Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation by Swenson, Samantha A, Dobish, Kasidy K, Peters, Hendrik C, Bea Winship, C, Willow Hynes-Smith, R, Caplan, Mika, Wittorf, Karli J, Ghosal, Gargi, Buckley, Shannon M

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Enzymatic removal of sialic acid enables iCIEF stability monitoring of charge variants of a highly sialylated bispecific antibody by Peters, Björn‐Hendrik, Bautista, James, Slaney, Thomas R., Guo, Hongyue, Huang, Richard Y.‐C., Krause, Mary E., Zeng, Ming, Cheng, Julie, Chen, Zhi

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Towards a thesaurus of plant characteristics: an ecological contribution by Garnier, Eric, Stahl, Ulrike, Laporte, Marie-Angélique, Kattge, Jens, Mougenot, Isabelle, Kühn, Ingolf, Laporte, Baptiste, Amiaud, Bernard, Ahrestani, Farshid S., Bönisch, Gerhard, Bunker, Daniel E., Cornelissen, J. Hans C., Díaz, Sandra, Enquist, Brian J., Gachet, Sophie, Jaureguiberry, Pedro, Kleyer, Michael, Lavorel, Sandra, Maicher, Lutz, Pérez-Harguindeguy, Natalia, Poorter, Hendrik, Schildhauer, Mark, Shipley, Bill, Violle, Cyrille, Weiher, Evan, Wirth, Christian, Wright, Ian J., Klotz, Stefan

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Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial by van der Pas, Martijn HGM, MD, Haglind, Eva, Prof, Cuesta, Miguel A, Prof, Fürst, Alois, Prof, Lacy, Antonio M, Prof, Hop, Wim CJ, PhD, Bonjer, Hendrik Jaap, Prof

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Signatures of diversifying selection in European pig breeds by Wilkinson, Samantha, Lu, Zen H, Megens, Hendrik-Jan, Archibald, Alan L, Haley, Chris, Jackson, Ian J, Groenen, Martien A M, Crooijmans, Richard P M A, Ogden, Rob, Wiener, Pamela

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Morphological and Transcriptional Responses to CRISPRi Knockdown of Essential Genes in Escherichia coli by Silvis, Melanie R, Rajendram, Manohary, Shi, Handuo, Osadnik, Hendrik, Gray, Andrew N, Cesar, Spencer, Peters, Jason M, Hearne, Cameron C, Kumar, Parth, Todor, Horia, Huang, Kerwyn Casey, Gross, Carol A

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Common Carotid Intima-Media Thickness Measurements in Cardiovascular Risk Prediction: A Meta-analysis by Den Ruijter, Hester M, Peters, Sanne A. E, Anderson, Todd J, Britton, Annie R, Dekker, Jacqueline M, Eijkemans, Marinus J, Engström, Gunnar, Evans, Gregory W, de Graaf, Jacqueline, Grobbee, Diederick E, Hedblad, Bo, Hofman, Albert, Holewijn, Suzanne, Ikeda, Ai, Kavousi, Maryam, Kitagawa, Kazuo, Kitamura, Akihiko, Koffijberg, Hendrik, Lonn, Eva M, Lorenz, Matthias W, Mathiesen, Ellisiv B, Nijpels, Giel, Okazaki, Shuhei, O’Leary, Daniel H, Polak, Joseph F, Price, Jackie F, Robertson, Christine, Rembold, Christopher M, Rosvall, Maria, Rundek, Tatjana, Salonen, Jukka T, Sitzer, Matthias, Stehouwer, Coen D. A, Witteman, Jacqueline C, Moons, Karel G, Bots, Michiel L

