DNA methylation and body-mass index: a genome-wide analysis

by Dick, Katherine J, PhD, Nelson, Christopher P, PhD, Tsaprouni, Loukia, PhD, Sandling, Johanna K, PhD, Aïssi, Dylan, MSc, Wahl, Simone, MSc, Meduri, Eshwar, PhD, Morange, Pierre-Emmanuel, Prof, Gagnon, France, PhD, Grallert, Harald, PhD, Waldenberger, Melanie, PhD, Peters, Annette, Prof, Erdmann, Jeanette, Prof, Hengstenberg, Christian, Prof, Cambien, Francois, Prof, Goodall, Alison H, Prof, Ouwehand, Willem H, Prof, Schunkert, Heribert, Prof, Thompson, John R, Prof, Spector, Tim D, FRCP, Gieger, Christian, PhD, Trégouët, David-Alexandre, PhD, Deloukas, Panos, Prof, Samani, Nilesh J, Prof
Published in The Lancet (British edition)

Homocysteine and coronary heart disease: meta-analysis of MTHFR case-control studies, avoiding publication bias

by Clarke, Robert, Bennett, Derrick A, Parish, Sarah, Verhoef, Petra, Dötsch-Klerk, Mariska, Lathrop, Mark, Xu, Peng, Nordestgaard, Børge G, Holm, Hilma, Hopewell, Jemma C, Saleheen, Danish, Tanaka, Toshihiro, Anand, Sonia S, Chambers, John C, Kleber, Marcus E, Ouwehand, Willem H, Yamada, Yoshiji, Elbers, Clara, Peters, Bas, Stewart, Alexandre F R, Reilly, Muredach M, Thorand, Barbara, Yusuf, Salim, Engert, James C, Assimes, Themistocles L, Kooner, Jaspal, Danesh, John, Watkins, Hugh, Samani, Nilesh J, Collins, Rory, Peto, Richard
Published in PLoS medicine

Repeated Replication and a Prospective Meta-Analysis of the Association Between Chromosome 9p21.3 and Coronary Artery Disease

by SCHUNKERT, Heribert, GÖTZ, Anika, BLANKENBERG, Stefan, TIRET, Laurence, DUCIMETIERE, Pierre, KENIRY, Andrew, GHORI, Mohammed J. R, SCHREIBER, Stefan, EL MOKHTARI, Nour Eddine, HALL, Alistair S, DIXON, Richard J, GOODALL, Alison H, BRAUND, Peter, LIPTAU, Henrike, POLLARD, Helen, SCHWARZ, Daniel F, HOTHOM, Ludwig A, WICHMANN, H.-Erich, KÖNIG, Inke R, FISCHER, Marcus, MEISINGER, Christa, OUWEHAND, Willem, DELOUKAS, Panos, MCGINNIS, Ralph, THOMPSON, John R, ERDMANN, Jeanette, ZIEGLER, Andreas, SAMANI, Nilesh J, TREGOUET, David-Alexandre, MANGINO, Massimo, LINSEL-NITSCHKE, Patrick, CAMBIEN, Francois, HENGSTENBERG, Christian, STARK, Klaus
Published in Circulation (New York, N.Y.)

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

by Tsaprouni, Loukia G, Yang, Tsun-Po, Bell, Jordana, Dick, Katherine J, Kanoni, Stavroula, Nisbet, James, Viñuela, Ana, Grundberg, Elin, Nelson, Christopher P, Meduri, Eshwar, Buil, Alfonso, Cambien, Francois, Hengstenberg, Christian, Erdmann, Jeanette, Schunkert, Heribert, Goodall, Alison H, Ouwehand, Willem H, Dermitzakis, Emmanouil, Spector, Tim D, Samani, Nilesh J, Deloukas, Panos
Published in Epigenetics

Integrating genome-wide genetic variations and monocyte expression data reveals trans-regulated gene modules in humans

by Rotival, Maxime, Zeller, Tanja, Wild, Philipp S, Maouche, Seraya, Szymczak, Silke, Schillert, Arne, Castagné, Raphaele, Deiseroth, Arne, Proust, Carole, Brocheton, Jessy, Godefroy, Tiphaine, Perret, Claire, Germain, Marine, Eleftheriadis, Medea, Sinning, Christoph R, Schnabel, Renate B, Lubos, Edith, Lackner, Karl J, Rossmann, Heidi, Münzel, Thomas, Rendon, Augusto, Erdmann, Jeanette, Deloukas, Panos, Hengstenberg, Christian, Diemert, Patrick, Montalescot, Gilles, Ouwehand, Willem H, Samani, Nilesh J, Schunkert, Heribert, Tregouet, David-Alexandre, Ziegler, Andreas, Goodall, Alison H, Cambien, François, Tiret, Laurence, Blankenberg, Stefan
Published in PLoS genetics

Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes

by Garnier, Sophie, Truong, Vinh, Brocheton, Jessy, Zeller, Tanja, Rovital, Maxime, Wild, Philipp S, Ziegler, Andreas, Munzel, Thomas, Tiret, Laurence, Blankenberg, Stefan, Deloukas, Panos, Erdmann, Jeannette, Hengstenberg, Christian, Samani, Nilesh J, Schunkert, Heribert, Ouwehand, Willem H, Goodall, Alison H, Cambien, François, Trégouët, David-Alexandre
Published in PLoS genetics

Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages

by Christofidou, Paraskevi, Nelson, Christopher P., Nikpay, Majid, Qu, Liming, Li, Mingyao, Loley, Christina, Debiec, Radoslaw, Braund, Peter S., Denniff, Matthew, Charchar, Fadi J., Arjo, Ares Rocanin, Trégouët, David-Alexandre, Goodall, Alison H., Cambien, Francois, Ouwehand, Willem H., Roberts, Robert, Schunkert, Heribert, Hengstenberg, Christian, Reilly, Muredach P., Erdmann, Jeanette, McPherson, Ruth, König, Inke R., Thompson, John R., Samani, Nilesh J., Tomaszewski, Maciej
Published in American journal of human genetics

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies

by Keating, Brendan J, Tischfield, Sam, Murray, Sarah S, Bhangale, Tushar, Price, Thomas S, Glessner, Joseph T, Galver, Luana, Barrett, Jeffrey C, Grant, Struan F A, Farlow, Deborah N, Chandrupatla, Hareesh R, Hansen, Mark, Ajmal, Saad, Papanicolaou, George J, Guo, Yiran, Li, Mingyao, Derohannessian, Stephanie, de Bakker, Paul I W, Bailey, Swneke D, Montpetit, Alexandre, Edmondson, Andrew C, Taylor, Kent, Gai, Xiaowu, Wang, Susanna S, Fornage, Myriam, Shaikh, Tamim, Groop, Leif, Boehnke, Michael, Hall, Alistair S, Hattersley, Andrew T, Frackelton, Edward, Patterson, Nick, Chiang, Charleston W K, Kim, Cecelia E, Fabsitz, Richard R, Ouwehand, Willem, Price, Alkes L, Munroe, Patricia, Caulfield, Mark, Drake, Thomas, Boerwinkle, Eric, Reich, David, Whitehead, A Stephen, Cappola, Thomas P, Samani, Nilesh J, Lusis, A Jake, Schadt, Eric, Wilson, James G, Koenig, Wolfgang, McCarthy, Mark I, Kathiresan, Sekar, Gabriel, Stacey B, Hakonarson, Hakon, Anand, Sonia S, Reilly, Muredach, Engert, James C, Nickerson, Deborah A, Rader, Daniel J, Hirschhorn, Joel N, Fitzgerald, Garret A
Published in PloS one

A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways

by Jones, Chris I., Bray, Sarah, Garner, Stephen F., Stephens, Jonathan, de Bono, Bernard, Angenent, Will G.J., Bentley, David, Burns, Philippa, Coffey, Alison, Deloukas, Panos, Earthrowl, Mark, Farndale, Richard W., Hoylaerts, Marc F., Koch, Kerstin, Rankin, Angela, Rice, Catherine M., Rogers, Jane, Samani, Nilesh J., Steward, Michael, Walker, Adam, Watkins, Nicholas A., Akkerman, Jan-Willem, Dudbridge, Frank, Goodall, Alison H., Ouwehand, Willem H.
Published in Blood

Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function

by Goodall, Alison H., Burns, Philippa, Salles, Isabelle, Macaulay, Iain C., Jones, Chris I., Ardissino, Diego, de Bono, Bernard, Bray, Sarah L., Deckmyn, Hans, Dudbridge, Frank, Fitzgerald, Desmond J., Garner, Stephen F., Gusnanto, Arief, Koch, Kerstin, Langford, Cordelia, O'Connor, Marie N., Rice, Catherine M., Stemple, Derek, Stephens, Jonathan, Trip, Mieke D., Zwaginga, Jaap-Jan, Samani, Nilesh J., Watkins, Nicholas A., Maguire, Patricia B., Ouwehand, Willem H.
Published in Blood

Powerful identification of cis-regulatory SNPs in human primary monocytes using allele-specific gene expression

by Almlöf, Jonas Carlsson, Lundmark, Per, Lundmark, Anders, Ge, Bing, Maouche, Seraya, Göring, Harald H H, Liljedahl, Ulrika, Enström, Camilla, Brocheton, Jessy, Proust, Carole, Godefroy, Tiphaine, Sambrook, Jennifer G, Jolley, Jennifer, Crisp-Hihn, Abigail, Foad, Nicola, Lloyd-Jones, Heather, Stephens, Jonathan, Gwilliam, Rhian, Rice, Catherine M, Hengstenberg, Christian, Samani, Nilesh J, Erdmann, Jeanette, Schunkert, Heribert, Pastinen, Tomi, Deloukas, Panos, Goodall, Alison H, Ouwehand, Willem H, Cambien, François, Syvänen, Ann-Christine
Published in PloS one

Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk

by Walsh, Kyle M, Codd, Veryan, Rice, Terri, Nelson, Christopher P, Smirnov, Ivan V, McCoy, Lucie S, Hansen, Helen M, Elhauge, Edward, Ojha, Juhi, Francis, Stephen S, Madsen, Nils R, Bracci, Paige M, Pico, Alexander R, Molinaro, Annette M, Tihan, Tarik, Berger, Mitchel S, Chang, Susan M, Prados, Michael D, Jenkins, Robert B, Wiemels, Joseph L, Samani, Nilesh J, Wiencke, John K, Wrensch, Margaret R
Published in Oncotarget

A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function

by Soranzo, Nicole, Rendon, Augusto, Gieger, Christian, Jones, Chris I., Watkins, Nicholas A., Menzel, Stephan, Döring, Angela, Stephens, Jonathan, Prokisch, Holger, Erber, Wendy, Potter, Simon C., Bray, Sarah L., Burns, Philippa, Jolley, Jennifer, Falchi, Mario, Kühnel, Brigitte, Erdmann, Jeanette, Schunkert, Heribert, Samani, Nilesh J., Illig, Thomas, Garner, Stephen F., Rankin, Angela, Meisinger, Christa, Bradley, John R., Thein, Swee Lay, Goodall, Alison H., Spector, Tim D., Deloukas, Panos, Ouwehand, Willem H.
Published in Blood

Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome

by Charchar, Fadi J, PhD, Bloomer, Lisa DS, MSc, Barnes, Timothy A, PhD, Cowley, Mark J, PhD, Nelson, Christopher P, PhD, Wang, Yanzhong, PhD, Denniff, Matthew, BSc, Debiec, Radoslaw, MD, Christofidou, Paraskevi, MSc, Nankervis, Scott, PhD, Dominiczak, Anna F, MD, Bani-Mustafa, Ahmed, PhD, Balmforth, Anthony J, MD, Hall, Alistair S, MD, Erdmann, Jeanette, PhD, Cambien, Francois, PhD, Deloukas, Panos, PhD, Hengstenberg, Christian, MD, Packard, Chris, MD, Schunkert, Heribert, MD, Ouwehand, Willem H, MD, Ford, Ian, PhD, Goodall, Alison H, PhD, Jobling, Mark A, PhD, Samani, Nilesh J, MD, Tomaszewski, Maciej, Dr
Published in The Lancet (British edition)

A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site

by Nürnberg, Sylvia T., Rendon, Augusto, Smethurst, Peter A., Paul, Dirk S., Voss, Katrin, Thon, Jonathan N., Lloyd-Jones, Heather, Sambrook, Jennifer G., Tijssen, Marloes R., Italiano, Joseph E., Deloukas, Panos, Gottgens, Berthold, Soranzo, Nicole, Ouwehand, Willem H.
Published in Blood

