Analytical validation of a standardised scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicentre collaboration by Leung, Samuel C Y, Nielsen, Torsten O, Zabaglo, Lila A, Arun, Indu, Badve, Sunil S, Bane, Anita L, Bartlett, John M S, Borgquist, Signe, Chang, Martin C, Dodson, Andrew, Ehinger, Anna, Fineberg, Susan, Focke, Cornelia M, Gao, Dongxia, Gown, Allen M, Gutierrez, Carolina, Hugh, Judith C, Kos, Zuzana, Lænkholm, Anne‐Vibeke, Mastropasqua, Mauro G., Moriya, Takuya, Nofech‐Mozes, Sharon, Osborne, C Kent, Penault‐Llorca, Frédérique M, Piper, Tammy, Sakatani, Takashi, Salgado, Roberto, Starczynski, Jane, Sugie, Tomoharu, Vegt, Bert, Viale, Giuseppe, Hayes, Daniel F, McShane, Lisa M, Dowsett, Mitch

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Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group by Nielsen, Torsten O, Leung, Samuel C. Y, Rimm, David L, Dodson, Andrew, Acs, Balazs, Badve, Sunil, Denkert, Carsten, Ellis, Matthew J, Fineberg, Susan, Flowers, Margaret, Kreipe, Hans H, Laenkholm, Anne-Vibeke, Pan, Hongchao, Penault-Llorca, Frédérique M, Polley, Mei-Yin, Salgado, Roberto, Smith, Ian E, Sugie, Tomoharu, Bartlett, John M. S, McShane, Lisa M, Dowsett, Mitch, Hayes, Daniel F

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Analytical validation of a standardized scoring protocol for Ki67: phase 3 of an international multicenter collaboration by Leung, Samuel C Y, Nielsen, Torsten O, Zabaglo, Lila, Arun, Indu, Badve, Sunil S, Bane, Anita L, Bartlett, John M S, Borgquist, Signe, Chang, Martin C, Dodson, Andrew, Enos, Rebecca A, Fineberg, Susan, Focke, Cornelia M, Gao, Dongxia, Gown, Allen M, Grabau, Dorthe, Gutierrez, Carolina, Hugh, Judith C, Kos, Zuzana, Lænkholm, Anne-Vibeke, Lin, Ming-Gang, Mastropasqua, Mauro G, Moriya, Takuya, Nofech-Mozes, Sharon, Osborne, C Kent, Penault-Llorca, Frédérique M, Piper, Tammy, Sakatani, Takashi, Salgado, Roberto, Starczynski, Jane, Viale, Giuseppe, Hayes, Daniel F, McShane, Lisa M, Dowsett, Mitch

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An international study to increase concordance in Ki67 scoring by Polley, Mei-Yin C, Leung, Samuel C Y, Gao, Dongxia, Mastropasqua, Mauro G, Zabaglo, Lila A, Bartlett, John M S, McShane, Lisa M, Enos, Rebecca A, Badve, Sunil S, Bane, Anita L, Borgquist, Signe, Fineberg, Susan, Lin, Ming-Gang, Gown, Allen M, Grabau, Dorthe, Gutierrez, Carolina, Hugh, Judith C, Moriya, Takuya, Ohi, Yasuyo, Osborne, C Kent, Penault-Llorca, Frédérique M, Piper, Tammy, Porter, Peggy L, Sakatani, Takashi, Salgado, Roberto, Starczynski, Jane, Lænkholm, Anne-Vibeke, Viale, Giuseppe, Dowsett, Mitch, Hayes, Daniel F, Nielsen, Torsten O

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Prospective Clinical Utility Study of the Use of the 21‐Gene Assay in Adjuvant Clinical Decision Making in Women With Estrogen Receptor‐Positive Early Invasive Breast Cancer: Resul... by Gligorov, Joseph, Pivot, Xavier B., Jacot, William, Naman, Hervé L., Spaeth, Dominique, Misset, Jean‐Louis, Largillier, Rémy, Sautiere, Jean‐Loup, Roquancourt, Anne, Pomel, Christophe, Rouanet, Philippe, Rouzier, Roman, Penault‐Llorca, Frederique M.