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Large-scale gene-centric analysis identifies novel variants for coronary artery disease by Butterworth, AS, Farrall, M, Hardwick, RJ, Saleheen, D, Peden, JF, Soranzo, N, Chambers, JC, Sivapalaratnam, S, Kleber, ME, Klopp, N, Erdmann, J, Assimes, TL, Ball, SG, Balmforth, AJ, Barnes, TA, Basart, H, Baumert, J, Bezzina, CR, Boerwinkle, E, Boehm, BO, Brocheton, J, Bugert, P, Cambien, F, Clarke, R, Codd, V, Collins, R, Couper, D, Cupples, LA, de Jong, JS, Diemert, P, Ejebe, K, Elbers, CC, Elliott, P, Fornage, M, Franzosi, MG, Frossard, P, Garner, S, Goel, A, Goodall, AH, Hengstenberg, C, Hunt, SE, Kastelein, JJP, Klungel, OH, Kluter, H, Koch, K, Konig, IR, Kooner, AS, Laaksonen, R, Lathrop, M, Li, MY, Liu, K, McPherson, R, Musameh, MD, Musani, S, Nelson, CP, O'Donnell, CJ, Ongen, H, Papanicolaou, G, Peters, A, Peters, BJM, Potter, S, Psaty, BM, Qu, LM, Rader, DJ, Rasheed, A, Rice, C, Scott, J, Seedorf, U, Sehmi, JS, Sotoodehnia, N, Stark, K, Stephens, J, van der Schoot, CE, van der Schouw, YT, Tomaszewski, M, van der Harst, P, Vasan, RS, Wilde, AAM, Willenborg, C, Winkelmann, BR, Zaidi, M, Zhang, WH, Ziegler, A, de Bakker, PIW, Koenig, W, Marz, W, Trip, MD, Reilly, MP, Kathiresan, S, Schunkert, H, Hamsten, A, Hall, AS, Kooner, JS, Thompson, SG, Thompson, JR, Deloukas, P, Ouwehand, WH, Watkins, H, Danesh, J, Samani, NJ

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Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally... by Bahadoer, Renu R, Dijkstra, Esmée A, van Etten, Boudewijn, Marijnen, Corrie A M, Putter, Hein, Kranenbarg, Elma Meershoek-Klein, Nagtegaal, Iris D, Beets-Tan, Regina G H, Blomqvist, Lennart K, Fokstuen, Tone, Capdevila, Jaume, Cervantes, Andrés, Glimelius, Bengt, Østergaard, L., Svendsen Jensen, F., Pfeiffer, P., Jensen, K.E.J., Schreurs, W.H., van der Vliet, J.J., Bruynzeel, A.M.E., Kerver, E.D., van Leerdam, M.E., Tanis, P.J., Bleeker, W.A., Ten Tije, A.J., Immink, J.M., Marinelli, A.W.K.S., Ceha, H.M., Bekker, J.H.M., Creemers, G.J., Nieuwenhuijzen, G.A.P., van den Berg, H., van der Deure, W.M., Olieman, A.F.T., van den Bergh, A.C.M., de Groot, D.J.A., Havenga, K., Beukema, J.C., Vanstiphout, J.W.P., de Valk, B., Eijsbouts, Q.A.J., Polée, M.B., Hoff, C., Peters, F.P., Radema, S.A., de Wilt, H., Braam, P., Veldhuis, G.J., Hess, D., Rozema, T., Reerink, O., Pronk, A., Vos, J., Tascilar, M., Patijn, G.A., Kersten, C., Mjåland, O., Nesbakken, A.N., Benedik, J., Velenik, V., Capdevila, J., Espin, E., Salazar, R., Biondo, S., die Trill, J., Aparicio, J., Garcia Granero, E., Safont, M.J., Cervantes, A., Espí Macías, A., Malmberg, L., Dafnis, G., Berglund, A., Österlund, L., Kovacs, K., Hol, J., Ottosson, S., Carlsson, G., Bratthäll, C., Assarsson, J., Lödén, B.L., Hede, P., Verbiené, I., Hallböök, O., Johnsson, A., Lydrup, M.L., Villmann, K., Matthiessen, P., Haux, J., Skullman, S., Holm, T., Flygare, P., Walldén, M., Lundberg, O., Radu, C., Påhlman, L., Palenius, U., Parinkh, P., Kim, H., Silviera, M.L.

