Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned? by Deng, Rong, Iyer, Suhasini, Theil, Frank-Peter, Mortensen, Deborah L., Fielder, Paul J., Prabhu, Saileta

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An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ by Adolfsson, Oskar, Pihlgren, Maria, Toni, Nicolas, Varisco, Yvan, Buccarello, Anna Lucia, Antoniello, Katia, Lohmann, Sophie, Piorkowska, Kasia, Gafner, Valerie, Atwal, Jasvinder K, Maloney, Janice, Chen, Mark, Gogineni, Alvin, Weimer, Robby M, Mortensen, Deborah L, Friesenhahn, Michel, Ho, Carole, Paul, Robert, Pfeifer, Andrea, Muhs, Andreas, Watts, Ryan J

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Effect of antigen binding affinity and effector function on the pharmacokinetics and pharmacodynamics of anti-IgE monoclonal antibodies by Mortensen, Deborah L., Prabhu, Saileta, Stefanich, Eric G., Kadkhodayan-Fischer, Saloumeh, Gelzleichter, Thomas R., Baker, Dana, Jiang, Jenny, Wallace, Kristin, Iyer, Suhasini, Fielder, Paul J., Putnam, Wendy S.

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Molecular Mimics of Insulin-like Growth Factor 1 (IGF-1) for Inhibiting IGF-1:  IGF-Binding Protein Interactions by Lowman, Henry B, Chen, Yvonne M, Skelton, Nicholas J, Mortensen, Deborah L, Tomlinson, Elizabeth E, Sadick, Michael D, Robinson, Iain C. A. F, Clark, Ross G

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Pharmacokinetics and Pharmacodynamics of Multiple Weekly Subcutaneous Efalizumab Doses in Patients With Plaque Psoriasis by Mortensen, Deborah L., Walicke, Patricia A., Wang, Xiaolin, Kwon, Paul, Kuebler, Peter, Gottlieb, Alice B., Krueger, James G., Leonardi, Craig, Miller, Bruce, Joshi, Amita

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A Phase I Study With MABT5102A, an Anti-abeta Antibody, in Patients With Mild to Moderate Alzheimer's Disease by Boxer, Adam L, Mortensen, Deborah L, Li, Jing, Pham, Khanh, Friesenhahn, Michel, Ho, Carole, Paul, Robert

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Selection of an anti-Abeta antibody that binds various forms of Abeta and blocks toxicity both in vitro and in vivo by Watts, Ryan J, Chen, Mark, Atwal, Jasvinder, Greve, Joan M, Wu, Yongjian, Mortensen, Deborah L, Varisco, Yvan, Aldolfsson, Oskar, Pihlgren, Maria, Pfeifer, Andrea, Muhs, Andreas

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Binding Protein-3-Selective Insulin-Like Growth Factor I Variants: Engineering, Biodistributions, and Clearance by Dubaquié, Yves, Mortensen, Deborah L, Intintoli, Anthony, Hogue, Deborah A, Nakamura, Gerald, Rancatore, Patricia, Lester, Philip, Sadick, Michael D, Filvaroff, Ellen, Fielder, Paul J, Lowman, Henry B

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P4‐082: A Phase I Study With MABT5102A, an Anti‐abeta Antibody, in Patients With Mild to Moderate Alzheimer's Disease by Boxer, Adam L., Mortensen, Deborah L., Li, Jing, Pham, Khanh, Friesenhahn, Michel, Ho, Carole, Paul, Robert

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P3‐283: Selection of an anti‐Abeta antibody that binds various forms of Abeta and blocks toxicity both in vitro and in vivo by Watts, Ryan J., Chen, Mark, Atwal, Jasvinder, Greve, Joan M., Wu, Yongjian, Mortensen, Deborah L., Varisco, Yvan, Aldolfsson, Oskar, Pihlgren, Maria, Pfeifer, Andrea, Muhs, Andreas

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Differential long-term effects of insulin-like growth factor-I (IGF-I) growth hormone (GH), and IGF-I plus GH on body growth and IGF binding proteins in hypophysectomized rats by Fielder, P J, Mortensen, D L, Mallet, P, Carlsson, B, Baxter, R C, Clark, R G

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Growth Hormone Secretagogues: Characterization, Efficacy, and Minimal Bioactive Conformation by McDowell, Robert S., Elias, Kathleen A., Stanley, Mark S., Burdick, Daniel J., Burnier, John P., Chan, Kathryn S., Fairbrother, Wayne J., Hammonds, R. Glenn, Gladys S.Ingle, Jacobsen, Neil E., Mortensen, Deborah L., Rawson, Thomas E., Won, Wesley B., Clark, Ross G., Somers, Todd C.

