Identification, Optimization, and Pharmacology of Acylurea GHS-R1a Inverse Agonists

by McCoull, William, Barton, Peter, Brown, Alastair J. H, Bowker, Suzanne S, Cameron, Jennifer, Clarke, David S, Davies, Robert D. M, Dossetter, Alexander G, Ertan, Anne, Fenwick, Mark, Green, Clive, Holmes, Jane L, Martin, Nathaniel, Masters, David, Moore, Jane E, Newcombe, Nicholas J, Newton, Claire, Pointon, Helen, Robb, Graeme R, Sheldon, Christopher, Stokes, Stephen, Morgan, David
Published in Journal of medicinal chemistry

Making medicinal chemistry more effective—application of Lean Sigma to improve processes, speed and quality

by Andersson, Shalini, Armstrong, Alan, Björe, Annika, Bowker, Sue, Chapman, Steve, Davies, Rob, Donald, Craig, Egner, Bryan, Elebring, Thomas, Holmqvist, Sara, Inghardt, Tord, Johannesson, Petra, Johansson, Magnus, Johnstone, Craig, Kemmitt, Paul, Kihlberg, Jan, Korsgren, Pernilla, Lemurell, Malin, Moore, Jane, Pettersson, Jonas A., Pointon, Helen, Pontén, Fritiof, Schofield, Paul, Selmi, Nidhal, Whittamore, Paul
Published in Drug discovery today

Assessment of cardiomyocyte contraction in human-induced pluripotent stem cell-derived cardiomyocytes

by Pointon, Amy, Harmer, Alexander R, Dale, Ian L, Abi-Gerges, Najah, Bowes, Joanne, Pollard, Christopher, Garside, Helen
Published in Toxicological sciences

Screening of healthcare workers for SARS-CoV-2 highlights the role of asymptomatic carriage in COVID-19 transmission

by Rivett, Lucy, Sridhar, Sushmita, Sparkes, Dominic, Routledge, Matthew, Jones, Nick K, Forrest, Sally, Young, Jamie, Pereira-Dias, Joana, Hamilton, William L, Ferris, Mark, Torok, M Estee, Meredith, Luke, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Samworth, Richard J, Bradley, John R, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Matheson, Nicholas J, Wright, Giles, Goodfellow, Ian G, Baker, Stephen, Weekes, Michael P
Published in eLife

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

by Mancuso, Renzo, Fryatt, Gemma, Cleal, Madeleine, Obst, Juliane, Pipi, Elena, Monzón-Sandoval, Jimena, Ribe, Elena, Winchester, Laura, Webber, Caleb, Nevado, Alejo, Jacobs, Tom, Austin, Nigel, Theunis, Clara, Grauwen, Karolien, Daniela Ruiz, Eva, Mudher, Amrit, Vicente-Rodriguez, Marta, Parker, Christine A, Simmons, Camilla, Cash, Diana, Richardson, Jill, Jones, Declan N C, Lovestone, Simon, Gómez-Nicola, Diego, Perry, V Hugh
Published in Brain (London, England : 1878)

A Multi-proxy Provenance Study of Late Carboniferous to Middle Jurassic Sandstones in the Eastern Sverdrup Basin and Its Bearing on Arctic Palaeogeographic Reconstructions

by Pointon, Michael A., Smyth, Helen, Omma, Jenny E., Morton, Andrew C., Schneider, Simon, Hülse, Peter, Rippington, Stephen J., Lopez-Mir, Berta, Crowley, Quentin G., Millar, Ian, Whitehouse, Martin J., Frei, Dirk, Scott, Robert A., Flowerdew, Michael J.
Published in Geosciences (Basel)

Inflammatory biomarkers in Alzheimer's disease plasma

by Morgan, Angharad R., Touchard, Samuel, Barkhof, Frederik, Bertram, Lars, Bos, Isabelle, Dobricic, Valerija, Frisoni, Giovanni, Frölich, Lutz, Gabel, Silvey, Kettunen, Petronella, Lleó, Alberto, Martinez-Lage, Pablo, Mecocci, Patrizia, Meersmans, Karen, Molinuevo, José Luis, Peyratout, Gwendoline, Popp, Julius, Richardson, Jill, Scheltens, Philip, Soininen, Hikka, Tsolaki, Magda, Vos, Stephanie, Wahlund, Lars-Olof, Wallin, Anders, Westwood, Sarah, Lovestone, Simon, Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Crofts, Anna L., Foster, Andrew C., Kitzbichler, Manfred G., Lynall, Mary-Ellen, Maurice, Christina, St George Hyslop, Peter, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, Claire A., Morgan, Angharad R., O'Hagan, Caroline, Cavanagh, Jonathan, Deith, Catherine, McColl, Alison, Scouller, Paul, Sutherland, Murray, Khan, Shahid, Murphy, Phil, Patel, Jai, de Boer, Peter, Drevets, Wayne C., Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Cash, Diana, Mondelli, Valeria, Nikkheslat, Naghmeh, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Van Loo, Victoria, Vicente-Rodriguez, Marta, Worrell, Courtney, Plath, Niels, Egebjerg, Jan, Gastambide, Francois, Pederson, Jan Torleif, Campbell, Brian, Möller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu (Dante), Jones, Helen, Lovestone, Simon, Mada, Francisca, Oladejo, Akintayo, Ribe, Elena, Smith, Katy, Vyas, Anviti, Sporn, Jonathan, Fryatt, Gemma, Gomez-Nicola, Diego, Mancuso, Renzo, Reynolds, Richard, Cercignani, Mara, Clarke, Charlotte L., Hoskins, Elizabeth, Murray, Rosemary, Wlazly, Dominika, Mount, Howard
Published in Alzheimer's & dementia

Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wi...

by Reilly, Muredach P, Dr, Li, Mingyao, PhD, He, Jing, PhD, Ferguson, Jane F, PhD, Stylianou, Ioannis M, PhD, Mehta, Nehal N, MD, Burnett, Mary Susan, PhD, Devaney, Joseph M, PhD, Knouff, Christopher W, MD, Thompson, John R, Prof, Horne, Benjamin D, PhD, Stewart, Alexandre FR, PhD, Assimes, Themistocles L, MD, Wild, Philipp S, MD, Allayee, Hooman, PhD, Nitschke, Patrick Linsel, MD, Patel, Riyaz S, MD, Martinelli, Nicola, MD, Girelli, Domenico, Prof, Quyyumi, Arshed A, Prof, Anderson, Jeffrey L, Prof, Erdmann, Jeanette, Prof, Hall, Alistair S, MD, Schunkert, Heribert, Prof, Quertermous, Thomas, Prof, Blankenberg, Stefan, Prof, Hazen, Stanley L, Prof, Roberts, Robert, Prof, Kathiresan, Sekar, MD, Samani, Nilesh J, Prof, Epstein, Stephen E, Prof, Rader, Daniel J, Prof
Published in The Lancet (British edition)

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

by Burton, Paul R, Clayton, David G, Cardon, Lon R, Craddock, Nick, Deloukas, Panos, Duncanson, Audrey, Kwiatkowski, Dominic P, McCarthy, Mark I, Ouwehand, Willem H, Samani, Nilesh J, Todd, John A, Donnelly, Peter, Barrett, Jeffrey C
Published in Nature

Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

by Nejentsev, Sergey, Bailey, Rebecca, Hardy, Matthew, Cooper, Jason D, Howson, Joanna M. M, Walker, Neil M, Maier, Lisa M, Ribas, Gloria, King, Erna, Szeszko, Jeffrey, Field, Sarah F, Reynolds, Pamela, Smyth, Deborah, Todd, John A, Hulme, John, Clayton, David G, Masters, Jennifer, Stevens, Helen E, Campbell, R. Duncan
Published in Nature

Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes

by Weedon, Michael N, Lindgren, Cecilia M, Timpson, Nicholas J, Freathy, Rachel M, Morris, Andrew P, Walker, Mark, Doney, Alex S.F, Clayton, David G, Craddock, Nick, Deloukas, Panos, Ouwehand, Willem H, Todd, John A, Evans, David, Leung, Hin-Tak, Attwood, Antony P, Boorman, James P, Everson, Ursula, Knight, Alexandra S, Stevens, Helen E, Walters, Graham R, Walker, Neil M, Winzer, Thilo, Ring, Susan M, Strachan, David P, Pembrey, Marcus, Fraser, Christine, Jones, Ian R, Kirov, George, Williamson, Richard, Young, Allan H, Ferrier, I. Nicol, Iles, Mark M, Maqbool, Azhar, Hall, Alistair S, Braund, Peter S, Stevens, Suzanne, Thompson, John R, Bredin, Francesca, Lees, Charles W, Forbes, Alastair, Lewis, Cathryn M, Prescott, Natalie J, Todhunter, Catherine E, Ahmad, Tariq, Cummings, Fraser R, Jewell, Derek P, Webster, John, Connell, John, Dominiczak, Anna, Gungadoo, Johannie, Lee, Kate L, Munroe, Patricia B, Onipinla, Abiodun, Caulfield, Mark, Farrall, Martin, Potter, Catherine, Silman, Alan J, Worthington, Jane, Newport, Melanie, Sirugo, Giorgio, Lyons, Emily, Farrar, Claire, Brown, Matthew A, Simmonds, Matthew J, Gough, Stephen C.L, Ban, Maria, Goris, An, Compston, Alastair, Hunt, Sarah E, Inouye, Michael, McGinnis, Ralph, Widden, Claire, Su, Zhan, Teo, Yik Ying, Ouwehand, Nilesh J, Samani, Michael R, Ardern-Jones, A, Brice, G, Castle, B, Donaldson, A, Eeles, R, Goodman, S, Gray, J, Greenhalgh, L, Hodgson, S.V, Izatt, L, Jeffers, L, Locke, I, Longmuir, M, Mackay, J, Magee, A, Miedzybrodzka, Z, Paterson, J, Porteous, M, Rowe, S, Shanley, S, Saggar, A, Side, L, Steel, M, Thomas, M
Published in Science (American Association for the Advancement of Science)