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Abstract P5-02-01: Analytical validation and prognostic potential of an automated digital scoring protocol for Ki67: An International Ki67 Working Group study by Acs, Balazs, Leung, Samuel C.Y., Kidwell, Kelley M., Arun, Indu, Augulis, Renaldas, Badve, Sunil S., Bai, Yalai, Bane, Anita L., Bartlett, John M.S., Bayani, Jane, Bigras, Gilbert, Blank, Annika, Borgquist, Signe, Buikema, Henk, Chang, Martin C., Dietz, Robin L., Dodson, Andrew, Ehinger, Anna, Fineberg, Susan, Focke, Cornelia M., Gao, Dongxia, Gown, Allen M., Gutierrez, Carolina, Hartman, Johan, Hugh, Judith C., Kos, Zuzana, Lænkholm, Anne-Vibeke, Laurinavicius, Arvydas, Levenson, Richard M., Mahboubi-Ardakani, Rustin, Mastropasqua, Mauro G., Moriya, Takuya, Nofech-Mozes, Sharon, Osborne, C. Kent, Pantanowitz, Liron, Penault-Llorca, Frédérique M., Piper, Tammy, Quintayo, Mary Anne, Rau, Tilman T., Reinhard, Stefan, Robertson, Stephanie, Sakatani, Takashi, Salgado, Roberto, Spears, Melanie, Starczynski, Jane, Sugie, Tomoharu, van der Vegt, Bert, Viale, Giuseppe, Virk, Shakeel, Zabaglo, Lila A., Hayes, Daniel F., Dowsett, Mitch, Nielsen, Torsten O., Rimm, David L.

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Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study by Acs, Balazs, Leung, Samuel C.Y., Augulis, Renaldas, Bai, Yalai, Bane, Anita L., Bartlett, John M.S., Bayani, Jane, Bigras, Gilbert, Buikema, Henk, Chang, Martin C., Fineberg, Susan, Focke, Cornelia M., Gao, Dongxia, Gown, Allen M., Gutierrez, Carolina, Kos, Zuzana, Lænkholm, Anne-Vibeke, Laurinavicius, Arvydas, Levenson, Richard M., Mahboubi-Ardakani, Rustin, Mastropasqua, Mauro G., Osborne, C. Kent, Penault-Llorca, Frédérique M., Piper, Tammy, Quintayo, Mary Anne, Rau, Tilman T., Reinhard, Stefan, Robertson, Stephanie, Salgado, Roberto, Sugie, Tomoharu, van der Vegt, Bert, Viale, Giuseppe, Zabaglo, Lila A., Hayes, Daniel F., Rimm, David L., Dowsett, Mitch, Hayes, Daniel F., McShane, Lisa M., Nielsen, Torsten, Leung, Samuel, Acs, Balazs, Arun, Indu, Augulis, Renaldas, Badve, Sunil S., Bai, Yalai, Bane, Anita L., Bartlett, John M.S., Bayani, Jane, Bigras, Gilbert, Blank, Annika, Buikema, Henk, Chan, Angela, Chang, Martin C., Dodson, Andrew, Ehinger, Anna, Ellis, Matthew, Flowers, Margaret, Focke, Cornelia M., Galderisi, Chad, Gholap, Abhi, Gown, Allen M., Gutierrez, Carolina, Hartman, Douglas J., Hartman, Johan, Hugh, Judith C., Jadhav, Anagha, Kornaga, Elizabeth N., Kreipe, Hans, Lænkholm, Anne-Vibeke, Laurinavicius, Arvydas, Levenson, Richard, Mastropasqua, Mauro, Moriya, Takuya, Nofech-Mozes, Sharon, Osborne, C. Kent, Pan, Hongchao, Pantanowitz, Liron, Penault-Llorca, Frédérique M., Polley, Mei-Yin, Piper, Tammy, Quintayo, Mary Anne, Rau, Tilman T., Rimm, David L., Reinhard, Stefan, Robertson, Stephanie, Ruan, Jason, Salgado, Roberto, Shepherd, Lois, Smith, Ian, Sparano, Joseph, Spears, Melanie, Sugie, Tomoharu, Todd, Austin, van der Vegt, Bert, Viale, Giuseppe, Virk, Shakeel, Wang, Yihong, Yang, Hua, Zhang, Zhiwei, Zlobec, Inti