Whole-exome sequencing in an extended family with myocardial infarction unmasks familial hypercholesterolemia

by Brænne, Ingrid, Reiz, Benedikt, Medack, Anja, Kleinecke, Mariana, Fischer, Marcus, Tuna, Salih, Hengstenberg, Christian, Deloukas, Panos, Erdmann, Jeanette, Schunkert, Heribert
Published in BMC cardiovascular disorders

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation

by Huang, Jie, Sabater-Lleal, Maria, Asselbergs, Folkert W., Tregouet, David, Shin, So-Youn, Ding, Jingzhong, Baumert, Jens, Oudot-Mellakh, Tiphaine, Folkersen, Lasse, Johnson, Andrew D., Smith, Nicholas L., Williams, Scott M., Ikram, Mohammad A., Kleber, Marcus E., Becker, Diane M., Truong, Vinh, Mychaleckyj, Josyf C., Tang, Weihong, Yang, Qiong, Sennblad, Bengt, Moore, Jason H., Williams, Frances M.K., Dehghan, Abbas, Silbernagel, Günther, Schrijvers, Elisabeth M.C., Smith, Shelly, Karakas, Mahir, Tofler, Geoffrey H., Silveira, Angela, Navis, Gerjan J., Lohman, Kurt, Chen, Ming-Huei, Peters, Annette, Goel, Anuj, Hopewell, Jemma C., Chambers, John C., Saleheen, Danish, Lundmark, Per, Psaty, Bruce M., Strawbridge, Rona J., Boehm, Bernhard O., Carter, Angela M., Meisinger, Christa, Peden, John F., Bis, Joshua C., McKnight, Barbara, Öhrvik, John, Taylor, Kent, Franzosi, Maria Grazia, Seedorf, Udo, Collins, Rory, Franco-Cereceda, Anders, Syvänen, Ann-Christine, Goodall, Alison H., Yanek, Lisa R., Cushman, Mary, Müller-Nurasyid, Martina, Folsom, Aaron R., Basu, Saonli, Matijevic, Nena, van Gilst, Wiek H., Kooner, Jaspal S., Hofman, Albert, Danesh, John, Clarke, Robert, Meigs, James B., Kathiresan, Sekar, Reilly, Muredach P., Klopp, Norman, Harris, Tamara B., Winkelmann, Bernhard R., Grant, Peter J., Hillege, Hans L., Watkins, Hugh, Spector, Timothy D., Becker, Lewis C., Tracy, Russell P., März, Winfried, Uitterlinden, Andre G., Eriksson, Per, Cambien, Francois, Morange, Pierre-Emmanuel, Koenig, Wolfgang, Soranzo, Nicole, van der Harst, Pim, Liu, Yongmei, O'Donnell, Christopher J., Hamsten, Anders
Published in Blood

Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression

by Greliche, Nicolas, Zeller, Tanja, Wild, Philipp S, Rotival, Maxime, Schillert, Arne, Ziegler, Andreas, Deloukas, Panos, Erdmann, Jeanette, Hengstenberg, Christian, Ouwehand, Willem H, Samani, Nilesh J, Schunkert, Heribert, Munzel, Thomas, Lackner, Karl J, Cambien, François, Goodall, Alison H, Tiret, Laurence, Blankenberg, Stefan, Trégouët, David-Alexandre
Published in PloS one

Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene

by Davison, Lucy J, Wallace, Chris, Cooper, Jason D, Cope, Nathan F, Wilson, Nicola K, Smyth, Deborah J, Howson, Joanna M.M, Saleh, Nada, Al-Jeffery, Abdullah, Angus, Karen L, Stevens, Helen E, Nutland, Sarah, Duley, Simon, Coulson, Richard M.R, Walker, Neil M, Burren, Oliver S, Rice, Catherine M, Cambien, Francois, Zeller, Tanja, Munzel, Thomas, Lackner, Karl, Blankenberg, Stefan, Fraser, Peter, Gottgens, Berthold, Todd, John A
Published in Human molecular genetics

Single nucleotide polymorphisms with cis-regulatory effects on long non-coding transcripts in human primary monocytes

by Almlöf, Jonas Carlsson, Lundmark, Per, Lundmark, Anders, Ge, Bing, Pastinen, Tomi, Goodall, Alison H, Cambien, François, Deloukas, Panos, Ouwehand, Willem H, Syvänen, Ann-Christine
Published in PloS one