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Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001 by Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores by Gusev, Alexander, Ripke, Stephan, Walters, James T.R., Agartz, Ingrid, Albus, Margot, Bene, Judit, Bevilacqua, Elizabeth, Bigdeli, Tim B., Bruggeman, Richard, Buckner, Randy L., Carr, Vaughan J., Catts, Stanley V., Chan, Raymond C.K., Cheng, Wei, Cohen, Nadine, Curtis, David, Dikeos, Dimitris, Dinan, Timothy, Eriksson, Johan, Escott-Price, Valentina, Franke, Lude, Godard, Stephanie, Goldstein, Jacqueline I., de Haan, Lieuwe, Hartmann, Annette M., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Kim, Yunjung, Kucinskas, Vaidutis, Laurent, Claudine, Limborska, Svetlana, Loughland, Carmel M., Macek, Milan, Marsal, Sara, Mattheisen, Manuel, Milanova, Vihra, Mors, Ole, Mortensen, Preben B., Olsen, Line, Parkhomenko, Elena, Paunio, Tiina, Pimm, Jonathan, Purcell, Shaun M., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roussos, Panos, Ruderfer, Douglas M., Sigurdsson, Engilbert, Silverman, Jeremy M., So, Hon-Cheong, Spencer, Chris C.A., Stefansson, Hreinn, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Svrakic, Dragan M., Tosato, Sarah, Veijola, Juha, Walsh, Dermot, Wang, Dai, Weiser, Mark, Wolen, Aaron R., Wong, Emily H.M., Stefansson, Kari, Andreassen, Ole A., Ehrenreich, Hannelore, Gill, Michael, Hultman, Christina M., Jablensky, Assen V., McQuillin, Andrew, Pato, Carlos N., Rietschel, Marcella, Sham, Pak C., Sklar, Pamela, Weinberger, Daniel R., Daly, Mark J., Crisponi, Laura, Figueroa, Jonine, Gaudet, Mia M., Hall, Per, Hein, Rebecca, Irwanto, Astrid, Johansson, Mattias, Lund, Eiliv, Peto, Julian, Rahman, Nazneen, Southey, Melissa C., Travis, Ruth, Waisfisz, Quinten, Pato, Carlos, Stahl, Eli, Belbin, Gillian, Kenny, Eimear E., Purcell, Shaun, Chasman, Daniel, Neale, Benjamin

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Synthesis and Biological Evaluation of a Novel Series of Furans:  Ligands Selective for Estrogen Receptor α by Mortensen, Deborah S, Rodriguez, Alice L, Carlson, Kathryn E, Sun, Jun, Katzenellenbogen, Benita S, Katzenellenbogen, John A

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A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple Cohorts by Ni, Guiyan, Wang, Ying, Ge, Tian, Smoller, Jordan W., Ripke, Stephan, Farh, Kai-How, Holmans, Peter A., Agartz, Ingrid, Belliveau, Richard A., Bigdeli, Tim B., Black, Donald W., Buckner, Randy L., Cheng, Wei, Degenhardt, Franziska, Dudbridge, Frank, Eichhammer, Peter, Farrell, Martilias S., Frank, Josef, Freedman, Robert, Friedl, Marion, Giegling, Ina, Giusti-Rodríguez, Paola, Gratten, Jacob, Hartmann, Annette M., Hollegaard, Mads V., Kahn, René S., Karachanak-Yankova, Sena, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Knowles, James A., Kucinskiene, Zita Ausrele, Li, Tao, Loughland, Carmel M., Lubinski, Jan, Maier, Wolfgang, Mallet, Jacques, Michie, Patricia T., Myin-Germeys, Inez, Nertney, Deborah A., Nicodemus, Kristin K., Nikitina-Zake, Liene, O’Callaghan, Eadbhard, O’Dushlaine, Colm, Pejovic-Milovancevic, Milica, Pocklington, Andrew J., Powell, John, Pulver, Ann E., Ruderfer, Douglas M., Salomaa, Veikko, Shi, Jianxin, Sim, Kang, Slominsky, Petr, Spencer, Chris C.A., Stahl, Eli A., Steinberg, Stacy, Stogmann, Elisabeth, Suvisaari, Jaana, Williams, Nigel M., Witt, Stephanie H., Wormley, Brandon K., Blackwood, Douglas H.R., Bramon, Elvira, Buxbaum, Joseph D., Esko, Tõnu, Gurling, Hugh, Moran, Jennifer L., Mowry, Bryan J., Owen, Michael J., Petryshen, Tracey L., Weinberger, Daniel R., Byrne, Enda M., Abdellaoui, Abdel, Andlauer, Till F.M., Castelao, Enrique, Derks, Eske M., Foo, Jerome C., Forstner, Andreas J., Hall, Lynsey S., Homuth, Georg, Jansen, Rick, Jones, Ian, Jones, Lisa A., Kretzschmar, Warren W., McGuffin, Peter, Mihailov, Evelin, Mostafavi, Sara, Nivard, Michel G., O’Reilly, Paul F., Quiroz, Jorge A., Smith, Daniel J., Thompson, Wesley, Treutlein, Jens, Umbricht, Daniel, Wu, Yang, Zhang, Futao, Grabe, Hans J., Hayward, Caroline, Lewis, Glyn, Wray, Naomi R.