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Abstract P2-03-01: Analytical validation of a standardized scoring protocol for Ki67 assessed on breast excision whole sections: An international multicenter collaboration by Nielsen, TO, Leung, SCY, Zabaglo, LA, Arun, I, Badve, SS, Bane, AL, Bartlet, JMS, Borgquist, S, Chang, MC, Dodson, A, Ehinger, A, Fineberg, S, Focke, CM, Gao, D, Gown, AM, Gutierrez, C, Hugh, JC, Kos, Z, Lænkholm, A-V, Mastropasqua, MG, Moriya, T, Nofech-Mozes, S, Osborne, CK, Penault-Llorca, FM, Piper, T, Sakatani, T, Salgado, R, Starczynski, J, Sugie, T, van der Vegt, B, Viale, G, Hayes, DF, McShane, LM, Dowsett, M

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Neoadjuvant FEC 100 for Operable Breast Cancer: Eight-Year Experience at Centre Jean Perrin by Mouret-Reynier, Marie-Ange, Abrial, Catherine J., Ferrière, Jean-Pierre, Amat, Sophie, Curé, Hervé D., Kwiatkowski, Fabrice G., Feillel, Viviane A., Lebouëdec, Guillaume, Penault-Llorca, Frédérique M., Chollet, Philippe J.M.

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The path to a better biomarker: application of a risk management framework for the implementation of PD‐L1 and TILs as immuno‐oncology biomarkers into breast cancer clinical trials... by Gonzalez-Ericsson, Paula, Stovgaard, Elisabeth S, Sua, Luz F, Reisenbichler, Emily, Kos, Zuzana, Carter, Jodi M, Michiels, Stefan, Le Quesne, John, Nielsen, Torsten O, Laenkholm, Anne Vibeke, Fox, Stephen B, Adam, Julien, Bartlett, John M S, Rimm, David L, Quinn, Cecily, Peeters, Dieter, Dieci, Maria V, Vincent-Salomon, Anne, Cree, Ian, Hida, Akira I, Balko, Justin M, Haynes, Harry R, Frahm, Isabel, Acosta-Haab, Gabriela, Balancin, Marcelo, Bellolio, Enrique, Yang, Wentao, Kirtani, Pawan, Sugie, Tomoharu, Ehinger, Anna, Castaneda, Carlos A, Kok, Marleen, McArthur, Heather, Siziopikou, Kalliopi, Badve, Sunil, Fineberg, Susan, Gown, Allen M, Viale, Giuseppe, Schnitt, Stuart J, Pruneri, Giancarlo, Penault-Llorca, Frédérique M, Hewitt, Stephen, Thompson, Aubrey, Allison, Kimberly H, Symmans, William F, Bellizzi, Andrew M, Brogi, Edi, Moore, David A., Larsimont, Denis, Dillon, Deborah A, Lazar, Alexander, Lien, Huangchun, Goetz, Matthew P, Broeckx, Glenn, El Bairi, Khalid, Harbeckj, Nadia, Cimino-Mathews, Ashley, Sotiriou, Christos, Adams, Sylvia, Liu, Shi-wei, Loibl, Sibylle, Chen, I-Chun, Lakhani, Sunil R, Juco, Jonathan W, Denkert, Carsten, Blackley, Elisabeth F, Demaria, Sandra, Leon-Ferre, Roberto, Gluz, Oleg, Zardavas, Dimitrios, Emancipator, Kenneth, Ely, Scott, Loi, Sherene, Salgado, Roberto, Sanders, Melinda