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Neuroinflammation in cognitive decline post-cardiac surgery (the FOCUS study): an observational study protocol by Peters van Ton, Annemieke M, Duindam, Harmke B., van Tuijl, Julia, Li, Wilson WL, Dieker, Hendrik-Jan, Riksen, Niels P, Meijer, FJ Anton, Kessels, Roy PC, Kohn, Nils, van der Hoeven, Johannes G., Pickkers, Peter, Rijpkema, Mark, Abdo, Wilson F

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Cover Image by Maasri, Alain, Jähnig, Sonja C., Adamescu, Mihai C., Adrian, Rita, Baigun, Claudio, Baird, Donald J., Batista‐Morales, Angelica, Bonada, Núria, Brown, Lee E., Cai, Qinghua, Campos‐Silva, Joao V., Clausnitzer, Viola, Contreras‐MacBeath, Topiltzin, Cooke, Steven J., Datry, Thibault, Delacámara, Gonzalo, De Meester, Luc, Dijkstra, Klaus‐Douwe B., Do, Van Tu, Domisch, Sami, Dudgeon, David, Erös, Tibor, Freitag, Hendrik, Freyhof, Joerg, Friedrich, Jana, Friedrichs‐Manthey, Martin, Geist, Juergen, Gessner, Mark O., Goethals, Peter, Gollock, Matthew, Gordon, Christopher, Grossart, Hans‐Peter, Gulemvuga, Georges, Gutiérrez‐Fonseca, Pablo E., Haase, Peter, Hering, Daniel, Hahn, Hans Jürgen, Hawkins, Charles P., He, Fengzhi, Heino, Jani, Hermoso, Virgilio, Hogan, Zeb, Hölker, Franz, Jeschke, Jonathan M., Jiang, Meilan, Johnson, Richard K., Kalinkat, Gregor, Karimov, Bakhtiyor K., Kasangaki, Aventino, Kimirei, Ismael A., Kohlmann, Bert, Kuemmerlen, Mathias, Kuiper, Jan J., Kupilas, Benjamin, Langhans, Simone D., Lansdown, Richard, Leese, Florian, Magbanua, Francis S., Matsuzaki, Shin‐ichiro S., Monaghan, Michael T., Mumladze, Levan, Muzon, Javier, Mvogo Ndongo, Pierre A., Nejstgaard, Jens C., Nikitina, Oxana, Ochs, Clifford, Odume, Oghenekaro Nelson, Opperman, Jeffrey J., Patricio, Harmony, Pauls, Steffen U., Raghavan, Rajeev, Ramírez, Alonso, Rashni, Bindiya, Ross‐Gillespie, Vere, Samways, Michael J., Schäfer, Ralf B., Schmidt‐Kloiber, Astrid, Seehausen, Ole, Shah, Deep Narayan, Sharma, Subodh, Soininen, Janne, Sommerwerk, Nike, Stockwell, Jason D., Suhling, Frank, Tachamo Shah, Ram Devi, Tharme, Rebecca E., Thorp, James H., Tickner, David, Tockner, Klement, Tonkin, Jonathan D., Valle, Mireia, Vitule, Jean, Volk, Martin, Wang, Ding, Wolter, Christian, Worischka, Susanne

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Pig domestication and human-mediated dispersal in western Eurasia revealed through ancient DNA and geometric morphometrics by Ottoni, Claudio, Flink, Linus Girdland, Evin, Allowen, Geörg, Christina, De Cupere, Bea, Van Neer, Wim, Bartosiewicz, László, Linderholm, Anna, Barnett, Ross, Peters, Joris, Decorte, Ronny, Waelkens, Marc, Vanderheyden, Nancy, Ricaut, François-Xavier, Cakirlar, Canan, Cevik, Ozlem, Hoelzel, A Rus, Mashkour, Marjan, Karimlu, Azadeh Fatemeh Mohaseb, Seno, Shiva Sheikhi, Daujat, Julie, Brock, Fiona, Pinhasi, Ron, Hongo, Hitomi, Perez-Enciso, Miguel, Rasmussen, Morten, Frantz, Laurent, Megens, Hendrik-Jan, Crooijmans, Richard, Groenen, Martien, Arbuckle, Benjamin, Benecke, Nobert, Vidarsdottir, Una Strand, Burger, Joachim, Cucchi, Thomas, Dobney, Keith, Larson, Greger