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Cosmopolitan Distribution of Endozoicomonas-Like Organisms and Other Intracellular Microcolonies of Bacteria Causing Infection in Marine Mollusks by Cano, Irene, Ryder, David, Webb, Steve C., Jones, Brian J., Brosnahan, Cara L., Carrasco, Noelia, Bodinier, Barbara, Furones, Dolors, Pretto, Tobia, Carella, Francesca, Chollet, Bruno, Arzul, Isabelle, Cheslett, Deborah, Collins, Evelyn, Lohrmann, Karin B., Valdivia, Ana L., Ward, Georgia, Carballal, María J., Villalba, Antonio, Marigómez, Ionan, Mortensen, Stein, Christison, Kevin, Kevin, Wakeman C., Bustos, Eduardo, Christie, Lyndsay, Green, Matthew, Feist, Stephen W.

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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders by Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Bergen, Sarah E., Cai, Guiqing, Chambert, Kimberly D., Chen, Eric Y.H., Cloninger, C. Robert, Cohen, David, Cormican, Paul, Djurovic, Srdjan, Drapeau, Elodie, Durmishi, Naser, Genovese, Giulio, Herms, Stefan, Hofman, Andrea, Kalaydjieva, Luba, Kim, Yunjung, Kuzelova-Ptackova, Hana, Liang, Kung-Yee, Lönnqvist, Jouko, Maher, Brion S., Meier, Sandra, Milanova, Vihra, Parkhomenko, Elena, Paunio, Tiina, Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Richards, Alexander L., Roussos, Panos, Sim, Kang, So, Hon-Cheong, Strengman, Eric, Strohmaier, Jana, Svrakic, Dragan M., Tosato, Sarah, Weiser, Mark, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Liu, Jianjun, McQuillin, Andrew, Rujescu, Dan, Sullivan, Patrick F., Barroso, Ines, Mathew, Christopher G., Trembath, Richard C., Su, Zhan, Bumpstead, Suzannah J., Gillman, Matthew, McCann, Owen T., Iyegbe, Conrad, Milani, Lili, Palotie, Aarno, Sanders, Alan R., Bramon, Elvira, Lee, Jimmy, Breen, Gerome, Whitehead Pavlides, Jennifer M., Pedersen, Carsten Bøcker, Bøen, Erlend, Coryell, William, Dobbyn, Amanda L., Garnham, Julie, Pedersen, Marianne Giørtz, Gordon-Smith, Katherine, Kupka, Ralph, Martinsson, Lina, McKay, James D., Meng, Fan, Mullins, Niamh, Rivera, Margarita, Shehktman, Tatyana, Spijker, Anne T., Streit, Fabian, Vedder, Helmut, Weickert, Thomas W., Zandi, Peter, Zöllner, Sebastian, Kogevinas, Manolis, Nöthen, Markus M., Smeland, Olav B., Andreassen, Ole A., Abdellaoui, Abdel, Andlauer, Till F.M., Eley, Thalia C., Lind, Penelope A., Mostafavi, Sara, Smith, Daniel J., Wellmann, Jürgen, Hayward, Caroline, Schaefer, Catherine, Boomsma, Dorret I., Willemsen, Gonneke, Teumer, Alexander, Van der Auwera, Sandra, Blokland, Gabriëlla A.M., Plath, Niels

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Genetic correlation between amyotrophic lateral sclerosis and schizophrenia by McLaughlin, Russell L, Schijven, Dick, van Rheenen, Wouter, van Eijk, Kristel R, O'Brien, Margaret, Kahn, René S, Ophoff, Roel A, Goris, An, Bradley, Daniel G, Al-Chalabi, Ammar, van den Berg, Leonard H, Luykx, Jurjen J, Hardiman, Orla, Veldink, Jan H

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Structure-based optimization of aminothiadiazole inhibitors of AKT by Mortensen, Deborah S., Hegde, Sayee G., Perrin-Ninkovic, Sophie M., Bahmanyar, Sogole, McCarrick, Meg, Harris, Roy, Hilgraf, Robert, Lee, Branden G. S., McKie, Jeff, Nadolny, Lisa, Sapienza, John, Collette, Alice, Cox, Sarah, Gamez, James C., Hensel, Jennifer L., Hua, Xuequn Helen, Leisten, Jim, Raymon, Heather K., Tran, Tam, Narla, Rama Krishna

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