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Angiogenesis as a prognostic marker in breast carcinoma with conventional adjuvant chemotherapy: a multiparametric and immunohistochemical analysis by Jacquemier, Jocelyne D., Penault-Llorca, Frederique M., Bertucci, Francois, Sun, Zhen Z., Houvenaeghel, Gilles F., Geneix, Jeanine A., Puig, Brigitte D., Bardou, Valerie Jeanne H., Hassoun, Jacques A., Birnbaum, Daniel, Viens, Patrice J.

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Analytical validation of a standardized scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicenter collaboration by Leung, Samuel CY, Nielsen, Torsten, Zabaglo, Lila A, Arun, Indu, Badve, Sunil S, Bane, Anita L, Bartlett, John, Borgquist, Signe, Chang, Martin C, Dodson, A, Ehinger, Anna, Fineberg, Susan, Focke, Cornelia, Gao, Dongxia, Gown, Allen M, Gutierrez, Carolina, Hugh, Judith C, Kos, Zuzana, Laenkholm, Anne Vibeke, Mastropasqua, Mauro G, Moriya, Takuya, Nofech-Mozes, Sharon, Osborne, C Kent, Penault-Llorca, Frédérique M, Piper, Tammy, Sakatani, Takashi, Salgado, Roberto, Starczynski, Jane, Sugie, Tomoharu, van der Vegt, Bert, Viale, Giuseppe, Hayes, Daniel, McShane, Lisa M, Dowsett, Mitch

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Comparison of the prognostic significance of Chevallier and Sataloff's pathologic classifications after neoadjuvant chemotherapy of operable breast cancer by Penault-Llorca, Frederique, MD, Abrial, Catherine, PhD, Raoelfils, Ines, MD, Cayre, Anne, PhD, Mouret-Reynier, Marie-Ange, MD, Leheurteur, Marianne, MD, Durando, Xavier, MD, Achard, Jean-Louis, MD, Gimbergues, Pierre, MD, Chollet, Philippe, MD

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Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT) by Barlesi, Fabrice, Dr Prof, Mazieres, Julien, Prof, Merlio, Jean-Philippe, Prof, Debieuvre, Didier, MD, Mosser, Jean, Prof, Lena, Hervé, MD, Ouafik, L'Houcine, Prof, Besse, Benjamin, MD, Rouquette, Isabelle, MD, Westeel, Virginie, Prof, Escande, Fabienne, MD, Monnet, Isabelle, MD, Lemoine, Antoinette, Prof, Veillon, Rémi, MD, Blons, Hélène, PharmD, Audigier-Valette, Clarisse, MD, Bringuier, Pierre-Paul, Prof, Lamy, Régine, MD, Beau-Faller, Michèle, MD, Pujol, Jean-Louis, Prof, Sabourin, Jean-Christophe, Prof, Penault-Llorca, Frédérique, Prof, Denis, Marc G, Prof, Lantuejoul, Sylvie, Prof, Morin, Franck, MSc, Tran, Quân, MSc, Missy, Pascale, PhD, Langlais, Alexandra, MSc, Milleron, Bernard, MD, Cadranel, Jacques, Prof, Soria, Jean-Charles, Prof, Zalcman, Gérard, Prof

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KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer by LIEVRE, Astrid, BACHET, Jean-Baptiste, ROUGIER, Philippe, PENAULT-LLORCA, Frédérique, LAURENT-PUIG, Pierre, LE CORRE, Delphine, BOIGE, Valérie, LANDI, Bruno, EMILE, Jean-Francois, COTE, Jean-Francois, TOMASIC, Gorana, PENNA, Christophe, DUCREUX, Michel

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MammaPrint and BluePrint comprehensively capture the cancer hallmarks in early‐stage breast cancer patients by Haan, Josien C., Bhaskaran, Rajith, Ellappalayam, Architha, Bijl, Yannick, Griffioen, Christian J., Lujinovic, Ersan, Audeh, William M., Penault‐Llorca, Frédérique, Mittempergher, Lorenza, Glas, Annuska M.

