, Taylor, Louise, Salinas, Monica, Feliubadaló, Lidia, Oldenburg, Rogier, Cremers, Ruben, Verhaegh, Gerald, Oosterwijk, Jan C, Cook, Jackie, Rosario, Derek J, Buys, Saundra S, Conner, Tom, Powers, Jacquelyn, Ausems, Margreet G E M, Teixeira, Manuel R, Maia, Sofia, Izatt, Louise, Schmutzler, Rita, Rhiem, Kerstin, Foulkes, William D, Boshari, Talia, Davidson, Rosemarie, Helderman-van den Enden, Apollonia T J M, Andrews, Lesley, Walker, Lisa, Snape, Katie, Henderson, Alex, Jobson, Irene, Lindeman, Geoffrey J, Liljegren, Annelie, Harris, Marion, Adank, Muriel A, Kirk, Judy, Susman, Rachel, Chen-Shtoyerman, Rakefet, Pachter, Nicholas, Side, Lucy, Zgajnar, Janez, Brewer, Carole, Gadea, Neus, Gallagher, David, van Os, Theo, Stefansdottir, Vigdis, Murphy, Declan, Friedman, Eitan, Obeid, Elias, Murthy, Vedang, McGrath, John, Teo, Soo-Hwang, Strom, Sara, Leongamornlert, Daniel A, Chamberlain, Anthony, Pope, Jenny, Newlin, Anna C, Aaronson, Neil, Ardern-Jones, Audrey, Castro, Elena, Dearnaley, David, Falconer, Alison, Foster, Christopher S, Gronberg, Henrik, Hamdy, Freddie C, Johannsson, Oskar, Khoo, Vincent, Lubinski, Jan, McKinley, Joanne, Shackleton, Kylie, Mitra, Anita V, Moynihan, Clare, Rennert, Gad, Suri, Mohnish, Tricker, Karen, Moss, Sue, Kote-Jarai, Zsofia, Vickers, Andrew, Helfand, Brian T, Eeles, Rosalind A
Published in British journal of cancer

Abstract 2830: Multiplexed shRNAs targeting FAS and PTPN2 enhance CAR T persistence and anti-tumor efficacy

by Gagnon, John, Litterman, Adam J., Hall, Jason A., Polyak, Dina, Zhou, Stanley, Joshi, Sahil, Takacsi-Nagy, Oliver, Pope, Hans, silva, luisa, Singh, brenal K., Granja, jeffrey M., DeTomaso, david, Aristil-Lepe, Edgar, Tan, Michelle, Galvin, Brendan, Zheng, Grace X., Santoro, Stephen, Cooper, Aaron, Bezman, Natalie, Haining, W Nicholas
Published in Cancer research (Chicago, Ill.)

Fit for School Study protocol: early child growth, health behaviours, nutrition, cardiometabolic risk and developmental determinants of a child’s school readiness, a prospective co...

by Birken, Catherine S, Omand, Jessica A, Nurse, Kim M, Borkhoff, Cornelia M, Koroshegyi, Christine, Lebovic, Gerald, Maguire, Jonathon L, Mamdani, Muhammad, Parkin, Patricia C, Randall Simpson, Janis, Tremblay, Mark S, Duku, Eric, Reid-Westoby, Caroline, Janus, Magdalena
Published in BMJ open

Design of the Rule Out Myocardial Ischemia/Infarction Using Computer Assisted Tomography: A multicenter randomized comparative effectiveness trial of cardiac computed tomography ve...

by Hoffmann, Udo, MD, MPH, Truong, Quynh A., MD, MPH, Fleg, Jerome L., MD, Goehler, Alexander, MD, PhD, Gazelle, Scott, MD, PhD, Wiviott, Stephen, MD, Lee, Hang, MD, Udelson, James E., MD, Schoenfeld, David, PhD
Published in The American heart journal