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To defer or not to defer? A German longitudinal multicentric assessment of clinical practice in urology during the COVID-19 pandemic by Harke, Nina N, Radtke, Jan P, Hadaschik, Boris A, Bach, Christian, Berger, Frank P, Blana, Andreas, Borgmann, Hendrik, Distler, Florian A, Edeling, Sebastian, Egner, Tobias, Engels, Christina L, Farzat, Mahmoud, Haese, Alexander, Hein, Rainer, Kuczyk, Markus A, Manseck, Andreas, Moritz, Rudolf, Musch, Michael, Peters, Inga, Pokupic, Sasa, Rocco, Bernardo, Schneider, Andreas, Schumann, André, Schwentner, Christian, Sighinolfi, Chiara M, Buse, Stephan, Stolzenburg, Jens-Uwe, Truß, Michael C, Waldner, Michael, Wülfing, Christian, Zimmermanns, Volker, Witt, Jörn H, Wagner, Christian

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Ventilation management and clinical outcomes in invasively ventilated patients with COVID-19 (PRoVENT-COVID): a national, multicentre, observational cohort study by Botta, Michela, Tsonas, Anissa M, Pillay, Janesh, Boers, Leonoor S, Algera, Anna Geke, Bos, Lieuwe D J, Dongelmans, Dave A, Hollmann, Marcus W, Horn, Janneke, Vlaar, Alexander P J, Schultz, Marcus J, Ary Serpa Neto, Frederique Paulus for the PRoVENT-COVID Collaborative Group

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Diet-related risk factors for leprosy: a case-control study by Wagenaar, Inge, van Muiden, Lisanne, Alam, Khorshed, Bowers, Robert, Hossain, Md Anwar, Kispotta, Kolpona, Richardus, Jan Hendrik

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Effect of Metformin on Left Ventricular Function After Acute Myocardial Infarction in Patients Without Diabetes: The GIPS-III Randomized Clinical Trial by Lexis, Chris P. H, van der Horst, Iwan C. C, Lipsic, Erik, Wieringa, Wouter G, de Boer, Rudolf A, van den Heuvel, Ad F. M, van der Werf, Hindrik W, Schurer, Remco A. J, Pundziute, Gabija, Tan, Eng S, Nieuwland, Wybe, Willemsen, Hendrik M, Dorhout, Bernard, Molmans, Barbara H. W, van der Horst-Schrivers, Anouk N. A, Wolffenbuttel, Bruce H. R, ter Horst, Gert J, van Rossum, Albert C, Tijssen, Jan G. P, Hillege, Hans L, de Smet, Bart J. G. L, van der Harst, Pim, van Veldhuisen, Dirk J

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2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy by Glikson, Michael, Nielsen, Jens Cosedis, Kronborg, Mads Brix, Michowitz, Yoav, Auricchio, Angelo, Barbash, Israel Moshe, Barrabés, José A, Boriani, Giuseppe, Braunschweig, Frieder, Brignole, Michele, Burri, Haran, Coats, Andrew J S, Deharo, Jean-Claude, Delgado, Victoria, Diller, Gerhard-Paul, Israel, Carsten W, Keren, Andre, Knops, Reinoud E, Kotecha, Dipak, Leclercq, Christophe, Merkely, Béla, Starck, Christoph, Thylén, Ingela, Tolosana, José Maria

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Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors by Reddy, Nakita, Girdhari, Letisha, Shungube, Mbongeni, Gouws, Arnoldus C, Peters, Byron K, Rajbongshi, Kamal K, Baijnath, Sooraj, Mdanda, Sipho, Ntombela, Thandokuhle, Arumugam, Thilona, Bester, Linda A, Singh, Sanil D, Chuturgoon, Anil, Arvidsson, Per I, Maguire, Glenn E M, Kruger, Hendrik G, Govender, Thavendran, Naicker, Tricia

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A Combined Metabonomic and Proteomic Approach Identifies Frontal Cortex Changes in a Chronic Phencyclidine Rat Model in Relation to Human Schizophrenia Brain Pathology by WESSELING, Hendrik, CHAN, Man K, TSANG, T. M, ERNST, Agnes, PETERS, Fabian, GUEST, Paul C, HOLMES, Elaine, BAHN, Sabine

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Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment by Meijs, Daniek A M, van Bussel, Bas C T, Stessel, Björn, Mehagnoul-Schipper, Jannet, Hana, Anisa, Scheeren, Clarissa I E, Peters, Sanne A E, van Mook, Walther N K A, van der Horst, Iwan C C, Marx, Gernot, Mesotten, Dieter, Ghossein-Doha, Chahinda

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