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HER2 in situ hybridization in breast cancer: clinical implications of polysomy 17 and genetic heterogeneity by Hanna, Wedad M, Rüschoff, Josef, Bilous, Michael, Coudry, Renata A, Dowsett, Mitch, Osamura, Robert Y, Penault-Llorca, Frédérique, van de Vijver, Marc, Viale, Giuseppe

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Update on tumor-infiltrating lymphocytes (TILs) in breast cancer, including recommendations to assess TILs in residual disease after neoadjuvant therapy and in carcinoma in situ: A... by Dieci, Maria Vittoria, Radosevic-Robin, Nina, Fineberg, Susan, van den Eynden, Gert, Ternes, Nils, Penault-Llorca, Frederique, Pruneri, Giancarlo, D’Alfonso, Timothy M., Demaria, Sandra, Castaneda, Carlos, Sanchez, Joselyn, Badve, Sunil, Michiels, Stefan, Bossuyt, Veerle, Rojo, Federico, Singh, Baljit, Nielsen, Torsten, Viale, Giuseppe, Kim, Seong-Rim, Hewitt, Stephen, Wienert, Stephan, Loibl, Sybille, Rimm, David, Symmans, Fraser, Denkert, Carsten, Adams, Sylvia, Loi, Sherene, Salgado, Roberto

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Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer by Taieb, Julien, Le Malicot, Karine, Shi, Qian, Penault-Llorca, Frédérique, Bouché, Olivier, Tabernero, Josep, Mini, Enrico, Goldberg, Richard M, Folprecht, Gunnar, Luc Van Laethem, Jean, Sargent, Daniel J, Alberts, Steven R, Emile, Jean Francois, Laurent Puig, Pierre, Sinicrope, Frank A

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Signatures of mutational processes in human cancer by Alexandrov, Ludmil B, Nik-Zainal, Serena, Wedge, David C, Aparicio, Samuel A J R, Behjati, Sam, Biankin, Andrew V, Bignell, Graham R, Bolli, Niccolò, Borg, Ake, Børresen-Dale, Anne-Lise, Boyault, Sandrine, Burkhardt, Birgit, Butler, Adam P, Caldas, Carlos, Davies, Helen R, Desmedt, Christine, Eils, Roland, Eyfjörd, Jórunn Erla, Foekens, John A, Greaves, Mel, Hosoda, Fumie, Hutter, Barbara, Ilicic, Tomislav, Imbeaud, Sandrine, Imielinski, Marcin, Imielinsk, Marcin, Jäger, Natalie, Jones, David T W, Jones, David, Knappskog, Stian, Kool, Marcel, Lakhani, Sunil R, López-Otín, Carlos, Martin, Sancha, Munshi, Nikhil C, Nakamura, Hiromi, Northcott, Paul A, Pajic, Marina, Papaemmanuil, Elli, Paradiso, Angelo, Pearson, John V, Puente, Xose S, Raine, Keiran, Ramakrishna, Manasa, Richardson, Andrea L, Richter, Julia, Rosenstiel, Philip, Schlesner, Matthias, Schumacher, Ton N, Span, Paul N, Teague, Jon W, Totoki, Yasushi, Tutt, Andrew N J, Valdés-Mas, Rafael, van Buuren, Marit M, van 't Veer, Laura, Vincent-Salomon, Anne, Waddell, Nicola, Yates, Lucy R, Zucman-Rossi, Jessica, Futreal, P Andrew, McDermott, Ultan, Lichter, Peter, Meyerson, Matthew, Grimmond, Sean M, Siebert, Reiner, Campo, Elías, Shibata, Tatsuhiro, Pfister, Stefan M, Campbell, Peter J, Stratton, Michael R

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