Effective control of SARS-CoV-2 transmission between healthcare workers during a period of diminished community prevalence of COVID-19

by Jones, Nick K, Rivett, Lucy, Sparkes, Dominic, Forrest, Sally, Sridhar, Sushmita, Young, Jamie, Pereira-Dias, Joana, Cormie, Claire, Gill, Harmeet, Reynolds, Nicola, Wantoch, Michelle, Routledge, Matthew, Warne, Ben, Levy, Jack, Córdova Jiménez, William David, Samad, Fathima Nisha Begum, McNicholas, Chris, Ferris, Mark, Gray, Jane, Gill, Michael, Curran, Martin D, Fuller, Stewart, Chaudhry, Afzal, Shaw, Ashley, Bradley, John R, Hannon, Gregory J, Goodfellow, Ian G, Dougan, Gordon, Smith, Kenneth Gc, Lehner, Paul J, Wright, Giles, Matheson, Nicholas J, Baker, Stephen, Weekes, Michael P
Published in eLife

Assessment of extracellular field potential and Ca2+ transient signals for early QT/pro-arrhythmia detection using human induced pluripotent stem cell-derived cardiomyocytes

by Abi-Gerges, Najah, Pointon, Amy, Oldman, Karen L., Brown, Martin R., Pilling, Mark A., Sefton, Clare E., Garside, Helen, Pollard, Christopher E.
Published in Journal of pharmacological and toxicological methods

Human papillomavirus vaccination in Auckland: Reducing ethnic and socioeconomic inequities

by Poole, Tracey, Goodyear-Smith, Felicity, Petousis-Harris, Helen, Desmond, Natalie, Exeter, Daniel, Pointon, Leah, Jayasinha, Ranmalie
Published in Vaccine

Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease

by Vicente-Rodríguez, Marta, Mancuso, Renzo, Peris-Yague, Alba, Simmons, Camilla, Gómez-Nicola, Diego, Perry, V Hugh, Turkheimer, Federico, Lovestone, Simon, Parker, Christine A, Cash, Diana
Published in Journal of neuroinflammation

Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility

by Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Gibbons, Laura, Plant, Darren, Wilson, Anthony G., Marinou, Ioanna, Morgan, Ann, Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille, Worthington, Jane
Published in Human molecular genetics

Would field potential duration, recorded from human induced pluripotent stem cell-derived cardiomyocytes, have utility as an early QT screen?

by Abi-Gerges, Najah, Oldman, Karen L., Garside, Helen, Pointon, Amy, Pollard, Chris E.
Published in Journal of pharmacological and toxicological methods

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

by BAN, Maria, GORIS, An, DUBOIS, Bénédicte, HARBO, Hanne F, CELIUS, Elisabeth G, SPURKLAND, Anne, STRANGE, Richard, HAWKINS, Clive, ROBERTSON, Neil P, DUDBRIDGE, Frank, WASON, James, DE JAGER, Philip L, LORENTZEN, Aslaug R, HAFLER, David, RIOUX, John D, IVINSON, Adrian J, MCCAULEY, Jacob L, PERICAK-VANCE, Margaret, OKSENBERG, Jorge R, HAUSER, Stephen L, SEXTON, David, HAINES, Jonathan, SAWCER, Stephen, BAKER, Amie, MIHALOVA, Tania, INGRAM, Gillian, BOOTH, David R, HEARD, Robert N, STEWART, Graeme J, BOGAERT, Elke
Published in European journal of human genetics : EJHG

Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23

by Orozco, Gisela, Hinks, Anne, Eyre, Steve, Ke, Xiayi, Gibbons, Laura J., Bowes, John, Flynn, Edward, Martin, Paul, Wilson, Anthony G., Bax, Deborah E., Morgan, Ann W., Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille, Thomson, Wendy, Barton, Anne, Worthington, Jane
Published in Human molecular genetics

Association of Novel Genetic Loci With Circulating Fibrinogen Levels: A Genome-Wide Association Study in 6 Population-Based Cohorts

by Dehghan, Abbas, Yang, Qiong, Peters, Annette, Basu, Saonli, Bis, Joshua C, Rudnicka, Alicja R, Kavousi, Maryam, Chen, Ming-Huei, Baumert, Jens, Lowe, Gordon D.O, McKnight, Barbara, Tang, Weihong, de Maat, Moniek, Larson, Martin G, Eyhermendy, Susana, McArdle, Wendy L, Lumley, Thomas, Pankow, James S, Hofman, Albert, Massaro, Joseph M, Rivadeneira, Fernando, Kolz, Melanie, Taylor, Kent D, van Duijn, Cornelia M, Kathiresan, Sekar, Illig, Thomas, Aulchenko, Yurii S, Volcik, Kelly A, Johnson, Andrew D, Uitterlinden, Andre G, Tofler, Geoffrey H, Gieger, Christian, Wellcome Trust Case Control Consortium, Psaty, Bruce M, Couper, David J, Boerwinkle, Eric, Koenig, Wolfgang, O'Donnell, Christopher J, Witteman, Jacqueline C, Strachan, David P, Smith, Nicholas L, Folsom, Aaron R
Published in Genetics (Austin)